Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,188

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Ji, Y. (1993) · Cell · doi:10.1016/0092-8674(93)90485-9 · Cited by 2,497

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

Kigerl, K. A., Gensel, J. C., Ankeny, D. P., Alexander, J. K., Donnelly, D. J., & Popovich, P. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3257-09.2009 · Cited by 2,130

Identification of RIP1 kinase as a specific cellular target of necrostatins

Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.83 · Cited by 2,059

New insights of necroptosis and immune infiltration in sepsis-induced myocardial dysfunction from bioinformatics analysis through RNA-seq in mice

Du, Y., Zhong, Y., Ding, R., Wang, X., Xia, F., Zhang, Q., & Peng, Q. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1068324 · Cited by 25

Ferroptosis: Underlying mechanism and the crosstalk with other modes of neuronal death after intracerebral hemorrhage

Cao, Y., Xiao, W., Liu, S., & Zeng, Y. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1080344 · Cited by 27

Repositioning linifanib as a potent anti-necroptosis agent for sepsis

Yu, L., Yang, K., He, X., Li, M., Gao, L., & Zha, Y. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01351-y · Cited by 26

Nuclear Export Inhibitors Selinexor (KPT-330) and Eltanexor (KPT-8602) Provide a Novel Therapy to Reduce Tumor Growth by Induction of PANoptosis

Camilli, S., Lockey, R. F., & Kolliputi, N. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01135-2 · Cited by 29

The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis

Rojas‐Rivera, D., Beltrán, S., Muñoz-Carvajal, F., Ahumada, P., Abarzúa, L., Gómez, L., Hernandez, F., Bergmann, C. A., Labrador, L., Nassif, M., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2367923 · Cited by 25

RIPK3: Beyond Necroptosis

Evans, A. S., & Coyne, C. B. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.031 · Cited by 25

Novel Methods of Necroptosis Inhibition for Spinal Cord Injury Using Translational Research to Limit Secondary Injury and Enhance Endogenous Repair and Regeneration

Fiani, B., Kondilis, A., Soula, M., Tao, A. Y., & Alvi, M. A. (2021) · Neurospine · doi:10.14245/ns.2040722.361 · Cited by 25

Ganoderic acid T improves the radiosensitivity of HeLa cells via converting apoptosis to necroptosis

Shao, C., Feng, N., Zhou, S., Zheng, X., Wang, P., Zhang, J., & Huang, Q. (2021) · Toxicology Research · doi:10.1093/toxres/tfab030 · Cited by 23

A Novel Model Based on Necroptosis-Related Genes for Predicting Prognosis of Patients With Prostate Adenocarcinoma

Li, X., You, J., Zhang, L., Su, L., & Yang, X. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.814813 · Cited by 25

TNF-α derived from arsenite-induced microglia activation mediated neuronal necroptosis

Wang, H., Chen, Y., Liu, X., Zhang, R., Wang, X., Zhang, Q., Wei, Y., Fang, F., Yuan, Y., Zhou, Q., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113468 · Cited by 26

Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T cell activation in autoimmune demyelination

Kim, S.-J., Lu, H. C., Steelman, A. J., & Li, J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2117636119 · Cited by 25

Neuroinflammation: Molecular Mechanisms And Therapeutic Perspectives

Meccariello, R., Marino, M., Mele, E., Pastorino, G. M. G., Operto, F. F., Santoro, A., & Viggiano, A. (2022) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524922666220929153215 · Cited by 29

Apolipoprotein A1 Protects Against Necrotic Core Development in Atherosclerotic Plaques: PDZK1-Dependent High-Density Lipoprotein Suppression of Necroptosis in Macrophages

Kluck, G. E. G., Qian, A. S., Sakarya, E. H., Quach, H., Deng, Y. D., & Trigatti, B. L. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318062 · Cited by 30

Resveratrol ameliorates myocardial ischemia/reperfusion induced necroptosis through inhibition of the Hippo pathway

Tian, H., Xiong, Y., & Xia, Z. (2022) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-022-09954-3 · Cited by 25

The Role of P53 in Myocardial Ischemia-Reperfusion Injury

Zhu, X.-Z., Qiu, Z., Lei, S., Leng, Y., Li, W., & Xia, Z. (2023) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-023-07480-x · Cited by 26

APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease

Liu, H., Mei, F., Ye, R., Han, X., Wang, S., Ding, Y., Zhi, Y., Pang, K., Guo, W., & Lu, B. (2024) · Cell Research · doi:10.1038/s41422-024-00957-w · Cited by 27

Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response

García‐Revilla, J., Ruiz, R., Espinosa‐Oliva, A. M., Santiago, M., García-Domínguez, I., Camprubí-Ferrer, L., Bachiller, S., Deierborg, T., Joseph, B., de Pablos, R. M., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07014-9 · Cited by 25

Immunoadjuvant therapy in the regulation of cell death in sepsis: recent advances and future directions

Islam, M. M., Watanabe, E., Salma, U., Ozaki, M., Irahara, T., Tanabe, S., Katsuki, R., Oishi, D., & Takeyama, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1493214 · Cited by 30

Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation

Cao, M., Guo, Z., Wang, J., Ma, H.-Y., Zhong, S.-J., Hu, Y., Qin, X., & Lan, R. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.03.014 · Cited by 25

The protein kinase CK1: Inhibition, activation, and possible allosteric modulation

Sunkari, Y. K., Meijer, L., & Flajolet, M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.916232 · Cited by 24

Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line

Tu, Y., Yang, Y., Wang, Y., Wu, N., Tao, J., Yang, G., & You, M. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120217 · Cited by 24

Mitochondrial dysfunction promotes the necroptosis of Purkinje cells in the cerebellum of acrylamide-exposed rats

Huang, Z., Wang, S., Yang, Y., Lou, J., Liu, Z., Liu, Z. Q., Yong, H., Shan, S., & Song, F. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113522 · Cited by 24

Unwinding the modalities of necrosome activation and necroptosis machinery in neurological diseases

Gupta, R. V., Kumari, S., Tripathi, R. S., Ambasta, R. K., & Kumar, P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101855 · Cited by 27

A phase I randomized, double‐blinded , placebo‐controlled study assessing the safety and pharmacokinetics of RIPK1 inhibitor GFH312 in healthy subjects

Lickliter, J. D., Wang, S., Zhang, W., Zhu, H., Wang, J., Zhao, C., Shen, H., & Wang, Y. (2023) · Clinical and Translational Science · doi:10.1111/cts.13580 · Cited by 24

Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage

Wu, Y., Xu, Y., Sun, J., Dai, K., Wang, Z., & Zhang, J. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114705 · Cited by 23

Ripa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma

Feng, L., Dai, S., Zhang, C., Zhang, W., Zhu, W., Wang, C., He, Y., & Song, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-54075-z · Cited by 23

Mechanistic Insights into Autophagy-Dependent Cell Death (ADCD): A Novel Avenue for Cancer Therapy

Rahman, M. A., Jalouli, M., Al-Zharani, M. M., Apu, E. H., & Harrath, A. H. (2025) · Cells · doi:10.3390/cells14141072 · Cited by 29

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

Zhuang, Y., Xu, H. C., Shinde, P. V., Warfsmann, J., Vasiļevska, J., Sundaram, B., Behnke, K., Huang, J., Hoell, J. I., Borkhardt, A., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318215 · Cited by 24

RIPK1-Associated Inborn Errors of Innate Immunity

Zhang, J., Jin, T., Aksentijevich, I. A., & Zhou, Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676946 · Cited by 22

Neuroinflammation in Gaucher disease, neuronal ceroid lipofuscinosis, and commonalities with Parkinson’s disease

Francelle, L., & Mazzulli, J. R. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147798 · Cited by 23

Inhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-κB pathway

Ma, X.-R., Yang, S., Zheng, S., Yan, H., Gu, H.-M., Wang, F., Wu, Y., Dong, Z.-J., Wang, D.-X., Wang, Y., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00929-2 · Cited by 24

Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis

Neel, D. V., Basu, H., Gunner, G., & Chiu, I. M. (2022) · Immunological Reviews · doi:10.1111/imr.13083 · Cited by 22

A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers

Torres, P., Anerillas, C., Ramírez‐Núñez, O., Fernàndez, A., Encinas, M., Povedano, M., Andrés‐Benito, P., Ferrer, I., Ayala, V., Pamplona, R., et al. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049059 · Cited by 23

PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death

Wu, G., Li, D., Liang, W. P., Sun, W., Xie, X., Tong, Y., Shan, B., Zhang, M., Lu, X., Yuan, J., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05206-9 · Cited by 24

Macrophage Infiltration Initiates RIP3/MLKL-Dependent Necroptosis in Paclitaxel-Induced Neuropathic Pain

Ma, D., Wang, X., Liu, X., Zhao, L., Liu, J., Cao, J., Wang, G., Guo, Y., & Zhao, S. (2022) · Mediators of Inflammation · doi:10.1155/2022/1567210 · Cited by 25

PGAM5 regulates DRP1-mediated mitochondrial fission/mitophagy flux in lipid overload-induced renal tubular epithelial cell necroptosis

Sang, D., Duan, X., Yu, X., Zang, J., Liu, L., & Wu, G. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.10.003 · Cited by 22

Manganese enhances macrophage defense against Mycobacterium tuberculosis via the STING-TNF signaling pathway

Qian, K., Shan, L., Shang, S., Li, T., Wang, S., Wei, M., Tang, B., & Xi, J. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109471 · Cited by 22

Molecular and functional characteristics of receptor-interacting protein kinase 1 (RIPK1) and its therapeutic potential in Alzheimer's disease

Pati, S., Gautam, A. S., Dey, M., Tiwari, A., & Singh, R. K. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103750 · Cited by 23

Dietary selenomethionine reduced oxidative stress by resisting METTL3-mediated m6A methylation level of Nrf2 to ameliorate LPS-induced liver necroptosis in laying hens

Li, S., Wang, Y., Xu, A., Zhao, B., Xia, Y., He, Y., Xue, H., & Li, S. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109563 · Cited by 23

RIPK3 deficiency blocks R-2-hydroxyglutarate–induced necroptosis in IDH-mutated AML cells

Zhu, S., Luo, Y., Li, K., Mei, C., Wang, Y., Jiang, L., Wang, W., Zhang, Q., Yang, W., Lang, W., et al. (2024) · Science Advances · doi:10.1126/sciadv.adi1782 · Cited by 24

Unmasking inborn errors of immunity: identifying the red flags of immune dysregulation

Cortesi, M., Dotta, L., Cattalini, M., Lougaris, V., Soresina, A., & Badolato, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1497921 · Cited by 22

Circular RNAs modulate cell death in cardiovascular diseases

Pan, R., Koo, C., Su, W., You, Q., Guo, H.-D., & Liu, B. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02504-x · Cited by 24

Double agents of cell death: novel emerging functions of apoptotic regulators

Lamb, H. M. (2020) · FEBS Journal · doi:10.1111/febs.15308 · Cited by 23

Pan-Caspase Inhibitor zVAD Induces Necroptotic and Autophagic Cell Death in TLR3/4-Stimulated Macrophages

Chen, Y.-S., Chuang, W., Kung, H., Cheng, C.-Y., Huang, D.-Y., Sekar, P., & Lin, W. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0193 · Cited by 23

Diverse pathways to neuronal necroptosis in Alzheimer's disease

Jayaraman, A., & Reynolds, R. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15662 · Cited by 21

Identification and Verification of Necroptosis-Related Gene Signature With Prognosis and Tumor Immune Microenvironment in Ovarian Cancer

Wang, Z., Chen, G., Dai, F., Liu, S., Hu, W., & Cheng, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.894718 · Cited by 22

Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis

Land, W. G. (2023) · Genes and Immunity · doi:10.1038/s41435-023-00198-8 · Cited by 23

Receptor-interacting protein kinase 1 (RIPK1) inhibitor: a review of the patent literature (2018-present)

Xu, L., Zhang, W., & Zhuang, C. (2023) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2023.2195548 · Cited by 22

Research Progress on Micro(nano)plastic-Induced Programmed Cell Death Associated with Disease Risks

Liu, H., Li, H., Chen, T., Fan, Y., Lin, Q., Zhao, H., Jin, L., & Peng, R. (2024) · Toxics · doi:10.3390/toxics12070493 · Cited by 23

Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in developing mouse neurons

Zhuravskaya, A., Yap, K., Hamid, F., & Makeyev, E. V. (2024) · Genome biology · doi:10.1186/s13059-024-03305-8 · Cited by 20

Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders

Miller, S., & Blanco, M.-J. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00036e · Cited by 21

Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1

Huang, X., Tan, S., Li, Y., Cao, S., Li, X., Pan, H., Shan, B., Qian, L., & Yuan, J. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202007127 · Cited by 20

The role of regulatory necrosis in traumatic brain injury

Nie, Z., Tan, L., Niu, J., & Wang, B. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1005422 · Cited by 21

Frequency of coexistent eye diseases and cognitive impairment or dementia: a systematic review and meta-analysis

Xu, Y. H., Phu, J., Aung, H. L., Hesam‐Shariati, N., Keay, L. J., Tully, P. J., Booth, A., Anderson, C. S., Anstey, K. J., & Peters, R. K. (2023) · Eye · doi:10.1038/s41433-023-02481-4 · Cited by 21

Can pyroptosis be a new target in rheumatoid arthritis treatment?

Wu, D., Li, Y., & Xu, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1155606 · Cited by 23

Necrostatin‑1 ameliorates the pathogenesis of experimental autoimmune encephalomyelitis by suppressing apoptosis and necroptosis of oligodendrocyte precursor cells

Wang, Y., Guo, L., Wang, J., Shi, W., Xia, Z., & Guo, L. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8005 · Cited by 21

Perampanel, an AMPAR antagonist, alleviates experimental intracerebral hemorrhage‑induced brain injury via necroptosis and neuroinflammation

Yang, L., Wang, Y., Zhang, C., Chen, T., & Cheng, H. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12183 · Cited by 21

A missense variant in SHARPIN mediates Alzheimer’s disease-specific brain damages

Park, J. Y., Lee, D., Lee, J. J., Gim, J., Gunasekaran, T. I., Choi, K. Y., Kang, S., Do, A. R., Jo, J., Park, J., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01680-5 · Cited by 21

Mechanisms of Myofibre Death in Muscular Dystrophies: The Emergence of the Regulated Forms of Necrosis in Myology

Bencze, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010362 · Cited by 20

RIPK1 and RIPK3 inhibitors: potential weapons against inflammation to treat diabetic complications

Ke, D., Zhang, Z., Liu, J., Chen, P., Dai, Y., Sun, X., Chu, Y., & Li, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1274654 · Cited by 22

Advances in the regulatory mechanisms of mTOR in necroptosis

Xie, Y., Zhao, G., Lei, X., Cui, N., & Wang, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1297408 · Cited by 21

Cell Death in Crustacean Immune Defense

Chen, Z., Tayyab, M., Yao, D., Aweya, J. J., Zheng, Z., Zhao, X., Lin, Z., & Zhang, Y. (2024) · Reviews in Aquaculture · doi:10.1111/raq.12976 · Cited by 20

Cognitive enhancing effects of pazopanib in D‑galactose/ovariectomized Alzheimer’s rat model: insights into the role of RIPK1/RIPK3/MLKL necroptosis signaling pathway

Abdelhady, R., Younis, N. S., Ali, O., Shehata, S., Sayed, R. H., & Nadeem, R. I. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01269-y · Cited by 20

The romantic history of signaling pathway discovery in cell death: an updated review

Wang, L., Liu, X., Li, Q.-Q., Zhu, Y., Ren, H.-L., Song, J., Zeng, J., Mei, J., Tian, H., Rong, D., et al. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04873-2 · Cited by 22

Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis

Wei, J. S., Li, M., Zhi, Y., Hu, X., He, X., Wang, J., Chen, G., Zou, C., Xu, D., Zhang, H., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01713-z · Cited by 20

Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

Mousavi, H., Rimaz, M., & Zeynizadeh, B. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00055 · Cited by 21

Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure

Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117367 · Cited by 22

Significance of Necroptosis in Cartilage Degeneration

Khaleque, M. A., Kim, J.-H., Tanvir, M. A. H., Park, J., & Kim, Y. (2024) · Biomolecules · doi:10.3390/biom14091192 · Cited by 20

Chemogenomics for drug discovery: clinical molecules from open access chemical probes

Quinlan, R. B. A., & Brennan, P. E. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00016k · Cited by 18

Hsp90α and cell death in cancers: a review

Liu, B., & Qian, D. (2024) · Discover Oncology · doi:10.1007/s12672-024-01021-0 · Cited by 21

Reduction of D2 receptors on microglia leads to ZBP1-mediated PANoptosis of mPFC in Parkinson's disease depression mice

