The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
Open accessAbstract
Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly consequence of exposure to severe psychological trauma. Although effective treatments exist for some individuals, they are limited. New approaches to intervention, treatment and prevention are therefore much needed. In the past few years, the field has rapidly developed a greater understanding of the dysfunctional brain circuits underlying PTSD, a shift in understanding that has been made possible by technological revolutions that have allowed the observation and perturbation of the macrocircuits and microcircuits thought to underlie PTSD-related symptoms. These advances have allowed us to gain a more translational knowledge of PTSD, have provided further insights into the mechanisms of risk and resilience and offer promising avenues for therapeutic discovery.
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“Much of our understanding draws from studies on the dissociative subtype of PTSD [105,143].”
From Treatment of dissociative identity disorder: leveraging neurobiology to optimize success (2024) · cites this paper as [143]
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“Additionally, induced ELS via the maternal separation model reduces pre- and post-synaptic protein expression of inhibitory neurons in the mPFC (124).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [124]
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Research works printed but not linked: 1
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Metadata
- Authors
- Fenster, R. J., Lebois, L. A. M., Ressler, K. J., & Suh, J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Ressler, Kerry J.
- Suh, Junghyup
- Venue
- Nature Reviews Neuroscience
- Published
- 2018-07-27
- Volume
- 19
- Issue
- 9
- Pages
- 535-551
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC6148363
- OpenAlex
- W2884319195
- Cited by
- 456
- References
- 227
- Citations by year
- 2026: 44 · 2025: 51 · 2024: 81 · 2023: 58 · 2022: 57 · 2021: 69 · 2020: 52 · 2019: 38 · 2018: 4
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Biogen
- Center of Excellence for Stress and Mental Health
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R21AA027450)
- National Institute of Mental Health (R21MH112956, R01MH094757, F32MH109274, R01MH117292, R01MH108665)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- post-traumatic stress disorder, neural circuits, trauma, resilience, risk factors, translational research, neural circuit manipulation, PTSD treatment, PTSD prevention
- MeSH terms
- Animals, Brain, Disease Models, Animal, Humans, Neural Pathways, Neurons, Stress Disorders, Post-Traumatic, Mice
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