Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

Spatial reconstruction of single-cell gene expression data

Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Tumeh, P. C., Harview, C. L., Yearley, J. H., Shintaku, I. P., Taylor, E. J. M., Robert, L., Chmielowski, B., Spasic, M., Henry, G., Ciobanu, V., et al. (2014) · Nature · doi:10.1038/nature13954 · Cited by 6,609

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

Snyder, A., Makarov, V., Merghoub, T., Yuan, J., Zaretsky, J. M., Desrichard, A., Walsh, L. A., Postow, M. A., Wong, P., Ho, T. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1406498 · Cited by 4,286

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062

Restoring function in exhausted CD8 T cells during chronic viral infection

Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes

Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Rácz, P., Tenner‐Racz, K., Dalesandro, M. R., Scallon, B. J., et al. (1999) · Science · doi:10.1126/science.283.5403.857 · Cited by 2,167

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K., & Anderson, A. C. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100643 · Cited by 2,072

Harnessing the immunotherapeutic potential of CDK4/6 inhibitors in melanoma: is timing everything?

Lelliott, E. J., Sheppard, K. E., & McArthur, G. A. (2022) · npj Precision Oncology · doi:10.1038/s41698-022-00273-9 · Cited by 34

CD200 + cytotoxic T lymphocytes in the tumor microenvironment are crucial for efficacious anti–PD-1/PD-L1 therapy

Wang, X., Zha, H., Wu, W., Yuan, T., Xie, S., Jin, Z., Long, H., Yang, F., Wang, Z., Zhang, A., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abn5029 · Cited by 34

Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma

Cheng, D., Qiu, K., Rao, Y., Mao, M., Li, L., Wang, Y., Song, Y., Chen, J., Yi, X., Shao, X., et al. (2023) · eLife · doi:10.7554/elife.82705 · Cited by 35

CCL21-DC in situ vaccination in murine NSCLC overcomes resistance to immunotherapy and generates systemic tumor-specific immunity

Salehi‐Rad, R., Lim, R. J., Du, Y., Tran, L. M., Li, R., Ong, S. L., Huang, Z. L., Dumitras, C., Zhang, T.-H., Park, S. J., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-006896 · Cited by 33

Unraveling temporal and spatial biomarkers of epithelial-mesenchymal transition in colorectal cancer: insights into the crucial role of immunosuppressive cells

Wang, M., Deng, C., Yang, C. H., Yan, M., Lu, H., Zhang, Y., Liu, H., Tong, Z., Ma, J., Wang, J., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04600-x · Cited by 33

NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment

Hao, J., Li, R., Zhao, X., Liu, X., Chen, X., Xie, T., Li, X., Yao, C., Sun, Q., Wei, K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114301 · Cited by 35

Lymphatic system regulation of anti-cancer immunity and metastasis

Lei, P., Fraser, C. S., Jones, D., Ubellacker, J. M., & Padera, T. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449291 · Cited by 39

Highly multiplexed 3D profiling of cell states and immune niches in human tumors

Yapp, C., Nirmal, A. J., Zhou, F., Wong, A. Y. H., Tefft, J. B., Lu, Y. D., Shang, Z., Maliga, Z., Llopis, P. D. L. M. M., Murphy, G. F., et al. (2025) · Nature Methods · doi:10.1038/s41592-025-02824-x · Cited by 55

Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer Therapy

Lecis, D., Sangaletti, S., Colombo, M. P., & Chiodoni, C. (2019) · Cancers · doi:10.3390/cancers11050624 · Cited by 33

Hybrid Fc‐fused interleukin‐7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy

Kim, J., Kim, Y., Choi, D., Jo, S.-B., Park, H. W., Hong, S., Park, S., Kim, S., Moon, S., You, G., et al. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1168 · Cited by 33

G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes

Lu, C., Yang, D., Klement, J. D., Colson, Y. L., Oberlies, N. H., Pearce, C. J., Colby, A. H., Grinstaff, M. W., Ding, H., Shi, H., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003543 · Cited by 34

Urinary detection of early responses to checkpoint blockade and of resistance to it via protease-cleaved antibody-conjugated sensors

