The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Representational drift in primary olfactory cortex
Open accessAbstract
Perceptual constancy requires the brain to maintain a stable representation of sensory input. In the olfactory system, activity in primary olfactory cortex (piriform cortex) is thought to determine odour identity1–5. Here we present the results of electrophysiological recordings of single units maintained over weeks to examine the stability of odour-evoked responses in mouse piriform cortex. Although activity in piriform cortex could be used to discriminate between odorants at any moment in time, odour-evoked responses drifted over periods of days to weeks. The performance of a linear classifier trained on the first recording day approached chance levels after 32 days. Fear conditioning did not stabilize odour-evoked responses. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This demonstration of continuous drift poses the question of the role of piriform cortex in odour perception. This instability might reflect the unstructured connectivity of piriform cortex6–12, and may be a property of other unstructured cortices. All odours elicit a unique pattern of neuronal activity in primary olfactory cortex but these patterns drift over time, posing a problem for the perceptual constancy of odours.
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Cites
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Cited by
Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings.
Steinmetz, N. A., Aydin, C., Lebedeva, A., Okun, M., Pachitariu, M., Bauza, M., Beau, M., Bhagat, J., Böhm, C., Broux, M., et al. (2021) · Science · doi:10.1126/science.abf4588 · Cited by 1,173
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A brain atlas of synapse protein lifetime across the mouse lifespan
Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A., Merino-Serrais, P., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.009 · Cited by 111
Selection of experience for memory by hippocampal sharp wave ripples
Yang, W., Sun, C., Huszár, R., Hainmueller, T., Kiselev, K., & Buzsáki, G. (2024) · Science · doi:10.1126/science.adk8261 · Cited by 95
Transforming a head direction signal into a goal-oriented steering command
Westeinde, E. A., Kellogg, E., Dawson, P. M., Lu, J., Hamburg, L., Midler, B., Druckmann, S., & Wilson, R. I. (2022) · doi:10.1101/2022.11.10.516039 · Cited by 85
Transforming a head direction signal into a goal-oriented steering command
Westeinde, E. A., Kellogg, E., Dawson, P. M., Lu, J., Hamburg, L., Midler, B., Druckmann, S., & Wilson, R. I. (2024) · Nature · doi:10.1038/s41586-024-07039-2 · Cited by 85
Metadata
- Authors
- Schoonover, C. E., Ohashi, S. N., Axel, R., & Fink, A. J. P.
- Venue
- Nature
- Published
- 2021-06-09
- Volume
- 594
- Issue
- 7864
- Pages
- 541-546
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3167740220
- Cited by
- 313
- References
- 11
- FWCI
- 24.12
- Type
- journal article
- Language
- en
- Open access
- green
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