Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice

Trimmomatic: a flexible trimmer for Illumina sequence data

Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works

SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing

Bankevich, A., Nurk, S., Antipov, D., Gurevich, A. A., Dvorkin, M. V., Kulikov, A. S., Lesin, V. M., Nikolenko, S., Pham, S., Prjibelski, A. D., et al. (2012) · Journal of Computational Biology · doi:10.1089/cmb.2012.0021 · Cited by 25,691 · see citing works

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Murray, C. J. L., Ikuta, K. S., Sharara, F., Swetschinski, L., Robles Aguilar, G., Gray, A., Han, C., Bisignano, C., Rao, P., Wool, E., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02724-0 · Cited by 16,316 · see citing works

Mash: fast genome and metagenome distance estimation using MinHash

(2016) · Genome biology · doi:10.1186/s13059-016-0997-x · Cited by 3,373 · see citing works

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

Brouns, S. J. J., Jore, M. M., Lundgren, M., Westra, E. R., Slijkhuis, R. J. H., Snijders, A. P., Dickman, M. J., Makarova, K. S., Koonin, E. V., & John van der, O. O. S. T. (2008) · Science · doi:10.1126/science.1159689 · Cited by 2,593 · see citing works

Multilocus Sequence Typing of Total-Genome-Sequenced Bacteria

Larsen, M. V., Cosentino, S., Rasmussen, S., Friis, C., Hasman, H., Marvig, R. L., Jelsbak, L., Sicheritz‐Pontén, T., Ussery, D. W., Aarestrup, F. M., et al. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.06094-11 · Cited by 2,333 · see citing works

Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements

Lutz, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1203 · Cited by 1,696 · see citing works

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

Dedrick, R. M., Guerrero-Bustamante, C. A., Garlena, R. A., Russell, D. A., Ford, K., Harris, K., Gilmour, K. C., Soothill, J. S., Jacobs‐Sera, D., Schooley, R. T., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0437-z · Cited by 1,418 · see citing works

Using ggtree to Visualize Data on Tree‐Like Structures

Yu, G. (2020) · Current Protocols in Bioinformatics · doi:10.1002/cpbi.96 · Cited by 1,388 · see citing works

Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection

Schooley, R. T., Biswas, B., Gill, J. J., Hernandez-Morales, A., Lancaster, J., Lessor, L., Barr, J. J., Reed, S. L., Rohwer, F., Benler, S., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00954-17 · Cited by 1,254 · see citing works

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

Bikard, D., Euler, C. W., Jiang, W., Nussenzweig, P. M., Goldberg, G. W., Duportet, X., Fischetti, V. A., & Marraffini, L. A. (2014) · Nature Biotechnology · doi:10.1038/nbt.3043 · Cited by 986 · see citing works

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

Jault, P., Leclerc, T., Jennes, S., Pirnay, J., Que, Y., Resch, G., Rousseau, A., Ravat, F., Carsin, H., Floch, R. L., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30482-1 · Cited by 878 · see citing works

Bacteriophage Host Range and Bacterial Resistance

Hyman, P., & Abedon, S. T. (2010) · Advances in applied microbiology · doi:10.1016/s0065-2164(10)70007-1 · Cited by 823 · see citing works

Standard reference strains of Escherichia coli from natural populations

Ochman, H., & Selander, R. K. (1984) · Journal of Bacteriology · doi:10.1128/jb.157.2.690-693.1984 · Cited by 811 · see citing works

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

Citorik, R. J., Mimee, M., & Lu, T. K. (2014) · Nature Biotechnology · doi:10.1038/nbt.3011 · Cited by 808 · see citing works

Levofloxacin to Prevent Bacterial Infection in Patients with Cancer and Neutropenia

Bucaneve, G., Micozzi, A., Menichetti, F., Martino, P., Dionisi, M., Martinelli, G., Allione, B., D’Antonio, D., Buelli, M., Nosari, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044097 · Cited by 643 · see citing works

Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update

Taplitz, R. A., Kennedy, E. B., Bow, E. J., Crews, J. R., Gleason, C. L., Hawley, D. K., Langston, A. A., Nastoupil, L. J., Rajotte, M., Rolston, K. V. I., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.18.00374 · Cited by 606 · see citing works

Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

Oechslin, F. (2018) · Viruses · doi:10.3390/v10070351 · Cited by 605 · see citing works

ClermonTyping: an easy-to-use and accurate in silico method for Escherichia genus strain phylotyping

Beghain, J., Bridier‐Nahmias, A., Nagard, H. L., Denamur, É., & Clermont, O. (2018) · Microbial Genomics · doi:10.1099/mgen.0.000192 · Cited by 583 · see citing works

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

Sarker, S. A., Sultana, S., Reuteler, G., Moine, D., Descombes, P., Charton, F., Bourdin, G., McCallin, S. E., Ngom‐Bru, C., Neville, T., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2015.12.023 · Cited by 543 · see citing works

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

Federici, S., Kredo-Russo, S., Valdés-Mas, R., Kviatcovsky, D., Weinstock, E., Matiuhin, Y., Silberberg, Y., Atarashi, K., Furuichi, M., Oka, A., et al. (2022) · Cell · doi:10.1016/j.cell.2022.07.003 · Cited by 542 · see citing works

CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3

Westra, E. R., van Erp, P. B. G., Künne, T., Wong, S. P., Staals, R. H. J., Seegers, C. L. C., Bollen, S., Jore, M. M., Semenova, E., Severinov, K., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.018 · Cited by 511 · see citing works

Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria

Yosef, I., Manor, M., Kiro, R., & Qimron, U. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500107112 · Cited by 501 · see citing works

RelE, a global inhibitor of translation, is activated during nutritional stress

Christensen, S. K., Mikkelsen, M., Pedersen, K. B., & Gerdes, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251327898 · Cited by 454 · see citing works

