Inflammasomes in neuroinflammatory and neurodegenerative diseases
Open accessAbstract
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host‐derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)‐1β and IL‐18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS‐resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, express and activate inflammasomes. In this review, we will discuss current understanding of the role of inflammasomes in common degenerative diseases of the brain and highlight inflammasome‐targeted strategies that may potentially treat these diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inflammasomes are cytosolic multiprotein complexes consisting of the cytosolic sensor protein, ASC, and pro-caspase-1.
“Inflammasomes are cytosolic multiprotein complexes consisting of the cytosolic sensor protein, the adapter apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and pro-caspase-1.346”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [346]
Caspase-1 processes pro-IL-18 and pro-IL-1β into active cytokines.
“Subsequently, caspase-1 will process the biologically inactive pro-IL-18 and pro-IL-1β into active cytokines.”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [346]
When brain tissue is damaged or stimulated by α-syn or bacteria and their metabolites in the brain, TLR4 is activated on microglia, and then the NF-κB pathway is activated to promote the secretion of proinflammatory factors such as IL-6, IL-1β, and TNF-α; the ultimate outcome is the death of neurons.
“When brain tissue is damaged or stimulated by α-syn or bacteria and their metabolites in the brain, TLR4 is activated on microglia, and then, the NF-κB pathway is activated to promote the secretion of proinflammatory factors such as IL-6, IL-1β, and TNF-α; the ultimate outcome is the death of neurons [30, 32].”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [32]
Fibrillar Aβ amyloids can induce secretion of IL-1β from microglia via the NLRP3 inflammasome.
“Fibrillar Aβ amyloids can induce the secretion of IL-1β from microglia, via the NLRP3 inflammasome (228, 249).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [249]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482 · see citing works
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500 · see citing works
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works
Ammonia as a case study for the spontaneous ionization of a simple hydrogen-bonded compound
Palasyuk, T., Troyan, I. A., Eremets, M. I., Drozd, V., Medvedev, S. A., Zaleski‐Ejgierd, P., Magos–Palasyuk, E., Wang, H., Bonev, S., Dudenko, D., et al. (2014) · Nature Communications · doi:10.1038/ncomms4460 · Cited by 3,235 · see citing works
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
Shi, J., Gao, W., & Shao, F. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.10.004 · Cited by 3,088 · see citing works
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, R. C., Robertson, A. A. B., Chae, J. J., Higgins, S. C., Muñoz-Planillo, R., Inserra, M. C., Vetter, I., Dungan, L. S., Monks, B. G., Stutz, A., et al. (2015) · Nature Medicine · doi:10.1038/nm.3806 · Cited by 2,849 · see citing works
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627 · see citing works
Non-canonical inflammasome activation targets caspase-11
Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530 · see citing works
Self-citationMechanisms and Functions of Inflammasomes
Lamkanfi, M., & Dixit, V. M. (2014) · Cell · doi:10.1016/j.cell.2014.04.007 · Cited by 2,521 · see citing works
Self-citationThe NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · see citing works
Decoding ALS: from genes to mechanism
Taylor, J. P., Brown, R. H., & Cleveland, D. W. (2016) · Nature · doi:10.1038/nature20413 · Cited by 2,047 · see citing works
The Cellular Phase of Alzheimer’s Disease
De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990 · see citing works
Targeting the NLRP3 inflammasome in inflammatory diseases
Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.97 · Cited by 1,885 · see citing works
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Dinarello, C., Simon, A., & van der Meer, J. V. D. (2012) · Nature reviews. Drug discovery · doi:10.1038/nrd3800 · Cited by 1,813 · see citing works
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works
Innate immune activation in neurodegenerative disease
Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3705 · Cited by 1,437 · see citing works
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works
Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131 · see citing works
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · see citing works
Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,056 · see citing works
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome
Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell · doi:10.1016/j.cell.2014.11.047 · Cited by 1,014 · see citing works
Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,009 · see citing works
Interleukin-1 and neuronal injury
Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992 · see citing works
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
Venegas, C., Kumar, S., Franklin, B. S., Dierkes, T., Brinkschulte, R., Tejera, D., Vieira-Saecker, A., Schwartz, S., Santarelli, F., Kummer, M. P., et al. (2017) · Nature · doi:10.1038/nature25158 · Cited by 983 · see citing works
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
Yuan, J., Amin, P., & Ofengeim, D. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0093-1 · Cited by 967 · see citing works
Multiple Sclerosis: Mechanisms and Immunotherapy
Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938 · see citing works
Inflammasomes and Their Roles in Health and Disease
Lamkanfi, M., & Dixit, V. M. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155745 · Cited by 935 · cited 5× · see citing works
“…its role in the maturation of pro-IL-1b and pro-IL-18, caspase-1 can also induce a pro-inflammatory form of cell death, pyroptosis, that features early plasma membrane rupture, thereby releasing the soluble intracellular fraction that fuels the inflammatory response (Lamkanfi & Dixit, 2012, 2014).”