Zhao, Q., Zhang, X., Zhang, J., Zhang, Y., Jia, L., Guo, S., Zhang, M., Wang, H., Wang, Y., Guan, Y., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114809 · Cited by 22

Chronic stepwise cerebral hypoperfusion differentially induces synaptic proteome changes in the frontal cortex, occipital cortex, and hippocampus in rats

Tukacs, V., Mittli, D., Györffy, B. A., Hunyady-Gulyás, É., Hlatky, D., Tóth, V., Ravasz, L., Medzihradszky, F. K., Nyitrai, G., Czurkó, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72868-w · Cited by 19

Bi-Directional Relationship Between Autophagy and Inflammasomes in Neurodegenerative Disorders

Panda, C., & Mahapatra, R. K. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01184-2 · Cited by 20

Potential role of PANoptosis in neuronal cell death: commentary on “PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons”

Sun, Y., & Zhu, C. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.346483 · Cited by 19

Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a

Clusmann, J., Franco, K.-D. C., Suárez, D. A. C., Katona, I., Schilling, M., Boersch, N., Pissas, K., Vanek, J., Tian, Y., & Gründer, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05139-3 · Cited by 19

Assessing regulated cell death modalities as an efficient tool for in vitro nanotoxicity screening: a review

Tkachenko, A. S., Onishchenko, A. I., Myasoedov, V. V., Yefimova, S. L., & Havránek, O. (2023) · Nanotoxicology · doi:10.1080/17435390.2023.2203239 · Cited by 21

Nrf2/HO-1 blocks TXNIP/NLRP3 interaction via elimination of ROS in oxygen-glucose deprivation-induced neuronal necroptosis

Liu, Z., Cheng, P., Feng, T., Xie, Z., Yang, M., Chen, Z., Hu, S., Han, D. K., & Chen, W. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148482 · Cited by 20

Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy

Jiang, S., Ma, F., Lou, J., Li, J., Shang, X., Li, Y., Wu, J., & Xu, S. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176455 · Cited by 19

Ursolic acid improves necroptosis via STAT3 signaling in intestinal ischemia/reperfusion injury

Shi, Y., Liu, J., Hou, M., Tan, Z., Chen, F., Zhang, J., Liu, Y., & Leng, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112463 · Cited by 19

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition

Brito, H., Marques, V., Afonso, M. B., Brown, D. G., Börjesson, U., Selmi, N., Smith, D. M., Roberts, I. O., Fitzek, M., Aniceto, N., et al. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-0240-0 · Cited by 19

Spatiotemporal expression patterns of ZBP1 in the brain of mouse experimental stroke model

Mutoh, T., Kikuchi, H., Jitsuishi, T., Kitajo, K., & Yamaguchi, A. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102362 · Cited by 18

PGAM5 promotes RIPK1-PANoptosome activity by phosphorylating and activating RIPK1 to mediate PANoptosis after subarachnoid hemorrhage in rats

Jiajia, D., Wen, Y. E., Enyan, J., Xiaojian, Z., Zhen, F., Jia, Z., Jikai, W., Xiaoxin, Y., Liu, A., Kong, F., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115072 · Cited by 18

HMGB1: Different secretion pathways with pivotal role in epilepsy and major depressive disorder

Shokr, M. M., & Eladawy, R. M. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.02.023 · Cited by 18

Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway

Li, T., Chen, J., Xie, Z., Fang, J., Wu, Q., Cao, X., Chen, Z., Wang, Y.-Y., Fan, Q., Wang, Q., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1528590 · Cited by 20

DAMP signaling networks: from receptors to diverse pathophysiological functions

Chen, R., Zou, J., Zhong, X. Y., Liu, J., Kang, R., & Tang, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.047 · Cited by 26

Maternal Plasma Metabolic Profile Demarcates a Role for Neuroinflammation in Non-Typical Development of Children

Schmidt, R. J., Liang, D., Busgang, S. A., Curtin, P. C. P., & Giulivi, C. (2021) · Metabolites · doi:10.3390/metabo11080545 · Cited by 18

Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production

Zu, R., Yu, Z., Zhao, J., Lu, X., Liang, W. P., Sun, L., Si, C., Zhu, K., Zhang, T., Li, G., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04290-7 · Cited by 18

