The m6A epitranscriptome: transcriptome plasticity in brain development and function

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884

Mammalian neural stem cells.

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N6-methyladenosine-dependent regulation of messenger RNA stability

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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

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Dynamic RNA Modifications in Gene Expression Regulation

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N6-methyladenosine Modulates Messenger RNA Translation Efficiency

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A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

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Critical Roles of METTL3 in Translation Regulation of Cancer

Meng, W., Han, X., Mei, P., Chen, J., Wang, Y., Zhao, R., & Liao, Y. (2023) · Biomolecules · doi:10.3390/biom13020243 · Cited by 21

The m6A-methylome in major depression: A bioinformatic analysis of publicly available datasets

Joshi, K., Wang, D. O., & Gururajan, A. (2022) · Psychiatry Research Communications · doi:10.1016/j.psycom.2022.100089 · Cited by 20

Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification

Lei, C., Li, N., Chen, J., & Wang, Q. (2023) · Molecules · doi:10.3390/molecules28093859 · Cited by 23

Subcellular relocalization and nuclear redistribution of the RNA methyltransferases TRMT1 and TRMT1L upon neuronal activation

Jonkhout, N., Cruciani, S., Vieira, H. G. S., Tran, J., Liu, H., Liu, G., Pickford, R., Kaczorowski, D. C., Franco, G. R., Vauti, F., et al. (2021) · RNA Biology · doi:10.1080/15476286.2021.1881291 · Cited by 19

Advances in brain epitranscriptomics research and translational opportunities

Zhang, F., Ignatova, V. V., Ming, G., & Song, H. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02339-x · Cited by 19

Altered m6A RNA methylation profiles in depression implicate the dysregulation of discrete cellular functions in males and females

Mitsuhashi, H., Lin, R., Chawla, A., Mechawar, N., Nagy, C., & Turecki, G. (2024) · iScience · doi:10.1016/j.isci.2024.111316 · Cited by 19

DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation

Wang, J., Deng, X., Jian, T., Yin, S., Chen, L. R., Vergnes, L., Li, Z., Liu, H.-C., Lee, R. C., Lim, S. Y., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.04.019 · Cited by 21

Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases

Tassinari, V., Rosa, P. L., Guida, E., Colopi, A., Caratelli, S., Paolis, F. D., Gallo, A., Cenciarelli, C., Sconocchia, G., Dolci, S., et al. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111807 · Cited by 19

Detection of brain space-occupying lesions using quantum machine learning

Amin, J., Anjum, M. A., Gul, N., & Sharif, M. I. (2023) · Neural Computing and Applications · doi:10.1007/s00521-023-08717-4 · Cited by 19

Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases

Li, C., Chen, K., Fang, Q., Shi, S., Nan, J., He, J., Yin, Y., Li, X., Li, J., Hou, L., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100605 · Cited by 21

Prediction of m6A and m5C at single-molecule resolution reveals a cooccurrence of RNA modifications across the transcriptomePreprint

Mateos, P. A., Sethi, A. J., Ravindran, A., Srivastava, A., Woodward, K., Mahmud, S., Kanchi, M., Guarnacci, M., Xu, J., Yuen, Z. W.-S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.14.484124 · Cited by 19

ALKBH5 demethylates the m 6 A modification of SOCS3 in microglia/macrophages and alleviates neuroinflammation after brain injury

Cai, L., Liang, Y., Li, X., Fu, R., Niu, X., Jin, Y., Li, Y., Zhang, Y., Ouyang, P., Wang, C., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2504697122 · Cited by 22

An epigenetic ‘extreme makeover’: the methylation of flaviviral RNA (and beyond)

Ruggieri, A., Helm, M., & Chatel‐Chaix, L. (2020) · RNA Biology · doi:10.1080/15476286.2020.1868150 · Cited by 17

The N6 ‐methyladenosine RNA landscape in the aged mouse hippocampus

Huang, H., Song, R., Wong, J. J. L., Anggono, V., & Widagdo, J. (2022) · Aging Cell · doi:10.1111/acel.13755 · Cited by 17

The role of N-methyladenosine modification in acute and chronic kidney diseases

Qi, S., Song, J., Chen, L., & Weng, H. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00764-w · Cited by 18

The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies

Hashmi, M. A. T. S., Fatima, H., Ahmad, S., Rehman, A., & Safdar, F. (2024) · Ibrain · doi:10.1002/ibra.12183 · Cited by 18

METTL3/IGF2BP2/IκBα axis participates in neuroinflammation in Alzheimer's disease by regulating M1/M2 polarization of microglia

Zhu, L., Liu, C., Wang, Y., Zhu, X., Wu, L., Chen, L.-H., Zhou, J., & Wang, F. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.105964 · Cited by 18

The Repertoire of RNA Modifications Orchestrates a Plethora of Cellular Responses

Adamopoulos, P. G., Athanasopoulou, K., Daneva, G. N., & Scorilas, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032387 · Cited by 18

In Search of a Function for the N6-Methyladenosine in Epitranscriptome, Autophagy and Neurodegenerative Diseases

Suga, N., Ikeda, Y., Yoshikawa, S., Taniguchi, K., Sawamura, H., & Matsuda, S. (2023) · Neurology International · doi:10.3390/neurolint15030062 · Cited by 16

Regulatory role of m6A epitranscriptomic modifications in normal development and congenital malformations during embryogenesis

Yao, Y., Liu, P., Li, Y., Wang, W., Jia, H., Bai, Y., Yuan, Z., & Yang, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116171 · Cited by 17

Visualization and Quantification of Single‐Base m 6 A Methylation

Zhang, Q., Dai, Y., Teng, X., & Li, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202420977 · Cited by 17

mRNA m6A detection

Moshitch-Moshkovitz, S., Sevilla-Sharon, M., Ashwal-Fluss, R., Glick‐Saar, E., Rechavi, G., & Dominissini, D. (2024) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00365-9 · Cited by 19

FMRP ribonucleoprotein complexes and RNA homeostasis

Suardi, G. A. M., & Haddad, L. A. (2020) · Advances in genetics · doi:10.1016/bs.adgen.2020.01.001 · Cited by 18

Positive natural selection of N6-methyladenosine on the RNAs of processed pseudogenes

Tan, L., Cheng, W., Liu, F., Wang, D. O., Wu, L., Cao, N., & Wang, J. (2021) · Genome biology · doi:10.1186/s13059-021-02402-2 · Cited by 16

m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina

Xin, Y., He, Q., Liang, H., Zhang, K., Guo, J., Zhong, Q., Chen, D., Li, J., Liu, Y., & Chen, S. (2022) · eLife · doi:10.7554/elife.79994 · Cited by 16

Transcriptome programs involved in the development and structure of the cerebellum

Farini, D., Marazziti, D., Geloso, M. C., & Sette, C. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03911-w · Cited by 18

Circular RNA: A novel and potential regulator in pathophysiology of schizophrenia

Singh, M., Dwibedy, S. L. L., Biswal, S. R., Muthuswamy, S., Kumar, A., & Kumar, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00978-7 · Cited by 15

Comprehensive analysis of differences in N6‐methyladenosine RNA methylomes in the rat adenohypophysis after GnRH treatment

Wang, H., Zhang, J., Zheng, Y., Zhang, W., Guo, H., Cong, S., Ding, Y., & Yuan, B. (2022) · The FASEB Journal · doi:10.1096/fj.202101608r · Cited by 15

Sex-specific transcriptomic and epitranscriptomic signatures of PTSD-like fear acquisition

Reis, A. L. M., Hammond, J. W., Stevanovski, I., Arnold, J. C., McGregor, I. S., Deveson, I. W., & Gururajan, A. (2022) · iScience · doi:10.1016/j.isci.2022.104861 · Cited by 16

METTL3 and METTL14-mediated N6-methyladenosine modification promotes cell proliferation and invasion in a model of endometriosis

Shen, L., Zhang, C., Zhang, Y., & Yang, Y. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.10.010 · Cited by 17

RNADSN: Transfer-Learning 5-Methyluridine (m5U) Modification on mRNAs from Common Features of tRNA

Li, Z.-R., Mao, J.-G., Huang, D.-Y., Song, B., & Meng, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113493 · Cited by 14

RNA N6-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications

Dang, Q., Shao, B., Zhou, Q., Chen, C., Guo, Y., Wang, G., Liu, J., Kan, Q., Yuan, W., & Sun, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.681781 · Cited by 16

The emerging roles of the interaction between m6A modification and c‐Myc in driving tumorigenesis and development

