Fontana, Luigi

Extending Healthy Life Span—From Yeast to Humans

Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 3,023

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science

Gut microbiota and healthMicrobial Community Ecology and Physiology

Cited by 1,988

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans

Fontana, L., Eagon, J. C., Trujillo, M. E., Scherer, P. E., & Klein, S. (2007) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Cited by 1,417

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 1,245

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C.-W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., et al. (2014) · Cell Metabolism

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 910

Long-Term Calorie Restriction Is Highly Effective in Reducing the Risk for Atherosclerosis in Humans

Fontana, L., Meyer, T. E., Klein, S., & Holloszy, J. O. (2004) · Proceedings of the National Academy of Sciences

Dietary Effects on HealthNutritional Studies and Diet

Cited by 902

Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms

Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A

Nutritional Studies and DietDietary Effects on Health

Cited by 762

Molecular mechanisms of dietary restriction promoting health and longevity

Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 714

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 592

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L., Phillips, D., Weinstock, G. M., Fontana, L., Cross, A. H., et al. (2018) · Cell Metabolism

Dietary Effects on HealthGut microbiota and health

Cited by 568

Dietary fiber and health outcomes: an umbrella review of systematic reviews and meta-analyses

Veronese, N., Solmi, M., Caruso, M. G., Giannelli, G., Osella, A. R., Evangelou, E., Maggi, S., Fontana, L., Stubbs, B., & Tzoulaki, I. (2018) · The American Journal of Clinical Nutrition

Food composition and propertiesNutritional Studies and Diet

Cited by 536

Calorie restriction in humans: An update

Most, J., Tosti, V., Redman, L. M., & Fontana, L. (2017) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 530

Aging, adiposity, and calorie restriction

Fontana, L. (2007) · JAMA

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 526

A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity

Ravussin, E., Redman, L. M., Rochon, J., Das, S. K., Fontana, L., Kraus, W. E., Romashkan, S., Williamson, D. A., Meydani, S. N., Villareal, D. T., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 489

Decreased consumption of branched-chain amino acids improves metabolic health

Fontana, L., Cummings, N. E., Arriola Apelo, S. I., Neuman, J. C., Kasza, I., Schmidt, B. A., Cava, E., Spelta, F., Tosti, V., Syed, F. A., et al. (2016) · Cell Reports

Diet, Metabolism, and DiseaseDietary Effects on Health

Cited by 466

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial

Kraus, W. E., Bhapkar, M., Huffman, K. M., Pieper, C. F., Krupa Das, S., Redman, L. M., Villareal, D. T., Rochon, J., Roberts, S. B., Ravussin, E., et al. (2019) · The Lancet Diabetes & Endocrinology

Dietary Effects on HealthNutritional Studies and Diet

Cited by 407

Long-term caloric restriction ameliorates the decline in diastolic function in humans

Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L. (2006) · Journal of the American College of Cardiology

Cardiovascular Function and Risk FactorsCardiovascular Health and Disease Prevention

Cited by 383

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

Longo, V. D., & Fontana, L. (2010) · Trends in Pharmacological Sciences

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 378

Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., Klein, S., & Holloszy, J. O. (2006) · The American Journal of Clinical Nutrition

Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

Cited by 353

Calorie restriction and prevention of age‐associated chronic disease

Omodei, D., & Fontana, L. (2011) · FEBS Letters

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 293

Calorie restriction in humans inhibits the PI 3 K/AKT pathway and induces a younger transcription profile

Mercken, E. M., Crosby, S. D., Lamming, D. W., JeBailey, L., Krzysik‐Walker, S., Villareal, D. T., Capri, M., Franceschi, C., Zhang, Y., Becker, K., et al. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

Cited by 261

Weight loss is associated with improvements in cognitive function among overweight and obese people: a systematic review and meta-analysis

Veronese, N., Facchini, S., Stubbs, B., Luchini, C., Solmi, M., Manzato, E., Sergi, G., Maggi, S., Cosco, T., & Fontana, L. (2017) · Neuroscience & Biobehavioral Reviews

Dementia and Cognitive Impairment ResearchObesity, Physical Activity, Diet

Cited by 251

One Year of Caloric Restriction in Humans: Feasibility and Effects on Body Composition and Abdominal Adipose Tissue

Racette, S. B., Weiss, E. P., Villareal, D. T., Arif, H., Steger-May, K., Schechtman, K. B., Fontana, L., Klein, S., & Holloszy, J. O. (2006) · The Journals of Gerontology: Series A

Dietary Effects on HealthRegulation of Appetite and Obesity

Cited by 237

Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults

Villareal, D. T., Miller, B. V., Banks, M., Fontana, L., Sinacore, D. R., & Klein, S. (2006) · The American Journal of Clinical Nutrition

Diabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and Health

Cited by 235