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Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy

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Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8+ T lymphocyte exhaustion

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Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation

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Quantitative and functional characteristics of circulating and bone marrow PD-1- and TIM-3-positive T cells in treated multiple myeloma patients

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Malignant Pleural Effusions—A Window Into Local Anti-Tumor T Cell Immunity?

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Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

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Prospects and Challenges for T Cell-Based Therapies of HCC

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Selective IL-1 activity on CD8+ T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication

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A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells

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Accumulation of dysfunctional tumor-infiltrating PD-1+ DCs links PD-1/PD-L1 blockade immunotherapeutic response in cervical cancer

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Pregnancy and Tumour: The Parallels and Differences in Regulatory T Cells

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SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8 + T cell cytotoxic function

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IL-1 receptor–associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy

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Tumor‐infiltrating gamma delta T‐cells reveal exhausted subsets with remarkable heterogeneity in colorectal cancer

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Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy

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Transcriptional mediators of treatment resistance in lethal prostate cancerPreprint

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The epigenetic immunomodulator, HBI-8000, enhances the response and reverses resistance to checkpoint inhibitors

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The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells

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T cell exhaustion and senescence for ovarian cancer immunotherapy

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Phenotypic and spatial heterogeneity of CD8+ tumour infiltrating lymphocytes

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Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates

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The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation

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Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma

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Resistance mechanisms to checkpoint inhibitors

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Immunologic Features in De Novo and Recurrent Glioblastoma Are Associated with Survival Outcomes

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Single-cell profiles reveal tumor cell heterogeneity and immunosuppressive microenvironment in Waldenström macroglobulinemia

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Alcohol reshapes a liver premetastatic niche for cancer by extra- and intrahepatic crosstalk-mediated immune evasion

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The role of transforming growth factor-β (TGF-β) in the formation of exhausted CD8 + T cells

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Adenosine Uptake through the Nucleoside Transporter ENT1 Suppresses Antitumor Immunity and T-cell Pyrimidine Synthesis

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Single‐Nucleus and Spatial Transcriptome Profiling Delineates the Multicellular Ecosystem in Hepatocellular Carcinoma After Hepatic Arterial Infusion Chemotherapy

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Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions

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Lipids for CD8+ TILs: Beneficial or harmful?

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Myeloid checkpoints for cancer immunotherapy

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Spatio-temporal heterogeneity in cancer evolution and tumor microenvironment of renal cell carcinoma with tumor thrombus

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FcγRIIB expressed on CD8+T cells limits responsiveness to PD-1 checkpoint inhibition in cancer

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DGKα/ζ inhibition lowers the TCR affinity threshold and potentiates antitumor immunity

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Targeted modulation of gut and intra-tumor microbiota to improve the quality of immune checkpoint inhibitor responses

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CD38–RyR2 axis–mediated signaling impedes CD8 + T cell response to anti-PD1 therapy in cancer

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Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

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Mechanistic rationales for combining immunotherapy with radiotherapy

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Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy

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OMIP ‐109: 45‐color full spectrum flow cytometry panel for deep immunophenotyping of the major lineages present in human peripheral blood mononuclear cells with emphasis on the T cell memory compartment

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Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth

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Differential predictive value of resident memory CD8 + T cell subpopulations in patients with non-small-cell lung cancer treated by immunotherapy

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Deciphering the deterministic role of TCR signaling in T cell fate determination

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Tumour-reactive heterotypic CD8 T cell clusters from clinical samples

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Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer

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SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling

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A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma

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Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection

Topchyan, P., Zander, R., Kasmani, M. Y., Nguyen, C. P., Brown, A. K., Lin, S., Burns, R., & Cui, W. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111736 · Cited by 22

Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes

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The nexus of dynamic T cell states and immune checkpoint blockade therapy in the periphery and tumor microenvironment

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Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells

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Enhanced cellular therapy: revolutionizing adoptive cellular therapy

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Combinatorial immunotherapy induces tumor-infiltrating CD8+ T cells with distinct functional, migratory, and stem-like properties

Budimir, N., Dolina, J. S., Wei, J., Wang, X., Chen, S.-H., Santiago, P., Tu, G., Micci, L., Al-Khami, A. A., Pfister, S. X., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003614 · Cited by 22

An etiology-stratified single-cell atlas identifies FABP4 as a prognostic marker for MASLD-related HCC

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SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine

Mise‐Omata, S., Ando, M., Srirat, T., Nakagawara, K., Hayakawa, T., Iizuka-Koga, M., Nishimasu, H., Nureki, O., Ito, M., & Yoshimura, A. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112940 · Cited by 23

Treatment strategies and molecular mechanism of radiotherapy combined with immunotherapy in colorectal cancer

Jin, Y., Jiang, J. F., Mao, W. B., Bai, M., Chen, Q., & Zhu, J. Y. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216858 · Cited by 24