Zheng, L., Li, M., Wei, J., Chen, S., Xue, C., Zhan, Y., Duan, Y., Deng, H., Xiong, W., Li, G., et al. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30733 · Cited by 15

Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids

Luo, X., Zhu, S., Li, J., Zeng, N., Wang, H., Wu, Y., Wang, L., & Liu, Z. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1143866 · Cited by 14

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

Yan, C., Xiong, J., Zhou, Z., Li, Q., Gao, C., Zhang, M., Yu, L., Li, J., Hu, M.-M., Zhang, C., et al. (2023) · eLife · doi:10.7554/elife.87283 · Cited by 13

m6A methylation in cellular senescence of age-associated diseases

Gao, P., Yao, F., Pang, J., Yin, K., & Zhu, X. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023107 · Cited by 15

Identification of differential m6A RNA methylomes and ALKBH5 as a potential prevention target in the developmental neurotoxicity induced by multiple sevoflurane exposures

Meng, X., Wang, Y., Zhao, W., Chen, Y., Li, W., Peng, K., Xu, H., Yang, Y., Shan, X.-S., Huo, W., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400664r · Cited by 14

METTL3: a multifunctional regulator in diseases

Li, N., Xiang, W., Dai, J., Yang, J., & Xiong, S. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05208-z · Cited by 14

Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD)

Rodriguez, F. D. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210203142539 · Cited by 15

The Role of N6-Methyladenosine (m6A) RNA Modification in the Pathogenesis of Parkinson’s Disease

Wang, Y., Zhao, T., Yuan, C., & Chen, X. (2025) · Biomolecules · doi:10.3390/biom15050617 · Cited by 14

Cross-Talk between N6-Methyladenosine and Their Related RNAs Defined a Signature and Confirmed m6A Regulators for Diagnosis of Endometriosis

Wang, X., Zhao, X., Wu, H., Wang, J., Cheng, Y., Guo, Q., Liang, T., & Zhang, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021665 · Cited by 13

Hypothalamic expression analysis of m6A RNA methylation associated genes suggests a potential role of epitranscriptomics in sexual maturation of Atlantic salmon

Ahi, E. P., Frapin, M., Hukkanen, M., & Primmer, C. R. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.740151 · Cited by 11

N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats

Deng, J.-H., Liao, Y.-L., Chen, J.-H., Chen, A.-D., Wu, S., Huang, Y.-X., Qian, H.-T., Gao, F., Wu, G.-X., Chen, Y.-S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06343-5 · Cited by 17

N6-methyladenosine (m6A) epitranscriptomics in synaptic plasticity and behaviors

Malovic, E., & Pandey, S. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01414-1 · Cited by 13

Small-molecule and peptide inhibitors of m6A regulators

Liu, X., & Kan, X. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1629864 · Cited by 13

The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches

Deacon, S., Walker, L., Radhi, M., & Smith, S. J. (2023) · Cancers · doi:10.3390/cancers15133307 · Cited by 13

Emerging role of N6-methyladenosine in the homeostasis of glucose metabolism

Sun, Y., Zhao, T., Li, L., Wang, Z., & Li, H. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00225.2023 · Cited by 13

Post-transcriptional mechanisms controlling neurogenesis and direct neuronal reprogramming

Papadimitriou, E., & Thomaidou, D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390976 · Cited by 14

m5C methylated lncRncr3–MeCP2 interaction restricts miR124a-initiated neurogenesis

Zhang, J., Li, H., & Niswander, L. A. (2024) · Nature Communications · doi:10.1038/s41467-024-49368-w · Cited by 12

Targeting neuronal epigenomes for brain rejuvenation

Zocher, S. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00148-8 · Cited by 13

m6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia

Yu, J., Gao, Y., Liu, F., Zhang, Y., Li, J., Ding, L., Ren, S., Yang, J., Jiao, J., Gong, F., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02932-4 · Cited by 12

NAD+ Modulates the Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells via Akt Signaling Pathway

Huang, X., Guo, H., Cheng, X., Zhang, J., Qu, W., Ding, Q., Sun, Q., Shu, Q., & Li, X. (2022) · Cells · doi:10.3390/cells11081283 · Cited by 12

