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New cytometry tools for immune monitoring during cancer immunotherapy

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Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

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Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient’s survival and immunotherapy responsiveness

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Strategies for overcoming tumour resistance to immunotherapy: harnessing the power of radiation therapy

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The molecular landscape of T cell exhaustion in the tumor microenvironment and reinvigoration strategies

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scMINER: a mutual information-based framework for clustering and hidden driver inference from single-cell transcriptomics data

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Active aldehydes accelerate CD8+ T cell exhaustion by metabolic alteration in the tumor microenvironment

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Aging-associated immune system changes in multiple myeloma: The dark side of the moon.

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Application of ATAC-seq in tumor-specific T cell exhaustion

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Steroid hormone regulation of immune responses in cancer

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Gastric Cancer and the Immune System: The Key to Improving Outcomes?

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High endothelial venules predict response to PD-1 inhibitors combined with anti-angiogenesis therapy in NSCLC

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Combined Autophagy Inhibition and Dendritic Cell Recruitment Induces Antitumor Immunity and Enhances Immune Checkpoint Blockade Sensitivity in Pancreatic Cancer

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p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy

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Case Report: Simultaneous Hyperprogression and Fulminant Myocarditis in a Patient With Advanced Melanoma Following Treatment With Immune Checkpoint Inhibitor Therapy

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Tumor-Infiltrating T Cells — A Portrait

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Immunometabolite L-2-HG promotes epigenetic modification of exhausted T cells and improves antitumor immunity

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CD8+ T Cell Subsets as Biomarkers for Predicting Checkpoint Therapy Outcomes in Cancer Immunotherapy

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Spectral Flow Cytometry: The Current State and Future of the Technology

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Immune correlates and mechanisms of TIL therapy efficacy: current insights and knowledge gaps

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Progenitor exhausted PD-1+ T cells are cellular targets of immune checkpoint inhibition in atherosclerosis

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The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction

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Modulating the wayward T cell: New horizons with immune checkpoint inhibitor treatments in autoimmunity, transplant, and cancer

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Global Pattern of CD8+ T-Cell Infiltration and Exhaustion in Colorectal Cancer Predicts Cancer Immunotherapy Response

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A Signature of N6-methyladenosine Regulator-Related Genes Predicts Prognoses and Immune Responses for Head and Neck Squamous Cell Carcinoma

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Identification and validation of a poor clinical outcome subtype of primary prostate cancer with Midkine abundance

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ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control

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Low-Dose Anti-VEGFR2 Therapy Promotes Anti-Tumor Immunity in Lung Adenocarcinoma by Down-Regulating the Expression of Layilin on Tumor-Infiltrating CD8 +T Cells

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Self-Renewing CD8+ T-cell Abundance in Blood Associates with Response to Immunotherapy

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A novel integrated approach to predicting cancer immunotherapy efficacy

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Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance

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Sézary syndrome originates from heavily mutated hematopoietic progenitors

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CD39 + conventional CD4 + T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

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High HPK1+PD-1+TIM-3+CD8+ T cells infiltration predicts poor prognosis to immunotherapy in NSCLC patients

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Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma

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Advancing immunotherapy for melanoma: the critical role of single-cell analysis in identifying predictive biomarkers

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Defining the niche for stem-like CD8+ T cell formation and function

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Systemic CD4 Immunity and PD-L1/PD-1 Blockade Immunotherapy

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PD1 and PD-L1 Inhibitors for the Treatment of Kidney Cancer: The Role of PD-L1 Assay

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Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans

Turano, P. S., Akbulut, E., Dewald, H. K., Vasilopoulos, T., Fitzgerald-Bocarsly, P., Herbig, U., & Martínez-Zamudio, R. I. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116795 · Cited by 16

Divergent Clinical and Immunologic Outcomes Based on STK11 Co-mutation Status in Resectable KRAS- Mutant Lung Cancers Following Neoadjuvant Immune Checkpoint Blockade

Rosner, S., Connor, S. C., Sanber, K. S., ZAHURAK, M. L., Zhang, T., Gurumurthy, I., Zeng, Z., Presson, B., Singh, D., Rayes, R. F., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-2983 · Cited by 18

