The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Diverse functional autoantibodies in patients with COVID-19
Open accessAbstract
COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune responses1–6. Although pathological innate immune activation is well-documented in severe disease1, the effect of autoantibodies on disease progression is less well-defined. Here we use a high-throughput autoantibody discovery technique known as rapid extracellular antigen profiling7 to screen a cohort of 194 individuals infected with SARS-CoV-2, comprising 172 patients with COVID-19 and 22 healthcare workers with mild disease or asymptomatic infection, for autoantibodies against 2,770 extracellular and secreted proteins (members of the exoproteome). We found that patients with COVID-19 exhibit marked increases in autoantibody reactivities as compared to uninfected individuals, and show a high prevalence of autoantibodies against immunomodulatory proteins (including cytokines, chemokines, complement components and cell-surface proteins). We established that these autoantibodies perturb immune function and impair virological control by inhibiting immunoreceptor signalling and by altering peripheral immune cell composition, and found that mouse surrogates of these autoantibodies increase disease severity in a mouse model of SARS-CoV-2 infection. Our analysis of autoantibodies against tissue-associated antigens revealed associations with specific clinical characteristics. Our findings suggest a pathological role for exoproteome-directed autoantibodies in COVID-19, with diverse effects on immune functionality and associations with clinical outcomes. Rapid extracellular antigen profiling of a cohort of 194 individuals infected with SARS-CoV-2 uncovers diverse autoantibody responses that affect COVID-19 disease severity, progression and clinical and immunological characteristics.
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Cites
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Self-citationLongitudinal analyses reveal immunological misfiring in severe COVID-19
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Self-citationA serological assay to detect SARS-CoV-2 seroconversion in humans
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Immunology of COVID-19: Current State of the Science
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Sex differences in immune responses that underlie COVID-19 disease outcomes
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Cited by
Long COVID: major findings, mechanisms and recommendations
Davis, H. E., McCorkell, L., Vogel, J. M., & Topol, E. J. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00846-2 · Cited by 4,153
Multiple early factors anticipate post-acute COVID-19 sequelae
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Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
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Unexplained post-acute infection syndromes
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Self-citationSystems vaccinology of the BNT162b2 mRNA vaccine in humans
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Metadata
- Authors
- Wang, E. Y., Mao, T., Klein, J., Dai, Y., Huck, J. D., Jaycox, J. R., Liu, F., Zhou, T., Israelow, B., Wong, P., Coppi, A., Lucas, C., Silva, J., Oh, J. E., Song, E., Perotti, E. S., Zheng, N. S., Fischer, S., Campbell, M., Fournier, J. B., Wyllie, A. L., Vogels, C. B. F., Ott, I. M., Kalinich, C. C., Petrone, M. E., Watkins, A. E., Yale IMPACT Team, Obaid, A., Moore, A. J., Casanovas-Massana, A., Lu-Culligan, A., Nelson, A., Nunez, A., Martin, A., Geng, B., Odio, C. D., Harden, C. A., Todeasa, C., Jensen, C., Kim, D., McDonald, D., Shepard, D., Courchaine, E., White, E. B., Silva, E., Kudo, E., DeIuliis, G., Rahming, H., Park, H.-J., Matos, I., Nouws, J., Valdez, J., Lim, J., Rose, K.-A., Anastasio, K., Brower, K., Glick, L., Sharma, L., Sewanan, L., Knaggs, L., Minasyan, M., Batsu, M., Kuang, M., Nakahata, M., Linehan, M., Askenase, M. H., Simonov, M., Smolgovsky, M., Sonnert, N., Naushad, N., Vijayakumar, P., Martinello, R., Datta, R., Handoko, R., Bermejo, S., Prophet, S., Bickerton, S., Velazquez, S., Rice, T., Khoury-Hanold, W., Peng, X., Yang, Y., Cao, Y., Strong, Y., Dela Cruz, C., Farhadian, S. F., Schulz, W. L., Ma, S., Grubaugh, N. D., Ko, A. I., Iwasaki, A., & Ring, A. M.
- Venue
- Nature
- Published
- 2021-05-19
- Volume
- 595
- Issue
- 7866
- Pages
- 283-288
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3160449499
- Cited by
- 992
- References
- 53
- FWCI
- 61.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, E. Y., Mao, T., Klein, J., Dai, Y., Huck, J. D., Jaycox, J. R., Liu, F., Zhou, T., Israelow, B., Wong, P., Coppi, A., Lucas, C., Silva, J., Oh, J. E., Song, E., Perotti, E. S., Zheng, N. S., Fischer, S., Campbell, M., . . . Ring, A. M. (2021). Diverse functional autoantibodies in patients with COVID-19. Nature. https://doi.org/10.1038/s41586-021-03631-y
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