Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation
Open accessAbstract
, or pharmacological stimulation using 6-formylindolo (3,2-b) carbazole (Ficz) decreased immunopathology in NOD/DQ8 mice exposed to gluten. We then determined AhR ligand production by the fecal microbiota and AhR activation in patients with active celiac disease compared to nonceliac control individuals. Patients with active celiac disease demonstrated reduced AhR ligand production and lower intestinal AhR pathway activation. These results highlight gut microbiota-dependent modulation of the AhR pathway in celiac disease and suggest a new therapeutic strategy for treating this disorder.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In celiac disease patients, the GM's ability to metabolize tryptophan into aryl hydrocarbon receptor ligands modulates gut inflammation.
“the importance of the GM’s ability to metabolize tryptophan into aryl hydrocarbon receptor ligands and, therefore, modulate gut inflammation, was demonstrated in patients with celiac disease (202).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [202]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954 · see citing works
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
Agus, A., Planchais, J., & Sokol, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.003 · Cited by 3,180 · see citing works
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614 · see citing works
Innate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Disanto, J. D., Eberl, G., Koyasu, S., Locksley, R., McKenzie, A., Mebius, R., et al. (2013) · Nature reviews. Immunology · doi:10.1038/nri3365 · Cited by 2,380 · see citing works
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works
Microbial tryptophan catabolites in health and disease
Roager, H. M., & Licht, T. R. (2018) · Nature Communications · doi:10.1038/s41467-018-05470-4 · Cited by 2,236 · see citing works
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893 · see citing works
Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482 · see citing works
Proteobacteria: A Common Factor in Human Diseases
Rizzatti, G., Lopetuso, L. R., Gibiino, G., Binda, C., & Gasbarrini, A. (2017) · BioMed Research International · doi:10.1155/2017/9351507 · Cited by 1,261 · see citing works
Rothhammer, V., & Quintana, F. J. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0125-8 · Cited by 1,197 · see citing works
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity
Schirmer, M., Smeekens, S. P., Vlamakis, H. C., Jaeger, M., Oosting, M., Franzosa, E. A., ter Horst, R., Jansen, T., Jacobs, L., Bonder, M. J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.020 · Cited by 1,159 · see citing works
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., Lehr, H.-A., Hirth, S., Weigmann, B., Wirtz, S., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082683 · Cited by 1,043 · see citing works
Sonnenberg, G. F., Fouser, L. A., & Artis, D. (2011) · Nature Immunology · doi:10.1038/ni.2025 · Cited by 1,041 · see citing works
The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909 · see citing works
<i>Lactobacillus reuteri</i> induces gut intraepithelial CD4 <sup>+</sup> CD8αα <sup>+</sup> T cells
Cervantes-Barragan, L., Chai, J. N., Tianero, M. D., Di Luccia, B., Ahern, P. P., Merriman, J., Cortez, V. S., Caparon, M. G., Donia, M. S., Gilfillan, S., et al. (2017) · Science · doi:10.1126/science.aah5825 · Cited by 896 · see citing works
Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 816 · see citing works
Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.001 · Cited by 732 · see citing works
Monteleone, I., Rizzo, A., Sarra, M., Sica, G., Sileri, P., Biancone, L., MacDonald, T. T., Pallone, F., & Monteleone, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.007 · Cited by 656 · see citing works
Natividad, J. M., Agus, A., Planchais, J., Lamas, B., Jarry, A. C., Martin, R., Michel, M.-L., Chong-Nguyen, C., Roussel, R., Straube, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.001 · Cited by 642 · see citing works
ALKBH1-Mediated tRNA Demethylation Regulates Translation
Liu, F., Clark, W. C., Luo, G., Wang, X., Fu, Y., Wei, J., Wang, X., Hao, Z., Dai, Q., Zheng, G., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.038 · Cited by 583 · see citing works
Feedback control of AHR signalling regulates intestinal immunity
Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W., et al. (2017) · Nature · doi:10.1038/nature21080 · Cited by 537 · see citing works
Aryl hydrocarbon receptor and intestinal immunity
