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Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

Binnewies, M., Pollack, J. L., Rudolph, J., Dash, S., Abushawish, M., Lee, T., Jahchan, N. S., Canaday, P., Lu, E., Norng, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109844 · Cited by 365

Spatiotemporal Co-Dependency between Macrophages and Exhausted CD8 + T Cells in Cancer

Kersten, K., Hu, K. H., Combes, A. J., Samad, B., Harwin, T., Ray, A., Rao, A. A., Cai, E., Marchuk, K., Artichoker, J., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2022.05.004 · Cited by 357

BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells

Seo, H., González‐Avalos, E., Zhang, W., Ramchandani, P., Yang, C., Lio, C. J., Rao, A., & Hogan, P. G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00964-8 · Cited by 354

Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment

Marzagalli, M., Ebelt, N. D., & Manuel, E. R. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.002 · Cited by 358

Treatment of Advanced Melanoma in 2020 and Beyond

Jenkins, R. W., & Fisher, D. E. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.03.943 · Cited by 362

Principles and therapeutic applications of adaptive immunity

Chi, H., Pepper, M., & Thomas, P. G. (2024) · Cell · doi:10.1016/j.cell.2024.03.037 · Cited by 394

Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy

Jiang, W., He, Y., He, W., Wu, G. S., Zhou, X., Sheng, Q., Zhong, W., Lu, Y., Ding, Y., Qi, L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.622509 · Cited by 351

Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

Leo, A. D., Ugolini, A., Yu, X., Scirocchi, F., Scocozza, D., Peixoto, B., Pace, A., D’Angelo, L., Liu, J. K., Etame, A. B., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.006 · Cited by 348

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Galletti, G., De Simone, G., Mazza, E. M. C., Puccio, S., Mezzanotte, C., Bi, T. M., Davydov, A. N., Metsger, M., Scamardella, E., Alvisi, G., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0791-5 · Cited by 299

Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

Wu, H., Zhao, X., Hochrein, S. M., Eckstein, M., Gubert, G. F., Knöpper, K., Mansilla, A. M., Öner, A., Doucet-Ladevèze, R., Schmitz, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42634-3 · Cited by 351

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

Koh, C., Lee, S., Kwak, M., Kim, B., & Chung, Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01105-x · Cited by 379

Epigenetic regulation of T cell exhaustion

Belk, J. A., Dániel, B., & Satpathy, A. T. (2022) · Nature Immunology · doi:10.1038/s41590-022-01224-z · Cited by 346

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Utzschneider, D. T., Gabriel, S. S., Chisanga, D., Gloury, R., Gubser, P. M., Vasanthakumar, A., Shi, W., & Kallies, A. (2020) · Nature Immunology · doi:10.1038/s41590-020-0760-z · Cited by 319

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

Baldominos, P., Barbera-Mourelle, A., Barreiro, O., Huang, Y., Wight, A. E., Cho, J.-W., Zhao, X., Estivill, G., Adam, I., Sanchez, X., et al. (2022) · Cell · doi:10.1016/j.cell.2022.03.033 · Cited by 318

SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

Guo, C., You, Z., Shi, H., Sun, Y., Du, X., Palacios, G. F., Guy, C. S., Yuan, S., Chapman, N. M., Lim, S. A., et al. (2023) · Nature · doi:10.1038/s41586-023-06299-8 · Cited by 325

The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion

