Cited by 416Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

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Macrophages at CNS interfaces: ontogeny and function in health and disease

Kierdorf, Katrin, Masuda, Takahiro, Jordão, Marta Joana Costa, Prinz, Marco·2019·Nature Reviews Neuroscience

DOI 10.1038/s41583-019-0201-x

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Abstract

The segregation and limited regenerative capacity of the CNS necessitate a specialized and tightly regulated resident immune system that continuously guards the CNS against invading pathogens and injury. Immunity in the CNS has generally been attributed to neuron-associated microglia in the parenchyma, whose origin and functions have recently been elucidated. However, there are several other specialized macrophage populations at the CNS borders, including dural, leptomeningeal, perivascular and choroid plexus macrophages (collectively known as CNS-associated macrophages (CAMs)), whose origins and roles in health and disease have remained largely uncharted. CAMs are thought to be involved in regulating the fine balance between the proper segregation of the CNS, on the one hand, and the essential exchange between the CNS parenchyma and the periphery, on the other. Recent studies that have been empowered by major technological advances have shed new light on these cells and suggest central roles for CAMs in CNS physiology and in the pathogenesis of diseases.

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Additional file 4 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
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Additional file 6 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673510
Additional file 1 of Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus
Muñoz‐Castro, C., Mejias‐Ortega, M., Sánchez‐Mejías, E., Navarro, V., Trujillo‐Estrada, L., Jiménez, S., León, J. A. G., Fernandez-Valenzuela, J. J., Sanchez-Mico, M. V., Romero‐Molina, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26571967
Additional file 8 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673516
Additional file 3 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673501
Additional file 2 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673498
Additional file 2 of Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body
Rosmus, D.-D., Koch, J., Hausmann, A., Chiot, A., Arnhold, F., Masuda, T., Kierdorf, K., Hansen, S. M., Kuhrt, H., Fröba, J. S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26742998
Self-citation
Additional file 9 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673519
Additional file 1 of Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body
Rosmus, D.-D., Koch, J., Hausmann, A., Chiot, A., Arnhold, F., Masuda, T., Kierdorf, K., Hansen, S. M., Kuhrt, H., Fröba, J. S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26742995
Self-citation
Additional file 1 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673495
Additional file 7 of IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Avloniti, M., Evangelidou, M., Gomini, M., Loupis, T., Emmanouil, M., Mitropoulou, A., Tselios, T., Lassmann, H., Gruart, A., Delgado-García, J. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673513
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Authors: Kierdorf, K., Masuda, T., Jordão, M. J. C., & Prinz, M.
Affiliations: University of Freiburg (DE)
Corresponding author: Prinz, Marco
ORCID: Kierdorf, Katrin
Masuda, Takahiro
Jordão, Marta Joana Costa
Prinz, Marco
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2019-07-29
Volume: 20
Issue: 9
Pages: 547-562
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/s41583-019-0201-x
OpenAlex: W2965570118
Semantic Scholar: 7aa0033e693c776f7718f0c2d90733dadf1d5769
Cited by: 416
References: 196
Citations by year: 2026: 54 · 2025: 49 · 2024: 74 · 2023: 56 · 2022: 62 · 2021: 70 · 2020: 42 · 2019: 8
FWCI: 4.71
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Keywords: perivascular macrophages, choroid plexus macrophages, macrophage ontogeny, meninges, blood-brain barrier, neuroinflammation, neurodegenerative diseases
MeSH terms: Animals, Central Nervous System, Humans, Macrophages, Neurons, Inflammation Mediators, Neurodegenerative Diseases

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Macrophages at CNS interfaces: ontogeny and function in health and disease

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