Cited by 448Mosquito-borne diseases and controlViral Infections and VectorsSARS-CoV-2 and COVID-19 Research

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Mxra8 is a receptor for multiple arthritogenic alphaviruses

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Zhang, Rong, Kim, Arthur S., Fox, Julie M., Nair, Sharmila, Basore, Katherine, Klimstra, William B., Rimkunas, Rebecca, Fong, Rachel H., Lin, Hueylie, Poddar, Subhajit, Crowe, James E., Doranz, Benjamin J., Fremont, Daved H., Diamond, Michael S.·2018·Nature

DOI 10.1038/s41586-018-0121-3PMC PMC5970976

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Abstract

Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease 1 . The host factors required for alphavirus entry remain poorly characterized 2 . Here we use a genome-wide CRISPR-Cas9-based screen to identify the cell adhesion molecule Mxra8 as an entry mediator for multiple emerging arthritogenic alphaviruses, including chikungunya, Ross River, Mayaro and O'nyong nyong viruses. Gene editing of mouse Mxra8 or human MXRA8 resulted in reduced levels of viral infection of cells and, reciprocally, ectopic expression of these genes resulted in increased infection. Mxra8 bound directly to chikungunya virus particles and enhanced virus attachment and internalization into cells. Consistent with these findings, Mxra8-Fc fusion protein or anti-Mxra8 monoclonal antibodies blocked chikungunya virus infection in multiple cell types, including primary human synovial fibroblasts, osteoblasts, chondrocytes and skeletal muscle cells. Mutagenesis experiments suggest that Mxra8 binds to a surface-exposed region across the A and B domains of chikungunya virus E2 protein, which are a speculated site of attachment. Finally, administration of the Mxra8-Fc protein or anti-Mxra8 blocking antibodies to mice reduced chikungunya and O'nyong nyong virus infection as well as associated foot swelling. Pharmacological targeting of Mxra8 could form a strategy for mitigating infection and disease by multiple arthritogenic alphaviruses.

