Cited by 386Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

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The pro-remyelination properties of microglia in the central nervous system

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Lloyd, Amy F., Miron, Veronique E.·2019·Nature Reviews Neurology

DOI 10.1038/s41582-019-0184-2

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Abstract

Microglia are resident macrophages of the CNS that are involved in its development, homeostasis and response to infection and damage. Microglial activation is a common feature of neurological disorders, and although in some instances this activation can be damaging, protective and regenerative functions of microglia have been revealed. The most prominent example of the regenerative functions is a role for microglia in supporting regeneration of myelin after injury, a process that is critical for axonal health and relevant to numerous disorders in which loss of myelin integrity is a prevalent feature, such as multiple sclerosis, Alzheimer disease and motor neuron disease. Although drugs that are intended to promote remyelination are entering clinical trials, the mechanisms by which remyelination is controlled and how microglia are involved are not completely understood. In this Review, we discuss work that has identified novel regulators of microglial activation - including molecular drivers, population heterogeneity and turnover - that might influence their pro-remyelination capacity. We also discuss therapeutic targeting of microglia as a potential approach to promoting remyelination.

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Additional file 4 of Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
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Additional file 3 of Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
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Additional file 5 of Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
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Additional file 5 of Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
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Additional file 7 of Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
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Additional file 6 of Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
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Additional file 2 of Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
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Additional file 4 of Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
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Additional file 6 of Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
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Additional file 2 of Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
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Additional file 1 of Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
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Additional file 1 of Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
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Authors: Lloyd, A. F., & Miron, V. E.
Affiliations: Multiple Sclerosis Society (GB)
ORCID: Lloyd, Amy F.
Miron, Veronique E.
Venue: Nature Reviews Neurology
Publisher: Springer Science and Business Media LLC
Published: 2019-06-29
Volume: 15
Issue: 8
Pages: 447-458
ISSN: 1759-4758 (ISSN-L)
1759-4766
DOI: 10.1038/s41582-019-0184-2
OpenAlex: W2954946400
Cited by: 381
References: 148
Citations by year: 2026: 47 · 2025: 48 · 2024: 59 · 2023: 65 · 2022: 57 · 2021: 57 · 2020: 37 · 2019: 11
FWCI: 4.27
Type: journal article
Language: en
Open access: green
www.research.ed.ac.uk
Licence: other-oa
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Neurology (publishedVersion)
PubMed (publishedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders: Action Medical Research
Medical Research Council (MR/M020827/1, MR/N022556/1)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: microglia, remyelination, microglial activation, demyelinating disease, multiple sclerosis, microglial heterogeneity
MeSH terms: Remyelination, Aging, Animals, Central Nervous System, Demyelinating Diseases, Homeostasis, Humans, Macrophage Activation, Microglia

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The pro-remyelination properties of microglia in the central nervous system

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