Cited by 962Cellular transport and secretionAutophagy in Disease and TherapyUbiquitin and proteasome pathways

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The many functions of ESCRTs

Vietri, Marina, Radulovic, Maja, Stenmark, Harald·2020·Nature Reviews Molecular Cell Biology

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Abstract

Cellular membranes can form two principally different involutions, which either exclude or contain cytosol. The 'classical' budding reactions, such as those occurring during endocytosis or formation of exocytic vesicles, involve proteins that assemble on the cytosol-excluding face of the bud neck. Inverse membrane involution occurs in a wide range of cellular processes, supporting cytokinesis, endosome maturation, autophagy, membrane repair and many other processes. Such inverse membrane remodelling is mediated by a heteromultimeric protein machinery known as endosomal sorting complex required for transport (ESCRT). ESCRT proteins assemble on the cytosolic (or nucleoplasmic) face of the neck of the forming involution and cooperate with the ATPase VPS4 to drive membrane scission or sealing. Here, we review similarities and differences of various ESCRT-dependent processes, with special emphasis on mechanisms of ESCRT recruitment.

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Additional file 23 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
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Additional file 6 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Pipaliya, S. V., Santos, R., Salas-Leiva, D. E., Balmer, E. A., Wirdnam, C. D., Roger, A. J., Hehl, A. B., Faso, C., & Dacks, J. B. (2021) · Figshare · doi:10.6084/m9.figshare.16456806
Additional file 5 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Pipaliya, S. V., Santos, R., Salas-Leiva, D. E., Balmer, E. A., Wirdnam, C. D., Roger, A. J., Hehl, A. B., Faso, C., & Dacks, J. B. (2021) · Figshare · doi:10.6084/m9.figshare.16456803
Additional file 3 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Pipaliya, S. V., Santos, R., Salas-Leiva, D. E., Balmer, E. A., Wirdnam, C. D., Roger, A. J., Hehl, A. B., Faso, C., & Dacks, J. B. (2021) · Figshare · doi:10.6084/m9.figshare.16456794
Additional file 18 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Pipaliya, S. V., Santos, R., Salas-Leiva, D. E., Balmer, E. A., Wirdnam, C. D., Roger, A. J., Hehl, A. B., Faso, C., & Dacks, J. B. (2021) · Figshare · doi:10.6084/m9.figshare.16456749
Additional file 8 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Pipaliya, S. V., Santos, R., Salas-Leiva, D. E., Balmer, E. A., Wirdnam, C. D., Roger, A. J., Hehl, A. B., Faso, C., & Dacks, J. B. (2021) · Figshare · doi:10.6084/m9.figshare.16456812
Additional file 1 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Pipaliya, S. V., Santos, R., Salas-Leiva, D. E., Balmer, E. A., Wirdnam, C. D., Roger, A. J., Hehl, A. B., Faso, C., & Dacks, J. B. (2021) · Figshare · doi:10.6084/m9.figshare.16456758
Additional file 2 of The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei
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Additional file 10 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Pipaliya, S. V., Santos, R., Salas-Leiva, D. E., Balmer, E. A., Wirdnam, C. D., Roger, A. J., Hehl, A. B., Faso, C., & Dacks, J. B. (2021) · Figshare · doi:10.6084/m9.figshare.16456737
Additional file 10 of The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways
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Additional file 4 of Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata
Pipaliya, S. V., Santos, R., Salas-Leiva, D. E., Balmer, E. A., Wirdnam, C. D., Roger, A. J., Hehl, A. B., Faso, C., & Dacks, J. B. (2021) · Figshare · doi:10.6084/m9.figshare.16456797
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Authors: Vietri, M., Radulovic, M., & Stenmark, H.
Affiliations: Oslo University Hospital (NO)
Corresponding author: Stenmark, Harald
ORCID: Vietri, Marina
Radulovic, Maja
Stenmark, Harald
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2019-11-08
Volume: 21
Issue: 1
Pages: 25-42
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/s41580-019-0177-4
OpenAlex: W2985101511
Cited by: 962
References: 221
Citations by year: 2026: 117 · 2025: 159 · 2024: 165 · 2023: 144 · 2022: 150 · 2021: 152 · 2020: 74 · 2019: 1
FWCI: 10.94
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: ESCRT, membrane fission, membrane sealing, cytokinesis, endosome maturation, autophagy, membrane repair, viral replication, budding
MeSH terms: Spastin, Animals, Cell Membrane, Humans, Neurons, Nuclear Envelope, Phagosomes, Endosomes, Virus Replication, Protein Transport, Cytokinesis, Host-Pathogen Interactions, Exosomes, Endosomal Sorting Complexes Required for Transport

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