The effect of HIF on metabolism and immunity

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

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Hypoxia-inducible factors in physiology and medicine

Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

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Altered metabolism in cancer: insights into energy pathways and therapeutic targets

Tufail, M., Jiang, C.-H., & Li, N. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02119-3 · Cited by 534

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Bai, R., Li, Y., Jian, L., Yue-hui, Y., Zhao, L., & Wei, M. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01645-2 · Cited by 296

Targeting hypoxia-inducible factors: therapeutic opportunities and challenges

Yuan, X., Ruan, W., Bobrow, B., Carmeliet, P., & Eltzschig, H. K. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00848-6 · Cited by 245

Mitochondrial metabolism and cancer therapeutic innovation

Du, H., Xu, T., Yu, S., Wu, S., & Zhang, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02311-x · Cited by 283

Protein neddylation and its role in health and diseases

Zhang, S., Yu, Q., Li, Z., Zhao, Y., & Sun, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01800-9 · Cited by 171

Inflammatory Fibroblast‐Like Synoviocyte‐Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis

Liu, B., Xian, Y., Chen, X. '., Shi, Y., Dong, J., Yang, L., An, X., Shen, T., Wu, W., Ma, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202307338 · Cited by 152

Nanomedicine Remodels Tumor Microenvironment for Solid Tumor Immunotherapy

Guo, Y., Hu, P., & Shi, J. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c14005 · Cited by 136

Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention

Huang, H., Li, G., He, Y., Chen, J., Yan, J., Zhang, Q., Li, L., & Cai, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1404441 · Cited by 155

METTL3‐mediated N6‐methyladenosine exacerbates ferroptosis via m6A‐IGF2BP2‐dependent mitochondrial metabolic reprogramming in sepsis‐induced acute lung injury

Zhang, H., Wu, D., Wang, Y., Guo, K., Spencer, C. B., Ortoga, L., Qu, M., Shi, Y., Shao, Y., Wang, Z., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1389 · Cited by 131

Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome

Gao, Y., Zou, Y., Wu, G., & Zheng, L. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1193749 · Cited by 128

Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research

Jung, E. S., Choi, H., & Mook-Jung, I. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00825-0 · Cited by 124

Why cells need iron: a compendium of iron utilisation

Teh, M. R., Armitage, A. E., & Drakesmith, H. (2024) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2024.04.015 · Cited by 114

Compressive stresses in cancer: characterization and implications for tumour progression and treatment

Linke, J. A., Munn, L. L., & Jain, R. K. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00745-z · Cited by 109

Mechanisms underlying the health benefits of intermittent hypoxia conditioning

Burtscher, J., Citherlet, T., Camacho-Cardeñosa, A., Camacho-Cardeñosa, M., Raberin, A., Krumm, B., Hohenauer, E., Egg, M., Lichtblau, M., Müller, J., et al. (2023) · The Journal of Physiology · doi:10.1113/jp285230 · Cited by 132

Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

Shen, X., Pan, D., Gong, Q., Gu, Z., & Luo, K. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.10.017 · Cited by 96

Lenvatinib in hepatocellular carcinoma: Resistance mechanisms and strategies for improved efficacy

Qin, Y., Han, S., Yu, Y., Ding, Q., Ran, M., Yang, M., Liu, Y., Li, Y., Lu, L., Liu, Y., et al. (2024) · Liver International · doi:10.1111/liv.15953 · Cited by 100

Mg-gallate metal-organic framework-based sprayable hydrogel for continuously regulating oxidative stress microenvironment and promoting neurovascular network reconstruction in diabetic wounds

Lian, C., Liu, J., Wei, W., Wu, X., Goto, T., Li, H., Tu, R., & Dai, H. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.04.028 · Cited by 94

Ovarian aging: energy metabolism of oocytes

Bao, S., Yin, T., & Liu, S. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01427-y · Cited by 92

The Interplay between Immune and Metabolic Pathways in Kidney Disease

Jiao, B., & Qu, L. (2023) · Cells · doi:10.3390/cells12121584 · Cited by 89

ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions

Chen, Y.-S., Tian, H., Rong, D., Wang, L., Chen, S., Zeng, J., Xu, H., Mei, J., Wang, L.-Y., Liou, Y., et al. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00338-8 · Cited by 96

Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies

Li, H., Zandberg, D. P., Kulkarni, A., Chiosea, S. I., Santos, P. M., Isett, B. R., Joy, M., Sica, G., Contrera, K. J., Tatsuoka, C. M., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.02.026 · Cited by 85

Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy

Wang, W., Yao, S., Luo, J., Ding, C., Huang, Q., Yang, Y., Shi, Z., Lin, J., Pan, Y., Zeng, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-55905-y · Cited by 92

Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis

Raslan, A., Pham, T. X., Lee, J., Kontodimas, K., Tilston-Lünel, A., Schmottlach, J., Hong, J., Dinc, M. T., Bujor, A. M., Caporarello, N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49545-x · Cited by 84

Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression

Jomová, K., Alomar, S. Y., Valko, R., Fresser, L., Nepovimová, E., Kuča, K., & Valko, M. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04146-5 · Cited by 103

Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy

Lv, Y., Li, Z., Liu, S., Zhou, Z., Jinling, S., Ba, Y., Weng, S., Zuo, A., Xu, H. W., Luo, P., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02407-6 · Cited by 93

Living in a hypoxic world: A review of the impacts of hypoxia on aquaculture

Zhan, Y., Ning, B., Sun, J., & Chang, Y. (2023) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2023.115207 · Cited by 75

Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism

Madai, S., Kilic, P., Schmidt, R. M., Orth, C. B., Korff, T., Büttner, M., Klinke, G., Poschet, G., Marti, H. H., & Kunze, R. (2024) · Theranostics · doi:10.7150/thno.88223 · Cited by 72

Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm

Wang, Y., Ge, M., Wang, J., Xu, Y., Wang, N., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08114-w · Cited by 83

How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia

Mirchandani, A. S., Sánchez-García, M. A., & Walmsley, S. R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01087-5 · Cited by 77

Tumor hypoxia unveiled: insights into microenvironment, detection tools and emerging therapies

Ciepła, J., & Smolarczyk, R. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01501-1 · Cited by 81

Inflammatory bowel diseases: pathological mechanisms and therapeutic perspectives

Yang, X., Guo, H., & Zou, M. (2026) · Molecular Biomedicine · doi:10.1186/s43556-025-00395-z · Cited by 85

Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity

Ortmann, B. M. (2024) · BMJ Oncology · doi:10.1136/bmjonc-2023-000154 · Cited by 67

Bioenergetic dysfunction in the pathogenesis of intervertebral disc degeneration

Song, C., Hu, P., Peng, R., Li, F., Fang, Z., & Xu, Y. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107119 · Cited by 69

Atherosclerosis: A Comprehensive Review of Molecular Factors and Mechanisms

Tasouli-Drakou, V., Ogurek, I., Shaikh, T., Ringor, M., Dicaro, M. V., & Lei, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031364 · Cited by 79

Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

Matsuoka, K., Bakiri, L., Bilban, M., Toegel, S., Haschemi, A., Yuan, H., Kasper, M., Windhager, R. H., & Wagner, E. F. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224002 · Cited by 65

Oxidative Stress Induced by Lipotoxicity and Renal Hypoxia in Diabetic Kidney Disease and Possible Therapeutic Interventions: Targeting the Lipid Metabolism and Hypoxia

Chae, S. Y., Kim, Y., & Park, C. W. (2023) · Antioxidants · doi:10.3390/antiox12122083 · Cited by 65

Hypoxia-Inducible Factor 1-Alpha (HIF-1α): An Essential Regulator in Cellular Metabolic Control

Basheeruddin, M., & Qausain, S. (2024) · Cureus · doi:10.7759/cureus.63852 · Cited by 69

Integrating bioelectronics with cell-based synthetic biology

Rivnay, J., Raman, R., Robinson, J. T., Schreib, C. C., Cohen‐Karni, T., Galloway, K. E., & Omid Veiseh, A. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00262-6 · Cited by 61

Metabolic alterations in hereditary and sporadic renal cell carcinoma

Coffey, N. J., & Simon, M. C. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00800-2 · Cited by 56

Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy

Yu, J., Wu, J., Huang, J., Xu, C., Xu, M., Koh, C. Z. H., Pu, K., & Zhang, Y. (2025) · Nature Communications · doi:10.1038/s41467-024-55529-8 · Cited by 52

Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy

Khouzam, R. A., Janji, B., Thiery, J., Zaarour, R. F., Chamseddine, A. N., Mayr, H., Savagner, P., Kiéda, C., Gad, S., Buart, S., et al. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.11.008 · Cited by 54

Nanoparticle-mediated Klotho gene therapy prevents acute kidney injury to chronic kidney disease transition through regulating PPARα signaling in renal tubular epithelial cells

Li, H., Ouyang, Y., Lv, H., Liang, H., Luo, S., Zhang, Y., Mao, H., Chen, T., Chen, W., Zhou, Y., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122926 · Cited by 50

Vitamin C: From nutrition to oxygen sensing and epigenetics

Kietzmann, T. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102753 · Cited by 57

Kupffer cell programming by maternal obesity triggers fatty liver disease

Huang, H., Balzer, N. R., Seep, L., Šplíchalová, I., Blank-Stein, N., Viola, M. F., Taveras, E. F., Acil, K., Fink, D., Petrovic, F., et al. (2025) · Nature · doi:10.1038/s41586-025-09190-w · Cited by 52

Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer

Viel, S., Vivier, É., Walzer, T., & Marçais, A. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01098-w · Cited by 53

Lactylation modification of HIF-1α enhances its stability by blocking VHL recognition

Li, C., Fu, C., Zhou, W., Li, H., Liu, Z., Wu, G., He, T., Shen, M., & Liu, H. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02366-x · Cited by 60

The Role of HIF-1α in Bone Regeneration: A New Direction and Challenge in Bone Tissue Engineering

You, J., Liu, M., Li, M., Zhai, S., Quni, S., Zhang, L., Liu, X., Jia, K., Zhang, Y., & Zhou, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098029 · Cited by 52

Redox regulation of cancer stem cells: Biology and therapeutic implications

Du, M., Zhang, J., Wicha, M. S., & Luo, M. (2024) · MedComm – Oncology · doi:10.1002/mog2.70005 · Cited by 45

Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy

Zhang, H., Fan, J., Kong, D., Sun, Y., Zhang, Q., Xiang, R., Lu, S., Yang, W., Feng, L., & Zhang, H. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02460-1 · Cited by 49

Systems pharmacology reveals the mechanism of Astragaloside IV in improving immune activity on cyclophosphamide-induced immunosuppressed mice

Yao, J., Liu, J., He, Y., Lin, X., Xu, Z., Lin, X., Liu, N., & Kai, G. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116533 · Cited by 48

Role of mitochondria in reno-cardiac diseases: A study of bioenergetics, biogenesis, and GSH signaling in disease transition

Lumpuy‐Castillo, J., Amador‐Martínez, I., Díaz-Rojas, M., Lorenzo, Ó., Pedraza-Chaverrí, J., Sánchez‐Lozada, L. G., & Aparicio‐Trejo, O. E. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103340 · Cited by 45

Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis

Steiner, C. A., Cartwright, I. M., Taylor, C. T., & Colgan, S. P. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00227.2022 · Cited by 44

The HIF Axes in Cancer - Angiogenesis, Metabolism and Immune-Modulation

Acuña-Pilarte, K., & Koh, M. Y. (2025) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2025.06.005 · Cited by 64

Immunometabolic reprogramming of macrophages with inhalable CRISPR/Cas9 nanotherapeutics for acute lung injury intervention

Huang, W., Fu, G., Wang, Y., Chen, C., Luo, Y., Yan, Q., Liu, Y., & Mao, C. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.03.031 · Cited by 44

Metabolic reprogramming in viral infections: the interplay of glucose metabolism and immune responses

Darweesh, M. F., Mohammadi, S., Rahmati, M., Al-Hamadani, M., & Al‐Harrasi, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1578202 · Cited by 51

Endothelial GLUTs and vascular biology

Wu, W., & Bai, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114151 · Cited by 42

Hypoxia signaling in the adipose tissue

Huynh, P. M., Wang, F., & An, Y. (2024) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjae039 · Cited by 42

