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The pro-remyelination properties of microglia in the central nervous system
Open accessAbstract
Microglia are resident macrophages of the CNS that are involved in its development, homeostasis and response to infection and damage. Microglial activation is a common feature of neurological disorders, and although in some instances this activation can be damaging, protective and regenerative functions of microglia have been revealed. The most prominent example of the regenerative functions is a role for microglia in supporting regeneration of myelin after injury, a process that is critical for axonal health and relevant to numerous disorders in which loss of myelin integrity is a prevalent feature, such as multiple sclerosis, Alzheimer disease and motor neuron disease. Although drugs that are intended to promote remyelination are entering clinical trials, the mechanisms by which remyelination is controlled and how microglia are involved are not completely understood. In this Review, we discuss work that has identified novel regulators of microglial activation - including molecular drivers, population heterogeneity and turnover - that might influence their pro-remyelination capacity. We also discuss therapeutic targeting of microglia as a potential approach to promoting remyelination.
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“Efficient clearance of myelin debris after demyelination can favorably impact OPC recruitment and differentiation into remyelinating oligodendrocytes [29].”
From TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis (2020) · cites this paper as [29]
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“Microglia activation and myelin debris clearance are critical steps for successful remyelination [29].”
From TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis (2020) · cites this paper as [29]
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“Microglia drive a critical response to demyelination by clearing myelin debris and enabling newly formed oligodendrocytes to remyelinate denuded axons (8).”
From Peroxisomal integrity in demyelination-associated microglia enables cellular debris clearance and myelin renewal in mice (2026) · cites this paper as [8]
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In the citing paper
“Long-term demyelination occurs post-SCI, with lipid-containing myelin debris being absorbed and processed by inflammatory cells, including microglia—a process crucial for paving the way for regenerative reactions and inflammation resolution [9–11].”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [11]
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Cites
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543
Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225
Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.006 · Cited by 2,210
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
Self-citationThe microglial sensome revealed by direct RNA sequencing
Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511
An environment-dependent transcriptional network specifies human microglia identity
Gosselin, D., Skola, D., Coufal, N. G., Holtman, I. R., Schlachetzki, J. C. M., Sajti, E., Jaeger, B. N., O’Connor, C., Fitzpatrick, C., Pasillas, M. P., et al. (2017) · Science · doi:10.1126/science.aal3222 · Cited by 1,220
Microglia development follows a stepwise program to regulate brain homeostasis
Matcovitch-Natan, O., Winter, D. R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., et al. (2016) · Science · doi:10.1126/science.aad8670 · Cited by 1,180
iPSC-derived human microglia-like cells to study neurological diseases
Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.042 · Cited by 1,154
Microglial brain region-dependent diversity and selective regional sensitivities to aging
Grabert, K., Michoel, T., Karavolos, M. H., Clohisey, S., Baillie, J. K., Stevens, M. P., Freeman, T. C., Summers, K. M., & McColl, B. W. (2016) · Nature Neuroscience · doi:10.1038/nn.4222 · Cited by 1,151
