The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index, and 1 are not checked yet.
Inter-homologue repair in fertilized human eggs?
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“Some results were interpreted to indicate repair of a CRISPR-Cas9targeted gene allele by homology-directed repair with the cell's other allele as the donor template 114 .”
From The promise and challenge of therapeutic genome editing (2020) · cites this paper as [114]
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“CRISPR-Cas9-induced deletions larger than these fragments in either direction would eliminate one or both PCR primer annealing sites.This in turn can lead to amplification of only one allele, giving the false impression that targeting was unsuccessful or that there is a single homozygous event at the on-target site (9,10,15).”
From Frequent loss of heterozygosity in CRISPR-Cas9–edited early human embryos (2021) · cites this paper as [9]
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Cites
Kosicki, M., Tomberg, K., & Bradley, A. (2018) · Nature Biotechnology · doi:10.1038/nbt.4192 · Cited by 1,883
Self-citationA quantitative and cytological study of germ cells in human ovaries
Baker, T. G. (1963) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1963.0055 · Cited by 1,094
Correction of a pathogenic gene mutation in human embryos
Ma, H., Marti-Gutierrez, N., Park, S.-W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., et al. (2017) · Nature · doi:10.1038/nature23305 · Cited by 992
Correction of a genetic disease in mouse via use of CRISPR-Cas9
Wu, Y., Liang, D., Wang, Y., Bai, M., Tang, W., Bao, S., Yan, Z., Li, D., & Li, J. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.016 · Cited by 614
Large deletions induced by Cas9 cleavage
Adikusuma, F., Piltz, S., Corbett, M. A., Turvey, M., McColl, S. R., Helbig, K. J., Beard, M. R., Hughes, J., Pomerantz, R. T., & Thomas, P. Q. (2018) · Nature · doi:10.1038/s41586-018-0380-z · Cited by 371
Whitworth, K. M., Lee, K., Benne, J. A., Beaton, B. P., Spate, L. D., Murphy, S. L., Samuel, M., Mao, J., O’Gorman, C., Walters, E. M., et al. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.121723 · Cited by 351
CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome
Shin, H. Y., Wang, C., Lee, H., Yoo, K. H., Zeng, X., Kuhns, T. M., Yang, C. M., Mohr, T., Liu, C., & Hennighausen, L. G. (2017) · Nature Communications · doi:10.1038/ncomms15464 · Cited by 317
Developmental reprogramming after chromosome transfer into mitotic mouse zygotes
Egli, D. M., Rosains, J., Birkhoff, G., & Eggan, K. C. (2007) · Nature · doi:10.1038/nature05879 · Cited by 301
Self-citationIntense and highly localized gene conversion activity in human meiotic crossover hot spots
Jeffreys, A. J., & May, C. A. (2004) · Nature Genetics · doi:10.1038/ng1287 · Cited by 291
Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants
Paull, D. J., Emmanuele, V., Weiss, K. A., Treff, N. R., Stewart, L. A., Hua, H., Zimmer, M., Kahler, D. J., Goland, R., Noggle, S., et al. (2012) · Nature · doi:10.1038/nature11800 · Cited by 259
Self-citation
Research works printed but not linked: 1
- Suzuki, T., Asami, M. & Perry, A. C. Asymmetric parental genome engineering by Cas9 during mouse meiotic exit. Sci. Rep. 4, 7621 (2014). · DOI
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Reproductive medicine involving genome editing
Ishii, T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-819178-1.00041-1
Boggio, A., Romano, C. P. R., & Almqvist, J. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108759083.002
Gen- und Zelltherapie 2.023 - Forschung, klinische Anwendung und Gesellschaft
Fehse, B., Schickl, H., Bartfeld, S., & Zenke, M. (2023) · Springer eBooks · doi:10.1007/978-3-662-67908-1 · Cited by 2
Editors' Corner: Interallelic Gene Conversion
Kmiec, E. B. (2025) · Gene · doi:10.1016/j.gene.2025.149707
Mianné, J., Nasri, A., Van, C. N., Bourguignon, C., Fieldès, M., Ahmed, E., Duthoit, C. T., Martin, N., Parrinello, H., Louis, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18070820
Manhattan Genomics and the New Ethics of Creation
Ilić, D., Ogilvie, C. M., Khalaf, Y., & Kopeika, J. (2025) · Bioethics Open Research · doi:10.12688/bioethopenres.17725.1
Mianné, J. (2020) · theses.fr (ABES) · doi:10.70675/179210b5z933bz4406zb297z7beef82bc3ae
Kordowitzki, P., Ratajewska, K., & Azab, S. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119507
Introduction to rare genetic diseases in fetal development
Bashir, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27660-6.00007-9
Metadata
- Authors
- Egli, D., Zuccaro, M. V., Kosicki, M., Church, G. M., Bradley, A., & Jasin, M.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Wellcome Sanger Institute (GB)
- Harvard University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Egli, Dieter
- Jasin, Maria
- Venue
- Nature
- Published
- 2018-08
- Volume
- 560
- Issue
- 7717
- Pages
- E5-E7
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2952775612
- Cited by
- 111
- References
- 19
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 21 · 2018: 26
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Oregon Health and Science University
- Leona M. and Harry B. Helmsley Charitable Trust
- South Australian Health and Medical Research Institute
- Temple University
- Consorzio Interuniversitario Biotecnologie
- Moxie Foundation
- La Trobe University
- University of Adelaide
- Government of Jiangxi Province
- Universitas Diponegoro
- Institute for Basic Science (IBSR021-D1, R021-D1)
- Directorate for Biological Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- human embryo, CRISPR/Cas9, DNA double-strand break repair, metaphase II oocytes, germline gene therapy, zygote, homologous recombination
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