Mac, Q. D., Sivakumar, A., Phuengkham, H., Xu, C., Bowen, J. R., Su, F., Stentz, S. Z., Sim, H., Harris, A. M., Li, T. T., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00852-y · Cited by 35

The new progress in cancer immunotherapy

Shimu, A. S., Wei, H.-X., Li, Q., Zheng, X., & Li, B. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00887-0 · Cited by 36

Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection

Cai, C., Samir, J., Pirozyan, M. R., Adikari, T. N., Gupta, M., Leung, P., Hughes, B., Byl, W. V. D., Rizzetto, S., Elthala, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35281-7 · Cited by 36

Biomechanics of T Cell Dysfunctions in Chronic Diseases

Gunasinghe, S. D., Peres, N. G., Goyette, J., & Gaus, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.600829 · Cited by 33

IOA-244 is a Non–ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance

Johnson, Z., Tarantelli, C., Civanelli, E., Cascione, L., Spriano, F., Fraser, A., Shah, P., Nomanbhoy, T. K., Napoli, S., Rinaldi, A., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0477 · Cited by 32

One-carbon metabolism shapes T cell immunity in cancer

Qiu, Y., Xie, E., Xu, H., Cheng, H., & Li, G. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.05.010 · Cited by 33

Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses

Oswald, B. M., DeCamp, L. M., Longo, J., Dahabieh, M. S., Bunda, N., Johnson, B. K., Watson, M. J., Ma, S., Preston, S. E. J., Sheldon, R. D., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01415-6 · Cited by 35

Cellular therapy approaches harnessing the power of the immune system for personalized cancer treatment

Bastien, J.-P., Minguy, A., Davé, V. P., & Roy, D. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101306 · Cited by 35

Analysis of single‐cell RNAseq identifies transitional states of T cells associated with hepatocellular carcinoma

Yang, Y., Liu, F., Liu, W., Ma, M., Gao, J., Lu, Y., Huang, L., Li, X., Shi, Y., Wang, X., et al. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.133 · Cited by 31

Applications of Single-Cell Omics to Dissect Tumor Microenvironment

Guo, T., Li, W., & Cai, X. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.548719 · Cited by 33

The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome

Foroutan, M., Molania, R., Pfefferle, A., Behrenbruch, C., Scheer, S., Kallies, A., Speed, T. P., Cursons, J., & Huntington, N. D. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0137 · Cited by 35

The roaring 2020s: a new decade of systemic therapy for renal cell carcinoma

Srivastava, A., Doppalapudi, S. K., Patel, H. V., Srinivasan, R., & Singer, E. A. (2022) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000831 · Cited by 31

TGF-β promotes stem-like T cells via enforcing their lymphoid tissue retention

Ma, C., Wang, L., Liao, W., Liu, Y., Mishra, S., Li, G., Zhang, X., Qiu, Y., Lu, Q., & Zhang, N. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211538 · Cited by 31

Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models

Parker, S., McDowall, C., Sanchez-Perez, L. A., Osorio, C., Duncker, P. C., Briley, A., Swartz, A. M., Herndon, J. E., Yu, Y.-R. A., McLendon, R. E., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abn5649 · Cited by 31

Cell-Intrinsic CD38 Expression Sustains Exhausted CD8 + T Cells by Regulating Their Survival and Metabolism during Chronic Viral Infection

DeRogatis, J. M., Neubert, E. N., Viramontes, K. M., Henriquez, M. L., Nicholas, D., & Tinoco, R. (2023) · Journal of Virology · doi:10.1128/jvi.00225-23 · Cited by 30

Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice

Onyshchenko, K., Luo, R., Guffart, E., Gaedicke, S., Grosu, A., Firat, E., & Niedermann, G. (2023) · Nature Communications · doi:10.1038/s41467-023-37825-x · Cited by 31

Loss of PBAF promotes expansion and effector differentiation of CD8+ T cells during chronic viral infection and cancer

Kharel, A., Shen, J., Brown, R. J., Chen, Y., Nguyen, C. P., Alson, D., Bluemn, T., Fan, J., Gai, K., Zhang, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112649 · Cited by 32

Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

Collier, J. L., Pauken, K. E., Lee, C. A. A., Patterson, D. G., Markson, S. C., Conway, T. S., Fung, M. E., France, J. A., Mucciarone, K., Lian, C. G., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221920 · Cited by 33

Cytokine signaling in chimeric antigen receptor T-cell therapy

Kagoya, Y. (2023) · International Immunology · doi:10.1093/intimm/dxad033 · Cited by 31

Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy

Ziblat, A., Horton, B. L., Higgs, E. F., Hatogai, K., Martinez, A., Shapiro, J. W., Kim, D. E., Zha, Y., Sweis, R. F., & Gajewski, T. F. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114141 · Cited by 31

Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy

Xiong, D., Yu, H., & Sun, Z. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.04.022 · Cited by 31

Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study

Eerkens, A. L., Brummel, K., Vledder, A., Paijens, S. T., Requesens, M., Loiero, D., van Rooij, N., Plat, A., Haan, F.-J., Klok, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52098-8 · Cited by 31

Transient EZH2 Suppression by Tazemetostat during In Vitro Expansion Maintains T-Cell Stemness and Improves Adoptive T-Cell Therapy

Hou, Y., Žák, J., Shi, Y., Pratumchai, I., Dinner, B., Wang, W., Qin, K., Weber, E. W., Teijaro, J. R., & Wu, P. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0089 · Cited by 33

Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection

Klawon, D. E. J., Pagane, N., Walker, M. T., Ganci, N. K., Miller, C. H., Gai, E., Rodriguez, D. M., Ryan-Payseur, B. K., Duncombe, R. K., Adams, E. J., et al. (2025) · Science · doi:10.1126/science.adk3248 · Cited by 33

Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment

Green, W. D., Gomez, A., Plotkin, A. L., Pratt, B. M., Merritt, E. F., Mullins, G. N., Kren, N. P., Modliszewski, J. L., Zhabotynsky, V., Woodcock, M. G., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.030 · Cited by 34

T cells in cancer: mechanistic insights and therapeutic advances

Pu, J., Liu, T., Zhou, Y., Chen, M., Fu, X., Wan, Y., Wang, J., Chen, B., Sharma, A., Lukacs‐Kornek, V., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00807-w · Cited by 33

Epigenetic regulation of T cell exhaustion in cancer

Kang, T. G., Johnson, J. T., Zebley, C. C., & Youngblood, B. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00883-y · Cited by 36

Exploiting the obesity-associated immune microenvironment for cancer therapeutics

Desharnais, L., Walsh, L. A., & Quail, D. F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107923 · Cited by 31

Targeting the PSGL-1 Immune Checkpoint Promotes Immunity to PD-1–Resistant Melanoma

DeRogatis, J. M., Viramontes, K. M., Neubert, E. N., Henriquez, M. L., Guerrero‐Juarez, C. F., & Tinoco, R. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0690 · Cited by 31

Imaging immunity in patients with cancer using positron emission tomography

Hegi‐Johnson, F., Rudd, S. E., Hicks, R. J., Ruysscher, D. D., Trapani, J. A., John, T., Donnelly, P. S., Blyth, B. J., Hanna, G. G., Everitt, S., et al. (2022) · npj Precision Oncology · doi:10.1038/s41698-022-00263-x · Cited by 33

Harnessing the immune system by targeting immune checkpoints: Providing new hope for Oncotherapy

Yu, L., Sun, M., Zhang, Q., Zhou, Q., & Wang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.982026 · Cited by 32

4-1BB Agonism Combined With PD-L1 Blockade Increases the Number of Tissue-Resident CD8+ T Cells and Facilitates Tumor Abrogation

Qu, Q.-X., Zhu, X.-Y., Du, W.-W., Wang, H.-B., Shen, Y., Zhu, Y.-B., & Chen, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00577 · Cited by 30

Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy

Chen, Z., Zhu, Z., Hu, T., Yao, C., & Wu, T. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01378-4 · Cited by 37