Li, Q., Cheng, Z., Zhou, L., Darmanis, S., Neff, N. F., Okamoto, J., Gulati, G., Bennett, M. L., Sun, L. O., Clarke, L. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.006 · Cited by 1,129
Debris clearance by microglia: an essential link between degeneration and regeneration
Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain · doi:10.1093/brain/awn109 · Cited by 1,111
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M., & Rossi, F. M. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2887 · Cited by 1,061
Microglial signatures and their role in health and disease
Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046
TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012
Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.011 · Cited by 1,010
Why does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862
Differential roles of microglia and monocytes in the inflamed central nervous system
Yamasaki, R., Lu, H., Butovsky, O., Ohno, N., Rietsch, A. M., Cialic, R., Wu, P. M., Doykan, C. E., Lin, J., Cotleur, A. C., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132477 · Cited by 856
Layer V cortical neurons require microglial support for survival during postnatal development
Ueno, M., Fujita, Y., Tanaka, T., Nakamura, Y., Kikuta, J., Ishii, M., & Yamashita, T. (2013) · Nature Neuroscience · doi:10.1038/nn.3358 · Cited by 781
Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2615-05.2006 · Cited by 768
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Galatro, T. F., Holtman, I. R., Lerario, A. M., Vainchtein, I. D., Brouwer, N., Sola, P. R., Veras, M. M., Pereira, T. F., Leite, R. E. P., Möller, T., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4597 · Cited by 741
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
Mathys, H., Adaikkan, C., Gao, F., Young, J. Z., Manet, E., Hemberg, M., De Jager, P. L., Ransohoff, R. M., Regev, A., & Tsai, L.-H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.039 · Cited by 740
Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain
Askew, K., Li, K., Olmos-Alonso, A., Garcia-Moreno, F., Liang, Y., Richardson, P., Tipton, T., Chapman, M. A., Riecken, K., Beccari, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.041 · Cited by 726
Turnover of resident microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., & Gordon, S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90500-2 · Cited by 709
Spangenberg, E. E., Lee, R. J., Najafi, A. R., Rice, R. A., Elmore, M. R. P., Blurton-Jones, M., West, B. L., & Green, K. N. (2016) · Brain · doi:10.1093/brain/aww016 · Cited by 695
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
Goldmann, T., Wieghofer, P., Müller, P. F., Wolf, Y., Varol, D., Yona, S., Brendecke, S. M., Kierdorf, K., Staszewski, O., Datta, M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3531 · Cited by 688
Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
Zrzavy, T., Hametner, S., Wimmer, I., Butovsky, O., Weiner, H. L., & Lassmann, H. (2017) · Brain · doi:10.1093/brain/awx113 · Cited by 684
Bohlen, C. J., Bennett, F. C., Tucker, A. F., Collins, H. Y., Mulinyawe, S. B., & Barres, B. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.043 · Cited by 658
Efficient derivation of microglia-like cells from human pluripotent stem cells
Muffat, J., Li, Y., Yuan, B., Mitalipova, M., Omer, A., Corcoran, S., Bakiasi, G., Tsai, L.-H., Aubourg, P., Ransohoff, R. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4189 · Cited by 651
Rejuvenation of Regeneration in the Aging Central Nervous System
Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649
Erblich, B., Zhu, L., Etgen, A. M., Dobrenis, K., & Pollard, J. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026317 · Cited by 649
Regenerating CNS myelin — from mechanisms to experimental medicines
Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647
Microglia innately develop within cerebral organoids
