Target gene-independent functions of MYC oncoproteins

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986

A Phase Separation Model for Transcriptional Control

Hnisz, D., Shrinivas, K., Young, R. A., Chakraborty, A. K., & Sharp, P. A. (2017) · Cell · doi:10.1016/j.cell.2017.02.007 · Cited by 1,753

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,543

MYC, Metabolism, and Cancer

Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,435

MYC regulates the antitumor immune response through CD47 and PD-L1

Casey, S. C., Tong, L., Li, Y., Do, R., Walz, S., Fitzgerald, K. N., Gouw, A. M., Baylot, V., Gütgemann, I., Eilers, M., et al. (2016) · Science · doi:10.1126/science.aac9935 · Cited by 1,403

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D. R., Tessarollo, L., Casellas, R. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.033 · Cited by 1,106

Genomic targets of the human c-Myc proteinPreprint

Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J. R., Cocito, A., & Amati, B. B. (2003) · Genes & Development · doi:10.1101/gad.1067003 · Cited by 963

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

Welcker, M., Orian, A., Jin, J., Grim, J. A., Harper, J. W., Eisenman, R. N., & Clurman, B. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402770101 · Cited by 942

Heart failure-specific cardiac fibroblasts contribute to cardiac dysfunction via the MYC–CXCL1–CXCR2 axis

Komuro, J., Hashimoto, H., Katsuki, T., Kusumoto, D., Katoh, M., Ko, T., Ito, M., Katagiri, M., Kubota, M., Yamada, S., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00698-y · Cited by 20

Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

Sampadi, B. K., Vermeulen, S., Mišovic, B., Boei, J. J. W. A., Batth, T. S., Chang, J.-G., Paulsen, M. T., Magnuson, B., Schimmel, J., Kool, H., et al. (2022) · Cells · doi:10.3390/cells11233794 · Cited by 18

The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage

Jin, C., Einig, E., Xu, W., Kollampally, R. B., Schlösser, A., Flentje, M., & Popov, N. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae004 · Cited by 17

Vibrio splendidus infection promotes circRNA-FGL1-regulated coelomocyte apoptosis via competitive binding to Myc with the deubiquitinase OTUB1 in Apostichopus japonicus

Guo, M. Z., Li, X., Tao, W., Teng, F., & Li, C. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012463 · Cited by 16

HPV16 integration regulates ferroptosis resistance via the c-Myc/miR-142-5p/HOXA5/SLC7A11 axis during cervical carcinogenesis

Chen, X., Guo, C.-H., Yang, Y., Wang, Z., Liang, Y., Cai, Y.-Q., Cui, X., Fan, L., & Wang, W. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01309-2 · Cited by 16

WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc

Li, J., Qi, X., Lai, M., Zhou, J., Yuan, M., You, J., Liu, Q., Pan, J., Zhao, L., Ying, M., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2407904121 · Cited by 17

c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle

Yegambaram, M., Sun, X., Lü, Q., Flores, A. G., Zemskova, M., Soto, J. E., Rauckhorst, A. J., Maltepe, E., Wang, T., Fineman, J. R., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103765 · Cited by 17

Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma

Gao, J., Wang, Q., Fu, F., Zhao, Y., Yang, T., Li, X., Sun, Y., Hu, H., Ma, L., Miao, L., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02306-8 · Cited by 20

Reprogramming the tumor microenvironment with c-MYC-based gene circuit platform to enhance specific cancer immunotherapy

Zhan, H., Wang, H., Pan, B., Lu, J., Xiao, K., Lai, J., Chen, Z., Jie, K., Chen, S., Li, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63377-3 · Cited by 18

Immune evasion: An imperative and consequence of MYC deregulation

Krenz, B., Lee, J., Kannan, T., & Eilers, M. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13695 · Cited by 15

Cellular senescence in neuroblastoma

Zanotti, S., Decaesteker, B., Vanhauwaert, S., Wilde, B. D., Vos, W. H. D., & Speleman, F. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01755-0 · Cited by 15

The emerging roles of the interaction between m6A modification and c‐Myc in driving tumorigenesis and development

