The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
Abstract
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure - the perinodal ECM - surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.
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In the citing paper
“PNNs are reticular CSPG-containing ECM structures surrounding the soma and proximal dendrites of a subpopulation of CNS neurons and important for controlling neuroplasticity [1, 13].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [1]
In the citing paper
“The lectican family of CSPGs (also called aggrecan-family CSPGs) are found within PNNs, including aggrecan, brevican, neurocan, and versican [1].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [1]
In the citing paper
“PNNs are now being considered as a target for the treatment of impaired memory.”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [1]
In the citing paper
“It has to be taken also into account that PNNs exclusively enwrap the soma and most proximal segments of dendrites (Celio et al., 1998;Fawcett et al., 2019)”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Fawcett et al., 2019
In the citing paper
“PNNs form preferentially around fast-spiking parvalbumin (PV)+ GABAergic interneurons throughout the brain during the closure of the critical period of plasticity, effectively “locking” proximal synapses in place and providing synaptic stability [21] soon after synaptic pruning is completed by developmental microglia [22].”
From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [21]
In the citing paper
“Although contrasting effects of PNN ablation on certain (specifically object recognition) memory tasks and measures of plasticity suggest this is not the case for all types of memory [21, 29, 87], such differences may also be at least partly attributable to the PNN ablation method utilized (e.g. enzymatic digestion vs genetic deletion of PNN components) which can produce differential effects on”
From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [21]
In the citing paper
“Depending on side chain sulphation pattern, CSPGs can also be preferentially incorporated into conventional PNNs”
From Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease (2020) · cites this paper as Fawcett et al., 2019
In the citing paper
“stabilizing the neuronal circuitry and inhibiting plasticity (Wang and Fawcett, 2012; Fawcett et al. , 2019).”
From Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease (2020) · cites this paper as Fawcett et al. , 2019
Citations
Cites
1 retracted
Matrix Metalloproteinase (MMP) 9 Transcription in Mouse Brain Induced by Fear Learning
Ganguly, K., Rejmak, E., Mikosz, M., Nikolaev, E., Knapska, E., & Kaczmarek, L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457903 · Cited by 106
RetractedStructural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Self-citationReactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679
Self-citationHensch, T. K. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144327 · Cited by 1,300
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., et al. (2018) · Science · doi:10.1126/science.aat8127 · Cited by 1,247
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
Lewis, D. A., Curley, A. A., Glausier, J. R., & Volk, D. W. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.10.004 · Cited by 1,071
Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007
Genome-wide association studies of brain imaging phenotypes in UK Biobank
Elliott, L. T., Sharp, K., Alfaro-Almagro, F., Shi, S., Miller, K. L., Douaud, G., Marchini, J., & Smith, S. M. (2018) · Nature · doi:10.1038/s41586-018-0571-7 · Cited by 834
Allen, B., Ingram, E., Takao, M., Smith, M. J., Jakes, R., Virdee, K., Yoshida, H., Holzer, M., Craxton, M., Emson, P. C., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09340.2002 · Cited by 763
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Pascual, G., Domínguez, D., Elosua-Bayés, M., Beckedorff, F., Laudanna, C., Bigas, C., Douillet, D., Greco, C. M., Symeonidi, A., Hernández, I., et al. (2021) · Nature · doi:10.1038/s41586-021-04075-0 · Cited by 322
Metadata
- Authors
- Fawcett, J. W., Oohashi, T., & Pizzorusso, T.
- Affiliations
- Czech Academy of Sciences (CZ)
- Okayama University (JP)
- Neuroscience Institute (IT)
- Corresponding author
- Fawcett, James W.
- Venue
- Nature Reviews Neuroscience
- Published
- 2019-07-01
- Volume
- 20
- Issue
- 8
- Pages
- 451-465
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2955918581
- Semantic Scholar
- e14cf9b70c48b98946ffcfb2145a00841a74cb04
- Cited by
- 589
- References
- 228
- Citations by year
- 2026: 85 · 2025: 114 · 2024: 89 · 2023: 83 · 2022: 74 · 2021: 79 · 2020: 54 · 2019: 9
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Scuola Normale Superiore di Pisa (submittedVersion)
- Funders
- Medical Research Council (MR/R004463/1, MR/R004544/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- perineuronal nets, chondroitin sulfate proteoglycans, extracellular matrix, critical period, developmental plasticity, CNS plasticity, memory regulation, mental illness, nodes of Ranvier, myelination
- MeSH terms
- Animals, Mental Disorders, Central Nervous System Diseases, Extracellular Matrix, Humans, Memory, Models, Neurological, Neuronal Plasticity, Neurons
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