Cited by 448Mosquito-borne diseases and controlViral Infections and VectorsSARS-CoV-2 and COVID-19 Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Mxra8 is a receptor for multiple arthritogenic alphaviruses

Open access

Zhang, Rong, Kim, Arthur S., Fox, Julie M., Nair, Sharmila, Basore, Katherine, Klimstra, William B., Rimkunas, Rebecca, Fong, Rachel H., Lin, Hueylie, Poddar, Subhajit, Crowe, James E., Doranz, Benjamin J., Fremont, Daved H., Diamond, Michael S.·2018·Nature

DOI 10.1038/s41586-018-0121-3PMC PMC5970976

Open this paper in CoChat — free account

Abstract

Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease 1 . The host factors required for alphavirus entry remain poorly characterized 2 . Here we use a genome-wide CRISPR-Cas9-based screen to identify the cell adhesion molecule Mxra8 as an entry mediator for multiple emerging arthritogenic alphaviruses, including chikungunya, Ross River, Mayaro and O'nyong nyong viruses. Gene editing of mouse Mxra8 or human MXRA8 resulted in reduced levels of viral infection of cells and, reciprocally, ectopic expression of these genes resulted in increased infection. Mxra8 bound directly to chikungunya virus particles and enhanced virus attachment and internalization into cells. Consistent with these findings, Mxra8-Fc fusion protein or anti-Mxra8 monoclonal antibodies blocked chikungunya virus infection in multiple cell types, including primary human synovial fibroblasts, osteoblasts, chondrocytes and skeletal muscle cells. Mutagenesis experiments suggest that Mxra8 binds to a surface-exposed region across the A and B domains of chikungunya virus E2 protein, which are a speculated site of attachment. Finally, administration of the Mxra8-Fc protein or anti-Mxra8 blocking antibodies to mice reduced chikungunya and O'nyong nyong virus infection as well as associated foot swelling. Pharmacological targeting of Mxra8 could form a strategy for mitigating infection and disease by multiple arthritogenic alphaviruses.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41586-018-0121-3

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures
Pushko, P., Pumpens, P., & Grens, E. (2013) · Intervirology · doi:10.1159/000346773 · Cited by 5,975
Improved vectors and genome-wide libraries for CRISPR screening
Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239
Genome-scale CRISPR-Cas9 knockout screening in human cells
Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
Li, W., Xu, H., Xiao, T., Cong, L., Love, M. I., Zhang, F., Irizarry, R. A., Liu, J. S., Brown, M., & Liu, X. S. (2014) · Genome Biology · doi:10.1186/s13059-014-0554-4 · Cited by 2,684
RNA-programmed genome editing in human cells
Jinek, M., East, A., Cheng, A., Lin, S., Ma, E., & Doudna, J. (2013) · eLife · doi:10.7554/elife.00471 · Cited by 2,098
Genome-scale CRISPR-Cas9 Knockout and Transcriptional Activation Screening
Joung, J., Konermann, S., Gootenberg, J. S., Abudayyeh, O. O., Platt, R. J., Brigham, M. D., Sanjana, N. E., & Zhang, F. (2017) · Nature Protocols · doi:10.1038/nprot.2017.016 · Cited by 1,243
Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography
Voss, J. E., Vaney, M. C., Duquerroy, S., Vonrhein, C., Girard-Blanc, C., Crublet, E., Thompson, A., Bricogne, G., & Rey, F. A. (2010) · Nature · doi:10.1038/nature09555 · Cited by 696
Junction Adhesion Molecule Is a Receptor for Reovirus
Barton, E. S., Forrest, J. C., Connolly, J. L., Chappell, J. D., Liu, Y., Schnell, F. J., Nusrat, A., Parkos, C. A., & Dermody, T. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00231-8 · Cited by 624
Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus
Oliphant, T., Engle, M. J., Nybakken, G. E., Doane, C., Johnson, S., Huang, L., Gorlatov, S. N., Mehlhop, E., Marri, A., Chung, K. M., et al. (2005) · Nature Medicine · doi:10.1038/nm1240 · Cited by 514