Lamas, B., Natividad, J. M., & Sokol, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0019-2 · Cited by 530 · see citing works
Bouziat, R., Hinterleitner, R., Brown, J. J., Stencel-Baerenwald, J., Ikizler, M. R., Mayassi, T., Meisel, M., Kim, S. M., Discepolo, V., Pruijssers, A. J. P., et al. (2017) · Science · doi:10.1126/science.aah5298 · Cited by 447 · see citing works
Metabolites: messengers between the microbiota and the immune systemPreprint
Levy, M., Thaiss, C. A., & Elinav, E. (2016) · Genes & Development · doi:10.1101/gad.284091.116 · Cited by 438 · see citing works
Qiu, J., Guo, X., Chen, Z. E., He, L., Sonnenberg, G. F., Artis, D., Fu, Y., & Zhou, L. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.002 · Cited by 415 · see citing works
Imbalance in the composition of the duodenal microbiota of children with coeliac disease
Nadal, I., Donant, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47410-0 · Cited by 396 · see citing works
Interleukin-22 protects intestinal stem cells against genotoxic stress
Gronke, K., Hernández, P. P., Zimmermann, J., Klose, C. S. N., Kofoed-Branzk, M., Guendel, F., Witkowski, M., Tizian, C., Amann, L., Schumacher, F., et al. (2019) · Nature · doi:10.1038/s41586-019-0899-7 · Cited by 373 · see citing works
Hendrikx, T., Duan, Y., Wang, Y., Oh, J., Alexander, L. M., Huang, W. J. M., Stärkel, P., Ho, S. B., Gao, B., Fiehn, O., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-317232 · Cited by 363 · see citing works
Microbiome-modulated metabolites at the interface of host immunity
Blacher, E., Levy, M., Tatirovsky, E., & Elinav, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601247 · Cited by 354 · see citing works
Risk of Pediatric Celiac Disease According to HLA Haplotype and Country
Liu, E., Lee, H., Aronsson, C. A., Hagopian, W., Koletzko, S., Rewers, M., Eisenbarth, G. S., Bingley, P. J., Bonifacio, E. E., Simell, V., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313977 · Cited by 323 · see citing works
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health
Laurans, L., Venteclef, N., Haddad, Y., Chajadine, M., Alzaïd, F., Metghalchi, S., Sovran, B., Denis, R., Dairou, J., Cardellini, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0060-4 · Cited by 305 · see citing works
Caminero, A., Galipeau, H. J., McCarville, J. L., Johnston, C. W., Bernier, S. P., Russell, A. K., Jury, J., Herran, A. R., Casqueiro, J., Tye-Din, J. A., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.06.041 · Cited by 250 · see citing works
Novel players in coeliac disease pathogenesis: role of the gut microbiota
Verdu, E. F., Galipeau, H. J., & Jabrì, B. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.90 · Cited by 247 · see citing works
IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease
Abadie, V., Kim, S. M., Lejeune, T., Palanski, B. A., Ernest, J. D., Tastet, O., Voisine, J., Discepolo, V., Marietta, E. V., Hawash, M. B. F., et al. (2020) · Nature · doi:10.1038/s41586-020-2003-8 · Cited by 231 · see citing works
Self-citationLinking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity
Schirmer, M., Smeekens, S. P., Vlamakis, H. C., Jaeger, M., Oosting, M., Franzosa, E. A., ter Horst, R., Jansen, T., Jacobs, L., Bonder, M. J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.046 · Cited by 206 · see citing works
Wacklin, P., Laurikka, P., Lindfors, K., Collin, P., Salmi, T. T., Lähdeaho, M., Saavalainen, P., Mäki, M., Mättö, J., Kurppa, K., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.355 · Cited by 202 · see citing works
Constante, M., Fragoso, G., Calvé, A., Samba-Mondonga, M., & Santos, M. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01809 · Cited by 161 · see citing works
HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22
Bodd, M., Ráki, M., Tollefsen, S., Fallang, L.-E., Bergseng, E., Lundin, K. E. A., & Sollid, L. M. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.36 · Cited by 155 · see citing works
D’Argenio, V., Casaburi, G., Precone, V., Pagliuca, C., Colicchio, R., Sarnataro, D., Discepolo, V., Kim, S. M., Russo, I., Blanco, G. D. V., et al. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.95 · Cited by 150 · see citing works
Caminero, A., McCarville, J. L., Galipeau, H. J., Deraison, C., Bernier, S. P., Constante, M., Rolland, C., Meisel, M., Murray, J. A., Yu, X. B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09037-9 · Cited by 139 · see citing works
Self-citationCaminero, A., McCarville, J. L., Zevallos, V. F., Pigrau, M., Yu, X. B., Jury, J., Galipeau, H. J., Clarizio, A. V., Casqueiro, J., Murray, J. A., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.02.028 · Cited by 136 · see citing works
