Cited by 243Neurogenesis and neuroplasticity mechanismsFetal and Pediatric Neurological DisordersGenetics and Neurodevelopmental Disorders

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Deconstructing cortical folding: genetic, cellular and mechanical determinants

Llinares-Benadero, Cristina, Borrell, Víctor·2019·Nature Reviews Neuroscience

DOI 10.1038/s41583-018-0112-2

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Abstract

Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and is associated with dramatic increases in size and complexity. New animal models, genetic tools and bioengineering materials have moved the study of cortical folding from simple phenomenological observation to sophisticated experimental testing. Here, we provide an overview of how genetics, cell biology and biomechanics shape this complex and multifaceted process and affect each other. We discuss the evolution of cortical folding and the genomic changes in the primate lineage that seem to be responsible for the advent of larger brains and cortical folding. Emerging technologies now provide unprecedented tools to analyse and manipulate cortical folding, with the promise of elucidating the mechanisms underlying the stereotyped folding of the cerebral cortex in its full complexity.

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Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivoPreprint
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Authors: Llinares-Benadero, C., & Borrell, V.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
ORCID: Llinares-Benadero, Cristina
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2019-01-04
Volume: 20
Issue: 3
Pages: 161-176
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-018-0112-2
OpenAlex: W2907389933
Semantic Scholar: 5e11290de5ea2c272c18ac0c97260aae0579a518
Cited by: 243
References: 216
Citations by year: 2026: 24 · 2025: 16 · 2024: 52 · 2023: 44 · 2022: 27 · 2021: 33 · 2020: 36 · 2019: 11
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: cortical folding, cerebral cortex, brain evolution
MeSH terms: Animals, Cell Movement, Cerebral Cortex, Biological Evolution, Humans, Neuroglia, Neurons, Neurogenesis

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Deconstructing cortical folding: genetic, cellular and mechanical determinants

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