Single-cell discovery of m 6 A RNA modifications in the hippocampusPreprint

Feng, S., Tellaetxe-Abete, M., Zhang, Y., Peng, Y., Zhou, H., Dong, M., Larrea, E., Xue, L., Zhang, L., & Koziol, M. J. (2024) · Genome Research · doi:10.1101/gr.278424.123 · Cited by 12

Homozygous EPRS1 missense variant causing hypomyelinating leukodystrophy-15 alters variant-distal mRNA m6A site accessibility

Khan, D., Ramachandiran, I., Vasu, K. I., China, A., Khan, K., Cumbo, F., Halawani, D., Terenzi, F., Zin, I., Long, B., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48549-x · Cited by 11

RNA methylation in neurodevelopment and related diseases

Xia, W., Liu, Y., Lu, J., Cheung, H., Meng, Q., & Huang, B. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024159 · Cited by 14

Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression

Xian, Z., Tian, L., Yao, Z., Cao, L., Jia, Z., & Li, G. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04614-6 · Cited by 11

Epitranscriptome–epigenome interactions in development and disease mechanisms

Li, C., Chen, K., Li, X., & Xiong, X. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.04.009 · Cited by 11

m6A RNA methylation-mediated control of global APC expression is required for local translation of β-actin and axon development

Broix, L., Roy, R., Shohayeb, B., Oomoto, I., Umeshima, H., & Wang, D. O. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115727 · Cited by 14

Metabolic turnover and dynamics of modified ribonucleosides by 13C labeling

Gameiro, P. A., Encheva, V., Dos Santos, M. S., MacRae, J. I., & Ule, J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101294 · Cited by 10

Active Fraction of Polyrhachis Vicina Roger (AFPR) Ameliorate Depression Induced Inflammation Response by FTO/miR-221-3p/SOCS1 Axis

He, J., Xie, J., Zhou, G., Jia, C., Han, D., Li, D., Wei, J., Li, Y., Huang, R., Li, C., et al. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s439912 · Cited by 11

Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson’s Disease

Gionco, J. T., & Bernstein, A. I. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230457 · Cited by 10

Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications

Xu, X. F., Chen, J., Long, L. H., Zhang, A. M., Yang, J., Li, Y. J., Chen, L., Zhong, X. L., Xu, Y., & Cao, W. Y. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.08.173 · Cited by 10

A robust deep learning approach for identification of RNA 5-methyluridine sites

Shaon, M. S. H., Karim, T., Ali, M. M., Ahmed, K., Bui, F. M., Chen, L., & Moni, M. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-76148-9 · Cited by 11

Mettl3 regulates the pathogenesis of Alzheimer’s disease via fine-tuning Lingo2

Zhao, X., Ma, C., Sun, Q., Huang, X., Qu, W., Chen, Y., Liu, Z., Bao, A., Sun, B., Yang, Y., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02984-4 · Cited by 10

Cotton (Gossypium hirsutum) VIRMA as an N6-Methyladenosine RNA Methylation Regulator Participates in Controlling Chloroplast-Dependent and Independent Leaf Development

Huang, X., Abuduwaili, N., Wang, X., Tao, M., Wang, X., & Huang, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179887 · Cited by 10

Prognostic and clinicopathological value of m6A regulators in human cancers: a meta-analysis

Su, Z., Xu, L., Dai, X., Zhu, M., Chen, X., Li, Y., Li, J., Ge, R., Cheng, B., & Wang, Y. (2022) · Aging · doi:10.18632/aging.204371 · Cited by 10

The cap epitranscriptome: Early directions to a complex life as mRNA

Anreiter, I., Tian, Y. W., & Soller, M. (2022) · BioEssays · doi:10.1002/bies.202200198 · Cited by 9

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

Yan, C., Xiong, J., Zhou, Z., Li, Q., Gao, C., Zhang, M., Yu, L., Li, J., Hu, M.-M., Zhang, C., et al. (2023) · eLife · doi:10.7554/elife.87283.3 · Cited by 10

The role of the methyltransferase METTL3 in prostate cancer: a potential therapeutic target

Zhou, X., Chai, K., Zhu, H., Luo, C., Zou, X., Zou, J., & Zhang, G. (2024) · BMC Cancer · doi:10.1186/s12885-023-11741-1 · Cited by 10

DNA Methylation Regulates Transcription Factor-Specific Neurodevelopmental but Not Sexually Dimorphic Gene Expression Dynamics in Zebra Finch Telencephalon