Mechanisms by which gut microorganisms influence food sensitivities
Caminero, A., Meisel, M., Jabrì, B., & Verdu, E. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0064-z · Cited by 130 · see citing works
Intestinal Microbiota Modulates Gluten-Induced Immunopathology in Humanized Mice
Galipeau, H. J., McCarville, J. L., Hübener, S., Litwin, O., Meisel, M., Jabrì, B., Sanz, Y., Murray, J. A., Jordana, M., Alaedini, A., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.07.018 · Cited by 128 · see citing works
Salmonella-Induced Mucosal Lectin RegIIIβ Kills Competing Gut Microbiota
Stelter, C., Käppeli, R., König, C., Krah, A., Hardt, W., Stecher, B., & Bumann, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020749 · Cited by 123 · see citing works
Miani, M., Naour, J. L., Waeckel-Énée, E., Verma, S. C., Straube, M., Emond, P., Ryffel, B., Endert, P. V., Sokol, H., & Diana, J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.012 · Cited by 120 · see citing works
Indoleamine 2,3 dioxygenase in intestinal disease
Ciorba, M. A. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835c9cb3 · Cited by 116 · see citing works
de Kauwe, A. L., Chen, Z., Anderson, R. P., Keech, C. L., Price, J. D., Wijburg, O. L. C., Jackson, D. C., Ladhams, J., Allison, J., & McCluskey, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900233 · Cited by 106 · see citing works
Prendergast, G. C., Chang, M. Y., Mandik‐Nayak, L., Metz, R. A., & Muller, A. J. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711795656072 · Cited by 96 · see citing works
Herrán, A. R., Pérez-Andrés, J., Caminero, A., Nistal, E., Vivas, S., de Morales, J. M. R., & Casqueiro, J. (2017) · Research in Microbiology · doi:10.1016/j.resmic.2017.04.008 · Cited by 89 · see citing works
Sensitization to Gliadin Induces Moderate Enteropathy and Insulitis in Nonobese Diabetic-DQ8 Mice
Galipeau, H. J., Rulli, N. E., Jury, J., Huang, X., Araya, R. E., Murray, J. A., David, C. S., Chirdo, F. G., McCoy, K. D., & Verdu, E. F. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100854 · Cited by 76 · see citing works
Lefèvre, A., Mavel, S., Nadal‐Desbarats, L., Galineau, L., Attucci, S., Dufour, D. F., Sokol, H., & Emond, P. (2018) · Talanta · doi:10.1016/j.talanta.2018.11.094 · Cited by 74 · see citing works
Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease
Torres, M. I., López-Casado, M. A., Lorite, P., & Ríos, A. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03365.x · Cited by 65 · see citing works
Koper, J. E. B., Loonen, L. M. P., Wells, J. M., Troise, A. D., Capuano, E., & Fogliano, V. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800722 · Cited by 58 · see citing works
Suwanai, H., Wilcox, M. A., Mathis, D. J., & Benoist, C. O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004492107 · Cited by 36 · see citing works
Dinallo, V., Marafini, I., Fusco, D. D., Grazia, A. D., Laudisi, F., Dwairi, R., Paoluzi, O. A., Monteleone, G., & Monteleone, I. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00091 · Cited by 26 · see citing works
Xu, H., Feely, S., Wang, X., Liu, D. X., Borda, J. T., Dufour, J., Li, W., Aye, P. P., Doxiadis, G. G. M., Khosla, C., et al. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.02.012 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gut microbiome and health: mechanistic insights
de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388 · see citing works
Paracellular permeability and tight junction regulation in gut health and disease
Horowitz, A., Chánez-Paredes, S. D., Haest, X., & Turner, J. R. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00766-3 · Cited by 725 · see citing works
Gasaly, N., de Vos, P., & Hermoso, M. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658354 · Cited by 596 · see citing works
Catassi, C., Verdu, E. F., Bai, J. C., & Lionetti, E. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00794-2 · Cited by 515 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
The Role of the Gut Microbiota in the Relationship Between Diet and Human Health
Perler, B. K., Friedman, E. S., & Wu, G. D. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031522-092054 · Cited by 385 · see citing works
Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review
Ma, T., Shen, X., Shi, X., Sakandar, H. A., Quan, K., Li, Y., Jin, H., Kwok, L., Zhang, H., & Sun, Z. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.06.013 · Cited by 344 · see citing works