Zheng, L., Li, M., Wei, J., Chen, S., Xue, C., Zhan, Y., Duan, Y., Deng, H., Xiong, W., Li, G., et al. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30733 · Cited by 15

Distinct immunophenotypic profiles and neutrophil heterogeneity in colorectal cancer

Bai, M., Jin, Y., Jin, Z., Xie, Y., Chen, J., Zhong, Q., Wang, Z., Zhang, Q., Cai, Y., Qun, F., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217570 · Cited by 17

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer

Ruan, H., Leibowitz, B. J., Peng, Y., Shen, L., Chen, L., Kuang, C., Schoen, R. E., Lu, X., Zhang, L., & Yu, J. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00070-7 · Cited by 14

PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma

Gaballa, A., Gebhardt-Wolf, A., Krenz, B., Mattavelli, G., John, M., Cossa, G., Andreani, S., Schülein‐Völk, C., Montesinos, F., Vidal, R. S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45760-8 · Cited by 14

MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription

Liu, Z., Zhang, X., Xu, M., Hong, J. J., Ciardiello, A. K., Lei, H., Shern, J. F., & Thiele, C. J. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002240 · Cited by 14

Phase separation of Myc differentially modulates the transcriptomePreprint

Yang, J., Chung, C.-I., Koach, J., Liu, H., Navalkar, A., Zhao, Q. C., Yang, X., He, L., Mittag, T., Shen, Y., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.28.498043 · Cited by 14

Nuak kinase signaling in development and disease of the central nervous system

Bennison, S. A., Liu, X., & Toyo‐oka, K. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110472 · Cited by 14

Rapid flow-based synthesis of post-translationally modified peptides and proteins: a case study on MYC's transactivation domain

Williams, E. T., Schiefelbein, K., Schuster, M., Ahmed, I. M. M., De Vries, M., Beveridge, R., Zerbe, O., & Hartrampf, N. (2024) · Chemical Science · doi:10.1039/d4sc00481g · Cited by 13

Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune evasion

Sun, Y., Nie, W., Xiahou, Z., Wang, X., Liu, W., Liu, Z., Lin, Z., & Zd, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1591123 · Cited by 13

Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue

Beaulieu, M.-E., Martínez-Martín, S., Kaur, J., Castillo Cano, V., Massó-Vallés, D., Foradada Felip, L., López-Estévez, S., Serrano del Pozo, E., Thabussot, H., & Soucek, L. (2023) · Cancers · doi:10.3390/cancers15030826 · Cited by 12

MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids

Uhl, L., Aziba, A., Loebbert, S., Russell, T. J., Krenz, B., Montesinos, F., Kannan, T., Valanju, O. R., Schülein‐Völk, C., de Martines, T., et al. (2026) · Cell · doi:10.1016/j.cell.2025.12.019 · Cited by 12

MYC drives autophagy to adapt to stress in Penaeus vannamei

Dong, W., Liao, M., Zhuang, X., Huang, L., Liu, C., Wang, F., Yin, X., Liu, Y., Liang, Q., & Wang, W. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.05.020 · Cited by 12

Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest

Kubíčková, A., Sanctis, J. B. D., & Hajdúch, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417524 · Cited by 11

TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC

Yu, J., Li, M., Ju, L., Zhou, F., Wang, Y., Zhang, Y., Zhang, R., Du, W., Huang, R., Qian, K., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02922-0 · Cited by 12

Polydatin: A natural compound with multifaceted anticancer properties

Imtiyaz, K., Shafi, M., Fakhri, K. U., Uroog, L., Zeya, B., Anwer, S. T., & Rizvi, M. M. A. (2024) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2024.06.006 · Cited by 15

The Role of the PAX Genes in Renal Cell Carcinoma

Li, L., Hossain, S. M., & Eccles, M. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126730 · Cited by 11

Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing

Altinbay, M., Wang, J., Chen, J., Schäfer, D., Sprang, M., Blagojevic, B., Wölfl, S., Andrade-Navarro, M. A., Đikić, I., Knapp, S., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae798 · Cited by 14

Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease

Northoff, B. H., Herbst, A., Wenk, C., Weindl, L., Gäbel, G., Brezski, A., Zarnack, K., Küpper, A., Dimmeler, S., Moretti, A., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf013 · Cited by 12

Mxi1-0 Promotes Hypoxic Pulmonary Hypertension Via ERK/c-Myc-dependent Proliferation of Arterial Smooth Muscle Cells

Dong, L., Liu, X., Wu, B., Li, C., Wei, X., Wumaier, G., Zhang, X., Wang, J., Xia, J., Zhang, Y., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.810157 · Cited by 12

Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers

Vízkeleti, L., & Spisák, S. (2023) · Cells · doi:10.3390/cells12131745 · Cited by 10

The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer

Zhu, X., Li, C., Gao, Y., Zhang, Q., Wang, T., Zhou, H., Bu, F., Chen, J., Mao, X., He, Y., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02873-0 · Cited by 11

Magnetic-driven hydrogel microrobots for promoting osteosarcoma chemo-therapy with synthetic lethality strategy

Tao, Y., Li, L., Yang, X., Yin, S., Zhang, Z., Wang, H., Pu, R., Wang, Z., Zhang, Q., Mu, H., et al. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1386076 · Cited by 12

Mono a Mano: ZBP1’s Love–Hate Relationship with the Kissing Virus

Herbert, A. G., Fedorov, A., & Poptsova, M. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063079 · Cited by 13

ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1

Mayro, B., Hoj, J. P., Cerda-Smith, C. G., Hutchinson, H. M., Caminear, M. W., Thrash, H. L., Winter, P. S., Wardell, S. E., McDonnell, D. P., Wu, C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210418120 · Cited by 11

Detecting Double Expression Status in Primary Central Nervous System Lymphoma Using Multiparametric MRI Based Machine Learning

Liu, G., Zhang, X., Zhang, N., Xiao, H.-F., Chen, X., & Ma, L. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28782 · Cited by 11

RPF2 mediates the CARM1‑MYCN axis to promote chemotherapy resistance in colorectal cancer cells

Lu, M., Hu, X., Cheng, C., Zhang, Y., Huang, L., Kong, X., Li, Z., Zhang, Q., & Zhang, Y. (2023) · Oncology Reports · doi:10.3892/or.2023.8670 · Cited by 11

Mycndeficiency underlies the development of orofacial clefts in mice and humans

Yang, R., Li, R., Huang, Z., Zuo, Y., Yue, H., Wu, H., Gu, F., Wang, F., He, M., & Bian, Z. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab288 · Cited by 11

PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice

Zhang, X., Schuhmachers, P., Mourão, A., Giansanti, P., Murer, A., Thumann, S., Kuklik‐Roos, C., Beer, S., Hauck, S. M., Hammerschmidt, W., et al. (2021) · EMBO Reports · doi:10.15252/embr.202153007 · Cited by 10

MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells

Rosa, P. D., Severi, F., Zadran, S. K., Russo, M. V., Aloisi, S., Rigamonti, A., Capranico, G., Milazzo, G., & Perini, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065408 · Cited by 10

TTC36 promotes proliferation and drug resistance in hepatocellular carcinoma cells by inhibiting c-Myc degradation

Shao, F., Wang, R., Li, X., Hu, Y., Zhang, Z., Cai, J., Yang, J.-R., Feng, X., Ren, S., Huang, Z., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07663-4 · Cited by 10

CREATE: cell-type-specific cis-regulatory element identification via discrete embedding

Cui, X., Yin, Q., Gao, Z., Li, Z., Chen, X., Lv, H., Chen, S., Liu, Q., Zeng, W., & Jiang, R. (2025) · Nature Communications · doi:10.1038/s41467-025-59780-5 · Cited by 10

Functional Repercussions of Hypoxia-Inducible Factor-2α in Idiopathic Pulmonary Fibrosis

Torres-Soria, A. K., Romero, Y., Balderas-Martínez, Y. I., Velázquez‐Cruz, R., Espíndola, L. M. T., Camarena, Á., Flores‐Soto, E., Solís‐Chagoyán, H., Ruiz, V., Carlos‐Reyes, Á., et al. (2022) · Cells · doi:10.3390/cells11192938 · Cited by 11