Diddens, J., Coussement, L., Frankl‐Vilches, C., Majumdar, G., Steyaert, S., ter Haar, S. M., Galle, J., Meester, E. D., Keulenaer, S. D., Criekinge, W. V., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.583555 · Cited by 9

Aerial View of the Association Between m6A-Related LncRNAs and Clinicopathological Characteristics of Pancreatic Cancer

Huang, B., Liu, J., Lü, J., Gao, W., Zhou, L., Tian, F., Wang, Y., Luo, M., Liu, D., Xie, C., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.812785 · Cited by 10

YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through m6A-dependent binding

Chang, X., Li, B., Huang, W., Chen, A., Zhu, S., Liu, Y., Liu, X., Yang, J., & Wang, D. O. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10061-3 · Cited by 9

Interpretability-guided RNA N6-methyladenosine modification site prediction with invertible neural networks

Li, G., Su, X., Yang, Y., Li, D., Cui, Z., Deng, X., Hu, P., & Hu, L. (2025) · Communications Biology · doi:10.1038/s42003-025-08265-8 · Cited by 9

Epitranscriptomic signatures in stem cell differentiation to the neuronal lineage

Șelaru, A., Costache, M., & Dinescu, S. (2021) · RNA Biology · doi:10.1080/15476286.2021.1985348 · Cited by 10

m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement

Qu, W., Li, Q., Wang, M., Zhao, X., Wu, J., Liu, D., Hong, S., Yang, Y., Shu, Q., & Li, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.903179 · Cited by 9

Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic control

Patra, S. K., & Szyf, M. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166527 · Cited by 9

RNA m6A methyltransferase activator affects anxiety-related behaviours, monoamines and striatal gene expression in the rat

Kanarik, M., Liiver, K., Školnaja, M., Teino, I., Org, T., Laugus, K., Shimmo, R., Karelson, M. M., Saarma, M., & Harro, J. (2024) · Acta Neuropsychiatrica · doi:10.1017/neu.2024.36 · Cited by 8

Division of labor in epitranscriptomics: What have we learnt from the structures of eukaryotic and viral multimeric RNA methyltransferases?

Graille, M. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1673 · Cited by 9

m 6 A Pathway Regulators Are Frequently Mutated in Breast Invasive Carcinoma and May Play an Important Role in Disease Pathogenesis

Demircan, T., Yavuz, M., & Akgül, S. (2021) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2021.0114 · Cited by 9

Cloning of the RNA m6A Methyltransferase 3 and Its Impact on the Proliferation and Differentiation of Quail Myoblasts

Liu, J., Zhang, W., Luo, W., Liu, S., Jiang, H., Liu, S., Xu, J., & Chen, B. (2023) · Veterinary Sciences · doi:10.3390/vetsci10040300 · Cited by 8

Studying m6A in the brain: a perspective on current methods, challenges, and future directions

Tegowski, M., & Meyer, K. D. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1393973 · Cited by 8

The m6A modification regulates the composition of myofiber types in chicken skeletal muscle

Shan, Y., Liu, Y., Zhang, M., Pang, L., Ji, G., Ju, X., Tu, Y., & Shu, J. (2025) · Poultry Science · doi:10.1016/j.psj.2025.104811 · Cited by 8

Targeting m6A RNA Modification in Tumor Therapeutics

Mao, Z., Li, M., & Wang, S. (2025) · Current Oncology · doi:10.3390/curroncol32030159 · Cited by 8

Unraveling brain complexity: from single-cell to spatial m6A technologies

Feng, S., & Koziol, M. J. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.06.010 · Cited by 8

YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring

Lu, L., Shi, Y., Wei, B., Li, W., Yu, X., Zhao, Y., Yu, D., & Sun, M. (2023) · iScience · doi:10.1016/j.isci.2023.108703 · Cited by 11

Imbalance of mitochondrial quality control regulated by STING and PINK1 affects cyfluthrin-induced neuroinflammation

Zhao, J., Qiu, Y.-K., Xie, Y.-X., Li, X.-Y., Li, Y., Wu, B., Wang, Y., Tian, X.-Y., Lv, Y.-L., Zhang, L.-H., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174313 · Cited by 9