Indications for and Contraindications of Immune Checkpoint Inhibitors in Cancer Patients with COVID-19 Vaccination

Luo, B., Li, J., Hou, X., Yang, Q., Zhou, Y., Ye, J., Wu, X., Feng, Y., Hu, T., Xu, Z. Z., et al. (2021) · Future Oncology · doi:10.2217/fon-2021-0288 · Cited by 30

Heterologous prime-boost vaccination targeting MAGE-type antigens promotes tumor T-cell infiltration and improves checkpoint blockade therapy

McAuliffe, J., Chan, H. F., Noblecourt, L., Ramirez-Valdez, R. A., Almeida, V. P., Zhou, Y., Pollock, E., Cappuccini, F., Redchenko, I., Hill, A. V. S., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003218 · Cited by 33

Immune checkpoint expression and relationships to anti‐PD‐L1 immune checkpoint blockade cancer immunotherapy efficacy in aged versus young mice

Garcia, M. G., Deng, Y., Murray, C. E., Reyes, R. M., Padron, A. S., Bai, H., Kancharla, A., Gupta, H. B., Shen-Orr, S. S., & Curiel, T. J. (2022) · Aging and Cancer · doi:10.1002/aac2.12045 · Cited by 29

CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes

Koyama‐Nasu, R., Kimura, M. Y., Kiuchi, M., Aoki, A., Wang, Y., Mita, Y., Hasegawa, I., Endo, Y., Onodera, A., Hirahara, K., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0406 · Cited by 28

Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D

Linsley, P. S., & Long, S. A. (2019) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000488 · Cited by 30

Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer

Riesenberg, B., Hunt, E. G., Tennant, M. D., Hurst, K. E., Andrews, A. M., Leddy, L. R., Neskey, D. M., Hill, E. G., Rivera, G. O. R., Paulos, C. M., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1744 · Cited by 30

Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols

Barboy, O., Bercovich, A., Li, H., Eyal-Lubling, Y., Yalin, A., Itai, Y. S., Abadie, K., Zada, M., David, E., Shlomi-Loubaton, S., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00734-z · Cited by 32

Safety and Preliminary Efficacy of Pembrolizumab Following Transarterial Chemoembolization for Hepatocellular Carcinoma: The PETAL Phase Ib Study

Pinato, D. J., D’Alessio, A., Fulgenzi, C. A. M., Schlaak, A. E., Celsa, C., Killmer, S., Blanco, J. M., Ward, C. E., Stikas, C., Openshaw, M. R., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-0177 · Cited by 29

CAR-NK cell therapy combined with checkpoint inhibition induces an NKT cell response in glioblastoma

Straßheimer, F., Elleringmann, P., Ludmirski, G., Roller, B., Macas, J., Alekseeva, T., Cakmak, P., Aliraj, B., Krenzlin, H., Demes, M. C., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-02977-8 · Cited by 29

Magnesium microspheres for enhanced transarterial chemoembolization therapy of hepatocellular carcinoma: From animal models to a pilot clinical study

Gong, F., Zheng, L., Xu, J., Wu, Y., Jin, Q., Lu, J., Pei, Z., Zhao, Z., Chen, M., Tu, J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv0885 · Cited by 29

Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus

Suda, Y., Nakashima, T., Matsumoto, H., Sato, D., Nagano, S., Mikata, H., Yoshida, S., Tanaka, K., Hamada, Y., Kuzumaki, N., et al. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.12.086 · Cited by 28

mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

Conti, B. D. P., Miluzio, A., Grassi, F., Abrignani, S., Biffo, S., & Ricciardi, S. (2021) · eLife · doi:10.7554/elife.69015 · Cited by 29

Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies

Beider, K., Itzhaki, O., Schachter, J., Grushchenko-Polaq, A. H., Voevoda-Dimenshtein, V., Rosenberg, E., Ostrovsky, O., Devillers, O., Frommer, R. S., Zeltzer, L., et al. (2022) · Cells · doi:10.3390/cells11071140 · Cited by 30

Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction

Zhao, H., Yu, Y., Wang, Y., Zhao, L., Yang, A., Hu, Y., Pan, Z., Wang, Z., Yang, J., Han, Q., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00939-1 · Cited by 31

Lenvatinib enhances antitumor immunity by promoting the infiltration of TCF1 + CD8 + T cells in HCC via blocking VEGFR2

Mei, Z., Gao, X., Pan, C., Wu, Q., Wang, S., Qian, J., Xu, Z., Xu, K., Zhou, L., & Zhen, S. (2023) · Cancer Science · doi:10.1111/cas.15719 · Cited by 29

Terminally Exhausted CD8+ T Cells Resistant to PD-1 Blockade Promote Generation and Maintenance of Aggressive Cancer Stem Cells

Chakravarti, M., Dhar, S., Bera, S., Sinha, A., Roy, K., Sarkar, A., Dasgupta, S., Bhuniya, A., Saha, A., Das, J., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-3864 · Cited by 30

Tumor-derived semaphorin 4A improves PD-1–blocking antibody efficacy by enhancing CD8 + T cell cytotoxicity and proliferation

Naito, Y., Koyama, S., Masuhiro, K., Hirai, T., Uenami, T., Inoue, T., Osa, A., Machiyama, H., Watanabe, G., Sax, N., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade0718 · Cited by 29

Determinants of anti-PD1 response and resistance in clear cell renal cell carcinomaPreprint

Au, L., Hatipoglu, E., de Massy, M. R., Litchfield, K., Rowan, A., Thompson, R. H., Schnidrig, D., Byrne, F., Beattie, G., Horswell, S. D., et al. (2021) · medRxiv · doi:10.1101/2021.03.19.21253661 · Cited by 29

Obesity and adipose tissue impact on T-cell response and cancer immune checkpoint blockade therapy

Pasquarelli-do-Nascimento, G., Machado, S. A., de Carvalho, J. M. A., & Magalhães, K. G. (2022) · Immunotherapy Advances · doi:10.1093/immadv/ltac015 · Cited by 29

Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity

Fernandez-Rodriguez, L., Cianciaruso, C., Bill, R., Trefny, M. P., Klar, R., Kirchhammer, N., Buchi, M., Festag, J., Michel, S., Köhler, R. H., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-006714 · Cited by 28

PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer

Ali, L. R., Lenehan, P. J., Cardot‐Ruffino, V., Costa, A. D., Katz, M. H. G., Bauer, T. W., Nowak, J. A., Wolpin, B. M., Abrams, T. A., Patel, A. K., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-1444 · Cited by 28

Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease

Chen, Y.-H., Yang, M., Zhang, M., Wang, H., Zheng, Y., Sun, R., & Li, X. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320188 · Cited by 29

Microbiota-Derived Inosine Programs Protective CD8 T Cell Responses Against Influenza in Newborns

Stevens, J., Culberson, E., Kinder, J. M., Ramiriqui, A., Gray, J. K., Bonfield, M., Shao, T., Gharaibeh, F. N. A., Peterson, L. S., Steinmeyer, S. H., et al. (2024) · Cell · doi:10.1016/j.cell.2025.05.013 · Cited by 32

Organoids as models of immune-organ interaction

Harter, M. F., Recaldin, T., & Gjorevski, N. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116214 · Cited by 31

Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell–Mediated Antitumor Immunity

Danahy, D. B., Kurup, S. P., Winborn, C. S., Jensen, I. J., Harty, J. T., Griffith, T. S., & Badovinac, V. P. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900435 · Cited by 29

Identification of a T-bethi Quiescent Exhausted CD8 T Cell Subpopulation That Can Differentiate into TIM3+CX3CR1+ Effectors and Memory-like Cells

Raju, S., Xia, Y., Dániel, B., Yost, K. E., Bradshaw, E., Tonc, E., Verbaro, D., Kometani, K., Yokoyama, W. M., Kurosaki, T., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001348 · Cited by 31

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy

Anderson, K. G., Oda, S. K., Bates, B. M., Burnett, M. G., Suarez, M. L. R., Ruskin, S. L., & Greenberg, P. D. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003959 · Cited by 28

DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells

Quon, S., Yu, B., Russ, B. E., Tsyganov, K., Nguyen, H., Toma, C., Heeg, M., Hocker, J. D., Milner, J. J., Crotty, S., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.03.017 · Cited by 28

Metabolic Control of Memory T-Cell Generation and StemnessPreprint

Raynor, J. L., Chapman, N. M., & Chi, H. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037770 · Cited by 28

PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells

Viramontes, K. M., Neubert, E. N., DeRogatis, J. M., & Tinoco, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869768 · Cited by 27

A novel polysaccharide isolated from Coriolus versicolor polarizes M2 macrophages into an M1 phenotype and reversesits immunosuppressive effect on tumor microenvironment

Bi, S., Jing, Y., Cui, X., Gong, Y., Zhang, J., Feng, X., Shi, Z., Zheng, Q., & Li, D. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129352 · Cited by 27

TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response

León-Rodríguez, S. G. D., Aguilar-Flores, C., Gajón, J. A., Juárez-Flores, Á., Mantilla, A., Gerson-Cwilich, R., Martínez‐Herrera, J. F., Osorno, D. A. V., Gutiérrez-Quiroz, C. T., Buenaventura‐Cisneros, S., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008739 · Cited by 27

Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming

Lawton, M. L., Inge, M. M., Blum, B. C., Smith-Mahoney, E. L., Bolzan, D., Lin, W., McConney, C., Porter, J., Moore, J., Youssef, A., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002943 · Cited by 25

Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node

Shen, Y., Connolly, E. C., Aiello, M., Zhou, C., Chappa, P., Song, H., Tippitak, P., Clark, T. Y., Cardenas, M. A., Prokhnevska, N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58510-1 · Cited by 27

PD-1 is requisite for skin TRM cell formation and specification by TGFβ

Devi, K. S. P., Wang, E., Jaiswal, A., Konieczny, P., Kim, T., Nirschl, C. J., Verma, A., Liu, Y., Milczanowski, J., Christo, S. N., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02228-1 · Cited by 27

Obesity, COVID-19 and Immunotherapy: the Complex Relationship!

Finelli, C. (2020) · Immunotherapy · doi:10.2217/imt-2020-0178 · Cited by 27

The Paradoxical Roles of Inflammation during PD-1 Blockade in Cancer

Hill, M., Segovia, M., Russo, S., Girotti, M. R., & Rabinovich, G. A. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.09.003 · Cited by 26

Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses

Devenish, L. P., Mhlanga, M. M., & Negishi, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662565 · Cited by 27

Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control

Perdomo-Celis, F., Passaes, C., Monceaux, V., Volant, S., Boufassa, F., de Truchis, P., Marcou, M., Bourdic, K., Weiss, L., Jung, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 27

Exhaustion of CD39-Expressing CD8+ T Cells in Crohn’s Disease Is Linked to Clinical Outcome

Globig, A.-M., Mayer, L., Heeg, M., Andrieux, G., Ku, M., Otto-Mora, P., Hipp, A. V., Zoldan, K., Pattekar, A., Rana, N., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.045 · Cited by 30

Differential expression of HAVCR2 gene in pan-cancer: A potential biomarker for survival and immunotherapy

Li, H., Yang, D., Hao, M., & Liu, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.972664 · Cited by 27

Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade

Sun, B., Xun, Z., Zhang, N., Liu, K., Chen, X., & Zhao, H. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03158-4 · Cited by 31

High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpoints

Raghubar, A. M., Matigian, N. A., Crawford, J., Francis, L., Ellis, R., Healy, H. G., Kassianos, A. J., Ng, M. S. Y., Roberts, M. J., Wood, S., et al. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00441-5 · Cited by 26

Targeting tumor microenvironment for non-small cell lung cancer immunotherapy

Wang, L., Jia, Q., Chu, Q., & Zhu, B. (2023) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2022.11.001 · Cited by 30

Late-stage MC38 tumours recapitulate features of human colorectal cancer – implications for appropriate timepoint selection in preclinical studies