Cuproplasia characterization in colon cancer assists to predict prognosis and immunotherapeutic response

Zhang, B., Li, Y., Song, L., Xi, H., Wang, S., Yu, C., & Cui, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1061084 · Cited by 10

Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm

Chen, J., Sun, M., Chen, C., Jiang, B., & Fang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016683 · Cited by 9

Integrative characterization of MYC RNA-binding function

Li, S., Wang, Z., Wang, X., Wang, Y., Pattarayan, D., Zhang, Y. L., Nguyen, P., Bhuniya, A., Chen, Y., Huang, H., et al. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100878 · Cited by 10

Tumor cell cycle regulation: integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies

Wan, Q., Yang, Z., Huang, L., Xia, Y., Long, L., Xu, Z., & Li, J. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00411-w · Cited by 10

Tumor heterogeneity: development, mechanisms, and therapeutic implications

Zhang, J., Li, H., Ru, S., Feng, H., Guo, J., Sun, D., Xiang, T., Xu, D., & Luo, Y. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02749-7 · Cited by 12

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

Zanotti, S., Vanhauwaert, S., Neste, C. V., Olexiouk, V., Laere, J. V., Verschuuren, M., der Meulen, J. V., Mus, L. M., Durinck, K., Tilleman, L., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93863-9 · Cited by 9

Linking neural crest development to neuroblastoma pathology

Malagon, S. G. G., & Liu, K. J. (2022) · Development · doi:10.1242/dev.200331 · Cited by 9

Crystal structure of a covalently linked Aurora-A–MYCN complex

Diebold, M., Schönemann, L., Eilers, M., Sotriffer, C., & Schindelin, H. (2022) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798322011433 · Cited by 9

The UVSSA complex alleviates MYC-driven transcription stress

Sato, M., Liebau, R. C., Liu, Z., Liu, L., Rabadán, R., & Gautier, J. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.201807163 · Cited by 8

Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network Pharmacology and Experiments

He, B., Chen, Z., Nie, Y., Luo, M., Xu, S., Yan, J., & Chen, Z. (2022) · Journal of Immunology Research · doi:10.1155/2022/6588144 · Cited by 9

Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway

Gu, J., Wang, X., Zhang, L., Xiang, J., Li, J., Chen, Z., Zhang, Y., Chen, J., & Shen, J. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03315-0 · Cited by 9

MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma

Liu, Z., Hong, J. J., Zhang, X., Sayers, C. M., Fang, W., Xu, M., Loria, S. M., Maskal, S., Lei, H., Wu, H., et al. (2025) · Oncogenesis · doi:10.1038/s41389-025-00557-2 · Cited by 8

Targeting SUMOylation in ovarian cancer: Sensitivity, resistance, and the role of MYC

Littler, S., Barnes, B. M., Owen, R., Nelson, L., Tighe, A., Lin, I., Osborne, H. C., Schmidt, C. K., McGrail, J. C., & Taylor, S. S. (2025) · iScience · doi:10.1016/j.isci.2025.112555 · Cited by 8

Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer

Hibshman, P. S., Stalnecker, C. A., Klomp, J. A., Drizyte‐Miller, K., Klomp, J. E., Edwards, A. C., Pita, L. M., Hodge, R. G., Diehl, J. N., Mouery, R. D., et al. (2025) · Science Signaling · doi:10.1126/scisignal.adu7145 · Cited by 9

MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation

Guan, Q., Chen, Z., Yu, F., Liu, L., Huang, Y., Wei, G., Chiang, C., Wong, J., & Li, J. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2281-6 · Cited by 9

Prognostic characteristics of a six-gene signature based on ssGSEA in sarcoma

Liu, J., Lu, J., Wang, G., Gu, L., & Li, W. (2024) · Aging · doi:10.18632/aging.205443 · Cited by 8

G-Quadruplex Matters in Tissue-Specific Tumorigenesis by BRCA1 Deficiency

Kim, S., & Hwang, S. (2022) · Genes · doi:10.3390/genes13030391 · Cited by 8

The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP

Mödlhammer, A., Pfurtscheller, S., Feichtner, A., Hartl, M., & Schneider, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.660481 · Cited by 7

Alternative Strategies of Reducing MYC Expression for the Treatment of Cancers

Chen, H., Jingfeng, S., Wang, Y., Peng, Z., Zeng, H., Zhou, H., Shang, W., & Chen, Y. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02684 · Cited by 8

INSM1 promotes breast carcinogenesis by regulating C-MYC.