Lactobacillus and intestinal diseases: Mechanisms of action and clinical applications
Huang, R., Wu, F. L., Zhou, Q., Wei, W., Juan, Y., Xiao, B., & Luo, Z. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127019 · Cited by 258 · see citing works
Fu, Y., Lyu, J., & Wang, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1277102 · Cited by 175 · see citing works
Fournier, E., Leveque, M., Ruiz, P., Ratel, J., Durif, C., Chalançon, S., Amiard, F., Edely, M., Bézirard, V., Gaultier, E., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130010 · Cited by 151 · see citing works
Modoux, M., Rolhion, N., Lefèvre, J. H., Oeuvray, C., Nádvorník, P., Illéš, P., Emond, P., Parc, Y. R., Mani, S., Dvořák, Z., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2105637 · Cited by 145 · see citing works
Zhao, C., Hu, X., Bao, L., Wu, K., Feng, L., Qiu, M., Hao, H., Fu, Y., & Zhang, N. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009774 · Cited by 143 · see citing works
The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease
Gill, P. A., Inniss, S., Kumagai, T., Rahman, F. Z., & Smith, A. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.866059 · Cited by 149 · see citing works
Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases
Belvončíková, P., Marônek, M., & Gardlík, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810729 · Cited by 108 · see citing works
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor
Larigot, L., Benoit, L., Koual, M., Tomkiewicz, C., Barouki, R., & Coumoul, X. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-115707 · Cited by 108 · see citing works
Nonresolving inflammation redux
Nathan, C. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.016 · Cited by 103 · see citing works
Immunopathogenesis and environmental triggers in coeliac disease
Levescot, A., Malamut, G., & Cerf–Bensussan, N. (2022) · Gut · doi:10.1136/gutjnl-2021-326257 · Cited by 95 · see citing works
Gut microbiota as a key regulator of intestinal mucosal immunity
Wang, J., He, M., Yang, M., & Ai, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122612 · Cited by 96 · see citing works
The aryl hydrocarbon receptor: structure, signaling, physiology and pathology
Coumoul, X., Barouki, R., Esser, C., Haarmann‐Stemmann, T., Lawrence, B. P., Lehmann, J., Moura‐Alves, P., Murray, I. A., Opitz, C. A., Perdew, G. H., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02500-8 · Cited by 103 · see citing works
The emerging roles of bacterial proteases in intestinal diseases
Caminero, A., Guzman, M., Libertucci, J., & Lomax, A. E. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181922 · Cited by 92 · see citing works
Self-citationRole of gut microbiota-derived signals in the regulation of gastrointestinal motility
Zheng, Z., Tang, J., Hu, Y., & Zhang, W. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.961703 · Cited by 91 · see citing works
Fournier, E., Ratel, J., Denis, S., Leveque, M., Ruiz, P., Mazal, C., Amiard, F., Edely, M., Bézirard, V., Gaultier, E., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130383 · Cited by 88 · see citing works
Pinto-Sánchez, M. I., Silvester, J. A., Lebwohl, B., Leffler, D. A., Anderson, R. P., Therrien, A., Kelly, C. P., & Verdu, E. F. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00511-8 · Cited by 109 · see citing works
The exposome as the science of social-to-biological transitions
Vineis, P., & Barouki, R. (2022) · Environment International · doi:10.1016/j.envint.2022.107312 · Cited by 82 · see citing works
Dietary compounds in modulation of gut microbiota-derived metabolites
Feng, W., Liu, J., Cheng, H., Zhang, D., Tan, Y., & Peng, C. Y. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.939571 · Cited by 83 · see citing works
Baldi, S., Mundula, T., Nannini, G., & Amedei, A. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i39.6715 · Cited by 85 · see citing works
The gut microbiome-immune axis as a target for nutrition-mediated modulation of food allergy
Wang, Z., Zhong, J., Meng, X., Gao, J., Li, H., Sun, J., Li, X., & Chen, H. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.05.021 · Cited by 81 · see citing works
Tudela, H., Claus, S. P., & Saleh, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.719072 · Cited by 77 · see citing works
Mar, J. S., Ota, N., Pokorzynski, N. D., Peng, Y., Jaochico, A., Sangaraju, D., Skippington, E., Lekkerkerker, A., Rothenberg, M. E., Tan, M., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01486-1 · Cited by 76 · see citing works
From taxonomy to metabolic output: what factors define gut microbiome health?
