Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Álvaro F.; Sebti, Salwa; Wei, Yongjie; Zou, Zhongju; Shi, Mingjun; McMillan, Kathryn L.; He, Congcong; Ting, Tabitha; Liu, Yang; Chiang, Wei-Chung; Marciano, Denise K.; Schiattarella, Gabriele G.; Bhagat, Govind; Moe, Orson W.; Hu, Ming Chang; Levine, Beth

doi:10.1038/s41586-018-0162-7

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established1,2. Here we report lifespan and healthspan extension in a mouse model with increased basal autophagy. To determine the effects of constitutively increased autophagy on …