Guan, Y., Sun, Y., Liu, Z., Zhang, Y., Cao, M., Wang, W., Tao, J., & Yao, Y. (2023) · PubMed Central · Cited by 7

BMSC derived EVs inhibit colorectal Cancer progression by transporting MAGI2-AS3 or something similar

Ma, T., Wang, M., Wang, S., Hu, H., Zhang, X., Wang, H., Wang, G., & Jin, Y. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111235 · Cited by 7

RBPMS inhibits bladder cancer metastasis by downregulating MYC pathway through alternative splicing of ANKRD10

Yu, J., Chen, L., Wang, G., Qian, K., Weng, H., Yang, Z., Zheng, H., & Lü, M. (2025) · Communications Biology · doi:10.1038/s42003-025-07842-1 · Cited by 8

High Expression of TIMELESS Predicts Poor Prognosis: A Potential Therapeutic Target for Skin Cutaneous Melanoma

Zhao, S., Wen, S., Liu, H., Zhou, Z., Liu, Y., Zhong, J., & Xie, J. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.917776 · Cited by 7

Identification of immune subtypes to guide immunotherapy and targeted therapy in clear cell renal cell carcinoma

Chen, X., Li, Y., Su, W. C., Wang, Z., Ma, Z., Zhou, L., Zhou, Y., Chen, J., Jiang, M., & Liu, M. (2022) · Aging · doi:10.18632/aging.204252 · Cited by 7

STAT3 Inhibition Attenuates MYC Expression by Modulating Co-Activator Recruitment and Suppresses Medulloblastoma Tumor Growth by Augmenting Cisplatin Efficacy In Vivo

Rohrer, K., Song, H., Akbar, A., Chen, Y., Pramanik, S., Wilder, P. J., McIntyre, E. M., Chaturvedi, N. K., Bhakat, K. K., Rizzino, A., et al. (2023) · Cancers · doi:10.3390/cancers15082239 · Cited by 10

Trim33 masks a non-transcriptional function of E2f4 in replication fork progression

Rousseau, V., Einig, E., Jin, C., Horn, J., Riebold, M., Poth, T., Jarboui, M. A., Flentje, M., & Popov, N. (2023) · Nature Communications · doi:10.1038/s41467-023-40847-0 · Cited by 7

Circular RNAs With Efficacy in PreclinicalIn VitroandIn VivoModels of Esophageal Squamous Cell Carcinoma

Weidle, U. H., Sela, T., Brinkmann, U., & Niewoehner, J. (2022) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20320 · Cited by 7

Comparative analysis of compound NSC13728 as Omomyc homodimer stabilizer by molecular dynamics simulation and MM/GBSA free energy calculation

Gao, J., Wang, Y., Li, K., Zhang, J., & Geng, X. (2022) · Journal of Molecular Modeling · doi:10.1007/s00894-022-05082-2 · Cited by 6

A high-throughput screening platform to identify MYCN expression inhibitors for liver cancer therapy

Xu, Y., Mishra, H., Furutani, Y., Yanaka, K., Nishimura, H., Furuhata, E., Takahashi, M., Gailhouste, L., Suenaga, Y., Hippo, Y., et al. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1486671 · Cited by 6

MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment

Xu, J., Sun, Y., Fu, W., & Fu, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115208 · Cited by 6

MYCN in neuroblastoma: The kings' new clothes and drugs

Müller, M., Trunk, K., Fleischhauer, D., & Büchel, G. (2024) · EJC Paediatric Oncology · doi:10.1016/j.ejcped.2024.100182 · Cited by 7

Strategy against super-resistant bacteria: Curdlan-induced trained immunity combined with multi-epitope subunit vaccine