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Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures
Pushko, P., Pumpens, P., & Grens, E. (2013) · Intervirology · doi:10.1159/000346773 · Cited by 5,975
Improved vectors and genome-wide libraries for CRISPR screening
Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239
Genome-scale CRISPR-Cas9 knockout screening in human cells
Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
Li, W., Xu, H., Xiao, T., Cong, L., Love, M. I., Zhang, F., Irizarry, R. A., Liu, J. S., Brown, M., & Liu, X. S. (2014) · Genome Biology · doi:10.1186/s13059-014-0554-4 · Cited by 2,684
RNA-programmed genome editing in human cells
Jinek, M., East, A., Cheng, A., Lin, S., Ma, E., & Doudna, J. (2013) · eLife · doi:10.7554/elife.00471 · Cited by 2,098
Genome-scale CRISPR-Cas9 Knockout and Transcriptional Activation Screening
Joung, J., Konermann, S., Gootenberg, J. S., Abudayyeh, O. O., Platt, R. J., Brigham, M. D., Sanjana, N. E., & Zhang, F. (2017) · Nature Protocols · doi:10.1038/nprot.2017.016 · Cited by 1,243
Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography
Voss, J. E., Vaney, M. C., Duquerroy, S., Vonrhein, C., Girard-Blanc, C., Crublet, E., Thompson, A., Bricogne, G., & Rey, F. A. (2010) · Nature · doi:10.1038/nature09555 · Cited by 696
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Barton, E. S., Forrest, J. C., Connolly, J. L., Chappell, J. D., Liu, Y., Schnell, F. J., Nusrat, A., Parkos, C. A., & Dermody, T. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00231-8 · Cited by 624
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Oliphant, T., Engle, M. J., Nybakken, G. E., Doane, C., Johnson, S., Huang, L., Gorlatov, S. N., Mehlhop, E., Marri, A., Chung, K. M., et al. (2005) · Nature Medicine · doi:10.1038/nm1240 · Cited by 514
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Wang, X., Huang, X., Yang, Q., Yan, Z., Wang, P., Gao, X., Luo, R., & Gun, S. (2022) · PeerJ · doi:10.7717/peerj.13006 · Cited by 4
Research trends on alphavirus receptors: a bibliometric analysis
Chen, R., Wang, Z., & Zhang, L. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1388360 · Cited by 4
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Tang, P. C. H., Ng, W. H., & Liu, X. (2022) · Zoonoses · doi:10.15212/zoonoses-2022-0028 · Cited by 4
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Pujhari, S. K., Brustolin, M., Heu, C. C., Smithwick, R. W., Larrosa, M., Hafenstein, S. L., & Rasgon, J. L. (2022) · Journal of General Virology · doi:10.1099/jgv.0.001794 · Cited by 4
Potent Inhibition of Chikungunya Virus Entry by a Pyrazole–Benzene Derivative: A Computational Study Targeting the E1–E2 Glycoprotein Complex
Rahman, M. M., Limon, M. B. H., Saikat, T. A., Saha, P., Nahid, A. H., Alam, M. M., & Rahman, M. Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136480 · Cited by 3
Advances and perspectives for animal models of chikungunya virus infection
Zou, M., Zheng, Z., Wang, W., & Liu, H. (2025) · Biosafety and Health · doi:10.1016/j.bsheal.2025.09.008 · Cited by 3
Advances in molecular regulation and function of LDLR family in viral infection
Yao, Q. H., Gong, J., Lu, H., Liu, W., & Ding, L. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1702637 · Cited by 3
Phospho-activated non-muscle myosin IIA heavy chain supports different mechanisms of virus uptake
Ansin, N., Guardado, K., Ponce, M., García, M. P., Ladra, C., Ferreiro, I., Moratorio, G., & Sarute, N. (2025) · Journal of Virology · doi:10.1128/jvi.00241-25 · Cited by 3
Adjuvant-free biopolymer particles mimicking the Chikungunya virus surface induce protective immunity
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Self-citation
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Kim, H., Xu, C., Washington, C., Shi, C., Lowman, M., & Kebschull, J. M. (2026) · Neuron · doi:10.1016/j.neuron.2026.05.005 · Cited by 6
Defining Efficacy of Chikungunya Virus Candidate Vaccines: Different Endpoints Derived From the Virus—Cytokine—Ferritin (VCF) Model
Lim, S. M., Dutta, S. K., & Martina, B. E. E. (2021) · Frontiers in Virology · doi:10.3389/fviro.2021.693439 · Cited by 3
Hepatitis E Virus Life Cycle
Ju, X., Dong, L., & Ding, Q. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-1304-6_10 · Cited by 3
Distinct cellular and molecular responses to infection in three target cell types from horses, a species naturally susceptible to Ross River virus
Yuen, K. Y., Eng, M. D., Hudson, N. J., Sole‐Guitart, A., Coyle, M. P., & Bielefeldt‐Ohmann, H. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107408 · Cited by 3
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Peng, Q., Yang, X., Chen, C., He, J., Liang, Y., Luo, X., Huang, C., Wu, W., Zhang, P., & Liu, C. (2025) · Journal of Virology · doi:10.1128/jvi.00977-25 · Cited by 3
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Sun, Q., Du, X., & Cheng, W. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.05.011 · Cited by 3
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Retracted
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Campos, D., Sugasti-Salazar, M., Galán-Jurado, P. E., Valdés-Torres, P., Zegarra, D., & González, J. (2024) · Frontiers in Virology · doi:10.3389/fviro.2023.1325282 · Cited by 3
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Poudyal, S., Bandyopadhyay, A., & Kuhn, R. J. (2025) · Viruses · doi:10.3390/v17071019 · Cited by 3
The role of natural and nature-based compounds against Chikungunya and Mayaro alphaviruses and their vectors
Rodrigues, É. E. D. S., de Araújo‐Júnior, J. X., Anderson, L., Bassi, Ê. J., & da Silva‐Júnior, E. F. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819485-0.00006-2 · Cited by 3
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Tétard, M., Peterson, N. A., & Egan, E. S. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102221 · Cited by 3
Conessine inhibits enveloped viruses replication through up-regulating cholesterol level
Zhou, S., Li, J., Ling, X., Dong, S., Zhang, Z., & Li, M. (2023) · Virus Research · doi:10.1016/j.virusres.2023.199234 · Cited by 3
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Ito, R., Kitamura, K., Inohara, H., Yusa, K., Kaneda, Y., & Nimura, K. (2022) · Frontiers in Virology · doi:10.3389/fviro.2022.870922 · Cited by 3
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Alvarez-García, L., Sánchez‐García, F. J., Vázquez-Pichardo, M., & Moreno‐Altamirano, M. M. B. (2023) · Metabolites · doi:10.3390/metabo13111143 · Cited by 3
Soluble MFGE8 mediates cell entry of Crimean-Congo hemorrhagic fever virus
Ma, X., Xu, Z., Fu, Y., Ma, Y., Du, W.-T., Li, Q., Zhan, R., Tian, S., Yang, L., Wang, Z., et al. (2025) · mBio · doi:10.1128/mbio.01617-25 · Cited by 2
Self-citation
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Fogaça, M. M. C., Souza, M. S., Brito, R. D. D. S., Aguiar, E. R. G. R., Luiz, W. B., Vidal, P. O., Birbrair, A., Antunes, P. D. S., Durães‐Carvalho, R., & Amorim, J. H. (2025) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2025.108193 · Cited by 2
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Liang, S., Xu, Z., Liu, X., Yang, Y., Zhao, L., Hu, C., Hou, J., Wei, Z., Zhang, Y., Li, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66330-6 · Cited by 2
Saffold virus exploits integrin αvβ8 and sulfated glycosaminoglycans as cooperative attachment receptors for infection
Okuwa, T., Himeda, T., Kobayashi, K., Nomura, N., Utani, K., Koike, S., Nakamura, A., & Higuchi, M. (2025) · Nature Communications · doi:10.1038/s41467-025-67236-z · Cited by 2
Molecular basis of ApoER2-mediated Semliki Forest virus entry
Du, B., Song, X., Zhao, B., Shi, Z., Liu, Z., Wang, S., Wei, L., He, X., Huiskonen, J. T., Yang, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67550-6 · Cited by 2
Silent Intruders: The Gut Virome in Brain Aging and Cognitive Decline
Silvestro, S., Midiri, A., Biondo, C., Casilli, S., Borrello, L., Zummo, S., & Mancuso, G. (2026) · Pathogens · doi:10.3390/pathogens15020180 · Cited by 2
Visualized analysis of core themes and emerging frontiers in global chikungunya virus studies
Tian, J., Li, Y., Zhao, Y., & Tao, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1707833 · Cited by 2
Chikungunya fever—What we know and have done in the face of a new global public health threat
Yu, X.-L., Zhou, R.-Y., Xie, X.-Y., Zhang, Y., & Jia, J. (2026) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2026.04.001 · Cited by 2
Research advances in chikungunya virus: Epidemiology, pathogenesis, and control
Dai, S., Li, H., Li, S., Shao, X., & Cheng, X. (2026) · One Health · doi:10.1016/j.onehlt.2026.101413 · Cited by 2
Immunopathological mechanisms and targeted intervention strategies for chronic chikungunya arthritis: from viral persistence to autoimmunity
Zeng, L., Lai, W. P., Li, Y. P., Yang, M., Liang, J., Li, M., Mo, Z., Li, Y. P., Liu, Y., Li, X., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1775493 · Cited by 2
Innate immune sensing of alphavirus chikungunya: balancing antiviral defense and pathogenesis
da Silva, J. S. D. F., Ferreira, C. V., dos Santos, L. M. S., de Andrade‐Neto, V. F., Guedes, P. M. D. M., Yaochite, J. N. U., França, R. F. D. O., Brito, R. M. D. M., & Nascimento, M. S. L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1810208 · Cited by 3
Getah virus non-structural protein 2 inhibits type I interferon production by preventing K63-linked polyubiquitination of IKKε and causing widespread cellular shutoff
Zhao, M., Ji, L., Zhao, Y., Yang, S., Yang, H., He, B., Wang, S., & Zhang, W. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.03419-25 · Cited by 2