A chemical labeling of N6-formyl adenosine (f6A) RNA

Xie, L., Lin, C.-L., Liu, L., & Cheng, L. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.09.028 · Cited by 8

Determining RNA Natural Modifications and Nucleoside Analog-Labeled Sites by a Chemical/Enzyme-Induced Base Mutation Principle

Bao, Z., Li, T., & Liu, J. (2023) · Molecules · doi:10.3390/molecules28041517 · Cited by 8

Understanding the Epitranscriptome for Avant-Garde Brain Tumour Diagnostics

Tűzesi, Á., Hallal, S. M., Satgunaseelan, L., Buckland, M. E., & Alexander, K. L. (2023) · Cancers · doi:10.3390/cancers15041232 · Cited by 8

Genome-wide identification of m6A-associated single nucleotide polymorphisms in complex diseases of nervous system

Guo, F., Kang, J., Xu, J., Wei, S., Tao, J., Dong, Y., Ma, Y., Tian, H., Guo, X., Bi, S., et al. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137513 · Cited by 8

Enhancing m6A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

Qin, T., Jin, Y., Qin, Y., Yuan, F., Lü, H., Hu, J., Cao, Y. B., & Li, C. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01477 · Cited by 8

N6-methyladenosine (m6A) dysregulation contributes to network excitability in temporal lobe epilepsy

Mathoux, J., Wilson, M., Srinivas, S., Litovskich, G., Villalba‐Benito, L., Tran, C., Kesavan, J., Harnett, A., Auer, T., Sanz‐Rodriguez, A., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.188612 · Cited by 7

RNA-m5C regulatory atlas of human fetal tissues uncover the activities of Nsun2/Jarid2/Alyref axis

Hu, X., Ding, C., Lu, J., Li, J., Ren, X., Xia, W., Qian, C., Li, H., Cheung, H., & Huang, B. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.004 · Cited by 7

RNA Aptamers and Epitranscriptomics: Charting Unexplored Territories in RNA Biology

Khorshid, M., & Ahi, E. P. (2026) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-026-00841-w · Cited by 7

RNA Modifications in the Central Nervous System

Wang, D. O. (2020) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190686307.013.23 · Cited by 6

Gene Signatures and Prognostic Values of N6-Methyladenosine Related Genes in Ovarian Cancer

Na, Z., Fan, L., & Wang, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.542457 · Cited by 7

The Potential Role of m6A in the Regulation of TBI-Induced BGA Dysfunction

Huang, P., Liu, M., Zhang, J., Zhong, X., & Zhong, C. (2022) · Antioxidants · doi:10.3390/antiox11081521 · Cited by 7

Comprehensive analysis of m6A methylation modification in chronic spinal cord injury in mice

Li, C., Zhao, J., Qin, T., Jin, Y., Duan, C., Wu, T., Manini, D. R., Cao, Y. B., Lü, H., & Hu, J. (2022) · Journal of Orthopaedic Research® · doi:10.1002/jor.25457 · Cited by 7

Role of transcription factors, noncoding RNAs , epitranscriptomics, and epigenetics in post‐ischemic neuroinflammation

Mehta, S. L., Arruri, V. K., & Vemuganti, R. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16055 · Cited by 7

A neural m6A pathway regulates behavioral aggregation in migratory locusts

Huang, X., Li, Q., Xu, Y., Li, A., Wang, S., Chen, Y., Zhang, C., Zhang, X., Wang, H., Lv, C., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2476-1 · Cited by 7

The m6A‐epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity

Widagdo, J., & Anggono, V. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14481 · Cited by 157

Epitranscriptomics: Regulating Brain Plasticity Through Dynamic RNA Modifications

McGarragle, K., Yip, R. C. S., & Anreiter, I. (2024) · Springer eBooks · doi:10.1007/978-3-031-59286-7_7 · Cited by 1

New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System

Dermentzaki, G., & Lotti, F. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.555372 · Cited by 36

Epitranscriptomic regulation by m 6 A RNA methylation in brain development and diseases

Chokkalla, A. K., Mehta, S. L., & Vemuganti, R. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20960033 · Cited by 93

The effects of N6-methyladenosine RNA methylation on the nervous system

Shao, N., Ye, T., Xuan, W.-T., Zhang, M., Chen, Q., Liu, J., Zhou, P., Song, H., & Cai, B. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04691-6 · Cited by 14