The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
Open accessAbstract
Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite) 1 . It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary metabolic complications 2 , 3 . In addition, adipose tissue functions as a signalling hub that regulates systemic metabolism through paracrine and endocrine signals 4 . Here we use single-nucleus RNA-sequencing (snRNA-seq) analysis in mice and humans to characterize adipocyte heterogeneity. We identify a rare subpopulation of adipocytes in mice that increases in abundance at higher temperatures, and we show that this subpopulation regulates the activity of neighbouring adipocytes through acetate-mediated modulation of their thermogenic capacity. Human adipose tissue contains higher numbers of cells of this subpopulation, which could explain the lower thermogenic activity of human compared to mouse adipose tissue and suggests that targeting this pathway could be used to restore thermogenic activity. Single-nucleus RNA sequencing in mouse and human adipose tissue identifies a subpopulation of adipocytes that regulates thermogenesis in neighbouring adipocytes in a paracrine manner by modulating acetate signalling.
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Cited by
Fleming, S. J., Chaffin, M. D., Arduini, A., Akkad, A.-D., Banks, E., Marioni, J. C., Philippakis, A. A., Ellinor, P. T., & Babadi, M. (2023) · Nature Methods · doi:10.1038/s41592-023-01943-7 · Cited by 867
A single-cell atlas of human and mouse white adipose tissue
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Self-citationLipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
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Reassessing human adipose tissue
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Metadata
- Authors
- Sun, W., Dong, H., Balaz, M., Slyper, M., Drokhlyansky, E., Colleluori, G., Giordano, A., Kovanicova, Z., Stefanicka, P., Balazova, L., Ding, L., Husted, A. S., Rudofsky, G., Ukropec, J., Cinti, S., Schwartz, T. W., Regev, A., & Wolfrum, C.
- Venue
- Nature
- Published
- 2020-10-28
- Volume
- 587
- Issue
- 7832
- Pages
- 98-102
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3097526205
- Cited by
- 371
- References
- 73
- FWCI
- 27.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, W., Dong, H., Balaz, M., Slyper, M., Drokhlyansky, E., Colleluori, G., Giordano, A., Kovanicova, Z., Stefanicka, P., Balazova, L., Ding, L., Husted, A. S., Rudofsky, G., Ukropec, J., Cinti, S., Schwartz, T. W., Regev, A., & Wolfrum, C. (2020). snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature. https://doi.org/10.1038/s41586-020-2856-x
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