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

Yehl, K. M., Lemire, S., Yang, A. C., Ando, H., Mimee, M., Torres, M. D. T., de la Fuente‐Núñez, C., & Lu, T. K. (2019) · Cell · doi:10.1016/j.cell.2019.09.015 · Cited by 443 · see citing works

Cas3 is a single‐stranded DNA nuclease and ATP‐dependent helicase in the CRISPR/Cas immune system

Šinkūnas, T., Gasiūnas, G., Fremaux, C., Barrangou, R., Horvath, P., & Šikšnys, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.41 · Cited by 441 · see citing works

Antibacterial Prophylaxis after Chemotherapy for Solid Tumors and Lymphomas

Cullen, M. H., Steven, N. M., Billingham, L. J., Gaunt, C. H., Hastings, M., Simmonds, P., Stuart, N., Rea, D. W., Bower, M., Fernando, I. N., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050078 · Cited by 417 · see citing works

Bacteraemia in febrile neutropenic cancer patients

Klastersky, J. A., Ameye, L., Maertens, J. A., Georgala, A., Muanza, F., Aoun, M., Ferrant, A., Rapoport, B. L., Rolston, K. V. I., & Paesmans, M. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.06.012 · Cited by 342 · see citing works

Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial

Leitner, L., Ujmajuridze, A., Чанішвілі, Н., Goderdzishvili, M., Chkonia, I., Rigvava, S., Chkhotua, A. B., Changashvili, G., McCallin, S. E., Schneider, M. P., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30330-3 · Cited by 325 · see citing works

Antimicrobial Resistance in Gram-Negative Rods Causing Bacteremia in Hematopoietic Stem Cell Transplant Recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group

Averbuch, D., Tridello, G., Hoek, J., Mikulska, M., Akan, H., Yáñez, L., Pabst, T., Özçelik, T., Klyasova, G. A., Donnini, I., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix646 · Cited by 274 · see citing works

Gut flora in health and disease

Knight, D., & Girling, K. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13438-1 · Cited by 267 · see citing works

Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury—a case report

Jennes, S., Merabishvili, M., Soentjens, P. H. P., Pang, K. W., Rose, T., Keersebilck, E., Soete, O., François, P.-M., Teodorescu, S., Verween, G., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1709-y · Cited by 249 · see citing works

Current epidemiology and antimicrobial resistance data for bacterial bloodstream infections in patients with hematologic malignancies: an Italian multicentre prospective survey

Trecarichi, E. M., Pagano, L., Candoni, A., Pastore, D., Cattaneo, C. M., Fanci, R., Nosari, A., Caira, M., Spadea, A., Busca, A., et al. (2014) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2014.11.022 · Cited by 247 · see citing works

In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials

Selle, K., Fletcher, J. R., Tuson, H. H., Schmitt, D. S., McMillan, L. J., Vridhambal, G. S., Rivera, A. J., Montgomery, S. A., Fortier, L., Barrangou, R., et al. (2020) · mBio · doi:10.1128/mbio.00019-20 · Cited by 228 · see citing works

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

Lam, K. N., Spanogiannopoulos, P., Soto-Perez, P., Alexander, M., Nalley, M. J., Bisanz, J. E., Nayak, R. R., Weakley, A. M., Yu, F. B., & Turnbaugh, P. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109930 · Cited by 172 · see citing works

Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Girmenia, C., Bertaina, A., Piciocchi, A., Perruccio, K., Algarotti, A., Busca, A., Cattaneo, C. M., Raiola, A. M., Guidi, S., Iori, A. P., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix690 · Cited by 169 · see citing works

The Escherichia coli CRISPR System Protects from λ Lysogenization, Lysogens, and Prophage Induction

Edgar, R., & Qimron, U. (2010) · Journal of Bacteriology · doi:10.1128/jb.00644-10 · Cited by 165 · see citing works

The gut microbiome: what the oncologist ought to know

Lee, K. A., Luong, M., Shaw, H. M., Nathan, P., Bataille, V. A., & Spector, T. D. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01467-x · Cited by 151 · see citing works

Changes in long term survival after diagnosis with common hematologic malignancies in the early 21st century

Pulte, D. D., Jansen, L., & Brenner, H. (2020) · Blood Cancer Journal · doi:10.1038/s41408-020-0323-4 · Cited by 148 · see citing works

Mucosal barrier injury, fever and infection in neutropenic patients with cancer: introducing the paradigm febrile mucositis

van der Velden, W. J. F. M., Herbers, A. H. E., Netea, M. G., & Blijlevens, N. M. A. (2014) · British Journal of Haematology · doi:10.1111/bjh.13113 · Cited by 146 · see citing works

Bacteriophages to reduce gut carriage of antibiotic resistant uropathogens with low impact on microbiota composition

Galtier, M., Sordi, L. D., Maura, D., Arachchi, H., Volant, S., Dillies, M., & Debarbieux, L. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13284 · Cited by 143 · see citing works

High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing

Neil, K., Allard, N., Roy, P., Grenier, F., Menéndez, A., Burrus, V., & Rodrigue, S. (2021) · Molecular Systems Biology · doi:10.15252/msb.202110335 · Cited by 143 · see citing works

In situ reprogramming of gut bacteria by oral delivery

Hsu, B. B., Plant, I. N., Lyon, L. G., Anastassacos, F. M., Way, J. C., & Silver, P. A. (2020) · Nature Communications · doi:10.1038/s41467-020-18614-2 · Cited by 138 · see citing works

Resolving the structure of phage–bacteria interactions in the context of natural diversity

Kauffman, K. M., Chang, W. K., Brown, J. M., Hussain, F. A., Yang, J., Polz, M. F., & Kelly, L. (2022) · Nature Communications · doi:10.1038/s41467-021-27583-z · Cited by 138 · see citing works