Self-citation

Show all 41 references

Sorted by citations

Items 101–200 of 447

Chikungunya Immunopathology as It Presents in Different Organ Systems
Traverse, E. M., Millsapps, E. M., Underwood, E. C., Hopkins, H. K., Young, M., & Barr, K. L. (2022) · Viruses · doi:10.3390/v14081786 · Cited by 27
Human monoclonal antibodies against Ross River virus target epitopes within the E2 protein and protect against disease
Powell, L. A., Fox, J. M., Kose, N., Kim, A. S., Majedi, M., Bombardi, R. G., Carnahan, R. H., Slaughter, J. C., Morrison, T. E., Diamond, M., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008517 · Cited by 27
Self-citation
A review of virus host factor discovery using CRISPR screening
See, W. R., Yousefi, M., & Ooi, Y. S. (2024) · mBio · doi:10.1128/mbio.03205-23 · Cited by 26
Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells
Ballista, J. M. R., Miazgowicz, K. L., Acciani, M. D., Jimenez, A. R., Belloli, R. S., Havranek, K. E., & Brindley, M. A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1085913 · Cited by 25
Mayaro Virus: An Emerging Alphavirus in the Americas
Wei, L. L. L., Tom, R., & Kim, Y. C. (2024) · Viruses · doi:10.3390/v16081297 · Cited by 25
Anti-Chikungunya Virus Monoclonal Antibody That Inhibits Viral Fusion and Release
Tumkosit, U., Siripanyaphinyo, U., Takeda, N., Tsuji, M., Maeda, Y., Ruchusatsawat, K., Shioda, T., Mizushima, H., Chetanachan, P., Wongjaroen, P., et al. (2020) · Journal of Virology · doi:10.1128/jvi.00252-20 · Cited by 25
Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein
Lukash, T., Agback, T., Domínguez, F. D. B. P., Shiliaev, N., Meshram, C. D., Frolova, E. I., Agback, P., & Frolov, I. V. (2020) · Journal of Virology · doi:10.1128/jvi.01672-20 · Cited by 25
Directed natural evolution generates a next-generation oncolytic virus with a high potency and safety profile
Guo, L., Hu, C., Liu, Y., Chen, X., Song, D., Shen, R., Liu, Z., Jia, X., Zhang, Q., Gao, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39156-3 · Cited by 25
Chikungunya virus requires cellular chloride channels for efficient genome replication
Müller, M., Slivinski, N. S. J., Todd, E. J. A. A., Khalid, H., Li, R., Karwatka, M., Merits, A., Mankouri, J., & Tuplin, A. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007703 · Cited by 25
Colocalization of Chikungunya Virus with Its Receptor MXRA8 during Cell Attachment, Internalization, and Membrane Fusion
Feng, F., Bouma, E. M., Hu, G., Zhu, Y., Yin, Y., Smit, J. M., Diamond, M., & Zhang, R. (2023) · Journal of Virology · doi:10.1128/jvi.01557-22 · Cited by 24
Self-citation
Monitoring Viral Entry in Real-Time Using a Luciferase Recombinant Vesicular Stomatitis Virus Producing SARS-CoV-2, EBOV, LASV, CHIKV, and VSV Glycoproteins
Mendoza, M. F. L., Acciani, M. D., Levit, C., Maria, C. S., & Brindley, M. A. (2020) · Viruses · doi:10.3390/v12121457 · Cited by 24
ADAM17 is an essential attachment factor for classical swine fever virus
Yuan, F., Li, D., Li, C., Zhang, Y., Song, H., Li, S., Deng, H., Gao, G. F., & Zheng, A. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009393 · Cited by 24
The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication
Laßwitz, L., Belinchón, F. J. Z., Moeller, R. A., Hülskötter, K., Laurent, T., Carlson, L. A., Goffinet, C., Simmons, G., Baumgärtner, W., & Gerold, G. (2022) · mBio · doi:10.1128/mbio.00731-22 · Cited by 24
Host Factors and Pathways Involved in the Entry of Mosquito-Borne Alphaviruses
Caluwé, L. D., Ariën, K. K., & Bartholomeeusen, K. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.10.011 · Cited by 23
A cross-reactive antibody protects against Ross River virus musculoskeletal disease despite rapid neutralization escape in mice