BackgroundInfluentialSelf-citationMicroglia in Alzheimer's disease
Sarlus, H., & Heneka, M. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90606 · Cited by 911 · see citing works
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
Boyden, E. D., & Dietrich, W. F. (2006) · Nature Genetics · doi:10.1038/ng1724 · Cited by 860 · see citing works
Mogi, M., Harada, M., Kondo, T., Riederer, P., Inagaki, H., Minami, M., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90508-8 · Cited by 855 · see citing works
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
Xu, H., Yang, J., Gao, W., Li, L., Li, P., Zhang, L., Gong, Y., Peng, X., Xi, J., Chen, S., et al. (2014) · Nature · doi:10.1038/nature13449 · Cited by 852 · see citing works
Inflammasome signalling in brain function and neurodegenerative disease
Heneka, M. T., McManus, R. M., & Latz, E. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0055-7 · Cited by 836 · see citing works
Hara, H., Friedlander, R. M., Gagliardini, V., Ayata, C., Fink, K., Huang, Z., Shimizu‐Sasamata, M., Yuan, J., & Moskowitz, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2007 · Cited by 835 · see citing works
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820 · see citing works
Self-citationInnate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
Miao, E. A., Mao, D. P., Yudkovsky, N., Bonneau, R., Lorang, C. G., Warren, S. E., Leaf, I. A., & Aderem, A. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913087107 · Cited by 800 · see citing works
Baroja-Mazo, A., Martín-Sánchez, F., Gomez, A. I., Martínez, C. M., Amores-Iniesta, J., Compan, V., Barberà-Cremades, M., Yagüe, J., Ruiz-Ortiz, E., Antón, J., et al. (2014) · Nature Immunology · doi:10.1038/ni.2919 · Cited by 790 · cited 1× · see citing works
“In addition, NLRP3 inflammasome activity also results in the extracellular release of micrometer-sized ASC particles that may function as danger signals and alert surrounding macrophages (Baroja-Mazo et al, 2014).”
BackgroundIdentification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders
Jiang, H., He, H., Chen, Y., Huang, W., Cheng, J., Ye, J., Wang, A., Tao, J., Wang, C., Liu, Q., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171419 · Cited by 771 · see citing works
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
Ona, V. O., Li, M., Vonsattel, J. P., Andrews, L. J., Khan, S. Q., Chung, W. M., Frey, A. S., Menon, A., Li, X., Stieg, P. E., et al. (1999) · Nature · doi:10.1038/20446 · Cited by 640 · see citing works
Walsh, J. G., Muruve, D. A., & Power, C. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3638 · Cited by 637 · cited 3× · see citing works
“Most research has focused on microglia, but other brain cell types also have functional inflammasomes which may contribute to disease pathology (Walsh et al, 2014).”
BackgroundWalle, L. V., & Lamkanfi, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.02.019 · Cited by 619 · see citing works
Self-citationBrož, P., von Moltke, J., Jones, J. W. M., Vance, R. E., & Monack, D. M. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.11.007 · Cited by 614 · see citing works
Rathkey, J. K., Zhao, J., Liu, Z., Chen, Y., Yang, J., Kondolf, H. C., Benson, B. L., Chirieleison, S. M., Huang, A. Y.-C., Dubyak, G., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat2738 · Cited by 610 · see citing works
Marchetti, C., Swartzwelter, B. J., Gamboni, F., Neff, C. P., Richter, K., Azam, T., Carta, S., Tengesdal, I. W., Nemkov, T. G., D’Alessandro, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716095115 · Cited by 596 · see citing works
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
Shi, Y., & Holtzman, D. M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0051-1 · Cited by 595 · see citing works
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies
Codolo, G., Plotegher, N., Pozzobon, T., Brucale, M., Tessari, I., Bubacco, L., & de Bernard, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055375 · Cited by 585 · see citing works
Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J., & Lynch, M. A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.014 · Cited by 571 · see citing works
Wellington, C. L., Ellerby, L., Hackam, A. S., Margolis, R. L., Trifiro, M. A., Singaraja, R. R., McCutcheon, K. M., Salvesen, G. S., Propp, S. S., Bromm, M., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.9158 · Cited by 562 · see citing works
Role of IL-1α and IL-1β in Ischemic Brain Damage
Boutin, H., Feuvre, R. A. L., Horai, R., Asano, M., Iwakura, Y., & Rothwell, N. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05528.2001 · Cited by 521 · see citing works
