The DOI matches its Crossref record; 179 of the 179 references it cites were found in a registry or an index.
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
Open accessAbstract
Apoptosis is crucial for the normal development of the nervous system, whereas neurons in the adult CNS are relatively resistant to this form of cell death. However, under pathological conditions, upregulation of death receptor family ligands, such as tumour necrosis factor (TNF), can sensitize cells in the CNS to apoptosis and a form of regulated necrotic cell death known as necroptosis that is mediated by receptor-interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like protein (MLKL). Necroptosis promotes further cell death and neuroinflammation in the pathogenesis of several neurodegenerative diseases, including multiple sclerosis, amyotrophic lateral sclerosis, Parkinson disease and Alzheimer disease. In this Review, we outline the evidence implicating necroptosis in these neurological diseases and suggest that targeting RIPK1 might help to inhibit multiple cell death pathways and ameliorate neuroinflammation. Necroptosis is a form of cell death mediated by receptor-interacting protein kinase 1 (RIPK1), and is observed in several CNS disorders. Here, Yuan, Amin and Ofengeim give an overview of necroptosis in the CNS and explain its relationship with inflammation in CNS disorders.
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“Increased activation of TNF/TNFR1 signalling following chronic activation of microglia can give rise to TNF-mediated necroptotic neuronal cell death, 160 which represents a possible therapeutic target in Parkinson's disease.161”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [161]
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“Yet, several genes that have been implicated in neuroinflammation38 (such as RIPK1) were seen specifically in microglial states associated with COVID-19.”
From Dysregulation of brain and choroid plexus cell types in severe COVID-19 (2021) · cites this paper as [38]
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Metadata
- Authors
- Yuan, J., Amin, P., & Ofengeim, D.
- Affiliations
- Harvard University (US)
- Sanofi (United States) (US)
- Corresponding author
- Yuan, Junying
- Venue
- Nature Reviews Neuroscience
- Published
- 2018-11-22
- Volume
- 20
- Issue
- 1
- Pages
- 19-33
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC6342007
- OpenAlex
- W2901410206
- Semantic Scholar
- a6626d511f6ce29e1ffd0f9740b5c693cadb4fb3
- Cited by
- 967
- References
- 179
- Citations by year
- 2026: 110 · 2025: 156 · 2024: 149 · 2023: 152 · 2022: 164 · 2021: 134 · 2020: 65 · 2019: 35
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Denali Therapeutics
- National Institutes of Health (4r01ns082257-04)
- National Institute on Aging (RF1AG055521, R01AG047231, R21AG059073)
- National Institute of Neurological Disorders and Stroke (R01-NS082257)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- necroptosis, RIPK1, neuroinflammation, RIPK3, MLKL, apoptosis, TNF-α, death receptor ligands, neurodegenerative diseases, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, central nervous system disorders
- MeSH terms
- Necroptosis, Animals, Brain, Humans, Inflammation, Neurons, Phosphorylation, Neurodegenerative Diseases, Receptor-Interacting Protein Serine-Threonine Kinases
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