Overcoming Resistance Mechanisms to Melanoma Immunotherapy

Zheng, D. X., Bozym, D. J., Tarantino, G., Sullivan, R. J., Liu, D., & Jenkins, R. W. (2024) · American Journal of Clinical Dermatology · doi:10.1007/s40257-024-00907-7 · Cited by 25

Restoration of LAT activity improves CAR T cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemia

Pham‐Danis, C., Novak, A. J., Danis, E. P., McClellan, S. M., Leach, L., Yarnell, M. C., Ebmeier, C. C., Tasian, S. K., & Kohler, M. E. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.02.008 · Cited by 23

Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade

Hill, C. N., Maita, G., Cabrolier, C., Aros, C., Vega-Letter, A. M., González, P., Kalergis, A. M., Luz‐Crawford, P., & Owen, G. I. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1600792 · Cited by 24

Tumor-Associated Macrophages Produce PGE2 to Promote CD8+ T-cell Exhaustion and Drive Resistance to PD-L1 Blockade in Microsatellite-Stable Colorectal Cancer

Fumet, J.-D., Latour, C., Nuttin, L., Dérangère, V., Ilie, A., Russo, P., Hampe, L., Daumoine, S., Thibaudin, M., Truntzer, C., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-0079 · Cited by 25

Unraveling How Tumor-Derived Galectins Contribute to Anti-Cancer Immunity Failure

Laderach, D. J., & Compagno, D. (2021) · Cancers · doi:10.3390/cancers13184529 · Cited by 22

Dynamics of Circulating Immune Cells During Chemoradiotherapy in Patients with Non-Small Cell Lung Cancer Support Earlier Administration of Anti-PD-1/PD-L1 Therapy

Kim, K. H., Pyo, H., Lee, H., Oh, D., Noh, J. M., Ahn, Y. C., Yoon, H. I., Moon, H., Lee, J., Park, S., et al. (2022) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2022.02.003 · Cited by 21

The emerging role of anti-PD-1 antibody-based regimens in the treatment of extranodal NK/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis

He, Y., Gao, Y., Ping, L., He, H., Huang, C., Bai, B., Wang, X., Li, Z., Cai, Q., Huang, Y., et al. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04147-2 · Cited by 21

Lysine-Specific Demethylase 1 Promises to Be a Novel Target in Cancer Drug Resistance: Therapeutic Implications

Yang, F., Xu, X.-L., Hu, T., Liu, J., Zhou, J.-Z., Ma, L., & Liu, H. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01527 · Cited by 21

Leveraging immune resistance archetypes in solid cancer to inform next-generation anticancer therapies

Anderson, K. G., Braun, D. A., Buqué, A., Gitto, S. B., Guerriero, J. L., Horton, B. L., Keenan, B. P., Kim, T. S., Overacre-Delgoffe, A. E., Ruella, M., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006533 · Cited by 22

Reactivation of low avidity tumor-specific CD8 + T cells associates with immunotherapeutic efficacy of anti-PD-1

Sugiyarto, G., Lau, D., Hill, S. L., Arcia, D., Boulanger, D. S. M., Parkes, E. E., James, E., & Elliott, T. J. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007114 · Cited by 22

Dendritic Cell Vaccination in Non-Small Cell Lung Cancer: Remodeling the Tumor Immune Microenvironment

Abascal, J. W., Oh, M. S., Liclican, E. L., Dubinett, S. M., Salehi‐Rad, R., & Liu, B. (2023) · Cells · doi:10.3390/cells12192404 · Cited by 23

Biomarkers and experimental models for cancer immunology investigation

Xu, H., Jia, Z., Liu, F., Li, J., Huang, Y., Jiang, Y., Pu, P., Shang, T., Tang, P., Zhou, Y., et al. (2023) · MedComm · doi:10.1002/mco2.437 · Cited by 21

Emerging roles of TBK1 in cancer immunobiology

Miranda, A., Shirley, C. A., & Jenkins, R. W. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.02.007 · Cited by 22

Stem‐like T cells in cancer and autoimmunity

Schnell, A. (2024) · Immunological Reviews · doi:10.1111/imr.13356 · Cited by 22

Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization

Becker, W., Olkhanud, P. B., Seishima, N., Moreno, P. A., Goldfarbmuren, K. C., Maeng, H. M., & Berzofsky, J. A. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-008970 · Cited by 21

Identification of hub genes associated with neutrophils infiltration in colorectal cancer

Su, H., Cai, T., Zhang, S., Yan, X., Zhou, L., He, Z., Xue, P., Li, J., Zheng, M., Yang, X., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16414 · Cited by 21

Revolutionizing tumor immunotherapy: unleashing the power of progenitor exhausted T cells