Fox, J. M., Huang, L., Tahan, S., Powell, L. A., Crowe, J. E., Wang, D., & Diamond, M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008743 · Cited by 23
Self-citation
Ly6C+ monocytes in the skin promote systemic alphavirus dissemination
Holmes, A. C., Lucas, C. J., Brisse, M. E., Ware, B. C., Hickman, H. D., Morrison, T. E., & Diamond, M. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113876 · Cited by 23
Self-citation
The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
Zhang, S., Xin, F., & Zhang, X. (2020) · iScience · doi:10.1016/j.isci.2020.101915 · Cited by 23
Emergent Arboviruses: A Review About Mayaro virus and Oropouche orthobunyavirus
Pereira, T. N., Virginio, F., Souza, J. I., & Moreira, L. A. (2021) · Frontiers in Tropical Diseases · doi:10.3389/fitd.2021.737436 · Cited by 22
The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes
Cao, D., Ma, B., Cao, Z., Xu, X., Zhang, X., & Xiang, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-51293-x · Cited by 22
The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses
Palakurty, S., Raju, S., Sariol, A., Chong, Z., Wagoner, N., Ma, H., Zimmerman, O., Adams, L. J., Carmona, C., Liu, Z., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114809 · Cited by 22
Self-citation
Host ESCRT factors are recruited during chikungunya virus infection and are required for the intracellular viral replication cycle
Torii, S., Orba, Y., Sasaki, M., Tabata, K., Wada, Y., Carr, M. J., Hobson‐Peters, J., Hall, R. A., Takada, A., Fukuhara, T., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012303 · Cited by 22
CRISPR Screening: Molecular Tools for Studying Virus–Host Interactions
Chulanov, V., Kostyusheva, A., Brezgin, S., Ponomareva, N. I., Gegechkori, V., Volchkova, E. V., Николаевич, П. Н., & Kostyushev, D. S. (2021) · Viruses · doi:10.3390/v13112258 · Cited by 21
FHL1 promotes chikungunya and o’nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design
Ng, W. H., Liu, X., Ling, Z. L., Santos, C. N. O., Magalhães, L. S., Kueh, A. J., Herold, M. J., Taylor, A., Freitas, J. R., Koit, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42330-2 · Cited by 21
The laminin receptor is a receptor for Micropterus salmoides rhabdovirus
Luo, S., Liang, J., Yang, G., Lu, J., & Chen, J. (2024) · Journal of Virology · doi:10.1128/jvi.00697-24 · Cited by 21
Structural basis for VLDLR recognition by eastern equine encephalitis virus
Yang, P., Li, W., Fan, X., Pan, J., Mann, C. J., Varnum, H., Clark, L. E., Clark, S. A., Coscia, A., Basu, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50887-9 · Cited by 21
Design of customized coronavirus receptors
Liu, P., Huang, M., Guo, H., McCallum, M., Si, J.-Y., Chen, Y., Wang, C., Xiao, Y., Shi, L., Xiong, Q., et al. (2024) · Nature · doi:10.1038/s41586-024-08121-5 · Cited by 21
Genetic control of alphavirus pathogenesis
Baxter, V. K., & Heise, M. T. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9776-1 · Cited by 21
Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication
Ohlson, M. B., Eitson, J. L., Wells, A. I., Kumar, A., Jang, S., Ni, C., Xing, C., Buszczak, M., & Schoggins, J. W. (2023) · mBio · doi:10.1128/mbio.00127-23 · Cited by 20
Small Molecule Inhibitors Targeting Chikungunya Virus
Haese, N. N., Powers, J. M., & Streblow, D. N. (2020) · Current topics in microbiology and immunology · doi:10.1007/82_2020_195 · Cited by 21
Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist
Mei, H., Zha, Z., Wang, W., Xie, Y., Huang, Y., Li, W., Wei, D., Zhang, X., Xie, J., Liu, J., et al. (2021) · Genome biology · doi:10.1186/s13059-021-02513-w · Cited by 20
Mayaro Virus: The State-of-the-Art for Antiviral Drug Development
Andreolla, A. P., Borges, A. A., Bordignon, J., & dos Santos, C. N. D. (2022) · Viruses · doi:10.3390/v14081787 · Cited by 19