Receptor interacting protein 3 kinase, not 1 kinase, through MLKL-mediated necroptosis is involved in UVA-induced corneal endothelium cell death

Yu, Z., Efstathiou, N. E., Correa, V., Chen, X., Ishihara, K., Iesato, Y., Narimatsu, T., Ntentakis, D. P., Chen, Y., & Vavvas, D. G. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00757-w · Cited by 18

Viral-induced neuronal necroptosis: Detrimental to brain function and regulation by necroptosis inhibitors

Panda, S. P., Kesharwani, A., Mallick, S. P., Prasanth, D., Pasala, P. K., & Tatipamula, V. B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115591 · Cited by 18

Global trends in PANoptosis research: bibliometrics and knowledge graph analysis

Zheng, Y., Li, J., Liu, B., Xie, Z., He, Y., Xue, D., Zhao, D., & Hao, C. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01889-3 · Cited by 19

Insight from Linker Investigations: Discovery of a Novel Phenylbenzothiazole Necroptosis Inhibitor Targeting Receptor-Interacting Protein Kinase 1 (RIPK1) from a Phenoxybenzothiazole Compound with Dual RIPK1/3 Targeting Activity

Fang, J., Yao, H., Zhuang, C., & Chen, F. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01351 · Cited by 18

Neurotoxicity of glyphosate: Focus on molecular mechanisms probably associated with alterations in cognition and behavior

Chávez‐Reyes, J., Reyes, C. D. G., Hernández-Cuellar, E., & Marichal‐Cancino, B. A. (2024) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2024.104381 · Cited by 18

PANoptosis, an indicator of COVID-19 severity and outcomes

Yang, Q., Song, W.-M., Reheman, H., Wang, D., Qu, J., & Li, Y. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae124 · Cited by 20

Ubiquitous regulation of cerebrovascular diseases by ubiquitin‐modifying enzymes

Huang, J., Zhu, Z., Schlüter, D., Lambertsen, K. L., Song, W., & Wang, X. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1719 · Cited by 18

Silk fibroin microneedles loaded with epigallocatechin gallate mitigate atrazine-induced testicular toxicity

Fang, C., Li, Y., He, G. Y., Gan, R., Luo, F., Lei, L., Hou, X., & Ye, Y. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136252 · Cited by 18

Involvement of inflammasomes in the pathogenesis of Alzheimer's disease

Beder, N., Belkhelfa, M., & Leklou, H. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241283677 · Cited by 20

RIP3/MLKL pathway‐regulated necroptosis: A new mechanism of paclitaxel‐induced peripheral neuropathy

Ma, D., Zhao, S., Liu, X. Z., Zhao, L., Li, H.-Z., Liu, J., Cao, J., & Wang, X. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22834 · Cited by 18

The regulatory role of Pin1 in neuronal death

Xiong, K., Wang, S., & Hu, X. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.341043 · Cited by 19

Mechanism of ferroptosis in heart failure: The role of the RAGE/TLR4-JNK1/2 pathway in cardiomyocyte ferroptosis and intervention strategies

Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102770 · Cited by 18

Immune Signaling Kinases in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

García-García, R., Martín-Herrero, L., Blanca-Pariente, L., Pérez-Cabello, J. A., & Roodveldt, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413280 · Cited by 17

Targets to watch in neuroinflammation: focus on RIPK1

Romano, M. (2022) · Drugs of the Future · doi:10.1358/dof.2022.47.5.3391879 · Cited by 1

Necroptosis: A Novel Pathway in Neuroinflammation

Yu, Z., Jiang, N., Su, W., & Zhuo, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.701564 · Cited by 134

Viral-induced neuronal necroptosis: Detrimental to brain function and regulation by necroptosis inhibitors

Panda, S. P., Kesharwani, A., Mallick, S. P., Prasanth, D., Pasala, P. K., & Tatipamula, V. B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115591 · Cited by 18

From RIPK1 to Necroptosis: Pathogenic Mechanisms in Neurodegenerative Diseases

Kang, A., Qiao, Y., Pan, S., Yan, F., Chen, H., & Bai, Y. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04448-1 · Cited by 17

Necroptosis in neurodegenerative disorders

Roy, T., Chatterjee, A., & Swarnakar, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32852-7.00014-0 · Cited by 1