The DOI matches its Crossref record; 213 of the 216 references it cites were found in a registry or an index.
Deconstructing cortical folding: genetic, cellular and mechanical determinants
Abstract
Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and is associated with dramatic increases in size and complexity. New animal models, genetic tools and bioengineering materials have moved the study of cortical folding from simple phenomenological observation to sophisticated experimental testing. Here, we provide an overview of how genetics, cell biology and biomechanics shape this complex and multifaceted process and affect each other. We discuss the evolution of cortical folding and the genomic changes in the primate lineage that seem to be responsible for the advent of larger brains and cortical folding. Emerging technologies now provide unprecedented tools to analyse and manipulate cortical folding, with the promise of elucidating the mechanisms underlying the stereotyped folding of the cerebral cortex in its full complexity.
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“Although the basic principles of cortical development may be similar in all mammals, the modifications of developmental events during millennia of primate evolution produce not only quantitative but also qualitative changes of its cellular structure and synaptic circuitry [13, 20].”
From Development of prefrontal cortex (2022) · cites this paper as [20]
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Metadata
- Authors
- Llinares-Benadero, C., & Borrell, V.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Nature Reviews Neuroscience
- Published
- 2019-01-04
- Volume
- 20
- Issue
- 3
- Pages
- 161-176
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2907389933
- Semantic Scholar
- 5e11290de5ea2c272c18ac0c97260aae0579a518
- Cited by
- 243
- References
- 216
- Citations by year
- 2026: 24 · 2025: 16 · 2024: 52 · 2023: 44 · 2022: 27 · 2021: 33 · 2020: 36 · 2019: 11
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- cortical folding, cerebral cortex, brain evolution
- MeSH terms
- Animals, Cell Movement, Cerebral Cortex, Biological Evolution, Humans, Neuroglia, Neurons, Neurogenesis
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