Wilmanski, T., Rappaport, N., Diener, C., Gibbons, S. M., & Price, N. D. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1907270 · Cited by 73 · see citing works
Tryptophan: From Diet to Cardiovascular Diseases
Melhem, N. J., & Taleb, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189904 · Cited by 72 · see citing works
AHR is a master regulator of diverse pathways in endogenous metabolism
Granados, J. C., Falah, K., Koo, I., Morgan, E. W., Perdew, G. H., Patterson, A. D., Jamshidi, N., & Nigám, S. K. (2022) · Scientific Reports · doi:10.1038/s41598-022-20572-2 · Cited by 72 · see citing works
Modulation of Immune Responses by Nutritional Ligands of Aryl Hydrocarbon Receptor
de Juan, A., & Segura, É. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.645168 · Cited by 69 · see citing works
Verdu, E. F., & Schuppan, D. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.08.016 · Cited by 72 · see citing works
<i>Limosilactobacillus reuteri</i> - a probiotic gut commensal with contextual impact on immunity
Lee, A. H., Rodriguez Jimenez, D. M., & Meisel, M. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2451088 · Cited by 66 · see citing works
Kim, H., Lee, E., Park, M. K., Min, K., Diep, Y. N., Kim, J., Ahn, H., Lee, E., Kim, S., Kim, Y., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.051 · Cited by 66 · see citing works
Biogeographic Variation and Functional Pathways of the Gut Microbiota in Celiac Disease
Constante, M., Libertucci, J., Galipeau, H. J., Szamosi, J. C., Rueda, G. H., Miranda, P. M., Pinto-Sánchez, M. I., Southward, C. M., Rossi, L., Fontes, M. E., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.088 · Cited by 63 · see citing works
Babies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life
Wells, J. M., Gao, Y., de Groot, N., Vonk, M. M., Ulfman, L. H., & van Neerven, R. J. J. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122221-103916 · Cited by 58 · see citing works
Huang, Z., Boekhorst, J., Fogliano, V., Capuano, E., & Wells, J. M. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08953 · Cited by 58 · see citing works
Zhang, T., Zhao, S., Dong, F., Jia, Y., Chen, X., Sun, Y., & Zhu, L. Y. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c04765 · Cited by 52 · see citing works
Zhao, C., Bao, L., Qiu, M., Feng, L., Chen, L., Liu, Z., Duan, S., Zhao, Y., Wu, K., Zhang, N., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00811-22 · Cited by 51 · see citing works
Koper, J. E. B., Troise, A. D., Loonen, L. M. P., Vitaglione, P., Capuano, E., Fogliano, V., & Wells, J. M. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04145 · Cited by 50 · see citing works
Tryptophan metabolites get the gut moving
Benech, N., Rolhion, N., & Sokol, H. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.01.009 · Cited by 49 · see citing works
Zhang, X., Shi, L. S., Wang, N., Li, Q., Zhang, L., Han, N., Yan, T., Ren, D., Zhang, B., Zhao, Y., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06517 · Cited by 48 · see citing works
Host–microbe serotonin metabolism
Nunzi, E., Pariano, M., Costantini, C., Garaci, E., Puccetti, P., & Romani, L. R. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.014 · Cited by 47 · see citing works
Kastl, A., Zong, W., Gershuni, V. M., Friedman, E. S., Tanes, C., Boateng, A., Mitchell, W. J., O’Connor, K., Bittinger, K. L., Terry, N. A., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2083417 · Cited by 46 · see citing works
Zhao, H., Zhao, T., & Li, P. (2024) · Integrative Medicine in Nephrology and Andrology · doi:10.1097/imna-d-23-00024 · Cited by 46 · see citing works
Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions
Coquant, G., Aguanno, D., Pham, S., Grellier, N., Thenet, S., Carrière, V., Grill, J.-P., & Seksik, P. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i42.7247 · Cited by 47 · see citing works
What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis
Vanholder, R. C., Nigám, S. K., Burtey, S., & Glorieux, G. (2022) · Toxins · doi:10.3390/toxins14030221 · Cited by 46 · see citing works
Bacterial extracellular vesicles: Vital contributors to physiology from bacteria to host
Nie, X., Li, Q., Chen, X., Onyango, S. O., Xie, J., & Nie, S. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127733 · Cited by 44 · see citing works
Celiac disease: mechanisms and emerging therapeutics
Besser, H. A., & Khosla, C. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.09.006 · Cited by 47 · see citing works
Hou, J., Ma, A.-H., & Qin, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1279172 · Cited by 42 · see citing works
Intestinal Permeability in Disorders of Gut–Brain Interaction: From Bench to Bedside
