The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
Open accessPublished version of a preprint
Abstract
Host genetics are known to influence the gut microbiome, yet their role remains poorly understood. To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project. Two robust, study-wide significant (P < 1.89 × 10−10) signals near the LCT and ABO genes were found to be associated with multiple microbial taxa and pathways and were replicated in two independent cohorts. The LCT locus associations seemed modulated by lactose intake, whereas those at ABO could be explained by participant secretor status determined by their FUT2 genotype. Twenty-two other loci showed suggestive evidence (P < 5 × 10−8) of association with microbial taxa and pathways. At a more lenient threshold, the number of loci we identified strongly correlated with trait heritability, suggesting that much larger sample sizes are needed to elucidate the remaining effects of host genetics on the gut microbiome. A genome-wide association study of 207 taxa and 205 pathways representing gut microbial composition and function from 7,738 individuals of the Dutch Microbiome Project identifies genetic associations at the LCT and ABO loci.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Lactase-persistence alleles at the LCT gene consistently track with higher abundances of Bifidobacterium spp.,61,62”
From Gut dysbiosis in oncology: a risk factor for immunoresistance (2026) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A global reference for human genetic variation
The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247
Fast and sensitive protein alignment using DIAMOND
Buchfink, B., Xie, C., & Huson, D. H. (2015) · Nature Methods · doi:10.1038/nmeth.3176 · Cited by 14,201
Second-generation PLINK: rising to the challenge of larger and richer datasets
Chang, C. C., Chow, C. C., Tellier, L. C., Vattikuti, S., Purcell, S. M., & Lee, J. J. (2015) · Gigascience · doi:10.1186/s13742-015-0047-8 · Cited by 12,709
Bowden, J., Davey Smith, G., & Burgess, S. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv080 · Cited by 9,816
The MR-Base platform supports systematic causal inference across the human phenome
Hemani, G., Zheng, J., Elsworth, B., Wade, K. H., Haberland, V., Baird, D., Laurin, C., Burgess, S., Bowden, J., Langdon, R., et al. (2018) · eLife · doi:10.7554/elife.34408 · Cited by 7,959
The GTEx Consortium atlas of genetic regulatory effects across human tissues
The GTEx Consortium, Aguet, F., Anand, S., Ardlie, K. G., Gabriel, S., Getz, G. A., Graubert, A., Hadley, K., Handsaker, R. E., Huang, K. H., et al. (2020) · Science · doi:10.1126/science.aaz1776 · Cited by 5,547
Self-citationGut microbiota in human metabolic health and disease
Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724
Willett, W. C. (1998) · doi:10.1093/acprof:oso/9780195122978.001.0001 · Cited by 4,541
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487
Self-citationPersonalized nutrition by prediction of glycemic responses
Zeevi, D., Korem, T., Zmora, N., Israeli, D., Rothschild, D., Weinberger, A., Ben-Yacov, O., Lador, D., Avnit-Sagi, T., Lotan-Pompan, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.001 · Cited by 2,929
Cited by
Sorted by citations
The gut microbiome and hypertension
O’Donnell, J. A., Zheng, T., Méric, G., & Marques, F. Z. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00654-0 · Cited by 302
Ma, Z., Zuo, T., Frey, N., & Rangrez, A. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01946-6 · Cited by 322
Lactobacillus and intestinal diseases: Mechanisms of action and clinical applications
Huang, R., Wu, F. L., Zhou, Q., Wei, W., Juan, Y., Xiao, B., & Luo, Z. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127019 · Cited by 268
Xu, S., Li, X., Zhang, S., Qi, C., Zhang, Z., Ma, R., Xiang, L., Chen, L., Zhu, Y., Tang, C., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02878-8 · Cited by 209
Self-citationABO genotype alters the gut microbiota by regulating GalNAc levels in pigs
Yang, H., Wu, J., Huang, X., Zhou, Y., Zhang, Y., Liu, M., Liu, Q., Ke, S., He, M., Fu, H., et al. (2022) · Nature · doi:10.1038/s41586-022-04769-z · Cited by 201
Metadata
- Authors
- Lopera-Maya, E. A., Kurilshikov, A., van der Graaf, A., Hu, S., Andreu-Sánchez, S., Chen, L., Vila, A. V., Gacesa, R., Sinha, T., Collij, V., Klaassen, M. A. Y., Bolte, L. A., Gois, M. F. B., Neerincx, P. B. T., Swertz, M. A., Study, L. C., Aguirre-Gamboa, R., Deelen, P., Franke, L., Kuivenhoven, J. A., Lopera-Maya, E. A., Nolte, I. M., Sanna, S., Snieder, H., Swertz, M. A., Vonk, J. M., Wijmenga, C., Harmsen, H. J. M., Wijmenga, C., Fu, J., Weersma, R. K., Zhernakova, A., & Sanna, S.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Zhernakova, Alexandra
- ORCID
- Kurilshikov, Alexander
- van der Graaf, Adriaan
- Hu, Shixian
- Andreu-Sánchez, Sergio
- Chen, Lianmin
- Vila, Arnau Vich
- Gacesa, Ranko
- Sinha, Trishla
- Collij, Valerie
- Bolte, Laura A.
- Gois, Milla F. Brandao
- Neerincx, Pieter B. T.
- Deelen, Patrick
- Franke, Lude
- Kuivenhoven, Jan A.
- Nolte, Ilja M.
- Snieder, Harold
- Vonk, Judith M.
- Harmsen, Hermie J. M.
- Fu, Jingyuan
- Weersma, Rinse K.
- Zhernakova, Alexandra
- Venue
- Nature Genetics
- Published
- 2022-02
- Volume
- 54
- Issue
- 2
- Pages
- 143-151
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W4225566784
- Cited by
- 553
- References
- 84
- Citations by year
- 2026: 107 · 2025: 153 · 2024: 156 · 2023: 105 · 2022: 28
- FWCI
- 39.64
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-07-25)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Genetics (publishedVersion, other-oa)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)
- Seerave Foundation (715772, 2018-27, 016.178.056)
- Stichting De Cock-Hadders (20:20-13)
- Rijksuniversiteit Groningen (2018-27, 715772)
- Ministerie van Volksgezondheid, Welzijn en Sport (024.003.001)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO Gravitation grant Exposome-NL 024.004.017, NWO SPI 92–266, 024.003.001, Exposome‐NL 024.004.017, 024.003, 016.178.056, 016.Vidi.178.056, 024.004.017, SPI 92-266)
- China Scholarship Council (024.004.017, CSC 201708320268)
- Universitair Medisch Centrum Groningen
- Interreg (202085)
- H2020 European Research Council (101001678, 715772)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- host genetics, gut microbiota, microbial community composition, microbial function, LCT gene, ABO gene, lactose intake, genetic association
- MeSH terms
- ABO Blood-Group System, Gastrointestinal Microbiome, Host Microbial Interactions, Galactoside 2-alpha-L-fucosyltransferase, Bifidobacterium, Diet, Fucosyltransferases, Humans, Netherlands, Triglycerides, Genetic Variation, Genome, Human, Sodium Chloride, Dietary, Bacterial Physiological Phenomena, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Gastrointestinal Tract, Lactase, Metabolic Networks and Pathways, Metagenome, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