McKenzie, B., Mamik, M. K., Saito, L. B., Boghozian, R., Monaco, M. C., Major, E. O., Lu, J., Branton, W. G., & Power, C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722041115 · Cited by 515 · see citing works
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis
Walle, L., Opdenbosch, N. V., Jacques, P., Fossoul, A., Verheugen, E., Vogel, P., Beyaert, R., Elewaut, D., Kanneganti, T., van Loo, G., et al. (2014) · Nature · doi:10.1038/nature13322 · Cited by 499 · see citing works
Self-citationThe NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
Saresella, M., La Rosa, F., Piancone, F., Zoppis, M., Marventano, I., Calabrese, E., Rainone, V., Nemni, R., Mancuso, R., & Clerici, M. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0088-1 · Cited by 489 · see citing works
Fann, D. Y., Lee, S.-Y., Manzanero, S., Tang, S.-C., Gelderblom, M., Chunduri, P., Bernreuther, C., Glatzel, M., Cheng, Y.-L., Thundyil, J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.326 · Cited by 476 · see citing works
Zhou, Y., Lu, M., Du, R.-H., Qiao, C., Jiang, C.-Y., Zhang, K.-Z., Ding, J.-H., & Hu, G. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0094-3 · Cited by 455 · see citing works
Daniels, M. J. D., Rivers‐Auty, J., Schilling, T., Spencer, N. G., Watremez, W., Fasolino, V., Booth, S., White, C., Baldwin, A. G., Freeman, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12504 · Cited by 445 · see citing works
Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., Miller, J.-N. H., Johnson, R. E., & O’Banion, M. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31450 · Cited by 433 · see citing works
Gris, D., Ye, Z., Iocca, H. A., Wen, H., Craven, R. R., Gris, P., Huang, M., Schneider, M., Miller, S. D., & Ting, J. P.-Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904145 · Cited by 429 · see citing works
Xu, B., Jiang, M., Chu, Y., Wang, W., Chen, D., Li, X., Zhang, Z., Zhang, D., Fan, D., Nie, Y., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.040 · Cited by 426 · see citing works
NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke
Yang, F., Wang, Z., Wei, X., Han, H., Meng, X., Zhang, Y., Shi, W., Li, F., Xin, T., Pang, Q., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.242 · Cited by 423 · see citing works
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
Freeman, L., Guo, H., David, C. N., Brickey, W. J., Jha, S., & Ting, J. P.-Y. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20150237 · Cited by 397 · see citing works
Ghosh, S., Wu, M. D., Shaftel, S. S., Kyrkanides, S., LaFerla, F. M., Olschowka, J. A., & O'Banion, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4361-12.2013 · Cited by 390 · see citing works
Animal models of multiple sclerosis: the good, the bad and the bottom line
Ransohoff, R. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3168 · Cited by 379 · see citing works
NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes
Gustin, A., Kirchmeyer, M., Koncina, E., Felten, P., Losciuto, S., Heurtaux, T., Tardivel, A., Heuschling, P., & Dostert, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130624 · Cited by 369 · see citing works
Moran, A., Bundy, B. N., BECKER, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Greenbaum, C. J., Herold, K. C., Marks, J. B., Raskin, P., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60023-9 · Cited by 356 · see citing works
Friedlander, R. M., Gagliardini, V., Hara, H., Fink, K., Li, W., MacDonald, G. C., Fishman, M. C., Greenberg, A. H., Moskowitz, M. A., & Yuan, J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.933 · Cited by 349 · see citing works
Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease
Tan, M.-S., Tan, L., Jiang, T., Zhu, X.-C., Wang, H.-F., Jia, C.-D., & Yu, J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.348 · Cited by 345 · see citing works
The two-century journey of Parkinson disease research
Przedborski, S. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.25 · Cited by 344 · see citing works
A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury
de Rivero Vaccari, J. P., Lotocki, G., Marcillo, A. E., Dietrich, W. D., & Keane, R. W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0157-08.2008 · Cited by 332 · see citing works
Kang, S.-J., Wang, S., Hara, H., Peterson, E. P., Namura, S., Amin‐Hanjani, S., Huang, Z., Srinivasan, A. N., Tomaselli, K. J., Thornberry, N. A., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.613 · Cited by 326 · see citing works
Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis
Meissner, F., Molawi, K., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002396107 · Cited by 319 · see citing works
Jha, S., Srivastava, S. Y., Brickey, W. J., Iocca, H., Toews, A., Morrison, J. P., Chen, V. S., Gris, D., Matsushima, G. K., & Ting, J. P.-Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4088-10.2010 · Cited by 310 · see citing works