Grover, M., Vanuytsel, T., & Chang, L. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.08.033 · Cited by 43 · see citing works
Girer, N. G., Tomlinson, C. R., & Elferink, C. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010049 · Cited by 40 · see citing works
Microbial modulation of tryptophan metabolism links gut microbiota to disease and its treatment
Zhao, P., Chen, Y., Zhou, S., & Li, F. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107896 · Cited by 40 · see citing works
Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes
Castellano, F., & Molinier‐Frenkel, V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613416 · Cited by 37 · see citing works
Huang, Z., Schoones, T., Wells, J. M., Fogliano, V., & Capuano, E. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100092 · Cited by 36 · see citing works
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis
Yang, C.-E., Wang, Y., Hua, M.-R., Miao, H., Zhao, Y., & Cao, G. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101662 · Cited by 34 · see citing works
How does Quorum Sensing of Intestinal Bacteria Affect Our Health and Mental Status?
Dicks, L. M. T. (2022) · Microorganisms · doi:10.3390/microorganisms10101969 · Cited by 35 · see citing works
Rannug, A. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.775010 · Cited by 33 · see citing works
Translating Microbiome Research From and To the Clinic
Zhang, Z. J., Lehmann, C. J., Cole, C. G., & Pamer, E. G. (2022) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041020-022206 · Cited by 32 · see citing works
Indoleamine 2,3-dioxygenase 1 in circumventing checkpoint inhibitor responses: Updated
Charehjoo, A., Majidpoor, J., & Mortezaee, K. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110032 · Cited by 33 · see citing works
Nieves, K., Hirota, S. A., & Flannigan, K. L. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00160.2021 · Cited by 32 · see citing works
Pan, X., Yin, M., Guo, M., Niu, X., & Han, L. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105201 · Cited by 32 · see citing works
How Changes in the Nutritional Landscape Shape Gut Immunometabolism
Tan, J., Ni, D., Ribeiro, R. V., Pinget, G. V., & Macia, L. (2021) · Nutrients · doi:10.3390/nu13030823 · Cited by 29 · see citing works
How Metabolomics Provides Novel Insights on Celiac Disease and Gluten-Free Diet: A Narrative Review
Vacca, M., Porrelli, A., Calabrese, F. M., Lippolis, T., Iacobellis, I., Celano, G., Pinto, D., Russo, F., Giannelli, G., & Angelis, M. D. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.859467 · Cited by 33 · see citing works
Rueda, G. H., Calo, N. C., Borojevic, R., Nardelli, A., Pinto-Sánchez, M. I., Constante, M., Libertucci, J., Mohan, V., Langella, P., Loonen, L. M. P., et al. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00306.2023 · Cited by 30 · see citing works
Targeting the gut microbiota in inflammatory bowel diseases: where are we?
Benech, N., & Sokol, H. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102319 · Cited by 31 · see citing works
Vacca, M., Pinto, D., Annunziato, A., Ressa, A., Calasso, M. P., Pontonio, E., Celano, G., & Angelis, M. D. (2023) · Antioxidants · doi:10.3390/antiox12040845 · Cited by 30 · see citing works
Jadhav, A., Bajaj, A., Yang, X. J., Markandey, M., Ahuja, V., & Kashyap, P. (2023) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061121-094908 · Cited by 27 · see citing works
D’Avino, P., Serena, G., Kenyon, V., & Fasano, A. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1880320 · Cited by 29 · see citing works
The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential
Galipeau, H. J., & Verdu, E. F. (2022) · Mucosal Immunology · doi:10.1038/s41385-021-00479-3 · Cited by 30 · see citing works
Non-Host Factors Influencing Onset and Severity of Celiac Disease
Galipeau, H. J., Hinterleitner, R., Leonard, M. M., & Caminero, A. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.030 · Cited by 28 · see citing works
Kiernan, D. P., O’Doherty, J. V., & Sweeney, T. (2023) · Animals · doi:10.3390/ani13192996 · Cited by 28 · see citing works
How the Microbiota May Affect Celiac Disease and What We Can Do
Matera, M., & Guandalini, S. (2024) · Nutrients · doi:10.3390/nu16121882 · Cited by 23 · see citing works
González, A., Guerra‐Ojeda, S., Villa, M. A. C., Valls, A., Alegre, E., Quintero-Bernal, R., Martorell, P., Chenoll, E., Serna‐García, M., Mauricio, M. D., et al. (2024) · Foods · doi:10.3390/foods13213479 · Cited by 26 · see citing works
Tryptophan Metabolism and COVID-19-Induced Skeletal Muscle Damage: Is ACE2 a Key Regulator?