Shields, N. J., Peyroux, E. M., Ferguson, A. L., Steain, M. C., Neumann, S., & Young, S. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1152035 · Cited by 31

The Tumor-Specific Immune Landscape in HPV+ Head and Neck Cancer

Conarty, J. P., & Wieland, A. (2023) · Viruses · doi:10.3390/v15061296 · Cited by 27

Stem-like CD8+ T cells in cancer

Steiner, C., Denlinger, N., Huang, X., & Yang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1426418 · Cited by 28

Potential mechanisms of cancer stem‐like progenitor T‐cell bio‐behaviours

Ni, L. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1817 · Cited by 26

Syndecan-1 inhibition promotes antitumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy

Liu, Y., Xu, C., Zhang, L., Xu, G., Yang, Z., Xiang, L., Jiao, K., Chen, Z., Zhang, X., & Liu, Y. (2024) · Science Advances · doi:10.1126/sciadv.adi7764 · Cited by 27

Pathophysiology and preclinical relevance of experimental graft-versus-host disease in humanized mice

Ehx, G., Ritacco, C., & Baron, F. (2024) · Biomarker Research · doi:10.1186/s40364-024-00684-9 · Cited by 26

Subclonal immune evasion in non-small cell lung cancer

Dijkstra, K. K., Vendramin, R., Karagianni, D., Witsen, M., Gálvez‐Cancino, F., Hill, M. S., Foster, K. A., Barbè, V., Angelova, M., Hynds, R. E., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.06.012 · Cited by 34

ICOS limits memory-like properties and function of exhausted PD-1 + CD8 T cells

Humblin, É., Korpas, I., Prokhnevska, N., Vaidya, A. B., Filipescu, D., Lu, J., van der Heide, V., Fraga, C. A. D. C., Bobrowski, T., Marks, A. R., et al. (2024) · Immunity · doi:10.1016/j.immuni.2025.06.001 · Cited by 26

Injectable Liquid Crystal Formation System for Reshaping Tumor Immunosuppressive Microenvironment to Boost Antitumor Immunity: Postoperative Chemoimmunotherapy

Hu, M. Y., Zhang, J., Yu, Y., Tu, K., Yang, T., Wang, Y., Hu, Q., Kong, L., & Zhang, Z. (2020) · Small · doi:10.1002/smll.202004905 · Cited by 26

Challenges and the Evolving Landscape of Assessing Blood-Based PD-L1 Expression as a Biomarker for Anti-PD-(L)1 Immunotherapy

Wang, T., Denman, D., Bacot, S. M., & Feldman, G. M. (2022) · Biomedicines · doi:10.3390/biomedicines10051181 · Cited by 27

Tissue-resident memory T cells from a metastatic vaginal melanoma patient are tumor-responsive T cells and increase after anti-PD-1 treatment

Pizzolla, A., Keam, S. P., Vergara, I. A., Caramia, F., Thio, N., Wang, M., Kocovski, N., Tantalo, D. G. M., Jabbari, J. S., Au‐Yeung, G., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004574 · Cited by 26

Current Therapeutic Strategies for Metastatic Triple-Negative Breast Cancer: From Pharmacists’ Perspective

Li, S., Bao, C., Huang, L., & Wei, J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11206021 · Cited by 28

Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2019) · Immunology · doi:10.1158/1538-7445.sabcs18-2701

Abstract A83: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6074.tumimm19-a83 · Cited by 3

Abstract A216: Functionally specialized subsets of exhausted CD8+ T-cells mediate tumor control and response to checkpoint blockade

Sen, D. R., Miller, B. C., Abosy, R. A., Bi, K., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., Manos, M. P., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr18-a216

Abstract 4683: Distinct subsets of dysfunctional CD8+ T cells underlie response to checkpoint blockade

Miller, B. C., Sen, D. R., Al-Abosy, R., Bi, K., Yates, K. B., Gjini, E., Felt, K. D., Manguso, R. T., Rodig, S. J., Sharpe, A. H., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4683

Chromatin State and Immunotherapy

Haining, W. N. (2018) · Blood · doi:10.1182/blood-2018-99-109432