Zhang, F., Ding, X., Huang, H., Jiang, H., Jiang, J., & Zheng, X. W. (2024) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2024.0105 · Cited by 25

Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti–TIM-3 therapy in mice

Talvard-Balland, N., Braun, L. M., Dixon, K. O., Zwick, M., Engel, H., Hartmann, A., Duquesne, S., Penter, L., Andrieux, G., Rindlisbacher, L., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci177460 · Cited by 25

Systematic analysis of human colorectal cancer scRNA-seq revealed limited pro-tumoral IL-17 production potential in gamma delta T cells

Ran, R., Trapečar, M., & Brubaker, D. K. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101072 · Cited by 19

XCL1-secreting CEA CAR-T cells enhance endogenous CD8 + T cell responses to tumor neoantigens to confer a long-term antitumor immunity

Li, X.-N., Wang, F., Chen, K., Wu, Z., Zhang, R., Xiao, C., Zhao, F., Wang, D., Zhao, H., Ran, Y., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010581 · Cited by 20

A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours

Pretto, S., Yu, Q., Bourdely, P., Cafarello, S. T., Acker, H. H. V., Verelst, J., Richiardone, E., Vanheer, L., Roshanzadeh, A., Schneppenheim, F., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01233-w · Cited by 21

Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and roles in disease

Park, S. L., Painter, M. M., Manne, S., Alcalde, V., McLaughlin, M., Sullivan, M. A., Mathew, D., Torres, L., Huang, Y., Reeg, D. B., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02352-y · Cited by 23

SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond

O’Connell, P., Amalfitano, A., & Aldhamen, Y. A. (2019) · Vaccines · doi:10.3390/vaccines7040184 · Cited by 20

CD8 + T Cells Exhibit an Exhausted Phenotype in Hemophagocytic Lymphohistiocytosis

Kelkar, M. G., Bargir, U. A., Yadav, R. M., Gupta, M., Dalvi, A. D., Jodhawat, N., Shinde, S., & Madkaikar, M. R. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-021-01109-0 · Cited by 20

Programmed death (PD)‐1/PD‐ligand 1 blockade mediates antiangiogenic effects by tumor‐derived CXCL10/11 as a potential predictive biomarker

Mitsuhashi, A., Kondoh, K., Horikawa, K., Koyama, K., Nguyen, N. T., Afroj, T., Yoneda, H., Otsuka, K., Ogino, H., Nokihara, H., et al. (2021) · Cancer Science · doi:10.1111/cas.15161 · Cited by 19

PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemic Function

Suematsu, M., Yagyu, S., Nagao, N., Kubota, S., Shimizu, Y., Tanaka, M., Nakazawa, Y., & Imamura, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.770132 · Cited by 21

Multimodal predictors for precision immunotherapy

Roelofsen, L. M., Kaptein, P., & Thommen, D. S. (2022) · Immuno-Oncology Technology · doi:10.1016/j.iotech.2022.100071 · Cited by 19

Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission

Holley, J. M., Stanbouly, S., Pecaut, M. J., Willey, J. S., Delp, M. D., & Mao, X. W. (2022) · npj Microgravity · doi:10.1038/s41526-022-00217-4 · Cited by 22

Functional status and spatial interaction of T cell subsets driven by specific tumor microenvironment correlate with recurrence of non-small cell lung cancer

Yang, L., Zhang, W., Sun, J., Yang, G., Cai, S., Sun, F., Xing, L., & Sun, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1022638 · Cited by 22

Regulation and function of poised mRNAs in lymphocytes

Turner, M. (2023) · BioEssays · doi:10.1002/bies.202200236 · Cited by 19

The metabolic cross-talk between cancer and T cells

Miguel, S. C.-D., Lucianer, G., & Elia, I. (2023) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2023.03.004 · Cited by 22

PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer

Meymandi, A. R. P., Akbari, B., Soltantoyeh, T., Shahosseini, Z., Hosseini, M., Hadjati, J., & Mirzaei, H. R. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1357801 · Cited by 21

Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2019) · Immunology · doi:10.1158/1538-7445.sabcs18-2701

Abstract A83: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6074.tumimm19-a83 · Cited by 3

Abstract A216: Functionally specialized subsets of exhausted CD8+ T-cells mediate tumor control and response to checkpoint blockade

Sen, D. R., Miller, B. C., Abosy, R. A., Bi, K., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., Manos, M. P., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr18-a216

Abstract 4683: Distinct subsets of dysfunctional CD8+ T cells underlie response to checkpoint blockade

Miller, B. C., Sen, D. R., Al-Abosy, R., Bi, K., Yates, K. B., Gjini, E., Felt, K. D., Manguso, R. T., Rodig, S. J., Sharpe, A. H., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4683

Chromatin State and Immunotherapy

Haining, W. N. (2018) · Blood · doi:10.1182/blood-2018-99-109432