Neural and behavioural state switching during hippocampal dentate spikes
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Distinct brain and behavioural states are associated with organized neural population dynamics that are thought to serve specific cognitive functions 1–3 . Memory replay events, for example, occur during synchronous population events called sharp-wave ripples in the hippocampus while mice are in an ‘offline’ behavioural state, enabling cognitive mechanisms such as memory consolidation and planning 4–11 . But how does the brain re-engage with the external world during this behavioural state and permit access to current sensory information or promote new memory formation? Here we found that the hippocampal dentate spike, an understudied population event that frequently occurs between sharp-wave ripples 12 , may underlie such a mechanism. We show that dentate spikes are associated with distinctly elevated brain-wide firing rates, primarily observed in higher order networks, and couple to brief periods of arousal. Hippocampal place coding during dentate spikes aligns to the mouse’s current spatial location, unlike the memory replay accompanying sharp-wave ripples. Furthermore, inhibiting neural activity during dentate spikes disrupts associative memory formation. Thus, dentate spikes represent a distinct brain state and support memory during non-locomotor behaviour, extending the repertoire of cognitive processes beyond the classical offline functions.
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Changes in arousal modulate the membrane potential of hippocampal pyramidal neurons and hippocampal dynamics, and are gated by spatial location.
“Our findings are in line with previous work, which showed that changes in arousal modulate the membrane potential of hippocampal pyramidal neurons75 and hippocampal dynamics75–78, and are gated by spatial location77.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [76]
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Place and behavioral modulation of hippocampal neurons during immobility
Sartorato, N., Zouridis, I. S., Narantsatsralt, U.-U., Blanco-Hernández, E., & Burgalossi, A. (2026) · Nature Communications · doi:10.1038/s41467-026-75492-w · Cited by 1 · see citing works
- Authors
- Farrell, J. S., Hwaun, E., Dudok, B., & Soltesz, I.
- Affiliations
- Boston Children's Hospital (US)
- Stanford Medicine (US)
- Baylor College of Medicine (US)
- Corresponding author
- Farrell, Jordan S.
- Venue
- Nature
- Published
- 2024-03-13
- Volume
- 628
- Issue
- 8008
- Pages
- 590-595
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC11023929
- OpenAlex
- W4392739899
- Cited by
- 47
- References
- 44
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 7
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nature (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons-TMC (Texas Medical Center) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Wu Tsai Neurosciences Institute, Stanford University
- National Institute of Neurological Disorders and Stroke (K99NS126725, U19NS104590, R01NS121106, R00NS117795, R00NS126725, K99NS117795)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD105351)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, sharp-wave ripples, neural population dynamics, brain states, arousal, place coding, memory consolidation, memory replay, neural inhibition
- MeSH terms
- Memory Consolidation, Action Potentials, Animals, Arousal, Cognition, Female, Hippocampus, Male, Neural Inhibition, Mice, Brain Waves
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