Reduced Ischemic Brain Injury in Interleukin-1β Converting Enzyme—Deficient Mice
Schielke, G. P., Yang, G., Shivers, B. D., & Betz, A. L. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199802000-00009 · Cited by 302 · see citing works
Alboni, S., Cervia, D., Sugama, S., & Conti, B. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-9 · Cited by 301 · see citing works
Kaushal, V, Dye, R., Pakavathkumar, P., Foveau, B., Flores, J., Hyman, B., Ghetti, B., Koller, B. H., & LeBlanc, A. C. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.16 · Cited by 297 · see citing works
NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage
Ma, Q., Chen, S., Hu, Q., Feng, H., Zhang, J. H., & Tang, J. (2013) · Annals of Neurology · doi:10.1002/ana.24070 · Cited by 296 · see citing works
Gong, Z., Pan, J., Shen, Q., Li, M., & Peng, Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1282-6 · Cited by 289 · see citing works
Inoue, M., Williams, K. L., Gunn, M. D., & Shinohara, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201836109 · Cited by 288 · see citing works
Flores, J., Noël, A., Foveau, B., Lynham, J., Lecrux, C., & LeBlanc, A. C. (2018) · Nature Communications · doi:10.1038/s41467-018-06449-x · Cited by 288 · see citing works
Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment
Lampron, A., ElAli, A., & Rivest, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.005 · Cited by 282 · see citing works
Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model
Liu, H., Li, W., Chen, Z.-R., Hu, Y.-C., Zhang, D.-D., Shen, W., Zhou, M., Zhu, L., & Hang, C. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1115-z · Cited by 276 · see citing works
Johann, S., Heitzer, M., Kanagaratnam, M., Goswami, A., Rizo, T., Weis, J., Troost, D., & Beyer, C. (2015) · Glia · doi:10.1002/glia.22891 · Cited by 276 · see citing works
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
Dénes, Á., Coutts, G., Lénárt, N., Cruickshank, S. M., Pelegrı́n, P., Skinner, J., Rothwell, N. J., Allan, S. M., & Brough, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419090112 · Cited by 270 · see citing works
Wang, W., Nguyen, L. T. T., Burlak, C., Chegini, F., Guo, F., Chataway, T., Ju, S., Fisher, O. S., Miller, D. W., Datta, D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610099113 · Cited by 270 · see citing works
Sheng, J. G., Ito, K., Skinner, R. D., Mrak, R. E., Rovnaghi, C. R., van Eldik, L. J., & Griffin, W. S. T. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00104-2 · Cited by 269 · see citing works
Marchetti, C., Chojnacki, J. E., Toldo, S. A., Mezzaroma, E., Tranchida, N., Rose, S. W., Federici, M., Tassell, B. W. V., Zhang, S., & Abbate, A. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000053 · Cited by 268 · see citing works
Xu, X. J., Yin, D., Ren, H., Gao, W., Li, F., Sun, D., Wu, Y., Zhou, S., Lyu, L., Yang, M., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.05.016 · Cited by 240 · see citing works
Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke
Ismael, S., Zhao, L., Nasoohi, S., & Ishrat, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-24350-x · Cited by 236 · see citing works
Opdenbosch, N. V., Gurung, P., Walle, L. V., Fossoul, A., Kanneganti, T., & Lamkanfi, M. (2014) · Nature Communications · doi:10.1038/ncomms4209 · Cited by 235 · see citing works
Self-citationFerrari, C. C., Pott Godoy, M. C., Tarelli, R., Chertoff, M., Depino, A. M., & Pitossi, F. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.06.013 · Cited by 235 · see citing works
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
Voet, S., Mc Guire, C., Hagemeyer, N., Martens, A., Schroeder, A., Wieghofer, P., Daems, C., Staszewski, O., Vande Walle, L., Jordao, M. J. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04376-5 · Cited by 227 · see citing works
Self-citationRen, H., Kong, Y., Liu, Z., Zang, D., Yang, X., Wood, K., Li, M., & Liu, Q. (2017) · Stroke · doi:10.1161/strokeaha.117.018904 · Cited by 226 · see citing works
Pasinelli, P., Borchelt, D., Houseweart, M. K., Cleveland, D. W., & Brown, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15763 · Cited by 221 · see citing works
Granowitz, E. V., Porat, R., Mier, J. W., Pribble, J. P., Stiles, D., Bloedow, D. C., Catalano, M. A., Wolff, S. M., & Dinarello, C. A. (1992) · Cytokine · doi:10.1016/1043-4666(92)90078-6 · Cited by 220 · see citing works
Perregaux, D. G., McNiff, P. A., Laliberte, R. E., Hawryluk, N. A., Peurano, H., Stam, E. J., Eggler, J., Griffiths, R., Dombroski, M. A., & Gabel, C. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29317-4 · Cited by 218 · see citing works
