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COVID-19 revisiting inflammatory pathways of arthritis
Open accessAbstract
Coronavirus disease 2019 (COVID-19) is an infectious disease, caused by severe acute respiratory syndrome coronavirus 2, which predominantly affects the lungs and, under certain circumstances, leads to an excessive or uncontrolled immune activation and cytokine response in alveolar structures. The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signalling via Janus kinase inhibition in the treatment of COVID-19. Despite these similarities, COVID-19 and other zoonotic coronavirus-mediated diseases do not induce clinical arthritis, suggesting that a local inflammatory niche develops in alveolar structures and drives the disease process. COVID-19 constitutes a challenge for patients with inflammatory arthritis for several reasons, in particular, the safety of immune interventions during the pandemic. Preliminary data, however, do not suggest that patients with inflammatory arthritis are at increased risk of COVID-19.
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“Furthermore, chronic diseases, such as RA, characterized by immune dysfunction and dysbiosis, are of great clinical and mechanistic interest as they provide insights into the pathophysiology of viral infections (Schett et al., 2020).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Schett et al., 2020
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Metadata
- Authors
- Schett, G., Manger, B., Simon, D., & Caporali, R.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Milan (IT)
- Corresponding author
- Schett, Georg
- Venue
- Nature Reviews Rheumatology
- Published
- 2020-06-19
- Volume
- 16
- Issue
- 8
- Pages
- 465-470
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- PMC
- PMC7304381
- OpenAlex
- W3036280377
- Cited by
- 191
- References
- 63
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 15 · 2023: 31 · 2022: 51 · 2021: 65 · 2020: 20
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Reviews Rheumatology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- Deutsche Forschungsgemeinschaft (TRR 241, SFB1181, FOR 2438)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- COVID-19 pandemic, SARS-CoV-2, rheumatoid arthritis, inflammatory arthritis, inflammatory cytokines, interleukin-6, IL-1β, TNF-α, Janus kinase inhibition, anti-cytokine therapy, immune activation
- MeSH terms
- Betacoronavirus, Janus Kinase Inhibitors, Tumor Necrosis Factor Inhibitors, Cytokine Release Syndrome, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Arthritis, Rheumatoid, Azetidines, Delivery of Health Care, Pneumonia, Viral, Pulmonary Alveoli, Purines, Pyrazoles, Rheumatology, Sulfonamides, Tumor Necrosis Factor-alpha, Interleukin-6, Coronavirus Infections, Antirheumatic Agents, Arthralgia, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein, Pandemics, Antibodies, Monoclonal, Humanized, Myalgia
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