Ormel, P. R., de Sá, R. V., van Bodegraven, E. J., Karst, H., Harschnitz, O., Sneeboer, M. A. M., Johansen, L. E., van Dijk, R. E., Scheefhals, N., van Berlekom, A. B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06684-2 · Cited by 642
Bruttger, J., Karram, K., Wörtge, S., Regen, T., Marini, F., Hoppmann, N., Klein, M., Blank, T., Yona, S., Wolf, Y., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.012 · Cited by 634
Holtman, I. R., Raj, D. D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0203-5 · Cited by 619
Microglial dysfunction in brain aging and Alzheimer's disease
Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618
Age-related myelin degradation burdens the clearance function of microglia during aging
Safaiyan, S., Kannaiyan, N., Snaidero, N., Brioschi, S., Biber, K., Yona, S., Edinger, A. L., Jung, S., Rossner, M. J., & Simons, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4325 · Cited by 604
Saederup, N., Cardona, A. E., Croft, K., Mizutani, M., Cotleur, A. C., Tsou, C.-L., Ransohoff, R. M., & Charo, I. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013693 · Cited by 599
A new fate mapping system reveals context-dependent random or clonal expansion of microglia
Tay, T. L., Mai, D., Dautzenberg, J., Fernández-Klett, F., Lin, G., Sagar, Datta, M., Drougard, A., Stempfl, T., Ardura-Fabregat, A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4547 · Cited by 597
Inefficient clearance of myelin debris by microglia impairs remyelinating processes
Lampron, A., Larochelle, A., Laflamme, N., Préfontaine, P., Plante, M.-M., Sánchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M.-È., & Rivest, S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141656 · Cited by 595
Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis
Mei, F., Fancy, S. P. J., Shen, Y. A., Niu, J., Zhao, C., Presley, B., Miao, E., Lee, S., Mayoral, S. R., Redmond, S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3618 · Cited by 595
Butowski, N. A., Colman, H., de Groot, J., Omuro, A. M. P., Nayak, L., Wen, P. Y., Cloughesy, T. F., Marimuthu, A., Haidar, S., Perry, A., et al. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov245 · Cited by 593
Haenseler, W., Sansom, S. N., Buchrieser, J., Newey, S. E., Moore, C. S., Nicholls, F. J., Chintawar, S., Schnell, C., Antel, J. P., Allen, N. D., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.017 · Cited by 593
Green, A. J., Gelfand, J. M., Cree, B. A., Bevan, C., Boscardin, W. J., Mei, F., Inman, J., Arnow, S., Devereux, M., Abounasr, A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32346-2 · Cited by 593
Defective cholesterol clearance limits remyelination in the aged central nervous system
Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science · doi:10.1126/science.aan4183 · Cited by 586
Szalay, G., Martinecz, B., Lénárt, N., Környei, Z., Orsolits, B., Judák, L., Császár, E., Fekete, R., West, B. L., Katona, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms11499 · Cited by 573
Huang, Y., Xu, Z., Xiong, S., Sun, F., Qin, G., Hu, G., Wang, J., Zhao, L., Liang, Y.-X., Wu, T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0090-8 · Cited by 560
Hagemeyer, N., Hanft, K.-M., Akriditou, M.-A., Unger, N., Park, E. S., Stanley, E. R., Staszewski, O., Dimou, L., & Prinz, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1747-1 · Cited by 558
A novel microglial subset plays a key role in myelinogenesis in developing brain
Wlodarczyk, A., Holtman, I. R., Krueger, M., Yogev, N., Bruttger, J., Khorooshi, R., Benmamar‐Badel, A., de Boer‐Bergsma, J. J., Martin, N. A., Karram, K., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696056 · Cited by 535
TREM2 sustains microglial expansion during aging and response to demyelination
Poliani, P. L., Wang, Y., Fontana, E., Robinette, M. L., Yamanishi, Y., Gilfillan, S., & Colonna, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77983 · Cited by 525
A combination of ontogeny and CNS environment establishes microglial identity
Bennett, F. C., Bennett, M. L., Yaqoob, F., Mulinyawe, S. B., Grant, G. A., Hayden Gephart, M., Plowey, E. D., & Barres, B. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.014 · Cited by 524