Li, H., Niu, L., Wang, J., Chang, Q., Zhang, S., Wang, J., Zeng, J., Gao, M., & Ge, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135663 · Cited by 6

Leptin Modulates Ovarian Granulosa Cell Apoptosis by Regulating Telomerase Activity and Telomere Length in Polycystic Ovary Syndrome

Feijing, Z., Sun, Z., Cheng, L., & Dong, Y. (2024) · Laboratory Investigation · doi:10.1016/j.labinv.2024.102169 · Cited by 6

SE ‐ lncRNAs in Cancer: Classification, Subcellular Localisation, Function and Corresponding TFs

Bao, Y., Teng, S., Zhai, H., Zhang, Y., Xu, Y., Li, C., Chen, Z., Ren, F., & Wang, Y. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70296 · Cited by 6

Identification of molecular clusters and a risk prognosis model for diffuse large B-cell lymphoma based on lactate metabolism-related genes

Zhang, J., Gao, T., Chen, S., Wu, S., Mao, Y., Cai, D., & Lu, T. (2025) · Annals of Hematology · doi:10.1007/s00277-025-06321-1 · Cited by 6

Long non‑coding RNA expression profiles and related regulatory networks in areca nut chewing‑induced tongue squamous cell carcinoma

Li, P., Zhang, S., Mo, Y., Zhang, L., Wang, Y., Xiong, F., Zhang, S., Liu, J., Xu, Y., Zeng, Z., et al. (2020) · Oncology Letters · doi:10.3892/ol.2020.12165 · Cited by 6

Lessons from Using Genetically Engineered Mouse Models of MYC-Induced Lymphoma

Winkler, R., Piskor, E.-M., & Kosan, C. (2022) · Cells · doi:10.3390/cells12010037 · Cited by 6

Comprehensive analysis of autophagy-related clusters and individual risk model for immunotherapy response prediction in gastric cancer

Yao, Y., Hu, X., Ma, J., Wu, L., Tian, Y., Chen, K., & Liu, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1105778 · Cited by 6

High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein

Lechable, M., Tang, X., Siebert, S., Feldbacher, A., Fernández‐Quintero, M. L., Breuker, K., Juliano, C. E., Liedl, K. R., Hobmayer, B., & Hartl, M. (2023) · Cells · doi:10.3390/cells12091265 · Cited by 6

RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade

Oei, V., Chuang, L. S. H., Matsuo, J., Srivastava, S., Teh, M., & Ito, Y. (2023) · Communications Biology · doi:10.1038/s42003-023-05037-0 · Cited by 6

Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc

Bi, X., Zhang, M., Zhou, J., Yan, X., Cheng, L., Luo, L., Huang, C., & Yin, Z. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110913 · Cited by 6

PDE4B promotes the progression of gastric cancer via the PI3K/AKT/MYC pathway and immune infiltration

Su, R. (2024) · American Journal of Cancer Research · doi:10.62347/tyos8160 · Cited by 6

Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis

Zhu, Y., Liu, Y., Wang, X., Chen, Z., Chen, B., Hu, B., Tang, T., Cheng, H., Liu, X., & Ning, Y. (2025) · Advanced Science · doi:10.1002/advs.202413120 · Cited by 5

MYC: The Guardian of Its Own Chaos

Gaballa, A., Krenz, B., & Uhl, L. (2025) · BioEssays · doi:10.1002/bies.70010 · Cited by 5

Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding

Boisvert, O., Létourneau, D., Delattre, P., Tremblay, C., Jolibois, É., Montagne, M., & Lavigne, P. (2021) · Structure · doi:10.1016/j.str.2021.12.001 · Cited by 5

Cancer mutation profiles predict ICIs efficacy in patients with non-small cell lung cancer

Zhu, L., Ye, D., Lei, T., Wu, J., Wang, W., & Xu, B. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.9 · Cited by 5

Co-expression patterns explain how a basic transcriptional role for MYC modulates Wnt and MAPK pathways in colon and lung adenocarcinomas

Kucherlapati, M. H. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2060454 · Cited by 5

Gain-of-function MYCN causes a megalencephaly-polydactyly syndrome manifesting mirror phenotypes of Feingold syndrome

