The DOI matches its Crossref record; 309 of the 309 references it cites were found in a registry or an index.
Molecular mechanisms of dietary restriction promoting health and longevity
Open accessAbstract
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and extending healthspan and lifespan in diverse species, including rodents and non-human primates. In this Review, we discuss the effects of dietary restriction in these mammalian model organisms and discuss accumulating data that suggest that dietary restriction results in many of the same physiological, metabolic and molecular changes responsible for the prevention of multiple ageing-associated diseases in humans. We further discuss how different forms of fasting, protein restriction and specific reductions in the levels of essential amino acids such as methionine and the branched-chain amino acids selectively impact the activity of AKT, FOXO, mTOR, nicotinamide adenine dinucleotide (NAD+), AMP-activated protein kinase (AMPK) and fibroblast growth factor 21 (FGF21), which are key components of some of the most important nutrient-sensing geroprotective signalling pathways that promote healthy longevity.
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“Dietary interventions, such as caloric restriction and intermittent fasting, might be protective against development of age-related dysfunction and diseases based on studies in animal models134,135.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [135]
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“In addition to dietary interventions, dietary restriction mimetics (for example, pharmacological compounds or metabolites that mimic dietary restriction) have also been shown to reverse age-related declines in stem cell function209 (TABLE 1).”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [209]
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1 retracted
Bonkowski, M. S., Dominici, F. P., Arum, O., Rocha, J. S., Al-Regaiey, K., Westbrook, R., Spong, A., Panici, J. A., Masternak, M. M., Kopchick, J. J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004567 · Cited by 125
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
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Extending Healthy Life Span—From Yeast to Humans
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Self-citation
Research works printed but not linked: 2
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- Willcox, B. J. et al. in Healthy Aging and Longevity. Annals of the New York Academy of Sciences Vol. 1114 (eds Weller, N. J. & Rattan, S. I. S.) 434-455 (Springer, 2007).
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Cellular senescence and senolytics: the path to the clinic
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,134
Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407
Regulators of health and lifespan extension in genetically diverse mice on dietary restriction
Di Francesco, A., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Schott, W., Wright, K. M., et al. (2023) · doi:10.1101/2023.11.28.568901 · Cited by 194
Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00466-9 · Cited by 171
Self-citationObesity accelerates cardiovascular ageing
Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf216 · Cited by 73
Beneficial Effects of Intermittent Fasting: A Narrative Review
Song, D.-K., & Kim, Y.-W. (2023) · Journal of Yeungnam Medical Science · doi:10.12701/jyms.2022.00010 · Cited by 69
The Catabolic—Anabolic Cycling Hormesis Model of Health and Resilience
Calabrese, E. J., & Mattson, M. P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102588 · Cited by 38
microRNA-33 controls hunger signaling in hypothalamic AgRP neurons
Price, N. L., Fernández-Tussy, P., Varela, L., Cardelo, M. P., Shanabrough, M., Aryal, B., de Cabo, R., Suárez, Y., Horvath, T. L., & Fernández-Hernando, C. (2024) · Nature Communications · doi:10.1038/s41467-024-46427-0 · Cited by 25
“On the other hand, increased activity of these cells is associated with calorie restriction, the most robust intervention to promote health-and life-span across species 39 .”
BackgroundKriukov, D., Khrameeva, E. E., Gladyshev, V. N., Dmitriev, S. E., & Tyshkovskiy, A. (2022) · doi:10.1101/2022.12.12.520058 · Cited by 13
Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain
Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13
Metadata
- Authors
- Green, C. L., Lamming, D. W., & Fontana, L.
- Affiliations
- University of Wisconsin–Madison (US)
- The University of Sydney (AU)
- Corresponding author
- Fontana, Luigi
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2021-09-13
- Volume
- 23
- Issue
- 1
- Pages
- 56-73
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC8692439
- OpenAlex
- W3199223754
- Cited by
- 714
- References
- 309
- Citations by year
- 2026: 120 · 2025: 173 · 2024: 162 · 2023: 137 · 2022: 110 · 2021: 12
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01-BX004031)
- National Institute on Aging (R01AG062328, R21AG061635, R01AG056771, RF1AG056771, R56AG056771)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK125859)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- dietary restriction, aging, lifespan extension, healthspan, fasting, protein restriction, methionine restriction, branched-chain amino acids, Akt, FOXO, mTOR, NAD+, AMPK, FGF21, nutrient sensing, non-human primates, rodents
- MeSH terms
- Animals, Disease Models, Animal, Health, Humans, Longevity, Oxidative Stress, Caloric Restriction
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