The Lifespan and Turnover of Microglia in the Human Brain
Réu, P., Khosravi, A., Bernard, S., Mold, J. E., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Druid, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.004 · Cited by 515
Dagher, N. N., Najafi, A. R., Kayala, K. M. N., Elmore, M. R. P., White, T. E., Medeiros, R., West, B. L., & Green, K. N. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0366-9 · Cited by 505
Interleukin-1β Promotes Repair of the CNS
Mason, J. L., Suzuki, K., Chaplin, D. D., & Matsushima, G. K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07046.2001 · Cited by 502
A transcriptomic atlas of aged human microglia
Olah, M., Patrick, E., Villani, A.-C., Xu, J., White, C. C., Ryan, K. J., Piehowski, P., Kapasi, A., Nejad, P., Cimpean, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02926-5 · Cited by 482
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
Vogel, D. Y., Vereyken, E. J., Glim, J. E., Heijnen, P. D., Moeton, M., van der Valk, P., Amor, S., Teunissen, C. E., van Horssen, J., & Dijkstra, C. D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-35 · Cited by 479
Comparison of polarization properties of human adult microglia and blood‐derived macrophages
Durafourt, B. A., Moore, C. S., Zammit, D., Johnson, T., Zaguia, F., Guiot, M., Bar‐Or, A., & Antel, J. P. (2012) · Glia · doi:10.1002/glia.22298 · Cited by 470
Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain
Hill, R. A., Li, A. M., & Grutzendler, J. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0120-6 · Cited by 467
Epigenetic regulation of brain region-specific microglia clearance activity
Ayata, P., Badimon, A., Strasburger, H. J., Duff, M. K., Montgomery, S. E., Loh, Y.-H. E., Ebert, A., Pimenova, A. A., Ramirez, B. R., Chan, A. T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0192-3 · Cited by 460
Migration and differentiation of neural precursor cells can be directed by microglia
Aarum, J., Sandberg, K., Haeberlein, S. L. B., & Persson, M. A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237050100 · Cited by 450
NBB-Psy, Böttcher, C., Schlickeiser, S., Sneeboer, M. A. M., Kunkel, D., Knop, A., Paza, E., Fidzinski, P., Kraus, L., Snijders, G. J. L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0290-2 · Cited by 436
Local cues establish and maintain region-specific phenotypes of basal ganglia microglia
De Biase, L. M., Schuebel, K. E., Fusfeld, Z. H., Jair, K., Hawes, I. A., Cimbro, R., Zhang, H.-Y., Liu, Q.-R., Shen, H., Xi, Z.-X., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.020 · Cited by 432
Cronk, J. C., Filiano, A. J., Louveau, A., Marin, I., Marsh, R., Ji, E., Goldman, D. H., Smirnov, I., Geraci, N., Acton, S., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180247 · Cited by 412
Differentiation of human and murine induced pluripotent stem cells to microglia-like cells
Pandya, H., Shen, M. J., Ichikawa, D. M., Sedlock, A. B., Choi, Y., Johnson, K. R., Kim, G., Brown, M. A., Elkahloun, A. G., Maric, D., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4534 · Cited by 405
Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging
Füger, P., Hefendehl, J. K., Veeraraghavalu, K., Wendeln, A.-C., Schlosser, C., Obermüller, U., Wegenast-Braun, B. M., Neher, J. J., Martus, P., Kohsaka, S., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4631 · Cited by 401
Elmore, M. R. P., Hohsfield, L. A., Kramár, E. A., Soreq, L., Lee, R. J., Pham, S. T., Najafi, A. R., Spangenberg, E. E., Wood, M. A., West, B. L., et al. (2018) · Aging Cell · doi:10.1111/acel.12832 · Cited by 380
Skripuletz, T., Hackstette, D., Bauer, K., Gudi, V., Pul, R., Voss, E., Berger, K., Kipp, M., Baumgärtner, W., & Stangel, M. (2013) · Brain · doi:10.1093/brain/aws262 · Cited by 376
Identification of a microglia phenotype supportive of remyelination
Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., & Boddeke, H. W. G. M. (2012) · Glia · doi:10.1002/glia.21266 · Cited by 358