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer

Zhang, L., Guo, X., Sun, X., Liao, J., Liu, Q., Ye, Y., Yang, Z., Cressey, R., He, Q., & Yuan, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1486329 · Cited by 16

Neoadjuvant immune checkpoint therapy: Enabling insights into fundamental human immunology and clinical benefit

Pauken, K. E., Alhalabi, O., Goswami, S., & Sharma, P. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.03.005 · Cited by 18

Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects

Capello, M., Sette, A., Plantinga, T. S., Thalhauser, C. J., Spires, V. M., Nuermberger, K., Blum, J. M., Higgs, B. W., Castro, P. G., Yu, C. Y., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011377 · Cited by 16

INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma

Zhao, S., Zhang, Y., Meng, X., Wang, Y., Li, Y., Li, H., Zhao, X., Yang, P., Liu, S., & Yang, C. (2025) · BMC Cancer · doi:10.1186/s12885-025-14261-2 · Cited by 16

Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and anti-CTLA-4 cancer immunotherapies

Damei, I., Caidi, A., Auclin, É., Adam, J., Mella, S., Hasan, M., Tartour, É., Robert, C., Corgnac, S., & Mami‐Chouaib, F. (2025) · Nature Communications · doi:10.1038/s41467-025-60657-w · Cited by 21

RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma

Carvalho, L. A. D. C., Shifrin, N. T., Phadke, M. S., Emmons, M. F., Pechuan-Jorge, X., Mbuga, F., Ospina, O. E., Chow, C., Seu, L., Rose, O. L., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-25-0744 · Cited by 18

Erythropoietin receptor on cDC1s dictates immune tolerance

Zhang, X., McGinnis, C. S., Yu, G., Chen, S., Zheng, P., Schürch, C. M., Hiam-Galvez, K. J., Reticker-Flynn, N. E., Guo, W., Yao, W., et al. (2025) · Nature · doi:10.1038/s41586-025-09824-z · Cited by 17

Atlas-guided discovery of transcription factors for T cell programming

Chung, H. K., Liu, C., Battu, A., Jambor, A. N., Pratt, B. M., Xie, F., Riesenberg, B., Casillas, E., Sun, M., Landoni, E., et al. (2026) · Nature · doi:10.1038/s41586-025-09989-7 · Cited by 21

Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence

Le, P. T., Ha, N., Tran, N. K., Newman, A. G., Esselen, K. M., Dalrymple, J. L., Schmelz, E. M., Bhandoola, A., Xue, H., Singh, P. B., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.738958 · Cited by 16

The prognostic value of TCF1+CD8+T in primary small cell carcinoma of the esophagus

Ma, L., Sun, L., Zhao, K., Dong, Z., Huang, Z., & Meng, X. (2021) · Cancer Science · doi:10.1111/cas.15167 · Cited by 16

Antigen cross-presentation in young tumor-bearing hosts promotes CD8 + T cell terminal differentiation

Moustaki, A., Crawford, J. C., Alli, S., Fan, Y., Boi, S. K., Zamora, A. E., McDonald, N., Wu, G., Nakitandwe, J., Newman, S., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abf6136 · Cited by 17

Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products

Silva, D. N., Chrobok, M., Rovesti, G., Healy, K., Wagner, A. K., Maravelia, P., Gatto, F., Mazza, M., Mazzotti, L., Lohmann, V., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.896242 · Cited by 16

Intravenous administration of viral vectors expressing prostate cancer antigens enhances the magnitude and functionality of CD8+ T cell responses

Vardeu, A., Davis, C., McDonald, I., Stahlberg, G., Thapa, B., Piotrowska, K., Marshall, M. A., Evans, T. G., Wheeler, V., Sebastian, S., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005398 · Cited by 16

Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity

Zheng, H., Yu, X., Ibrahim, M. L., Foresman, D., Xie, M., Johnson, J., Boyle, T. A., Ruffell, B., Perez, B. A., Antonia, S. J., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0927 · Cited by 17

Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade

Fox, D. B., Ebright, R. Y., Hong, X., Russell, H. C., Guo, H., LaSalle, T. J., Wittner, B. S., Poux, N., Vuille, J. A., Toner, M., et al. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00362-3 · Cited by 15

TIGIT is a key inhibitory checkpoint receptor in lymphoma

Godfrey, J. K., Chen, X., Sunseri, N., Cooper, A. B., Yu, J., Varlamova, A., Zarubin, D., Popov, Y., Jacobson, C. A., Postovalova, E., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006582 · Cited by 16

Melanoma-intrinsic NR2F6 activity regulates antitumor immunity

Kim, H., Feng, Y.-M., Murad, R., Pozniak, J., Pelz, C., Chen, Y., Dalal, B., Sears, R., Sergienko, E., Jackson, M., et al. (2022) · bioRxiv · doi:10.1126/sciadv.adf6621 · Cited by 12

Targeting LSD1 in tumor immunotherapy: rationale, challenges and potential

Bao, L., Zhu, P., Mou, Y., Song, Y., & Ye, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1214675 · Cited by 17

Complementary HLH susceptibility factors converge on CD8 T-cell hyperactivation

Landy, E., Varghese, J., Dang, V., Szymczak-Workman, A. L., Kane, L., & Canna, S. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010502 · Cited by 16

Highly Active Myeloid Therapy for Cancer

Fredrich, I. R., Halabi, E. A., Köhler, R. H., Ge, X., Garris, C., & Weissleder, R. (2023) · ACS Nano · doi:10.1021/acsnano.3c08034 · Cited by 16

Circulating memory PD-1+CD8+ T cells and PD-1+CD8+T/PD-1+CD4+T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients

Liu, J., Liu, D., Hu, G., Wang, J., Chen, D., Song, C., Cai, Y., Zhai, C., & Xu, W. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03137-9 · Cited by 19

Nanoparticle-Based Immunotherapy for Reversing T-Cell Exhaustion

Li, F., Wang, Y. J., Chen, D., & Du, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031396 · Cited by 17

ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Yang, Y., Wang, Y., Wang, Z., Yan, H., Gong, Y., Hu, Y., Jiang, Y., Wen, S., Xu, F., Wang, B., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01351-9 · Cited by 18

The impact of Foxp3 + regulatory T‐cells on CD8 + T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

Attias, M., & Piccirillo, C. A. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16313 · Cited by 17

Network-based screening identifies sitagliptin as an antitumor drug targeting dendritic cells

Ng, I.-I., Zhang, J., Tian, T., Qi, P., Huang, Z., Xiao, K., Yao, X., Ng, L., Zeng, J., & Tang, H. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008254 · Cited by 17

TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes

Trivedi, P., Jhala, G., George, D. J. D., Chiu, C. Y. H., Selck, C., Ge, T., Catterall, T., Elkerbout, L., Boon, L., Joller, N., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1370907 · Cited by 17

Hypofractionated radiotherapy combined with lenalidomide improves systemic antitumor activity in mouse solid tumor models

Onyshchenko, K., Luo, R., Rao, X., Zhang, X., Gaedicke, S., Grosu, A., Firat, E., & Niedermann, G. (2024) · Theranostics · doi:10.7150/thno.88864 · Cited by 16

Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2019) · Immunology · doi:10.1158/1538-7445.sabcs18-2701

Abstract A83: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6074.tumimm19-a83 · Cited by 3

Abstract A216: Functionally specialized subsets of exhausted CD8+ T-cells mediate tumor control and response to checkpoint blockade

Sen, D. R., Miller, B. C., Abosy, R. A., Bi, K., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., Manos, M. P., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr18-a216

Abstract 4683: Distinct subsets of dysfunctional CD8+ T cells underlie response to checkpoint blockade

Miller, B. C., Sen, D. R., Al-Abosy, R., Bi, K., Yates, K. B., Gjini, E., Felt, K. D., Manguso, R. T., Rodig, S. J., Sharpe, A. H., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4683

Chromatin State and Immunotherapy

Haining, W. N. (2018) · Blood · doi:10.1182/blood-2018-99-109432