Sulfonylurea Receptor 1 in Central Nervous System Injury: A Focused Review
Simard, J. M., Woo, S. K., Schwartzbauer, G., & Gerzanich, V. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.91 · Cited by 201 · see citing works
Post-translational regulation of inflammasomes
Yang, J., Liu, Z., & Xiao, T. S. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.29 · Cited by 201 · see citing works
Necroptosis in neurodegenerative diseases: a potential therapeutic target
Zhang, S., Tang, M., Luo, H., Shi, C.-H., & Xu, Y.-M. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.286 · Cited by 198 · see citing works
Rabuffetti, M., Sciorati, C., Tarozzo, G., Clementi, E., Manfredi, A. A., & Beltramo, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04398.2000 · Cited by 197 · see citing works
Caspase-1 Regulates the Inflammatory Process Leading to Autoimmune Demyelination
Furlan, R., Martino, G., Galbiati, F., Poliani, P. L., Smiroldo, S., Bergami, A., Desina, G., Comı, G., Flavell, R. A., Su, M. S. S., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2403 · Cited by 194 · see citing works
Inoue, M., Williams, K. L., Oliver, T. N., Vandenabeele, P., Rajan, J. V., Miao, E. A., & Shinohara, M. L. (2012) · Science Signaling · doi:10.1126/scisignal.2002767 · Cited by 193 · see citing works
BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets
Lee, J., Rhee, M. H., Kim, E., & Cho, J. Y. (2012) · Mediators of Inflammation · doi:10.1155/2012/416036 · Cited by 184 · see citing works
Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease
Gustot, A., Gallea, J. I., Sarroukh, R., Celej, M. S., Ruysschaert, J., & Raussens, V. (2015) · Biochemical Journal · doi:10.1042/bj20150617 · Cited by 183 · see citing works
Yatsiv, I., Morganti-Kossmann, M. C., Perez, D. R., Dinarello, C. A., Novick, D., Rubinstein, M., Otto, V. I., Rancan, M., Kossmann, T., Redaelli, C., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200208000-00008 · Cited by 183 · see citing works
Clausen, F., Hånell, A., Björk, M., Hillered, L., Mir, A., Gram, H., & Marklund, N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06820.x · Cited by 181 · see citing works
GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
Kanneganti, A., Malireddi, R. K. S., Saavedra, P. H. V., Walle, L. V., Gorp, H. V., Kambara, H., Sheppard, H., Vogel, P., Luo, H. R., Xavier, R. J., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172060 · Cited by 180 · see citing works
Self-citationZendedel, A., Johann, S., Mehrabi, S., Joghataei, M. T., Hassanzadeh, G., Kipp, M., & Beyer, C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9203-5 · Cited by 174 · see citing works
Ismael, S., Nasoohi, S., & Ishrat, T. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5344 · Cited by 173 · see citing works
Cocco, M., Pellegrini, C., Martínez‐Banaclocha, H., Giorgis, M., Marini, E., Costale, A., Miglio, G., Fornai, M., Antonioli, L., López‐Castejón, G., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01624 · Cited by 172 · see citing works
Cellular and Molecular Mechanisms of Prion Disease
Sigurdson, C. J., Bartz, J. C., & Glatzel, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-013109 · Cited by 171 · see citing works
Adamczak, S. E., Dale, G. A., Vaccari, J. P. D. R., Bullock, M. R., Dietrich, W. D., & Keane, R. W. (2012) · Journal of neurosurgery · doi:10.3171/2012.9.jns12815 · Cited by 166 · see citing works
A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?
Barrington, J., Lemarchand, E., & Allan, S. M. (2016) · Brain Pathology · doi:10.1111/bpa.12476 · Cited by 166 · see citing works
Saadane, A., Masters, S., DiDonato, J. A., Li, J., & Berger, M. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0323oc · Cited by 161 · see citing works
Therapeutic approaches to Huntington disease: from the bench to the clinic
Caron, N. S., Dorsey, E. R., & Hayden, M. R. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.133 · Cited by 161 · see citing works
Mouton‐Liger, F., Rosazza, T., Sepulveda‐Diaz, J., Ieang, A., Hassoun, S., Claire, E., Mangone, G., Brice, A., Michel, P. P., Corvol, J., et al. (2018) · Glia · doi:10.1002/glia.23337 · Cited by 160 · see citing works
The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson’s Disease in Rats
Mao, Z., Liu, C., Ji, S., Yang, Q., Ye, H., Han, H., & Xue, Z. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2185-0 · Cited by 155 · see citing works
Lévesque, S. A., Paré, A., Mailhot, B., Bellver‐Landete, V., Kébir, H., Lécuyer, M., Alvarez, J. I., Prat, A., Vaccari, J. P. D. R., Keane, R. W., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151437 · Cited by 151 · see citing works
Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts
Mamik, M. K., & Power, C. (2017) · Brain : a journal of neurology · doi:10.1093/brain/awx133 · Cited by 151 · see citing works
Liu, W., Guo, W., Wu, J., Luo, Q., Tao, F., Gu, Y., Shen, Y., Li, J., Tan, R. X., Xu, Q., et al. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.03.008 · Cited by 142 · see citing works
Inhibiting the Inflammasome: A Chemical Perspective
Baldwin, A. G., Brough, D., & Freeman, S. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01091 · Cited by 140 · see citing works
Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice
Xiao, J., Wang, C., Yao, J.-C., Alippe, Y., Xu, C., Kress, D., Civitelli, R., Abu‐Amer, Y., Kanneganti, T., Link, D. C., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.3000047 · Cited by 139 · see citing works
Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey
Rossi‐Semerano, L., Fautrel, B., Wendling, D., HACHULLA, E., Galeotti, C., Semerano, L., Touitou, I., Koné‐Paut, I., & the MAIL1 (Maladies Auto-inflammatoires et Anti-IL-1) study Group on the behalf of CRI (Club Rhumatisme et Inflammation) (2015) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-015-0228-7 · Cited by 136 · see citing works
Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children
Wallisch, J. S., Simon, D. W., Bayır, H., Bell, M. J., Kochanek, P. M., & Clark, R. S. B. (2017) · Neurocritical Care · doi:10.1007/s12028-017-0378-7 · Cited by 130 · see citing works
Inflammasome Proteins As Biomarkers of Multiple Sclerosis
Keane, R. W., Dietrich, W. D., & Vaccari, J. P. D. R. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00135 · Cited by 124 · see citing works
Inoue, M., & Shinohara, M. L. (2013) · Autoimmune Diseases · doi:10.1155/2013/859145 · Cited by 123 · see citing works
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
Guey, B., Bodnar‐Wachtel, M., Manié, S. N., Tardivel, A., & Pétrilli, V. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415756111 · Cited by 123 · see citing works
Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury
Irrera, N., Pizzino, G., Calò, M., Pallio, G., Mannino, F., Famà, F., Arcoraci, V., Fodale, V., David, A., Francesca, C., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00459 · Cited by 120 · see citing works
Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics
Sala Frigerio, C., & De Strooper, B. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014015 · Cited by 116 · see citing works
Lammerding, L., Slowik, A., Johann, S., Beyer, C., & Zendedel, A. (2015) · Neuroendocrinology · doi:10.1159/000439435 · Cited by 115 · see citing works
Guo, C., Fulp, J., Jiang, Y., Li, X., Chojnacki, J. E., Wu, J., Wang, X., & Zhang, S. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00124 · Cited by 111 · see citing works
The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
Shi, F., Yang, L., Kouadir, M., Yang, Y., Wang, J., Zhou, X., Yin, X., & Zhao, D. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-73 · Cited by 109 · see citing works
Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke
Sheth, K. N., Kimberly, W. T., Elm, J., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.003352 · Cited by 106 · see citing works
Liu, L., & Chan, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.016 · Cited by 104 · see citing works
Role of interleukin-1 in prion disease-associated astrocyte activation.
Schultz, J., Schwarz, A., Neidhold, S., Burwinkel, M., Riemer, C., Simon, D., Kopf, M., Otto, M., & Baier, M. (2004) · American Journal of Pathology · doi:10.1016/s0002-9440(10)63331-7 · Cited by 101 · see citing works
NALP1/NLRP1 Genetic Variants are Associated With Alzheimer Disease
Pontillo, A., Catamo, E., Arosio, B., Mari, D., & Crovella, S. (2011) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318231a8ac · Cited by 98 · see citing works
Tsai, S.-J. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.06.001 · Cited by 98 · see citing works
Lai, M., Yao, H., Shah, S. Z. A., Wu, W., Wang, D., Zhao, Y., Wang, L., Zhou, X., Zhao, D., & Yang, L. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00116 · Cited by 97 · see citing works
The potential for caspases in drug discovery.
MacKenzie, S. H., Schipper, J. L., & Clark, A. C. (2010) · PubMed · Cited by 96 · see citing works
Craft, J. M., Watterson, D. M., Hirsch, E., & Van Eldik, L. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-15 · Cited by 96 · see citing works
Boron-Based Inhibitors of the NLRP3 Inflammasome
Baldwin, A. G., Rivers‐Auty, J., Daniels, M. J. D., White, C., Schwalbe, C. H., Schilling, T., Hammadi, H., Jaiyong, P., Spencer, N. G., England, H., et al. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.08.011 · Cited by 94 · see citing works
Sulfonylureas Differ in Effects on Ischemic Preconditioning—Is it Time to Retire Glyburide?