Takeshita, H., & Yamamoto, K. I. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.868845 · Cited by 22 · see citing works
Wu, S.-J., Gao, S., Lin, D., Bekhit, A. E. A., & Chen, Y. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116799 · Cited by 19 · see citing works
Glorieux, G., Burtey, S., Evenepoel, P., Jankowski, J., Koppe, L., Masereeuw, R., & Vanholder, R. C. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-01006-4 · Cited by 24 · see citing works
Hu, S., Luo, L., & Zeng, L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2040945 · Cited by 21 · see citing works
Vicentini, F., Mathews, A. J., Pittman, Q. J., Swain, M. G., Sharkey, K. A., & Hirota, S. A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.228 · Cited by 21 · see citing works
Intestinal permeability, food antigens and the microbiome: a multifaceted perspective
Valitutti, F., Mennini, M., Monacelli, G., Fagiolari, G., Piccirillo, M., Nardo, G. D., & Cara, G. D. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2024.1505834 · Cited by 22 · see citing works
Shi, T., Feng, Y., Liu, W., Liu, H., Li, T., Wang, M., Li, Z., Lu, J., Abudurexiti, A., Maimaitireyimu, A., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1020977 · Cited by 20 · see citing works
Turning Microbial AhR Agonists into Therapeutic Agents via Drug Delivery Systems
Puccetti, M., Pariano, M., Wojtylo, P., Schoubben, A., Giovagnoli, S., & Ricci, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020506 · Cited by 19 · see citing works
Regulation of host immune responses by Lactobacillus through aryl hydrocarbon receptors
Huang, Z., Xie, L., & Huang, Z. (2023) · Medicine in Microecology · doi:10.1016/j.medmic.2023.100081 · Cited by 19 · see citing works
Intestinal tryptophan metabolism in disease prevention and swine production
Hu, Z., Feng, L., Jiang, Q., Wang, W., Tan, B., Tang, X., & Yin, Y. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.08.002 · Cited by 19 · see citing works
Churchward, M. A., Michaud, E. R., Mullish, B. H., Blanco, J. M., Perez, I. G., Marchesi, J. R., Xu, H., Kao, D. H., & Todd, K. G. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16908 · Cited by 19 · see citing works
Nikoloudaki, O., Celano, G., Polo, A., Cappello, C., Granehäll, L., Costantini, A., Vacca, M., Speckmann, B., Cagno, R. D., Francavilla, R., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03524-23 · Cited by 18 · see citing works
Microbiota, IgA and Multiple Sclerosis
Boussamet, L., Rajoka, M. S. R., & Berthelot, L. (2022) · Microorganisms · doi:10.3390/microorganisms10030617 · Cited by 19 · see citing works
Nieves, K., Flannigan, K. L., Hughes, E., Stephens, M., Thorne, A. J., Delanne-Cuménal, A., Strayer, K., Kola-Ilesanmi, D., Wickramasinghe, S., Mirzadzare, N., et al. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00256.2024 · Cited by 18 · see citing works
Faber, S., Lahoti, T., Taylor, E., Lewis, L., Sapiro, J., Toledo Sales, V., Dragan, Y., & Jeffy, B. (2022) · Cells · doi:10.3390/cells11101708 · Cited by 16 · see citing works
Molecular Genetics and Probiotic Mechanisms of Saccharomyces cerevisiae var. boulardii
Ting, T., Lee, W.-J., & Goh, H. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10634-y · Cited by 16 · see citing works
Rayan, M., Sayed, T. S., Hussein, O., Therachiyil, L., Maayah, Z. H., Maccalli, C., Shahab Uddin, M. S., Prehn, J. H. M., & Korashy, H. M. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00538-0 · Cited by 18 · see citing works