Phage Therapy: Towards a Successful Clinical Trial

Górski, A., Borysowski, J., & Międzybrodzki, R. (2020) · Antibiotics · doi:10.3390/antibiotics9110827 · Cited by 111 · see citing works

Salmonella Phage S16 Tail Fiber Adhesin Features a Rare Polyglycine Rich Domain for Host Recognition

Dunne, M., Denyes, J. M., Arndt, H., Loessner, M. J., Leiman, P. G., & Klumpp, J. (2018) · Structure · doi:10.1016/j.str.2018.07.017 · Cited by 103 · see citing works

Constructing and Characterizing Bacteriophage Libraries for Phage Therapy of Human Infections

Gibson, S., Green, S. I., Liu, C. G., Salazar, K. C., Clark, J. R., Terwilliger, A. L., Kaplan, H. B., Maresso, A. W., Trautner, B. W., & Ramig, R. F. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02537 · Cited by 97 · see citing works

Development of a high throughput assay for indirectly measuring phage growth using the OmniLogTMsystem

Henry, M., Biswas, B., Vincent, L. R., Mokashi, V. P., Schuch, R., Bishop‐Lilly, K. A., & Sozhamannan, S. (2012) · Bacteriophage · doi:10.4161/bact.21440 · Cited by 91 · see citing works

Colonization With Levofloxacin-resistant Extended-spectrum β-Lactamase-producing Enterobacteriaceae and Risk of Bacteremia in Hematopoietic Stem Cell Transplant Recipients

Satlin, M. J., Chavda, K. D., Baker, T., Chen, L., Shashkina, E., Soave, R., Small, C. B., Jacobs, S. E., Shore, T. B., van Besien, K., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy363 · Cited by 77 · see citing works

A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella

Harms, A., Liesch, M., Körner, J., Québatte, M., Engel, P., & Dehio, C. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007077 · Cited by 76 · see citing works

Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury–Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant

Dandoy, C. E., Kim, S., Chen, M., Ahn, K. W., Ardura, M. I., Brown, V. I., Chhabra, S., Díaz, M. Á., Dvorak, C. C., Farhadfar, N., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.18668 · Cited by 76 · see citing works

Effect of Escherichia coli Morphogene bolA on Biofilms

Vieira, H. L. A., Freire, P., & Arraiano, C. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.9.5682-5684.2004 · Cited by 74 · see citing works

Causative Organisms and Associated Antimicrobial Resistance in Healthcare-Associated, Central Line–Associated Bloodstream Infections From Oncology Settings, 2009–2012

See, I., Freifeld, A. G., & Magill, S. S. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw113 · Cited by 73 · see citing works

Bacterial resistance to CRISPR-Cas antimicrobials

Vazquez-Uribe, R., Rathmer, C., Jahn, L. J., Ellabaan, M. M. H., Li, S. S., & Sommer, M. O. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-96735-4 · Cited by 67 · see citing works

Factors influencing mortality in neutropenic patients with haematologic malignancies or solid tumours with bloodstream infection

Marín, M., Gudiol, C., Ardanuy, C., García‐Vidal, C., Jiménez, L., Domingo‐Doménech, E., Pérez, F. J., & Carratalà, J. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.01.029 · Cited by 61 · see citing works

Colonization With Fluoroquinolone-Resistant Enterobacterales Decreases the Effectiveness of Fluoroquinolone Prophylaxis in Hematopoietic Cell Transplant Recipients

Satlin, M. J., Chen, L., Douglass, C., Hovan, M., Davidson, E., Soave, R., Spina, M. L., Gomez-Arteaga, A., van Besien, K., Mayer, S. A., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab404 · Cited by 59 · see citing works

Review article: bacteriophages in gastroenterology—from biology to clinical applications

Sabino, J., Hirten, R. P., & Colombel, J. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15557 · Cited by 50 · see citing works

Current Updates from the Long-Standing Phage Research Centers in Georgia, Poland, and Russia

Międzybrodzki, R., Hoyle, N. S., Zhvaniya, F., Łusiak-Szelachowska, M., Weber‐Dąbrowska, B., Łobocka, M. B., Borysowski, J., Alavidze, Z., Kutter, E. M., Górski, A., et al. (2018) · Springer eBooks · doi:10.1007/978-3-319-40598-8_31-1 · Cited by 30 · see citing works

Genetic analysis of bacteriophage T4 transducing bacteriophages

Young, K. K., Edlin, G. J., & Wilson, G. G. (1982) · Journal of Virology · doi:10.1128/jvi.41.1.345-347.1982 · Cited by 26 · see citing works

Biocontrol of Shiga Toxigenic Escherichia coli O157:H7 in T urkish Raw Meatball by Bacteriophage

Gençay, Y. E., Ayaz, N. D., Copuroglu, G., & Erol, İ. (2015) · Journal of Food Safety · doi:10.1111/jfs.12219 · Cited by 17 · see citing works

Current Updates from the Long-Standing Phage Research Centers in Georgia, Poland, and Russia

Międzybrodzki, R., Hoyle, N. S., Zhvaniya, F., Łusiak-Szelachowska, M., Weber‐Dąbrowska, B., Łobocka, M. B., Borysowski, J., Alavidze, Z., Kutter, E. M., Górski, A., et al. (2021) · Springer eBooks · doi:10.1007/978-3-319-41986-2_31 · Cited by 16 · see citing works

Targeted Genome Editing of Virulent Phages Using CRISPR-Cas9

Lemay, M.-L., Renaud, A. C., Rousseau, G. M., & Moineau, S. (2018) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2674 · Cited by 10 · see citing works

Epidemiology and Burden of Mucosal Barrier Injury Laboratory-Confirmed Bloodstream Infections in Bone Marrow Transplant and Hematology-Oncology Units