Authors: Zhang, R., Kim, A. S., Fox, J. M., Nair, S., Basore, K., Klimstra, W. B., Rimkunas, R., Fong, R. H., Lin, H., Poddar, S., Crowe, J. E., Doranz, B. J., Fremont, D. H., & Diamond, M. S.
Affiliations: Washington University in St. Louis (US)
University of Pittsburgh (US)
Integral Molecular (United States) (US)
Vanderbilt University Medical Center (US)
Corresponding author: Diamond, Michael S.
ORCID: Zhang, Rong
Kim, Arthur S.
Fox, Julie M.
Nair, Sharmila
Basore, Katherine
Klimstra, William B.
Fong, Rachel H.
Lin, Hueylie
Poddar, Subhajit
Crowe, James E.
Doranz, Benjamin J.
Fremont, Daved H.
Diamond, Michael S.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2018-05
Volume: 557
Issue: 7706
Pages: 570-574
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/s41586-018-0121-3
PMC: PMC5970976
OpenAlex: W2803841447
Cited by: 448
References: 41
Citations by year: 2026: 60 · 2025: 61 · 2024: 58 · 2023: 54 · 2022: 64 · 2021: 62 · 2020: 47 · 2019: 35 · 2018: 6
FWCI: 38.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI114816, R01AI123348, R01AI095436)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords: MXRA8, arthritogenic alphaviruses, chikungunya virus, Ross River virus, Mayaro virus, O'nyong-nyong virus, viral entry, adhesion molecules, foot swelling, synovial fibroblasts, CRISPR-Cas9 screen
MeSH terms: Animals, Chikungunya virus, Fibroblasts, Humans, Immunoglobulins, Male, Membrane Proteins, Osteoblasts, Receptors, Fc, Receptors, Virus, 3T3 Cells, Muscle, Skeletal, Antibodies, Blocking, Chondrocytes, Mice, CRISPR-Cas Systems, O'nyong-nyong Virus

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Mxra8 is a receptor for multiple arthritogenic alphaviruses

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