Depletion of microglia exacerbates postischemic inflammation and brain injury
Jin, W.-N., Shi, S. X.-Y., Li, Z., Li, M., Wood, K., Gonzales, R. J., & Liu, Q. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17694185 · Cited by 351
Mizutani, M., Pino, P. A., Saederup, N., Charo, I. F., Ransohoff, R. M., & Cardona, A. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100421 · Cited by 346
Ajami, B., Samusik, N., Wieghofer, P., Ho, P. P., Crotti, A., Bjornson, Z., Prinz, M., Fantl, W. J., Nolan, G. P., & Steinman, L. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0100-x · Cited by 338
Mei, F., Lehmann‐Horn, K., Shen, Y. A., Rankin, K. A., Stebbins, K. J., Lorrain, D. S., Pekarek, K. L., Sagan, S. A., Xiao, L., Teuscher, C., et al. (2016) · eLife · doi:10.7554/elife.18246 · Cited by 325
Remyelination can be extensive in multiple sclerosis despite a long disease course
Patani, R., Balaratnam, M. S., Vora, A., & Reynolds, R. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00805.x · Cited by 325
Mildner, A., Huang, H., Radke, J., Stenzel, W., & Priller, J. (2017) · Glia · doi:10.1002/glia.23097 · Cited by 301
TREM2 regulates microglial cell activation in response to demyelination in vivo
Cantoni, C., Bollman, B., Licastro, D., Xie, M., Mikesell, R., Schmidt, R., Yuede, C. M., Galimberti, D., Olivecrona, G., Klein, R. S., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1388-1 · Cited by 296
Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord
Wolswijk, G. (2002) · Brain · doi:10.1093/brain/awf031 · Cited by 268
Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease
Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.03.021 · Cited by 238
Microglial Recruitment, Activation, and Proliferation in Response to Primary Demyelination
Remington, L. T., Babcock, A. A., Zehntner, S. P., & Owens, T. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060783 · Cited by 234
A role for CXCR4 signaling in survival and migration of neural and oligodendrocyte precursors
Dziembowska, M., Tham, T. N., Lau, P., Vitry, S., Lazarini, F., & Dubois-Dalcq, M. (2005) · Glia · doi:10.1002/glia.20170 · Cited by 233
Microglial repopulation resolves inflammation and promotes brain recovery after injury: RICE et al.
Rice, R. A., Pham, J., Lee, R. J., Najafi, A. R., West, B. L., & Green, K. N. (2017) · Glia · doi:10.1002/glia.23135 · Cited by 228
Natrajan, M. S., de la Fuente, A. G., Crawford, A. H., Linehan, E., Núñez, V., Johnson, K. R., Wu, T., Fitzgerald, D. C., Ricote, M., Bielekova, B., et al. (2015) · Brain · doi:10.1093/brain/awv289 · Cited by 225
O’Koren, E. G., Mathew, R., & Saban, D. R. (2016) · Scientific Reports · doi:10.1038/srep20636 · Cited by 220
Behrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219
Greenhalgh, A. D., Zarruk, J. G., Healy, L. M., Jesudasan, S. J. B., Jhelum, P., Salmon, C. K., Formanek, A., Russo, M. V., Antel, J. P., McGavern, D. B., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005264 · Cited by 218
Voß, E. V., Škuljec, J., Gudi, V., Skripuletz, T., Pul, R., Trebst, C., & Stangel, M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.09.008 · Cited by 202
P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
Zabala, A., Vazquez‐Villoldo, N., Rissiek, B., Gejo, J., Martin, A., Palomino, A., Perez‐Samartín, A., Pulagam, K. R., Lukowiak, M., Capetillo‐Zarate, E., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708743 · Cited by 192
Critical data‐based re‐evaluation of minocycline as a putative specific microglia inhibitor
Möller, T., Bard, F., Bhattacharya, A., Biber, K. P. H., Campbell, B., Dale, E., Eder, C., Gan, L., Garden, G. A., Hughes, Z. A., et al. (2016) · Glia · doi:10.1002/glia.23007 · Cited by 192
Xiao, L., Xu, H., Zhang, Y., Wei, Z., He, J., Jiang, W., Li, X., Dyck, L. E., Devon, R. M., Deng, Y., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002064 · Cited by 191
Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain
Raj, D., Yin, Z., Breur, M., Doorduin, J., Holtman, I. R., Olah, M., Mantingh-Otter, I. J., Van Dam, D., De Deyn, P. P., den Dunnen, W., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00206 · Cited by 180
Peferoen, L. A. N., Vogel, D. Y. S., Ummenthum, K., Breur, M., Heijnen, P. D. A. M., Gerritsen, W. H., Peferoen-Baert, R. M. B., van der Valk, P., Dijkstra, C. D., & Amor, S. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000149 · Cited by 178
MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells
Healy, L. M., Perron, G., Won, S.-Y., Michell-Robinson, M. A., Rezk, A., Ludwin, S. K., Moore, C. S., Hall, J. A., Bar-Or, A., & Antel, J. P. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502562 · Cited by 174
Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery
Nissen, J. C., Thompson, K. K., West, B. L., & Tsirka, S. E. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.05.021 · Cited by 168
Li, W., Setzu, A., Zhao, C., & Franklin, R. J. M. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.08.011 · Cited by 161
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model
Locatelli, G., Theodorou, D., Kendirli, A., Jordão, M. J. C., Staszewski, O., Phulphagar, K., Cantuti-Castelvetri, L., Dagkalis, A., Bessis, A., Simons, M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0212-3 · Cited by 155
Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function
Pasquini, L. A., Millet, V, Hoyos, H. C., Giannoni, J. P., Croci, D. O., Marder, M., Liu, F. T., Rabinovich, G. A., & Pasquini, J. M. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.40 · Cited by 152
Giera, S., Luo, R., Ying, Y., Ackerman, S. D., Jeong, S.-J., Stoveken, H. M., Folts, C. J., Welsh, C. A., Tall, G. G., Stevens, B., et al. (2018) · eLife · doi:10.7554/elife.33385 · Cited by 145
Fingolimod modulates microglial activation to augment markers of remyelination
Jackson, S. J., Giovannoni, G., & Baker, D. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-76 · Cited by 145
Zhang, Y., Zhao, L., Wang, X., Ma, W., Lazere, A., Qian, H., Zhang, J., Abu-Asab, M. S., Fariss, R. N., Roger, J. E., et al. (2018) · Science Advances · doi:10.1126/sciadv.aap8492 · Cited by 145
Dual extra-retinal origins of microglia in the model of retinal microglia repopulation
Huang, Y., Xu, Z., Xiong, S., Qin, G., Sun, F., Yang, J. F., Yuan, T., Zhao, L., Wang, K., Liang, Y.-X., et al. (2018) · Cell Discovery · doi:10.1038/s41421-018-0011-8 · Cited by 134
Microglia-driven regulation of oligodendrocyte lineage cells, myelination, and remyelination
Miron, V. E. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri1116-494r · Cited by 134
Self-citationDynamic microglial modulation of spatial learning and social behavior
Torres, L., Danver, J., Ji, K., Miyauchi, J. T., Chen, D., Anderson, M. E., West, B. L., Robinson, J. K., & Tsirka, S. E. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.001 · Cited by 133
Beckmann, N., Giorgetti, E., Neuhaus, A., Zurbruegg, S., Accart, N., Smith, P., Perdoux, J., Perrot, L., Nash, M., Desrayaud, S., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0510-8 · Cited by 131
Nicholas, R. S., Wing, M. G., & Compston, A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01470.x · Cited by 129
Regulation of Microglial Development: A Novel Role for Thyroid Hormone
Lima, F. R. S., Gervais, A., Colin, C., Izembart, M., Moura‐Neto, V., & Mallat, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02028.2001 · Cited by 124
Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse
Zhang, Y., Xu, H., Jiang, W., Xiao, L., Yan, B., He, J., Wang, Y., Bi, X., Li, X., & Kong, J. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.09.013 · Cited by 120
Skihar, V., Silva, C., Chojnacki, A. K., Döring, A., Stallcup, W. B., Weiss, S., & Yong, V. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909607106 · Cited by 118
Achievements and obstacles of remyelinating therapies in multiple sclerosis
Stangel, M., Kuhlmann, T., Matthews, P. M., & Kilpatrick, T. J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.139 · Cited by 116