Riley, M. M.-S., Brown, J. W., Srinivas, S., Johnston, L., Tompkins, L. S., Madison, S., & Schaffner, T. (2017) · American Journal of Infection Control · doi:10.1016/j.ajic.2017.04.063 · Cited by 1 · see citing works

Past, present, and future of CRISPR genome editing technologies

Pacesa, M., Pelea, O., & Jinek, M. (2024) · Cell · doi:10.1016/j.cell.2024.01.042 · Cited by 609 · see citing works

Role of the microbiota in response to and recovery from cancer therapy

Blake, S. J., Wolf, Y., Boursi, B., & Lynn, D. J. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00951-0 · Cited by 146 · see citing works

In situ targeted base editing of bacteria in the mouse gut

Brödel, A. K., Charpenay, L. H., Galtier, M., Fuche, F. J., Terrasse, R., Poquet, C., Havránek, J., Pignotti, S., Krawczyk, A. O., Arraou, M., et al. (2024) · Nature · doi:10.1038/s41586-024-07681-w · Cited by 133 · see citing works

The gut microbiota in cancer immunity and immunotherapy

Xie, M., Li, X., Lau, H. C.-H., & Yu, J. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01326-2 · Cited by 125 · see citing works

Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial

Kim, P., Sanchez, A. M., Penke, T. J. R., Tuson, H. H., Kime, J., McKee, R. W., Slone, W. L., Conley, N. R., McMillan, L. J., Prybol, C. J., et al. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00424-9 · Cited by 121 · see citing works

Harnessing Engineered Microbial Consortia for Xenobiotic Bioremediation: Integrating Multi-Omics and AI for Next-Generation Wastewater Treatment

Renganathan, P., Gaysina, L. A., García-Gutiérrez, C., Puente, E. O. R., & Hernández, J. C. S. (2025) · Journal of Xenobiotics · doi:10.3390/jox15040133 · Cited by 85 · see citing works

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Jans, M., Kolata, M., Blancke, G., D’Hondt, A., Gräf, C., Ciers, M., Sze, M., Thiran, A., Petta, I., Andries, V., et al. (2024) · Nature · doi:10.1038/s41586-024-08135-z · Cited by 84 · see citing works

The global resistance problem and the clinical antibacterial pipeline

Theuretzbacher, U. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01169-8 · Cited by 75 · see citing works

Genomic surveillance as a scalable framework for precision phage therapy against antibiotic-resistant pathogens

Koncz, M., Stirling, T., Mehdi, H. H., Méhi, O., Eszenyi, B., Asbóth, A., Apjok, G., Tóth, Á., Orosz, L. I., Vásárhelyi, B. M., et al. (2024) · Cell · doi:10.1016/j.cell.2024.09.009 · Cited by 67 · see citing works

Phage therapy

Skurnik, M., Alkalay‐Oren, S., Boon, M., Clokie, M. R. J., Sicheritz‐Pontén, T., Dąbrowska, K., Hatfull, G. F., Hazan, R., Jalasvuori, M., Kiljunen, S., et al. (2025) · Nature Reviews Methods Primers · doi:10.1038/s43586-024-00377-5 · Cited by 65 · see citing works

Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors

Du, J., Meile, S., Baggenstos, J., Jaggi, T., Piffaretti, P., Hunold, L., Matter, C. I., Leitner, L., Kessler, T. M., Loessner, M. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39612-0 · Cited by 60 · see citing works

Antibiotics re-booted—time to kick back against drug resistance

Blaskovich, M. A. T., & Cooper, M. A. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00096-1 · Cited by 59 · see citing works

Modern microbiology: Embracing complexity through integration across scales

Eren, A. M., & Banfield, J. F. (2024) · Cell · doi:10.1016/j.cell.2024.08.028 · Cited by 55 · see citing works

The Environmental Lifecycle of Antibiotics and Resistance Genes: Transmission Mechanisms, Challenges, and Control Strategies

Li, Z., Tang, J., Wang, X., Ma, X., Yuan, H., Gao, C., Guo, Q., Guo, X., Wan, J., & Dagot, C. (2025) · Microorganisms · doi:10.3390/microorganisms13092113 · Cited by 51 · see citing works

Phage cocktails: state-of-the-art technologies and strategies for effective design

Kaneko, T., Nakatsuka, K., & Tsuneda, S. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf061 · Cited by 51 · see citing works

CRISPR innovations in tissue engineering and gene editing

Razavi, Z.-S., Soltani, M., Souri, M., & van Wijnen, A. J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123120 · Cited by 50 · see citing works

Optimizing phage therapy with artificial intelligence: a perspective

Doud, M. B., Robertson, J. M., & Strathdee, S. A. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1611857 · Cited by 50 · see citing works

Rapid design of bacteriophage cocktails to suppress the burden and virulence of gut-resident carbapenem-resistant Klebsiella pneumoniae

Rotman, E. R., McClure, S., Glazier, J., Fuerte-Stone, J., Foldi, J., Erani, A., McGann, R., Arnold, J. H., Lin, H., Valaitis, S. R., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.09.004 · Cited by 45 · see citing works

Antibacterial agents active against Gram Negative Bacilli in phase I, II, or III clinical trials

Paterson, D. L. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2326028 · Cited by 44 · see citing works

Role of the gut microbiota in tumorigenesis and treatment

Liu, Q., Yang, Y., Pan, M., Yang, F., Yu, Y., & Qian, Z. (2024) · Theranostics · doi:10.7150/thno.91700 · Cited by 43 · see citing works

Gut Phageome—An Insight into the Role and Impact of Gut Microbiome and Their Correlation with Mammal Health and Diseases

Zhang, Y., Sharma, S., Tom, L., Liao, Y., & Wu, V. C. H. (2023) · Microorganisms · doi:10.3390/microorganisms11102454 · Cited by 42 · see citing works

Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities

Venkataraman, S., Shahgolzari, M., Yavari, A., & Hefferon, K. (2025) · Bioengineering · doi:10.3390/bioengineering12050469 · Cited by 38 · see citing works