The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito
Cereghino, C., Roesch, F., Carrau, L., Hardy, A., Filho, H. V. R., Henrion-Lacritick, A., Koh, C., Marano, J. M., Bates, T. A., Rai, P., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1010491 · Cited by 19
Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection
Ma, N., Zhang, M., Zhou, J., Jiang, C., Ghonaim, A. H., Sun, Y., Zhou, P., Guo, G., Evers, A., Zhu, H., et al. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2400559 · Cited by 20
The neonatal Fc receptor is a cellular receptor for human astrovirus
Ingle, H., Molleston, J. M., Hall, P. D., Bui, D., Wang, L., Bhatt, K. D., Foster, L. R., Antia, A., Ding, S., Lee, S., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01855-y · Cited by 19
Self-citation
Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors
Wichit, S., Gumpangseth, N., Hamel, R., Yainoy, S., Arikit, S., Punsawad, C., & Missé, D. (2021) · Pathogens · doi:10.3390/pathogens10040448 · Cited by 19
Identification of matrix-remodeling associated 5 as a possible molecular oncotarget of pancreatic cancer
Peng, S.-Q., Zhu, X., Zhao, M.-Z., Zhang, Y., Wang, A.-R., Chen, M., & Ye, Z.-Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05684-5 · Cited by 19
A Review of the Biology of Chikungunya Virus Highlighting the Development of Current Novel Therapeutic and Prevention Approaches
Martelossi-Cebinelli, G., Carneiro, J. A., Yaekashi, K. M., Bertozzi, M. M., Bianchini, B. H. S., Rasquel-Oliveira, F. S., Zanluca, C., dos Santos, C. N. D., Arredondo, R., Blackburn, T. A., et al. (2025) · Pathogens · doi:10.3390/pathogens14101047 · Cited by 18
Rapid microfluidic platform for screening and enrichment of cells secreting virus neutralizing antibodies
Lin, W. N., Tay, M. Z., Wong, J. X. E., Lee, C. Y., Fong, S., Wang, C., Ng, L. F. P., Rénia, L., Chen, C., & Cheow, L. F. (2022) · Lab on a Chip · doi:10.1039/d2lc00018k · Cited by 18
Evolution and immunopathology of chikungunya virus informs therapeutic development
Sousa, F. H., Komarudin, A. G., Findlay-Greene, F., Bowolaksono, A., Sasmono, R. T., Stevens, C., & Barlow, P. G. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049804 · Cited by 18
Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice
Kafai, N. M., Jáňová, H., Cain, M. D., Alippe, Y., Muraro, S. P., Sariol, A., Elam-Noll, M., Klein, R. S., & Diamond, M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112946 · Cited by 18
Self-citation
A comparison of Chikungunya virus infection, progression, and cytokine profiles in human PMA-differentiated U937 and murine RAW264.7 monocyte derived macrophages
Guerrero‐Arguero, I., Høj, T. R., Tass, E. S., Berges, B. K., & Robison, R. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230328 · Cited by 18
Reconociendo el virus del chikunguña
Calvo, E., Hernández, E. D. A., López, L. S., & Castellanos, J. E. (2021) · Biomédica · doi:10.7705/biomedica.5797 · Cited by 18
The Putative Roles and Functions of Indel, Repetition and Duplication Events in Alphavirus Non-Structural Protein 3 Hypervariable Domain (nsP3 HVD) in Evolution, Viability and Re-Emergence
Abdullah, N., Ahemad, N., Aliazis, K., Khairat, J. E., Lee, T. C., Ahmad, S. A. A., Adnan, N. A. A., Macha, N. O., & Hassan, S. S. (2021) · Viruses · doi:10.3390/v13061021 · Cited by 17
Eastern Equine Encephalitis Virus Taxonomy, Genomics, and Evolution
Ciota, A. T. (2021) · Journal of Medical Entomology · doi:10.1093/jme/tjab079 · Cited by 17
Multipathway synergy promotes testicular transition from growth to spermatogenesis in early-puberty goats
Bo, D., Jiang, X., Liu, G., Xu, F., Hu, R., Wassie, T., Chong, Y., Ahmed, S., Liu, C., & Girmay, S. (2020) · BMC Genomics · doi:10.1186/s12864-020-6767-x · Cited by 17