Infiltrating Macrophages Are Key to the Development of Seizures following Virus Infection
Cusick, M. F., Libbey, J. E., Patel, D. C., Doty, D. J., & Fujinami, R. S. (2013) · Journal of Virology · doi:10.1128/jvi.02747-12 · Cited by 112
Lewis, N. D., Hill, J. D., Juchem, K. W., Stefanopoulos, D. E., & Modis, L. K. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.09.014 · Cited by 110
Lalive, P. H., Paglinawan, R., Biollaz, G., Kappos, E. A., Leone, D. P., Malipiero, U., Relvas, J. B., Moransard, M., Suter, T. B., & Fontana, A. (2005) · European Journal of Immunology · doi:10.1002/eji.200425430 · Cited by 110
Cerebellar Cortical Demyelination in the Murine Cuprizone Model
Skripuletz, T., Bussmann, J., Gudi, V., Koutsoudaki, P. N., Pul, R., Moharregh‐Khiabani, D., Lindner, M., & Stangel, M. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00271.x · Cited by 108
Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats
Kanazawa, M., Miura, M., Toriyabe, M., Koyama, M., Hatakeyama, M., Ishikawa, M., Nakajima, T., Onodera, O., Takahashi, T., Nishizawa, M., et al. (2017) · Scientific Reports · doi:10.1038/srep42582 · Cited by 106
Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration
Tay, T. L., Sagar, Dautzenberg, J., Grün, D., & Prinz, M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0584-3 · Cited by 102
A limited capacity for microglial repopulation in the adult brain
Najafi, A. R., Crapser, J., Jiang, S., Ng, W., Mortazavi, A., West, B. L., & Green, K. N. (2018) · Glia · doi:10.1002/glia.23477 · Cited by 99
Bruce, K. D., Gorkhali, S., Given, K., Coates, A. M., Boyle, K. E., Macklin, W. B., & Eckel, R. H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00057 · Cited by 94
Vainchtein, I. D., Vinet, J., Brouwer, N., Brendecke, S., Biagini, G., Biber, K., Boddeke, H. W. G. M., & Eggen, B. J. L. (2014) · Glia · doi:10.1002/glia.22711 · Cited by 92
Acute microglia ablation induces neurodegeneration in the somatosensory system
Rubino, S. J., Mayo, L., Wimmer, I., Siedler, V., Brunner, F., Hametner, S., Madi, A., Lanser, A., Moreira, T., Donnelly, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05929-4 · Cited by 91
MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination
Yu, Z., Sun, D., Feng, J., Tan, W., Xue, F., Zhao, M., Zhao, X., Pu, Y., Huang, A., Xiang, Z., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2468-14.2015 · Cited by 88
Clemastine Potentiates the Human P2X7 Receptor by Sensitizing It to Lower ATP Concentrations
Nörenberg, W., Hempel, C., Urban, N. D., Sobottka, H., Illés, P., & Schaefer, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.198879 · Cited by 84
Döring, A., Sloka, S., Lau, L. W., Mishra, M. K., van Minnen, J., Zhang, X., Kinniburgh, D. W., Rivest, S., & Yong, V. W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1797-14.2015 · Cited by 82
Pu, A., Stephenson, E. L., & Yong, V. W. (2018) · Glia · doi:10.1002/glia.23333 · Cited by 82
Isolating, Culturing, and Polarizing Primary Human Adult and Fetal Microglia
Durafourt, B. A., Moore, C. S., Blain, M., & Antel, J. P. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-520-0_19 · Cited by 80
TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord
Church, J. S., Kigerl, K. A., Lerch, J. K., Popovich, P. G., & McTigue, D. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0353-16.2016 · Cited by 75
Rawji, K. S., Kappen, J., Tang, W., Teo, W., Plemel, J. R., Stys, P. K., & Yong, V. W. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2341-17.2018 · Cited by 75
Activin receptors regulate the oligodendrocyte lineage in health and disease
Dillenburg, A., Ireland, G., Holloway, R. K., Davies, C. L., Evans, F. L., Swire, M., Bechler, M. E., Soong, D., Yuen, T. J., Su, G. H., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1813-3 · Cited by 75
Self-citationApolloni, S., Fabbrizio, P., Parisi, C., Amadio, S., & Volonté, C. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9019-8 · Cited by 72
Differential responses of human microglia and blood-derived myeloid cells to FTY720