Multi-year analysis of the global preclinical antibacterial pipeline: trends and gaps

Gigante, V., Alm, R. A., Melchiorri, D., Rocke, T. P., Arias, C. A., Czaplewski, L. G., FERNANDES, P. B., Franceschi, F. J., Harbarth, S., Kozlov, R. S., et al. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00535-24 · Cited by 37 · see citing works

A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes

Lee, D., Muir, P., Lundberg, S., Lundholm, A., Sandegren, L., & Koskiniemi, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-85334-2 · Cited by 37 · see citing works

Completing the BASEL phage collection to unlock hidden diversity for systematic exploration of phage–host interactions

Humolli, D., Piel, D., Maffei, E., Heyer, Y., Agustoni, E., Shaidullina, A., Willi, L., Imwinkelried, P., Estermann, F., Cuénod, A., et al. (2025) · PLOS Biology · doi:10.1371/journal.pbio.3003063 · Cited by 36 · see citing works

The Future of Microbiome Therapeutics

Pitashny, M., Kesten, I., Shlon, D., Hur, D. B., & Bar‐Yoseph, H. (2025) · Drugs · doi:10.1007/s40265-024-02107-3 · Cited by 36 · see citing works

Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases

Gelsinger, D. R., Ronda, C., Ma, J., Kar, O. B., Edwards, M., Huang, Y., Mavros, C. F., Sun, Y., Perdue, T., Vo, P. L. H., et al. (2025) · Science · doi:10.1126/science.adx7604 · Cited by 36 · see citing works

Advancing gene editing therapeutics: Clinical trials and innovative delivery systems across diverse diseases

Raigani, M., Eftekhari, Z., Adeli, A., & Kazemi‐Lomedasht, F. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102666 · Cited by 35 · see citing works

Characterization of two virulent Salmonella phages and transient application in egg, meat and lettuce safety

Sun, X., Xue, F., Cong, C., Murtaza, B., Wang, L., Li, X., Li, S., & Xu, Y. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114607 · Cited by 34 · see citing works

Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy

Kang, D., Bagchi, D., & Chen, I. A. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300355 · Cited by 33 · see citing works

Physiological drivers of pks+ E. coli in colorectal cancer

Jans, M., & Vereecke, L. (2025) · Trends in Microbiology · doi:10.1016/j.tim.2025.04.010 · Cited by 33 · see citing works

Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing

Roberts, A., Adler, B. A., Cress, B. F., Doudna, J. A., & Barrangou, R. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2504853122 · Cited by 33 · see citing works

Plasmid targeting and destruction by the DdmDE bacterial defence system

Bravo, J. P. K., Ramos, D., Ocampo, R. F., Ingram, C., & Taylor, D. W. (2024) · Nature · doi:10.1038/s41586-024-07515-9 · Cited by 32 · see citing works

Continuous multiplexed phage genome editing using recombitrons

Fishman, C. B., Crawford, K. D., Bhattarai-Kline, S., Poola, D., Zhang, K. H., González-Delgado, A., Rojas-Montero, M., & Shipman, S. L. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02370-5 · Cited by 32 · see citing works

Current application and future prospects of CRISPR-Cas in lactic acid Bacteria: A review

Xin, Y., Guo, T., & Qiao, M. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116315 · Cited by 32 · see citing works

Pathogen virulence genes: Advances, challenges and future directions in infectious disease research (Review)

Chen, Y., Wu, X., Xu, C., Huang, J., Zhang, L., Qiu, P., Zheng, D., Chen, W., & Zhang, S. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5614 · Cited by 32 · see citing works

Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

Fang, M., Zhang, R., Wang, C., Liu, Z.-Z., Fei, M., Tang, B., Yang, H., & Sun, D. (2024) · Applied and Environmental Microbiology · doi:10.1128/aem.00811-24 · Cited by 31 · see citing works

Microbiome-based therapeutics for Parkinson's disease

Hamilton, A. M., Krout, I. N., White, A. C., & Sampson, T. R. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00462 · Cited by 31 · see citing works

Decolonization and Pathogen Reduction Approaches to Prevent Antimicrobial Resistance and Healthcare-Associated Infections

Mangalea, M. R., Halpin, A. L., Haile, M., Elkins, C. A., & McDonald, L. C. (2024) · Emerging infectious diseases · doi:10.3201/eid3006.231338 · Cited by 30 · see citing works

From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit

Tanaka, M., & Vécsei, L. (2025) · Biomedicines · doi:10.3390/biomedicines13082020 · Cited by 29 · see citing works

CRISPR-phage antibacterials to address the antibiotic resistance crisis: scientific, economic, and regulatory considerations

Pacia, D. M., Brown, B. L., Minssen, T., & Darrow, J. J. (2024) · Journal of Law and the Biosciences · doi:10.1093/jlb/lsad030 · Cited by 28 · see citing works

Addressing the Research and Development Gaps in Modern Phage Therapy

Turner, P. E., Azeredo, J., Buurman, E. T., Green, S. I., Haaber, J., Haggstrom, D., Kameda, K., Kirchhelle, C., Moreno, M. G., Pirnay, J., et al. (2024) · PHAGE · doi:10.1089/phage.2023.0045 · Cited by 28 · see citing works

Antimicrobial resistance at a turning point: microbial drivers, one health, and global futures

Elbehiry, A., Marzouk, E., & Abalkhail, A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1698809 · Cited by 28 · see citing works

Evaluating phage lytic activity: from plaque assays to single-cell technologies

Panteleev, V., Kulbachinskiy, A. V., & Gelfenbein, D. M. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1659093 · Cited by 27 · see citing works

Gut microbiome influences incidence and outcomes of breast cancer by regulating levels and activity of steroid hormones in women

