The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
Open accessAbstract
Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly consequence of exposure to severe psychological trauma. Although effective treatments exist for some individuals, they are limited. New approaches to intervention, treatment and prevention are therefore much needed. In the past few years, the field has rapidly developed a greater understanding of the dysfunctional brain circuits underlying PTSD, a shift in understanding that has been made possible by technological revolutions that have allowed the observation and perturbation of the macrocircuits and microcircuits thought to underlie PTSD-related symptoms. These advances have allowed us to gain a more translational knowledge of PTSD, have provided further insights into the mechanisms of risk and resilience and offer promising avenues for therapeutic discovery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Much of our understanding draws from studies on the dissociative subtype of PTSD [105,143].”
From Treatment of dissociative identity disorder: leveraging neurobiology to optimize success (2024) · cites this paper as [143]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Additionally, induced ELS via the maternal separation model reduces pre- and post-synaptic protein expression of inhibitory neurons in the mPFC (124).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [124]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Posttraumatic Stress Disorder in the National Comorbidity Survey
Kessler, R. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240066012 · Cited by 10,379
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets.
Macosko, E. Z., Basu, A., Satija, R., Nemesh, J., Shekhar, K., Goldman, M., Tirosh, I., Bialas, A. R., Kamitaki, N., Martersteck, E. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.002 · Cited by 7,110
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
Core affect and the psychological construction of emotion.
Russell, J. A. (2003) · Psychological Review · doi:10.1037/0033-295x.110.1.145 · Cited by 6,113
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059
Toward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053
Research works printed but not linked: 1
- Shin, L. M. in Neurobiology of PTSD (eds Shiromani, P. J., Keane, T. M. & LeDoux, J. E.) (Humana Press, 2009).
Cited by
Sorted by citations
Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Ressler, K. J., Berretta, S., Bolshakov, V. Y., Rosso, I. M., Meloni, E. G., Rauch, S. L., & Carlezon, W. A. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00635-8 · Cited by 572
Self-citationThe role of the salience network in cognitive and affective deficits
Schimmelpfennig, J., Topczewski, J., Zajkowski, W. K., & Jankowiak-Siuda, K. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1133367 · Cited by 379
Resilience after trauma: The role of memory suppression
Mary, A., Dayan, J., Leone, G., Postel, C., Fraisse, F., Malle, C., Vallée, T., Klein-Peschanski, C., Viader, F., Sayette, V. D. L., et al. (2020) · Science · doi:10.1126/science.aay8477 · Cited by 272
Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236
Tran, M. N., Maynard, K. R., Spangler, A., Huuki, L. A., Montgomery, K. D., Sadashivaiah, V., Tippani, M., Barry, B. K., Hancock, D. B., Hicks, S. C., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.001 · Cited by 219
Metadata
- Authors
- Fenster, R. J., Lebois, L. A. M., Ressler, K. J., & Suh, J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Ressler, Kerry J.
- Suh, Junghyup
- Venue
- Nature Reviews Neuroscience
- Published
- 2018-07-27
- Volume
- 19
- Issue
- 9
- Pages
- 535-551
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC6148363
- OpenAlex
- W2884319195
- Cited by
- 456
- References
- 227
- Citations by year
- 2026: 44 · 2025: 51 · 2024: 81 · 2023: 58 · 2022: 57 · 2021: 69 · 2020: 52 · 2019: 38 · 2018: 4
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Biogen
- Center of Excellence for Stress and Mental Health
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R21AA027450)
- National Institute of Mental Health (R21MH112956, R01MH094757, F32MH109274, R01MH117292, R01MH108665)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- post-traumatic stress disorder, neural circuits, trauma, resilience, risk factors, translational research, neural circuit manipulation, PTSD treatment, PTSD prevention
- MeSH terms
- Animals, Brain, Disease Models, Animal, Humans, Neural Pathways, Neurons, Stress Disorders, Post-Traumatic, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