Prophylactic strategies to control chikungunya virus infection
Hucke, F. I. L., Bestehorn, M., & Bugert, J. J. (2021) · Virus Genes · doi:10.1007/s11262-020-01820-x · Cited by 20
Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer
Ichihara, R., Shiraki, Y., Mizutani, Y., Iida, T., Miyai, Y., Esaki, N., Kato, A., Mii, S., Ando, R., Hayashi, M., et al. (2022) · Pathology International · doi:10.1111/pin.13198 · Cited by 17
Cryo-EM structures of alphavirus conformational intermediates in low pH–triggered prefusion states
Chen, C.-L., Klose, T., Sun, C., Kim, A. S., Buda, G., Rossmann, M. G., Diamond, M., Klimstra, W. B., & Kuhn, R. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114119119 · Cited by 16
Self-citation
Reverse genetics in virology: A double edged sword
Chen, H., Liu, H., & Peng, X. (2022) · Biosafety and Health · doi:10.1016/j.bsheal.2022.08.001 · Cited by 16
Interferon-induced restriction of Chikungunya virus infection
Suzuki, Y. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105487 · Cited by 16
Emergence of ECSA-IOL E1-K211E/E2-V264A Lineage of Chikungunya virus during Malaysian 2021 outbreak
Kalyanasundram, J., Zawawi, Z. M., Kamel, K. A., Aroidoss, E. T., Ellan, K., Anasir, M. I., Azizan, M. A., Zulkifli, M. M. S., & Zain, R. M. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-10102-y · Cited by 16
Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8 + T cell responses against an arthritogenic alphavirus
Bullock, C. B., Wang, L., Ware, B. C., Wagoner, N., Ohara, R. A., Liu, T., Desai, P., Peters, B., MURPHY, K. M. M., Handley, S. A., et al. (2024) · mBio · doi:10.1128/mbio.02930-24 · Cited by 16
Self-citation
Memantine hydrochloride: a drug to be repurposed against Chikungunya virus?
Pereira, A. K. D. S., Santos, I. A., da Silva, W. W., Resende, F. A., Bergamini, F. R. G., Jardim, A. C. G., & Corbi, P. P. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00216-4 · Cited by 16
Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape
Torres‐Ruesta, A., Chee, R. S., & Ng, L. F. P. (2021) · Microorganisms · doi:10.3390/microorganisms9050899 · Cited by 16
Cytidine Monophosphate N -Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection
Urbanek, K., Sutherland, D. M., Orchard, R. C., Wilen, C. B., Knowlton, J. J., Aravamudhan, P., Taylor, G. M., Virgin, H. W., & Dermody, T. S. (2020) · Journal of Virology · doi:10.1128/jvi.01571-20 · Cited by 16
LRP8 is an entry receptor for tick-borne encephalitis viruses
Li, P., Hui, S., Chong, Z., Escaffre, O., Nguyen, M. N., Muraro, S. P., Jáňová, H., Ma, H., Cao, S., Kaszuba, T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2525771122 · Cited by 15
Self-citation
Chikungunya fever: pathogenesis and mechanisms underlying pain symptoms
Sun, W., Shi, S., Liao, S., & Zhai, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1679385 · Cited by 15
Host entry factors of Rift Valley Fever Virus infection
Ganaie, S. S., Leung, D. W., Hartman, A. L., & Amarasinghe, G. K. (2023) · Advances in virus research · doi:10.1016/bs.aivir.2023.09.001 · Cited by 15
Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity
Chang, M., Min, Y., Xu, Z., Dèng, F., Wáng, H., & Ning, Y. (2023) · Journal of Virology · doi:10.1128/jvi.01568-23 · Cited by 15
Visualizing the virus world inside the cell by cryo-electron tomography
Zhou, Q. F., & Lok, S. (2024) · Journal of Virology · doi:10.1128/jvi.01085-23 · Cited by 14
Species-specific MARCO-alphavirus interactions dictate chikungunya virus viremia
Li, F. S., Carpentier, K. S., Hawman, D. W., Lucas, C. J., Ander, S. E., Feldmann, H., & Morrison, T. E. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112418 · Cited by 15
Immunological impact of cytokines on the chikungunya virus pathophysiology: A literature narrative review