Chapadgaonkar, S. S., Bajpai, S., & Godbole, M. S. (2023) · Cancer Reports · doi:10.1002/cnr2.1847 · Cited by 27 · see citing works

Phage therapy in noncommunicable diseases

Kviatcovsky, D., Valdés‐Mas, R., Federici, S., & Elinav, E. (2023) · Science · doi:10.1126/science.adh2718 · Cited by 27 · see citing works

CRISPR–Cas therapies targeting bacteria

Benz, F., Beamud, B., Laurenceau, R., Maire, A., Duportet, X., Decrulle, A. L., & Bikard, D. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00311-8 · Cited by 26 · see citing works

Combination strategies of gut microbiota in cancer therapy through metabolic reprogramming and immune remodeling

Wang, L., Jiang, W., Yang, M., Danzeng, Q., Liu, S., & Cui, M. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02275-z · Cited by 26 · see citing works

Armed Phages: A New Weapon in the Battle Against Antimicrobial Resistance

Anastassopoulou, C. G., Tsakri, D., Panagiotopoulos, A.-P., Saldari, C., Sagona, A. P., & Tsakris, A. (2025) · Viruses · doi:10.3390/v17070911 · Cited by 26 · see citing works

Recent Advances in Antimicrobial Resistance: Insights from Escherichia coli as a Model Organism

Zhang, Z., Wei, M., Jia, B., & Yuan, Y. (2024) · Microorganisms · doi:10.3390/microorganisms13010051 · Cited by 25 · see citing works

Tackling antimicrobial resistance in people who are immunocompromised: leveraging diagnostic and antimicrobial stewardship

Liu, C., Rosen, E. A., Stohs, E. J., Imlay, H. N., Nigo, M., Gottesdiener, L. S., So, M., Tverdek, F. P., Dadwal, S., Gudiol, C., et al. (2025) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(25)00311-1 · Cited by 25 · see citing works

Advanced Strategies in Phage Research: Innovations, Applications, and Challenges

Wu, P., Li, W., Zhang, W., Li, S., Deng, B., Xu, S., & Li, Z. (2025) · Microorganisms · doi:10.3390/microorganisms13081960 · Cited by 25 · see citing works

Gut microbiome and its metabolites in liver cirrhosis: mechanisms and clinical implications

Chang, L., Liu, Y., Li, H., Yan, J., Wu, W., Chen, N., Ma, C., Zhao, X., Chen, J., & Zhang, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1717696 · Cited by 25 · see citing works

Strain dynamics of contaminating bacteria modulate the yield of ethanol biorefineries

Lino, F. S. D. O., Garg, S., Li, S. S., Misiakou, M.-A., Kang, K., da Costa, B. L. V., Beyer-Pedersen, T. S.-A., Giacon, T. G., Basso, T. O., Panagiotou, G., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49683-2 · Cited by 24 · see citing works

CRISPR-Cas-assisted phage engineering for personalized antibacterial treatments

Chaudhary, N., Sharma, K., Kaur, H., Prajapati, S., Mohan, B., & Taneja, N. (2024) · Indian Journal of Medical Microbiology · doi:10.1016/j.ijmmb.2024.100771 · Cited by 24 · see citing works

Personalized bacteriophage therapy for chronic biliary tract Pseudomonas aeruginosa infections

Li, N., Li, L., He, B., Li, D., Jin, W., Wu, Y. S., Zhu, B., Cheng, M., Wu, N., Tan, D., et al. (2025) · hLife · doi:10.1016/j.hlife.2025.03.004 · Cited by 24 · see citing works

Reconstructing the Antibiotic Pipeline: Natural Alternatives to Antibacterial Agents

Ekwueme, C. T., Anyiam, I. V., Ekwueme, D. C., Anumudu, C. K., & Onyeaka, H. N. (2025) · Biomolecules · doi:10.3390/biom15081182 · Cited by 24 · see citing works

Quorum sensing in bacteria: insights into communication and inhibition strategies—a review

Das, A., Biswas, R., Najiar, R., Thatharaju, P., Biswas, S., & Mohan, U. (2026) · Archives of Microbiology · doi:10.1007/s00203-025-04610-x · Cited by 24 · see citing works

A DNA Nanopatch‐Bacteriophage System Targeting Streptococcus Gallolyticus for Inflammatory Bowel Disease Treatment and Colorectal Cancer Prevention

Zhao, Y., Zhu, M., Ling, Y., Zhao, Y., Lu, X., Chu, B., He, Y., & Wang, H. (2025) · Advanced Materials · doi:10.1002/adma.202417334 · Cited by 23 · see citing works

Insights on Current Strategies to Decolonize the Gut from Multidrug-Resistant Bacteria: Pros and Cons

Roson-Calero, N., Ballesté‐Delpierre, C., Fernández, J., & Vilà, J. (2023) · Antibiotics · doi:10.3390/antibiotics12061074 · Cited by 24 · see citing works

Advanced Bioinspired Multifunctional Platforms Focusing on Gut Microbiota Regulation

Li, M., Wang, L., Lin, D., Liu, Z., Wang, H., Yang, Y., Sun, C., Ye, J., & Liu, Y. (2024) · ACS Nano · doi:10.1021/acsnano.4c05013 · Cited by 22 · see citing works

Phage–nanomaterial platforms for precision antimicrobial therapy: from design to therapeutic application

Qi, M., & Tay, A. K. P. (2025) · Nanoscale · doi:10.1039/d5nr02249e · Cited by 22 · see citing works

Synthetic and Functional Engineering of Bacteriophages: Approaches for Tailored Bactericidal, Diagnostic, and Delivery Platforms

Alessa, O., Aiba, Y., Arbaah, M., Hidaka, Y., Watanabe, S., Miyanaga, K., Wannigama, D. L., & Cui, L. (2025) · Molecules · doi:10.3390/molecules30153132 · Cited by 21 · see citing works

