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Cited by 194Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchPsychoanalysis and Psychopathology Research

Neuroimaging studies in post-traumatic stress disorder

Bremner, J. Douglas·2002·Current Psychiatry Reports
DOI 10.1007/s11920-996-0044-9
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Abstract

The past decade has seen a rapid advance in understanding of the neural circuits of post-traumatic stress disorder (PTSD), which has largely been due to the application of neuroimaging to the study of this disorder. Based on studies in animals of the effects of stress on the brain, dysfunction of the medial prefrontal cortex, hippocampus, and amygdala have been hypothesized to underlie symptoms of PTSD. Neuroimaging studies in PTSD have been consistent with these hypotheses, with the most replicated findings showing decreased medial prefrontal cortical function in PTSD. Other replicated findings include decreased inferior frontal gyrus function, decreased hippocampal function, increased posterior cingulate function, and, in some behavioral paradigms, increased amygdala function. Several studies have now shown changes in structure (smaller volume) of the hippocampus in PTSD. These studies are beginning to map out a neural circuitry of PTSD that may have future implications for diagnosis and treatment.

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Crossref · 10.1007/s11920-996-0044-9

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  • PTSD is associated with reduced medial PFC activity and grey matter volume and with heightened noradrenaline activity.

    “PTSD is associated with reduced medial PFC activity and grey matter volume144 and with heightened noradrenaline activity145.”

    From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [144]

  • In post-traumatic stress disorder and borderline personality disorder, atrophy of the hippocampus has been reported.

    “there are a variety of other anxiety-related disorders, such as post-traumatic stress disorder (PTSD) (Bremner, 2002) (Pitman, 2001) and borderline personality disorder (Driessen et al., 2000), in which atrophy of the hippocampus has been reported”

    From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Bremner, 2002

  • Atrophy of the hippocampus has been reported in PTSD and other anxiety-related disorders.

    “Moreover, there are a variety of other anxiety-related disorders, such as posttraumatic stress disorder (PTSD), in which atrophy of the hippocampus has been reported,13,14”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [14]

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Authors
Bremner, J. D.
Affiliations
Emory University (US)
Corresponding author
Bremner, J. Douglas
ORCID
Bremner, J. Douglas
Venue
Current Psychiatry Reports
Publisher
Springer Science and Business Media LLC
Published
2002-08
Volume
4
Issue
4
Pages
254-263
ISSN
  • 1523-3812 (ISSN-L)
  • 1535-1645
DOI
10.1007/s11920-996-0044-9
OpenAlex
W2138680553
Cited by
194
References
32
Citations by year
2026: 1 · 2025: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 11 · 2013: 5 · 2012: 9
FWCI
22.12
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Psychiatry Reports (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R01MH056120)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
post-traumatic stress disorder, neural circuits, medial prefrontal cortex, hippocampus, amygdala, inferior frontal gyrus, posterior cingulate cortex, hippocampal volume, brain structural changes
MeSH terms
Brain, Female, Humans, Male, Stress Disorders, Post-Traumatic, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon

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