Nunes, J. A. L., de Sousa, J. R., Smith, V. C., Quaresma, J. A. S., Vasconcelos, P. F. D. C., & Chiang, J. O. (2023) · Reviews in Medical Virology · doi:10.1002/rmv.2441 · Cited by 14
Changes in the chikungunya virus E1 glycoprotein domain II and hinge influence E2 conformation, infectivity, and virus-receptor interactions
Thannickal, S. A., Battini, L., Spector, S. N., Noval, M. G., Alvarez, D. E., & Stapleford, K. A. (2024) · Journal of Virology · doi:10.1128/jvi.00679-24 · Cited by 14
Insights into mosquito-borne arbovirus receptors
Liu, J., Quan, Y., Tong, H., Zhu, Y., Shi, X., Liu, Y., & Cheng, G. (2024) · Cell Insight · doi:10.1016/j.cellin.2024.100196 · Cited by 14
Use of Recombinant Chikungunya Virus expressing Nanoluciferase to Identify Chondrocytes as Target Cells in an Immunocompetent Mouse Model
Legros, V., Belarbi, E., Jeannin, P., Geolier, V., Kümmerer, B. M., Hardy, D., Desprès, P., Antoine Gessain, A., Roques, P., Ceccaldi, P., et al. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf232 · Cited by 14
Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts
Zhou, Z., Shen, Y. H., Yin, J., Xi, F., Xu, R., Lin, D., Saijilafu, Chen, J., & Wang, Y. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28438 · Cited by 14
CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251
Hucke, F. I. L., Bestehorn, M., Bassetto, M., Brancale, A., Zanetta, P., & Bugert, J. J. (2022) · Virus Genes · doi:10.1007/s11262-022-01892-x · Cited by 14
The many ways in which alphaviruses bind to cells
Raju, S., Adams, L. J., & Diamond, M. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.11.006 · Cited by 14
Self-citation
A Structural Perspective on the Alphavirus Life Cycle
Luo, D., Tan, Y. B., Law, M. C. Y., & Jin, J. (2025) · Annual Review of Virology · doi:10.1146/annurev-virology-093022-010359 · Cited by 13
Elevated Expression of miR-200c/141 in MDA-MB-231 Cells Suppresses MXRA8 Levels and Impairs Breast Cancer Growth and Metastasis In Vivo
Simpson, K. E., Watson, K. L. M., & Moorehead, R. A. (2022) · Genes · doi:10.3390/genes13040691 · Cited by 13
Studies on the antiviral activity of chebulinic acid against dengue and chikungunya viruses and in silico investigation of its mechanism of inhibition
Thomas, N., Patil, P., Sharma, A., Kumar, S., Singh, V. K., Alagarasu, K., Parashar, D., & Tapryal, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-13923-6 · Cited by 13
DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation
Han, J., Cho, H.-J., Park, D., & Han, S. (2022) · Cells · doi:10.3390/cells11192977 · Cited by 13
Rapid and Sparse Labeling of Neurons Based on the Mutant Virus-Like Particle of Semliki Forest Virus
Jia, F., Zhu, X., Lv, P., Hu, L., Liu, Q., Jin, S., & Xu, F. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00362-z · Cited by 13
Serotonergic Drugs Inhibit Chikungunya Virus Infection at Different Stages of the Cell Entry Pathway
Bouma, E. M., van de Pol, D. P. I., Sanders, I. D., Rodenhuis‐Zybert, I. A., & Smit, J. M. (2020) · Journal of Virology · doi:10.1128/jvi.00274-20 · Cited by 13
The Emergence of Chikungunya ECSA Lineage in a Mayaro Endemic Region on the Southern Border of the Amazon Forest
Vieira, C. J. D. S. P., da Silva, D. J. F., Kubiszeski, J. R., Machado, L. C., Pena, L., Bronzoni, R. V. D. M., & Wallau, G. L. (2020) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed5020105 · Cited by 13
BHK-21 Cell Clones Differ in Chikungunya Virus Infection and MXRA8 Receptor Expression
Yin, P., & Kielian, M. C. (2021) · Viruses · doi:10.3390/v13060949 · Cited by 13
Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action
Han, X., Ji, C., Tian, S., Wang, F., Cao, G.-P., Li, D., Duan, X., Tong, Z., Qi, J., Wang, Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64687-2 · Cited by 12