Phage-mediated virulence loss and antimicrobial susceptibility in carbapenem-resistant Klebsiella pneumoniae

Yu, Y., Wang, M., Ju, L., Li, M., Zhao, M., Deng, H., Rensing, C., Yang, Q., & Zhou, S. (2024) · mBio · doi:10.1128/mbio.02957-24 · Cited by 21 · see citing works

The gut virome and human health: From diversity to personalized medicine

Lathakumari, R. H., Vajravelu, L. K., Gopinathan, A., Vimala, P. B., Panneerselvam, V. P., Ravi, S. S. S., & Thulukanam, J. (2025) · Engineering Microbiology · doi:10.1016/j.engmic.2025.100191 · Cited by 21 · see citing works

Precise virulence inactivation using a CRISPR-associated transposase for combating Enterobacteriaceae gut pathogens

Ronda, C., Perdue, T., Schwanz, L. T., Gelsinger, D. R., Brockmann, L., Kaufman, A., Huang, Y., Sternberg, S. H., & Wang, H. H. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01453-1 · Cited by 21 · see citing works

Bacterial small molecule metabolites implicated in gastrointestinal cancer development

Turocy, T., & Crawford, J. M. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01103-4 · Cited by 20 · see citing works

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Huang, S., Zhao, S., Zhao, H., Wen, M., & Guo, Z. (2025) · Exploration · doi:10.1002/exp.20240045 · Cited by 19 · see citing works

CRISPR-based genetic tools for the study of host-microbe interactions

Galindo, M. E., & Lai, Y. (2025) · Infection and Immunity · doi:10.1128/iai.00510-24 · Cited by 19 · see citing works

Engineering bacteriophages for gut health: precision antimicrobials and beyond

Xu, M., Chen, S., Pei, H.-L., Hu, L., & Zhang, Y.-S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04038-5 · Cited by 17 · see citing works

Systematic interrogation of CRISPR antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity

Vialetto, E., Miele, S., Goren, M. G., Yu, J., Yu, Y., Collias, D., Beamud, B., Osbelt, L., Lourenço, M., Strowig, T., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae281 · Cited by 19 · see citing works

A review of bacteriophage and their application in domestic animals in a post-antibiotic era

Guo, X., Luo, G., Hou, F., Zhou, C., Liu, X., Lei, Z., Niu, D. X., Ran, T., & Tan, Z. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174931 · Cited by 18 · see citing works

Applications of bacteriophages in precision engineering of the human gut microbiome

Kuang, X., Shen, J., Zheng, L., Duan, Y., Ma, Y., Leung, E. L., & Dai, L. (2025) · Engineering Microbiology · doi:10.1016/j.engmic.2025.100189 · Cited by 18 · see citing works

Phages adapt to recognize an O-antigen polysaccharide site by mutating the “backup” tail protein ORF59, enabling reinfection of phage-resistant Klebsiella pneumoniae

Li, P., Ma, W., Cheng, J., Zhan, C., Lu, H., Shen, J., & Zhou, X. (2025) · Emerging Microbes & Infections · doi:10.1080/22221751.2025.2455592 · Cited by 18 · see citing works

The rise, fall, and resurgence of phage therapy for urinary tract infection

Zulk, J. J., Patras, K. A., & Maresso, A. W. (2024) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0029-2023 · Cited by 18 · see citing works

Targeted delivery of genome editors in vivo

Ngo, W., Wu, J. L. Y., Wasko, K. M., & Doudna, J. A. (2026) · Nature Biotechnology · doi:10.1038/s41587-025-02945-w · Cited by 17 · see citing works

Genome engineering of the human gut microbiome

Zheng, L., Shen, J., Chen, R., Hu, Y., Zhao, W., Leung, E. L., & Dai, L. (2024) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2024.01.002 · Cited by 17 · see citing works

Effects of intratumoral microbiota on tumorigenesis, anti-tumor immunity, and microbe-based cancer therapy

Zheng, J., & Chen, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1429722 · Cited by 17 · see citing works

Phage engineering using synthetic biology and artificial intelligence to enhance phage applications in food industry

Yuan, X., Fan, L., Jin, H., Wu, Q., & Ding, Y. (2025) · Current Opinion in Food Science · doi:10.1016/j.cofs.2025.101274 · Cited by 17 · see citing works

Avian Pathogenic Escherichia coli: Advances in Pathogenesis, Diagnosis, and Control

Kamal, O. M., Kneuper, H., Cogan, T. A., & Woodward, M. J. (2025) · Veterinary Sciences · doi:10.3390/vetsci13010019 · Cited by 16 · see citing works

The Role of Genomics in Advancing and Standardising Bacteriophage Therapy

Абдраймова, Н. К., Shitikov, E. A., & Kornienko, M. A. (2026) · Antibiotics · doi:10.3390/antibiotics15010055 · Cited by 16 · see citing works

Surface self-assembly via one-pot polymerization to construct high-strength and antibacterial polyethylene fabric

Wang, J., Su, X., Zhu, Q., Zhai, Y., Dai, X., Tang, N., Pan, W., Xiang, H., & Zhu, M. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152246 · Cited by 16 · see citing works

Trojan Horse virus delivering CRISPR-AsCas12f1 controls plant bacterial wilt caused by Ralstonia solanacearum

Peng, S., Xu, Y., Qu, H., Nong, F., Shu, F., Yuan, G., Ruan, L., & Zheng, D. (2024) · mBio · doi:10.1128/mbio.00619-24 · Cited by 16 · see citing works

Leveraging collateral sensitivity to counteract the evolution of bacteriophage resistance in bacteria

Mu, Y., Song, Y., Tian, X., Ding, Z., Yao, S., Li, Y., Wang, C., Wei, D., Vollmer, W., Zhang, G., et al. (2025) · mLife · doi:10.1002/mlf2.70003 · Cited by 15 · see citing works