Durafourt, B. A., Lambert, C., Johnson, T., Blain, M., Bar‐Or, A., & Antel, J. P. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.006 · Cited by 63
Kondo, Y., & Duncan, I. D. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22096 · Cited by 62
Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis
Brown, R. A., Narayanan, S., & Arnold, D. L. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.06.009 · Cited by 56
Laflamme, N., Cisbani, G., Préfontaine, P., Srour, Y., Bernier, J., St-Pierre, M.-K., Tremblay, M.-È., & Rivest, S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00178 · Cited by 55
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Mori, Y., Tomonaga, D., Kalashnikova, A., Furuya, F., Akimoto, N., Ifuku, M., Okuno, Y., Beppu, K., Fujita, K., Katafuchi, T., et al. (2015) · Glia · doi:10.1002/glia.22792 · Cited by 54
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Hillmer, A. T., Holden, D., Fowles, K., Nabulsi, N., West, B. L., Carson, R. E., & Cosgrove, K. (2017) · EJNMMI Research · doi:10.1186/s13550-017-0305-0 · Cited by 51
Wang, H., Liu, S., Tian, Y., Wu, X., He, Y., Li, C., Namaka, M., Kong, J., Li, H., & Xiao, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00492 · Cited by 50
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Yao, Y., Echeverry, S., Shi, X., Yang, M., Yang, Q. Z., Wang, G. Y. F., Chambon, J., Wu, Y. C., Fu, K., Koninck, Y. D., et al. (2016) · Scientific Reports · doi:10.1038/srep22839 · Cited by 49
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Mullin, A. P., Cui, C., Wang, Y., Wang, J., Troy, E. L., Caggiano, A. O., Parry, T. J., Colburn, R. W., & Pavlopoulos, E. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.05.015 · Cited by 48
Zhang, M., Zhan, X. L., Zi, Y., Chen, X. S., Cai, Q. Y., & Yao, Z. X. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370214565975 · Cited by 44
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Zorina, Y., Stricker, J., Caggiano, A. O., & Button, D. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-27559-y · Cited by 44
van Strien, M. E., Baron, W., Bakker, E. N. T. P., Bauer, J., Bol, J. G. J. M., Brevé, J. J. P., Binnekade, R., van der Laarse, W. J., Drukarch, B., & van Dam, A. (2011) · Glia · doi:10.1002/glia.21204 · Cited by 33
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Sarkar, S., D�ring, A., Zemp, F. J., Silva, C., Lun, X., Wang, X., Kelly, J., Hader, W. J., Hamilton, M. G., Mercier, P., et al. (2013) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.200407 · Cited by 29
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Samanani, S., Mishra, M. K., Silva, C., Verhaeghe, B., Wang, J., Tong, J. P.-W., & Yong, V. W. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660177 · Cited by 24
Hlavica, M., Delparente, A., Good, A., Good, N., Plattner, P. S., Seyedsadr, M. S., Schwab, M. E., Figlewicz, D. P., & Ineichen, B. V. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.03.047 · Cited by 24
Wang, J., Siffert, M., Spiliotis, M., & Gottstein, B. (2016) · Journal of Immunology Research · doi:10.1155/2016/1450398 · Cited by 13
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Metadata
- Authors
- Lloyd, A. F., & Miron, V. E.
- Affiliations
- Multiple Sclerosis Society (GB)
- Venue
- Nature Reviews Neurology
- Published
- 2019-06-29
- Volume
- 15
- Issue
- 8
- Pages
- 447-458
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2954946400
- Cited by
- 381
- References
- 148
- Citations by year
- 2026: 47 · 2025: 48 · 2024: 59 · 2023: 65 · 2022: 57 · 2021: 57 · 2020: 37 · 2019: 11
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Action Medical Research
- Medical Research Council (MR/M020827/1, MR/N022556/1)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microglia, remyelination, microglial activation, demyelinating disease, multiple sclerosis, microglial heterogeneity
- MeSH terms
- Remyelination, Aging, Animals, Central Nervous System, Demyelinating Diseases, Homeostasis, Humans, Macrophage Activation, Microglia
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