Metabolic pathways fueling the suppressive activity of myeloid-derived suppressor cells

Goldmann, O., & Medina, E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1461455 · Cited by 42

Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies

Ahuja, S., & Zaheer, S. (2025) · Immunology · doi:10.1111/imm.70045 · Cited by 43

Immune Cell Migration to Cancer

Ryan, A. T., Kim, M., & Lim, K. (2024) · Cells · doi:10.3390/cells13100844 · Cited by 35

Tissue niche influences immune and metabolic profiles to Staphylococcus aureus biofilm infection

Roy, Z. A. V., Arumugam, P., Bertrand, B. P., Shinde, D. D., Thomas, V. C., & Kielian, T. (2024) · Nature Communications · doi:10.1038/s41467-024-53353-8 · Cited by 36

Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury

Barakakis, P. A., Mavridis, T., Chlorogiannis, D., Barakakis, G., Laou, E., Sessler, D. I., Gkiokas, G., & Chalkias, A. F. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.70136 · Cited by 32

Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism

Han, Z., Fu, J., Gong, A., & Ren, W. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2789-1 · Cited by 33

The regulation of cell metabolism by hypoxia and hypercapnia

Reddan, B., & Cummins, E. P. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108252 · Cited by 34

Immune consequences of exercise in hypoxia: A narrative review

Burtscher, J., Pasha, Q., Chanana, N., Millet, G. P., Burtscher, M., & Strasser, B. (2023) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2023.09.007 · Cited by 34

Hypoxia-Induced Signaling in Gut and Liver Pathobiology

Solanki, S. A., & Shah, Y. M. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051122-094743 · Cited by 34

The cellular-centered view of hypoxia tumor microenvironment: Molecular mechanisms and therapeutic interventions

Zhang, T., Lv, Q., & Jin, W. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189137 · Cited by 36

Lactate modulates microglial inflammatory responses through HIF-1α-mediated CCL7 signaling after cerebral ischemia in mice

Zhang, Y., Zhang, S., Yang, L., Zhang, Y., Cheng, Y., Jia, P., Lv, Y., Wang, K., Fan, P., Zhang, P., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113801 · Cited by 31

Lactate mediated metabolic crosstalk between cancer and immune cells and its therapeutic implications

Farsani, S. S. M., & Verma, V. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1175532 · Cited by 33

Signaling Metabolite Succinylacetone Activates HIF-1α and Promotes Angiogenesis in GSTZ1-Deficient Hepatocellular Carcinoma

Luo, H., Wang, Q., Yang, F., Liu, R. R., Gao, Q., Cheng, B., Lin, X., Huang, L., Chen, C., Jin, X., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.164968 · Cited by 39

Photosynthetic and Self‐Draining Biohybrid Dressing for Accelerating Healing of Diabetic Wound

Ren, X., Hou, Z., Pang, B., Gao, C., & Tang, R. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302287 · Cited by 30

p53 in colorectal cancer: from a master player to a privileged therapy target

Yan, S., Zhan, F., He, Y., Zhu, Y., & Ma, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06566-4 · Cited by 33

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Lecoutre, S., Maqdasy, S., Rizo‐Roca, D., Renzi, G., Vlassakev, I., Alaeddine, L. M., Higos, R., Jalkanen, J., Zhong, J., Zareifi, D., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01083-y · Cited by 33

The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

Xu, J., Wakai, M., Xiong, K., Yang, Y., Prabakaran, A., Wu, S. P., Ahrens, D., Molina‐Portela, M. D. P., Ni, M., Bai, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115403 · Cited by 35

Fibroblast PI3K/AKT signaling and extracellular matrix homeostasis: mechanisms, targets, and delivery challenges

Fang, C., Zeng, Z., Ni, B., Wen, X., Fang, Z., Zou, J., & Zhang, G. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1681875 · Cited by 29

Role of HIF in fish inflammation

Shi, X., Gao, F., Zhao, X., Pei, C., Zhu, L., Zhang, J., Li, C., Li, L., & Kong, X. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109222 · Cited by 28

Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease

Ahn, J.-H., Pedrosa, M. D. S., Lopez, L. R., Tibbs, T., Jeyachandran, J. N., Vignieri, E. E., Rothemich, A., Cumming, I., Irmscher, A. D., Haswell, C. J., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.11.012 · Cited by 30

Harnessing CD8+ T cell dynamics in hepatitis B virus‐associated liver diseases: Insights, therapies and future directions

Yue, B., Gao, Y., Hu, Y., Zhan, M., Wu, Y., & Lu, L. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1731 · Cited by 26

Therapeutic Potential of Carbon Dots Derived from Phytochemicals as Nanozymes Exhibiting Superoxide Dismutase Activity for Anemia

Lu, Z., Li, H., Song, N., Wang, Z.-W., Wang, H., Rehman, A., Han, L., & Zeng, K. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c17885 · Cited by 27

YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice

Li, W., Chen, S., Lu, J., Mao, W., Zheng, S., Zhang, M., Wu, T., Chen, Y., Lu, K., Chu, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61560-0 · Cited by 30

Targeting mitochondrial transporters and metabolic reprogramming for disease treatment

Anselme, M., He, H., Lai, C., Luo, W., & Zhong, S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06976-4 · Cited by 33

Application of polymethylpentene, an oxygen permeable thermoplastic, for long-term on-a-Chip cell culture and organ-on-a-chip devices

Sønstevold, L., Czerkies, M., Escobedo-Cousin, E., Blonski, S., & Vereshchagina, E. (2023) · Micromachines · doi:10.3390/mi14030532 · Cited by 25

Coix seed oil alleviates synovial angiogenesis through suppressing HIF-1α/VEGF-A signaling pathways via SIRT1 in collagen-induced arthritis rats

Xu, Q., Kong, H., Ren, S., Meng, F., Liu, R., Jin, H., & Zhang, J. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00833-6 · Cited by 26

Circadian Clock and Hypoxia

Sartor, F., Ferrero‐Bordera, B., Haspel, J. A., Sperandio, M., Holloway, P. M., & Merrow, M. W. (2024) · Circulation Research · doi:10.1161/circresaha.124.323518 · Cited by 26

Cardiac fibrogenesis: an immuno-metabolic perspective

Hoque, M. M., Gbadegoye, J. O., Hassan, F. O., Raafat, A., & Lebeche, D. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1336551 · Cited by 30

Hypoxia-inducible factor-1α promotes ferroptosis by inducing ferritinophagy and promoting lactate production in yak longissimus thoracis et lumborum postmortem

Zhu, X., Yang, C., Yu, Q., & Han, L. (2024) · Meat Science · doi:10.1016/j.meatsci.2024.109692 · Cited by 27

An Evidence-Based Narrative Review of Scleral Hypoxia Theory in Myopia: From Mechanisms to Treatments

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Tumor microenvironment-induced tumor cell plasticity: relationship with hypoxic stress and impact on tumor resistance

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Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3

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Unraveling the pathogenesis and prevention strategies of acute high-altitude illness through gut microecology

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Role of Ischemia/Reperfusion and Oxidative Stress in Shock State

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Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives

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Detection, mechanisms, and therapeutic implications of oncometabolites

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Decoding Allosteric Control in Hypoxia-Inducible Factors

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Mitochondrial metabolism regulation and epigenetics in hypoxia

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Thermosensitive Hydrogel with Programmable, Self‐Regulated HIF‐1α Stabilizer Release for Myocardial Infarction Treatment

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A Bone‐Targeting Hydrogen Sulfide Delivery System for Treatment of Osteoporotic Fracture via Macrophage Reprogramming and Osteoblast‐Osteoclast Coupling

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Microenvironment of diabetic foot ulcers: Implications for healing and therapeutic strategies

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Astroimmunology: the effects of spaceflight and its associated stressors on the immune system

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The hypoxia-inducible factor 1 pathway plays a critical role in the development of breast muscle myopathies in broiler chickens: a comprehensive review

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HIF transcription factors, inflammation, and immunity

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The hypoxia-inducible factor (HIF) couples immunity with metabolism

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Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response

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Hypoxia and Innate Immunity: Keeping Up with the HIFsters

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Hypoxia, Metabolism and Immune Cell Function

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