The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Target gene-independent functions of MYC oncoproteins
Open accessAbstract
Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large body of evidence indicates that MYC proteins are transcription factors, studying their function has focused on the biology of their target genes. Detailed studies of MYC-dependent changes in RNA levels have provided contrasting models of the oncogenic activity of MYC proteins through either enhancing or repressing the expression of specific target genes, or as global amplifiers of transcription. In this Review, we first summarize the biochemistry of MYC proteins and what is known (or is unclear) about the MYC target genes. We then discuss recent progress in defining the interactomes of MYC and MYCN and how this information affects central concepts of MYC biology, focusing on mechanisms by which MYC proteins modulate transcription. MYC proteins promote transcription termination upon stalling of RNA polymerase II, and we propose that this mechanism enhances the stress resilience of basal transcription. Furthermore, MYC proteins coordinate transcription elongation with DNA replication and cell cycle progression. Finally, we argue that the mechanism by which MYC proteins regulate the transcription machinery is likely to promote tumorigenesis independently of global or relative changes in the expression of their target genes.
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“Myc proteins, synthesized after transcription and translation of Myc gene, plays a critical role in pathways related to tumor development, including proliferation, apoptosis, differentiation, metabolism, and adaptive cancer resistance.412–414”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [413]
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BindingDB Entry 50018504: Targeting MYC: From understanding its biology to drug discovery.
BindingDB (2024) · UC San Diego · doi:10.7270/q2qz2g61
BindingDB (2023) · UC San Diego · doi:10.7270/q2b85d61
Metadata
- Authors
- Baluapuri, A., Wolf, E., & Eilers, M.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Eilers, Martin
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2020-02-18
- Volume
- 21
- Issue
- 5
- Pages
- 255-267
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC7611238
- OpenAlex
- W3007097494
- Cited by
- 310
- References
- 130
- Citations by year
- 2026: 29 · 2025: 48 · 2024: 63 · 2023: 60 · 2022: 50 · 2021: 51 · 2020: 9
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- Myc oncoprotein, MYCN, transcription factors, target genes, RNA polymerase II stalling, transcription termination, transcription elongation, DNA replication, cell cycle progression, stress resilience, basal transcription, carcinogenesis, protein-protein interaction network, transcriptional regulation
- MeSH terms
- N-Myc Proto-Oncogene Protein, Cell Cycle, DNA Replication, Humans, Neoplasms, Transcription Factors, Transcription, Genetic, Oncogene Proteins, Proto-Oncogene Proteins c-myc, Cell Proliferation, Carcinogenesis
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