Cited by 179Celiac Disease Research and ManagementGut microbiota and healthInflammatory Bowel Disease

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

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Lamas, Bruno, Hernandez-Galan, Leticia, Galipeau, Heather J., Constante, Marco, Clarizio, Alexandra, Jury, Jennifer, Breyner, Natalia M., Caminero, Alberto +13 more·2020·Science Translational Medicine

Abstract

, or pharmacological stimulation using 6-formylindolo (3,2-b) carbazole (Ficz) decreased immunopathology in NOD/DQ8 mice exposed to gluten. We then determined AhR ligand production by the fecal microbiota and AhR activation in patients with active celiac disease compared to nonceliac control individuals. Patients with active celiac disease demonstrated reduced AhR ligand production and lower intestinal AhR pathway activation. These results highlight gut microbiota-dependent modulation of the AhR pathway in celiac disease and suggest a new therapeutic strategy for treating this disorder.

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  • In celiac disease patients, the GM's ability to metabolize tryptophan into aryl hydrocarbon receptor ligands modulates gut inflammation.

    “the importance of the GM’s ability to metabolize tryptophan into aryl hydrocarbon receptor ligands and, therefore, modulate gut inflammation, was demonstrated in patients with celiac disease (202).”

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Authors
Lamas, B., Hernandez-Galan, L., Galipeau, H. J., Constante, M., Clarizio, A., Jury, J., Breyner, N. M., Caminero, A., Rueda, G., Hayes, C. L., McCarville, J. L., Bermudez Brito, M., Planchais, J., Rolhion, N., Murray, J. A., Langella, P., Loonen, L. M. P., Wells, J. M., Bercik, P., Sokol, H., & Verdu, E. F.
Affiliations
  • McMaster University (CA)
  • Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • AgroParisTech (FR)
  • Inserm (FR)
  • Mayo Clinic (US)
  • Wageningen University & Research (NL)
Corresponding author
  • Lamas, Bruno
  • Sokol, Harry
  • Verdu, Elena F.
Venue
Science Translational Medicine
Published
2020-10-21
Volume
12
Issue
566
Pages
eaba0624
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3094545640
Cited by
179
References
59
Citations by year
2026: 20 · 2025: 26 · 2024: 33 · 2023: 27 · 2022: 43 · 2021: 27 · 2020: 3
FWCI
21.72
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • HAL (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Joint Programming Initiative A healthy diet for a healthy life (ANR-15-HDIM-0001-1, JPI-HDHL 50-52905-98-601)
  • Canadian Institutes of Health Research (CIHR-143922, 168840)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords
aryl hydrocarbon receptor, celiac disease, gut microbiota, intestinal inflammation, gluten, FICZ, fecal microbiota, immunopathology
MeSH terms
Gastrointestinal Microbiome, Animals, Celiac Disease, Humans, Inflammation, Ligands, RNA, Ribosomal, 16S, Receptors, Aryl Hydrocarbon, Mice

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