The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Mechanisms of bone development and repair
Open accessAbstract
Bone development occurs through a series of synchronous events that result in the formation of the body scaffold. The repair potential of bone and its surrounding microenvironment — including inflammatory, endothelial and Schwann cells — persists throughout adulthood, enabling restoration of tissue to its homeostatic functional state. The isolation of a single skeletal stem cell population through cell surface markers and the development of single-cell technologies are enabling precise elucidation of cellular activity and fate during bone repair by providing key insights into the mechanisms that maintain and regenerate bone during homeostasis and repair. Increased understanding of bone development, as well as normal and aberrant bone repair, has important therapeutic implications for the treatment of bone disease and ageing-related degeneration. This Review discusses the cell types, critical genes and transcription factors involved in bone development and repair. The dysfunctional cellular and molecular signalling that results in clinical bone disease is also outlined, thus informing the current state of science and clinical practice.
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Cited by
Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering
Xue, X., Hu, Y., Wang, S., Chen, X., Jiang, Y., & Su, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.10.029 · Cited by 423
Current Status of the Diagnosis and Management of Osteoporosis
Aibar-Almazán, A., Voltes-Martínez, A., Castellote-Caballero, Y., Afanador-Restrepo, D. F., Carcelén-Fraile, M. D. C., & López-Ruiz, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169465 · Cited by 412
Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds
Xu, Y., Zhang, F., Zhai, W., Cheng, S., Li, J., & Wang, Y. (2022) · Polymers · doi:10.3390/polym14030566 · Cited by 349
Guo, J., Wang, F., Hu, Y., Luo, Y., Wei, Y., Xu, K., Zhang, H., Liu, H., Bo, L., Lv, S., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100881 · Cited by 126
Hallmarks of peripheral nerve function in bone regeneration
Tao, R., Mi, B., Hu, Y., Lin, S., Xiong, Y., Lu, X., Panayi, A. C., Li, G., & Liu, G. (2023) · Bone Research · doi:10.1038/s41413-022-00240-x · Cited by 110
Metadata
- Authors
- Salhotra, A., Shah, H. N., Levi, B., & Longaker, M. T.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2020-09-08
- Volume
- 21
- Issue
- 11
- Pages
- 696-711
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W3083915579
- Cited by
- 1,186
- References
- 21
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- green
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