Cen, Q., Cui, Y., Feng, J., Li, Z., Wei, J., Wang, L., Chang, C., Pang, R., Wang, J., & Zhang, A. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10545-y · Cited by 17 · see citing works
Ongoing Clinical Trials in Aging-Related Tissue Fibrosis and New Findings Related to AhR Pathways
Yu, H., Feng, Z., Lin, W., Yang, K., Liu, R., Li, J., Liu, X., Pei, M., & Yang, H. (2022) · Aging and Disease · doi:10.14336/ad.2021.1105 · Cited by 14 · see citing works
Relevance of gut microbiome research in food safety assessment
Garrido‐Romero, M., Pazos, F., Sánchez‐Martínez, E., Benito, C., Ruiz, J. Á. G., Borrego‐Yaniz, G., Bowes, C., Broll, H., Caminero, A., Caro, E., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2410476 · Cited by 14 · see citing works
Metabolomics and metagenomics in mice reveal the role of the gut microbiota in tryptophan metabolism
Levé, M., Manghi, P., Bredon, M., Lefèvre, A., Manara, S., Armanini, F., Emond, P., Planchais, J., Rolhion, N., Segata, N., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113751 · Cited by 14 · see citing works
Akkerman, R., Logtenberg, M. J., Beukema, M., de Haan, B. J., Faas, M. M., Zoetendal, E. G., Schols, H. A., & de Vos, P. (2022) · Food & Function · doi:10.1039/d2fo00550f · Cited by 13 · see citing works
Pani, G. (2023) · Cancers · doi:10.3390/cancers15092583 · Cited by 15 · see citing works
Keppeler, K., Pesi, A., Lange, S., Helmstädter, J., Strohm, L., Ubbens, H., Kuntić, M., Kuntić, I., Mihaliková, D., Vujačić-Mirski, K., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103071 · Cited by 13 · see citing works
- Authors
- Lamas, B., Hernandez-Galan, L., Galipeau, H. J., Constante, M., Clarizio, A., Jury, J., Breyner, N. M., Caminero, A., Rueda, G., Hayes, C. L., McCarville, J. L., Bermudez Brito, M., Planchais, J., Rolhion, N., Murray, J. A., Langella, P., Loonen, L. M. P., Wells, J. M., Bercik, P., Sokol, H., & Verdu, E. F.
- Affiliations
- McMaster University (CA)
- Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
- AgroParisTech (FR)
- Inserm (FR)
- Mayo Clinic (US)
- Wageningen University & Research (NL)
- Corresponding author
- Lamas, Bruno
- Sokol, Harry
- Verdu, Elena F.
- ORCID
- Lamas, Bruno
- Galipeau, Heather J.
- Constante, Marco
- Clarizio, Alexandra
- Jury, Jennifer
- Breyner, Natalia M.
- Caminero, Alberto
- Rueda, Gaston
- Hayes, Christina L.
- McCarville, Justin L.
- Planchais, Julien
- Rolhion, Nathalie
- Murray, Joseph A.
- Langella, Philippe
- Loonen, Linda M. P.
- Wells, Jerry M.
- Bercik, Premysl
- Sokol, Harry
- Verdu, Elena F.
- Venue
- Science Translational Medicine
- Published
- 2020-10-21
- Volume
- 12
- Issue
- 566
- Pages
- eaba0624
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W3094545640
- Cited by
- 179
- References
- 59
- Citations by year
- 2026: 20 · 2025: 26 · 2024: 33 · 2023: 27 · 2022: 43 · 2021: 27 · 2020: 3
- FWCI
- 21.72
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Joint Programming Initiative A healthy diet for a healthy life (ANR-15-HDIM-0001-1, JPI-HDHL 50-52905-98-601)
- Canadian Institutes of Health Research (CIHR-143922, 168840)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- aryl hydrocarbon receptor, celiac disease, gut microbiota, intestinal inflammation, gluten, FICZ, fecal microbiota, immunopathology
- MeSH terms
- Gastrointestinal Microbiome, Animals, Celiac Disease, Humans, Inflammation, Ligands, RNA, Ribosomal, 16S, Receptors, Aryl Hydrocarbon, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review