Riddle, M. C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021971 · Cited by 92 · see citing works
Hafner‐Bratkovič, I., Benčina, M., Fitzgerald, K. A., Golenbock, D. T., & Jerala, R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1140-0 · Cited by 92 · see citing works
The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease
Everbroeck, B. V., Dewulf, E. M., Pals, P., Lübke, U., Martin, J., & Cras, P. P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00236-6 · Cited by 85 · see citing works
Wu, P.-J., Hung, Y.-F., Liu, H., & Hsueh, Y. (2017) · NeuroImmunoModulation · doi:10.1159/000477092 · Cited by 84 · see citing works
An interferon-β-resistant and NLRP3 inflammasome–independent subtype of EAE with neuronal damage
Inoue, M., Chen, P., Siecinski, S. K., Li, Q.-J., Liu, C., Steinman, L., Gregory, S. G., Benner, E. J., & Shinohara, M. L. (2016) · Nature Neuroscience · doi:10.1038/nn.4421 · Cited by 79 · see citing works
NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model
Gugliandolo, A., Giacoppo, S., Bramanti, P., & Mazzon, E. (2017) · Inflammation · doi:10.1007/s10753-017-0667-5 · Cited by 79 · see citing works
Lin, W., Xiong, G.-P., Lin, Q., Chen, X., Zhang, L., Shi, J., Ke, Q., & Lin, J. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0521-y · Cited by 73 · see citing works
Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory DiseasePreprint
Gorp, H. V., Opdenbosch, N. V., & Lamkanfi, M. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028563 · Cited by 69 · see citing works
Self-citationInflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice
Tzeng, T.-C., Hasegawa, Y., Iguchi, R., Cheung, A., Caffrey, D. R., Thatcher, E. J., Mao, W., Germain, G., Tamburro, N. D., Okabe, S., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801802115 · Cited by 67 · see citing works
Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis—A Pilot Study
Maier, A., Deigendesch, N., Müller, K., Weishaupt, J. H., Krannich, A., Röhle, R., Meissner, F., Molawi, K., Münch, C., Holm, T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139684 · Cited by 66 · see citing works
Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors
Hill, J. R., Coll, R. C., Sue, N., Reid, J. C., Dou, J., Holley, C. L., Pelingon, R., Dickinson, J. B., Biden, T. J., Schroder, K., et al. (2017) · ChemMedChem · doi:10.1002/cmdc.201700270 · Cited by 65 · see citing works
Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury
Brickler, T., Gresham, K., Meza, A. L., Coutermarsh-Ott, S. L., Williams, T., Rothschild, D. E., Allen, I., & Theus, M. (2016) · Mediators of Inflammation · doi:10.1155/2016/6373506 · Cited by 65 · see citing works
ROSS, J., Brough, D., GIBSON, R., et al. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.015 · Cited by 62 · see citing works
Dong, L., Qiao, H., Zhang, X., Zhang, X., Wang, C., Wang, L., Cui, L., Zhao, J., Xing, Y., Lǐ, Y., et al. (2013) · Mediators of Inflammation · doi:10.1155/2013/370804 · Cited by 61 · see citing works
Bertani, I., Iori, V., Trusel, M., Maroso, M., Foray, C., Mantovani, S., Tonini, R., Vezzani, A., & Chiesa, R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1301-17.2017 · Cited by 54 · see citing works
Fox, E., Jayaprakash, N., Pham, T., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.03.022 · Cited by 51 · see citing works
No Role for Interleukin-18 in Acute Murine Stroke-Induced Brain Injury
Wheeler, R. D., Boutin, H., Touzani, O., Luheshi, G. N., Takeda, K., & Rothwell, N. J. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000059587.71206.ba · Cited by 47 · see citing works
Yuan, B., Shen, H., Lin, L., Su, T., Zhong, S., & Yang, Z. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.08.002 · Cited by 45 · see citing works
Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes
Nuvolone, M., Sorce, S., Schwarz, P., & Aguzzi, A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117208 · Cited by 39 · see citing works
Iłżecka, J., Stelmasiak, Z., & Dobosz, B. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.d01-30.x · Cited by 39 · see citing works
Lehmann, S., Esch, E., Hartmann, P., Goswami, A., Nikolin, S., Weis, J., Beyer, C., & Johann, S. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12483 · Cited by 38 · see citing works
Kawana, N., Yamamoto, Y., Ishida, T., Saito, Y., Konno, H., Arima, K., & Satoh, J. (2013) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12068 · Cited by 34 · see citing works
Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin DPreprint
Hu, J., Liu, X., Zhao, J.-X., Xia, S., Ruan, J., Luo, X., Kim, J., Lieberman, J., & Wu, H. (2018) · bioRxiv · doi:10.1101/365908 · Cited by 34 · see citing works
Das, P., Smithson, L. A., Price, R. W., Holloway, V. M., Levites, Y., Chakrabarty, P., & Golde, T. E. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-17 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
“Inflammasomes Inflammasomes are cytosolic multiprotein complexes consisting of the cytosolic sensor protein, the adapter apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and pro-caspase-1.(346) Upon activation, the PRR protein, i.”
BackgroundInflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
Li, Y., Song, W., Tong, Y., Zhang, X., Zhao, J., Gao, X., Yong, J., & Wang, H. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02040-8 · Cited by 295 · see citing works
The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease
Hanslik, K. L., & Ulland, T. K. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.570711 · Cited by 236 · see citing works
Microglia and Neuroinflammation: What Place for P2RY12?
Gómez Morillas, A., Besson, V. C., & Lerouet, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041636 · Cited by 214 · see citing works
Di Benedetto, G., Burgaletto, C., Bellanca, C. M., Munafò, A., Bernardini, R., & Cantarella, G. (2022) · Cells · doi:10.3390/cells11172728 · Cited by 189 · see citing works
Glycosphingolipids and Neuroinflammation in Parkinson’s Disease
Belarbi, K., Cuvelier, E., Bonte, M.-A., Desplanque, M., Gressier, B., Devos, D., & Chartier-Harlin, M.-C. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00408-1 · Cited by 155 · see citing works
Cordaro, M., Cuzzocrea, S., & Crupi, R. (2020) · Antioxidants · doi:10.3390/antiox9030216 · Cited by 98 · see citing works
Zhou, X., Lu, J., Wei, K., Wei, J., Tian, P., Yue, M., Wang, Y., Hong, D., Li, F., Wang, B., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9424582 · Cited by 85 · see citing works
Szego, E. M., Malz, L., Bernhardt, N., Rösen-Wolff, A., Falkenburger, B. H., & Luksch, H. (2022) · eLife · doi:10.7554/elife.81943 · Cited by 94 · see citing works
Role of P2X7 Receptors in Immune Responses During Neurodegeneration
Oliveira-Giacomelli, Á., Petiz, L. L., Andrejew, R., Turrini, N., Silva, J. B., Sack, U., & Ulrich, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.662935 · Cited by 68 · see citing works
Elsallabi, O., Patruno, A., Pesce, M., Cataldi, A., Carradori, S., & Gallorini, M. (2022) · Molecules · doi:10.3390/molecules27030738 · Cited by 67 · see citing works
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
Huang, X., Ye, C., Zhao, X., Tong, Y., Lin, W., Huang, Q., Zheng, Y., Wang, J., Zhang, A., & Mo, Y. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02959-8 · Cited by 60 · see citing works
Therapeutic Role of Inflammasome Inhibitors in Neurodegenerative Disorders
Lahooti, B., Chhibber, T., Bagchi, S., Varahachalam, S. P., & Jayant, R. D. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.004 · Cited by 50 · see citing works
The role of immune-mediated alterations and disorders in ALS disease
Rodrigues Lima-Junior, J., Sulzer, D., Lindestam Arlehamn, C. S., & Sette, A. (2021) · Human Immunology · doi:10.1016/j.humimm.2021.01.017 · Cited by 33 · see citing works
Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals
Kozma, M., Mészáros, Á., Nyúl-Tóth, Á., Molnár, K., Costea, L., Hernádi, Z., Fazakas, C., Farkas, A. E., Wilhelm, I., & Krizbai, I. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116122 · Cited by 21 · see citing works
Dai, C., Liu, B., Peng, B., Qu, B., Lin, J., Peng, B., & Li, D.-M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.774539 · Cited by 19 · see citing works
- Authors
- Voet, S., Srinivasan, S., Lamkanfi, M., & van Loo, G.
- Affiliations
- Ghent University (BE)
- Janssen (Belgium) (BE)
- Corresponding author
- Lamkanfi, Mohamed
- Venue
- EMBO Molecular Medicine
- Published
- 2019-04-23
- Volume
- 11
- Issue
- 6
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC6554670
- OpenAlex
- W2941630117
- Cited by
- 761
- References
- 165
- Citations by year
- 2026: 70 · 2025: 107 · 2024: 122 · 2023: 131 · 2022: 105 · 2021: 111 · 2020: 89 · 2019: 23
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Queen Elisabeth Medical Foundation
- CBC Banque Prize
- Concerted Research Actions (GOA) of the Ghent University
- European Research Council (683144)
- Charcot Foundation
- FWO
- Belgian Foundation Against Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- inflammasome, neuroinflammation, neurodegenerative diseases, amyloid-beta, alpha-synuclein, prions, pyroptosis, IL-1β, IL-18, microglia, astrocytes, myeloid cells, inflammasome-targeted therapy, protein aggregation
- MeSH terms
- Animals, Brain, Humans, Immunity, Innate, Microglia, Neurodegenerative Diseases, Interleukin-18, alpha-Synuclein, Interleukin-1beta, Inflammasomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