Nishio, Y., Kato, K., Mau‐Them, F. T., Futagawa, H., Quēlin, C., Masuda, S., Vitobello, A., Otsuji, S., Shawki, H. H., Oishi, H., et al. (2023) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2023.100238 · Cited by 7

NCAPD2 serves as a potential prognostic biomarker for lung adenocarcinoma and promotes cell proliferation, migration, invasion and cell cycle in vitro

WU, P., ZHAO, L., Zhang, H., Lou, Y., CHEN, D., Xue, S., LIU, X., & JIANG, H. (2024) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2024.047490 · Cited by 5

Myc upregulates Ggct, γ‐glutamylcyclotransferase to promote development of p53‐deficient osteosarcoma

Ueno, T., Otani, S., Date, Y., Katsuma, Y., Nagayoshi, Y., Ito, T., Ii, H., Kageyama, S., Nakata, S., & Ito, K. (2024) · Cancer Science · doi:10.1111/cas.16255 · Cited by 4

Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer

Wang, Q., Cao, Z., Wei, Y., Zhang, J., & Cheng, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.724832 · Cited by 5

Ischemic Postconditioning Protects against Aged Myocardial Ischemia/Reperfusion Injury by Transcriptional and Epigenetic Regulation of miR‐181a‐2‐3p

Li, G., Ding, N., Xiong, J., Ma, S., Xie, L., Xu, L., Zhang, H., Yang, A., Yang, Y., Jiang, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9635674 · Cited by 5

Author response: Association with TFIIIC limits MYCN localization in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA Polymerase II

Vidal, R. S., Leen, E. N., Herold, S., Müller, M., Fleischhauer, D., Schülein‐Völk, C., Papadopoulos, D., Röschert, I., Uhl, L., Ade, C. P., et al. (2024) · eLife · doi:10.7554/elife.94407.2.sa0 · Cited by 4

Reviewer #3 (Public Review): Association with TFIIIC limits MYCN localization in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA Polymerase II

Vidal, R., Leen, E. N., Herold, S., et al. (2024) · eLife · doi:10.7554/elife.94407.2.sa1 · Cited by 4

Senkyunolide A interrupts TRAF6-HDAC3 interaction to epigenetically suppress c-MYC and attenuate cholestatic liver injury

Li, Y., Liu, R., Li, J., Gao, F., Ma, Z., Xie, K., Li, F., Xu, B., Zheng, Q., Cai, Y., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.04.002 · Cited by 4

VRK2 targeting potentiates anti-PD-1 immunotherapy in hepatocellular carcinoma through MYC destabilization

Chen, S., Liao, Z., Mo, J., Liu, F., Wang, W., Zhang, H., Zhang, H., Liu, Y., Pan, Y., Zhu, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64079-6 · Cited by 4

KAT2A Deficiency Suppresses Lung Cancer Progression by Downregulating MYC Through Decreasing MYC Succinylation

Li, J., Zhao, F., Wang, Z., Yang, S., Lu, Z., Li, X., Song, J., & Dai, Z. (2025) · Cancer Science · doi:10.1111/cas.70286 · Cited by 4

Tales of destruction and repair: the changing view of MYC proteins in tumorigenesisPreprint

Baranello, L., Papadopoulos, D., & Eilers, M. (2026) · Genes & Development · doi:10.1101/gad.353899.126

Beyond gene expression: how MYC relieves transcription stress

Papadopoulos, D., Uhl, L., Ha, S. A., & Eilers, M. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.06.008 · Cited by 33

Transcription-independent functions of MYC: regulation of translation and DNA replication

Cole, M. D., & Cowling, V. H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2467 · Cited by 170

MYC protein interactors in gene transcription and cancer

Lourenco, C., Resetca, D., Redel, C., Lin, P., MacDonald, A. S., Ciaccio, R., Kenney, T. M. G., Wei, Y., Andrews, D. W., Sunnerhagen, M., et al. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00367-9 · Cited by 351

Mechanism of transcriptional activation by the Myc oncoproteins

Cowling, V. H., & Cole, M. D. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.08.001 · Cited by 178