CRISPR-Based Programmable Nucleic Acid-Binding Protein Technology Can Specifically Detect Fatal Tropical Disease-Causing Pathogens
Rahman, M. R., Majumder, T. R., Apu, M. A. I., Paul, A. K., Afrose, A., & Dash, B. K. (2022) · Journal of Tropical Medicine · doi:10.1155/2022/5390685 · Cited by 12
Chikungunya virus infection disrupts lymph node lymphatic endothelial cell composition and function via MARCO
Lucas, C. J., Sheridan, R. M., Reynoso, G. V., Davenport, B., McCarthy, M. K., Uecker-Martin, A., Hesselberth, J. R., Hickman, H. D., Tamburini, B. A. J., & Morrison, T. E. (2024) · JCI Insight · doi:10.1172/jci.insight.176537 · Cited by 12
Pathogenicity and virulence of O’nyong-nyong virus: A less studied Togaviridae with pandemic potential
Tong, S. J. M., Jun, K. T. Y., & Carissimo, G. (2024) · Virulence · doi:10.1080/21505594.2024.2355201 · Cited by 12
TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry
Xie, Y., Cao, J., Gan, S., Xu, L.-D., Zhang, D., Qian, S., Xu, F., Ding, Q., Schoggins, J. W., & Fan, W. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012312 · Cited by 12
LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy
Wang, N., Merits, A., Veit, M., Lello, L. S., Kong, S., Jiao, H., Chen, J., Wang, Y., Dobrikov, G. M., Rey, F. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49301-1 · Cited by 11
Hepatitis E Virus: What More Do We Need to Know?
Shahini, E., Argentiero, A., Andriano, A., Losito, F., Maida, M. F., Facciorusso, A., Cozzolongo, R., & Villa, E. (2024) · Medicina · doi:10.3390/medicina60060998 · Cited by 11
A brief overview of chikungunya-related pain
Gonçalves, W. A., de Sousa, C. D. F., Teixeira, M. M., & Souza, D. G. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177322 · Cited by 11
Structural basis for plasticity in receptor engagement by an encephalitic alphavirus
Raju, S., Palakurty, S., Sariol, A., Wagoner, N., Adams, L. J., Hui, S., Klimstra, W. B., Fremont, D. H., & Diamond, M. (2025) · Cell · doi:10.1016/j.cell.2025.02.036 · Cited by 11
Self-citation
Chikungunya vaccines: An update in 2023
Roongaraya, P., & Boonyasuppayakorn, S. (2023) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-271222-1520 · Cited by 11
NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein
Sutherland, D. M., Strebl, M., Koehler, M., Welsh, O. L., Yu, X., Hu, L., Natividade, R. D. S., Knowlton, J. J., Taylor, G. M., Moreno, R. A., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219404120 · Cited by 11
Developing a Prototype Pathogen Plan and Research Priorities for the Alphaviruses
Powers, A. M., Williamson, L. E., Carnahan, R. H., Crowe, J. E., Hyde, J., Jonsson, C. B., Nasar, F., & Weaver, S. C. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac326 · Cited by 12
Self-citation
Attenuation of neurovirulence of chikungunya virus by a single amino acid mutation in viral E2 envelope protein
Chen, H., Phuektes, P., Yeo, L. S., Wong, Y. H., Lee, R. C. H., Yi, B., Hou, X., Liu, S., Cai, Y., & Chu, J. J. H. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-00995-x · Cited by 11
Inhibition of dengue virus infection by 1‐stearoyl‐2‐arachidonoyl‐phosphatidylinositol in vitro
Sanaki, T., Wakabayashi, M., Yoshioka, T., Yoshida, R., Shishido, T., Hall, W. W., Sawa, H., & Sato, A. (2019) · The FASEB Journal · doi:10.1096/fj.201901095rr · Cited by 11
Ross River Virus Infection of Horses: Appraisal of Ecological and Clinical Consequences
El-Hage, C. M., Bamford, N. J., Gilkerson, J. R., & Lynch, S. E. (2020) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2020.103143 · Cited by 11
The later stages of viral infection: An undiscovered country of host dependency factors
King, C. R., & Mehle, A. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008777 · Cited by 11
Replicon RNA vaccines: design, delivery, and immunogenicity in infectious diseases and cancer