Biofilm-associated Escherichia coli infections: pathogenesis, clinical implications, and treatment strategies

Thakur, D., & Kumar, L. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2548490 · Cited by 16 · see citing works

Phage Encapsulation and Delivery Technology: A Strategy for Treating Drug-Resistant Pathogenic Microorganisms

Yang, Y., Xu, Z., Soteyome, T., Premarathna, M., Yin, X., & Liu, J. (2025) · Pharmaceuticals · doi:10.3390/ph18111688 · Cited by 15 · see citing works

A Review of Clinical Trials Involving Genetically Modified Bacteria, Bacteriophages and Their Associated Risk Assessments

Gulig, P. A., Swindle, S., Fields, M. A., & Eisenman, D. (2024) · Applied Biosafety · doi:10.1089/apb.2024.0002 · Cited by 15 · see citing works

Making the leap from technique to treatment — genetic engineering is paving the way for more efficient phage therapy

Lewis, J. M., Williams, J., & Sagona, A. P. (2024) · Biochemical Society Transactions · doi:10.1042/bst20231289 · Cited by 15 · see citing works

Gut microbiota — bidirectional modulator: role in inflammatory bowel disease and colorectal cancer

Cui, X., Li, C., Zhong, J., Liu, Y., Xiao, P., Liu, C., Zhao, M., & Yang, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1523584 · Cited by 15 · see citing works

Phage Therapy for Urinary Tract Infections: Progress and Challenges Ahead

Morgan, C. J., Atkins, H., Wolfe, A. J., Brubaker, L. T., Aslam, S., Putonti, C., Doud, M. B., & Burnett, L. A. (2025) · International Urogynecology Journal · doi:10.1007/s00192-025-06136-8 · Cited by 14 · see citing works

Recent advances of engineered bacteria for therapeutic applications

Xiang, X., Zhou, Z., Rao, X., & Jiang, X. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.11.013 · Cited by 14 · see citing works

Cell-free synthesis of infective phages from in vitro assembled phage genomes for efficient phage engineering and production of large phage libraries

Kristensen, C. S., Petersen, A. Ø., Kilstrup, M., van der Helm, E., & Takos, A. M. (2024) · Synthetic Biology · doi:10.1093/synbio/ysae012 · Cited by 14 · see citing works

Advancements in CRISPR-Cas-based strategies for combating antimicrobial resistance

Zhang, R., Zhou, Q., Huang, S., Zhang, N., & Sun, D. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128232 · Cited by 14 · see citing works

Bacteriophage Therapy to Combat Microbial Infections and Antimicrobial Resistance

Sharma, D., Singh, I., Sharma, J., Verma, I. K., & Ratn, A. (2025) · Journal of Basic Microbiology · doi:10.1002/jobm.70090 · Cited by 14 · see citing works

Safety, recovery, and pharmacodynamics of CRISPR–Cas therapeutic SNIPR001: a phase 1, randomised, double-blind, first-in-human, dose-escalation study

Petersen, A. Ø., Damholt, B. B., Grove, M. F., Hink, J., Marotte-Hurbon, T., Söderqvist, J., Troy, A., Zdravkovic, M., Bayer, L., Brunner, K., et al. (2026) · The Lancet Microbe · doi:10.1016/j.lanmic.2025.101257 · Cited by 13 · see citing works

Opportunities and challenges in phage therapy for cardiometabolic diseases

Wortelboer, K., & Herrema, H. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.03.007 · Cited by 13 · see citing works

From resistance to remedy: the role of clustered regularly interspaced short palindromic repeats system in combating antimicrobial resistance—a review

Raza, A., Fatima, P., Yasmeen, B., Rana, Z. A., & Ellakwa, D. E. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03509-6 · Cited by 13 · see citing works

Cutting-edge tools for unveiling the dynamics of plasmid–host interactions

Yang, Q., Gao, J. T., Zhou, S. G., & Walsh, T. R. (2025) · Trends in Microbiology · doi:10.1016/j.tim.2024.12.013 · Cited by 13 · see citing works

Relationship between pediatric asthma and respiratory microbiota, intestinal microbiota: a narrative review

Liu, L., Zhao, W., Zhang, H., Shang, Y., Huang, W., & Cheng, Q. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1550783 · Cited by 13 · see citing works

Photoactivated in-situ engineered-bacteria as an efficient H2S generator to enhance photodynamic immunotherapy via remodeling the tumor microenvironment

Yin, J., Sun, W., Xiong, H., Yao, W., Liu, X., Jiang, H., & Wang, X. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123388 · Cited by 13 · see citing works

Armed phages are heading for clinical trials

Lewis, J. M., & Sagona, A. P. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01415-w · Cited by 5 · see citing works

CRISPR-ENGINEERED BACTERIOPHAGES, BIOFILM ERADICATION AND PRECISION TREATMENT OF MULTIDRUG-RESISTANT INFECTIONS

Selvakumar, G., Abirami, K., Divya, V. V., Kalaimani, A., Sathya, T. A., Kapur, M. A., & Dhayanithi, N. B. (2026) · Iterative International Publishers eBooks · doi:10.58532/nbennur3355c14

Three New Escherichia coli Phages from the Human Gut Show Promising Potential for Phage Therapy

Dalmasso, M., Strain, R., Neve, H., Franz, C. M. A. P., Cousin, F., Ross, R. P., & Hill, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156773 · Cited by 110 · see citing works

Mutant phages treat E. coli infection

Page, M. L. (2026) · The New Scientist · doi:10.1016/s0262-4079(26)01297-2

Phage engineering and phage‐assisted CRISPR‐Cas delivery to combat multidrug‐resistant pathogens

Khambhati, K., Bhattacharjee, G., Gohil, N., Dhanoa, G. K., Sagona, A. P., Mani, I., Bui, N. L., Chu, D., Karapurkar, J. K., Jang, S. H., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10381 · Cited by 115 · see citing works