Tang, L., Que, H., Wei, Y., Yang, T., Tong, A., & Wei, X. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01694-2 · Cited by 11
Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine
Zhang, J., Chavez, E. C., Winkler, M., Liu, J., Carver, S., Lin, A. E., Biswas, A. G., Tamura, T., Tseng, A. E., Wang, D., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02047-y · Cited by 10
Chikungunya virus: Current situation and future challenges
Zhao, T., Chen, T., Zhang, J., Li, C., & Qin, C. (2025) · Biosafety and Health · doi:10.1016/j.bsheal.2025.10.001 · Cited by 10
Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essential for Viral Infectivity
Lucas, C. J., Davenport, B., Carpentier, K. S., Tinega, A. N., & Morrison, T. E. (2022) · Journal of Virology · doi:10.1128/jvi.00064-22 · Cited by 10
Construction of a Chikungunya Virus, Replicon, and Helper Plasmids for Transfection of Mammalian Cells
Colunga-Saucedo, M., Rubio-Hernández, E. I., Coronado-Ipiña, M. Á., Rosales‐Mendoza, S., Castillo, C. G., & Comas‐García, M. (2022) · Viruses · doi:10.3390/v15010132 · Cited by 10
MXRA8 is an immune-relative prognostic biomarker associated with metastasis and CD8+ T cell infiltration in colorectal cancer
Tan, L., Fu, D., Liu, F., Liu, J., Zhang, Y., Li, X., Gao, J., Tao, K., Wang, G., Wang, L., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1094612 · Cited by 10
The Synthetic Peptide GA-Hecate and Its Analogs Inhibit Multiple Steps of the Chikungunya Virus Infection Cycle In Vitro
Ayusso, G. M., Sanches, P. R. D. S., Carvalho, T., Santos, I. A., Martins, D. O. S., Lima, M. L. D., da Conceição, P. J. P., Bittar, C., Merits, A., Cilli, E. M., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16101389 · Cited by 10
Structural basis of Semliki Forest virus entry using the very-low-density lipoprotein receptor
Li, Y., Zhao, Z., Liu, S., Wang, H., Sun, J., Chai, Y., Zhou, J., Wang, Y., Shi, Y., Song, H., et al. (2023) · hLife · doi:10.1016/j.hlife.2023.11.001 · Cited by 10

Authors: Zhang, R., Kim, A. S., Fox, J. M., Nair, S., Basore, K., Klimstra, W. B., Rimkunas, R., Fong, R. H., Lin, H., Poddar, S., Crowe, J. E., Doranz, B. J., Fremont, D. H., & Diamond, M. S.
Affiliations: Washington University in St. Louis (US)
University of Pittsburgh (US)
Integral Molecular (United States) (US)
Vanderbilt University Medical Center (US)
Corresponding author: Diamond, Michael S.
ORCID: Zhang, Rong
Kim, Arthur S.
Fox, Julie M.
Nair, Sharmila
Basore, Katherine
Klimstra, William B.
Fong, Rachel H.
Lin, Hueylie
Poddar, Subhajit
Crowe, James E.
Doranz, Benjamin J.
Fremont, Daved H.
Diamond, Michael S.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2018-05
Volume: 557
Issue: 7706
Pages: 570-574
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/s41586-018-0121-3
PMC: PMC5970976
OpenAlex: W2803841447
Cited by: 448
References: 41
Citations by year: 2026: 60 · 2025: 61 · 2024: 58 · 2023: 54 · 2022: 64 · 2021: 62 · 2020: 47 · 2019: 35 · 2018: 6
FWCI: 38.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI114816, R01AI123348, R01AI095436)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords: MXRA8, arthritogenic alphaviruses, chikungunya virus, Ross River virus, Mayaro virus, O'nyong-nyong virus, viral entry, adhesion molecules, foot swelling, synovial fibroblasts, CRISPR-Cas9 screen
MeSH terms: Animals, Chikungunya virus, Fibroblasts, Humans, Immunoglobulins, Male, Membrane Proteins, Osteoblasts, Receptors, Fc, Receptors, Virus, 3T3 Cells, Muscle, Skeletal, Antibodies, Blocking, Chondrocytes, Mice, CRISPR-Cas Systems, O'nyong-nyong Virus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mxra8 is a receptor for multiple arthritogenic alphaviruses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks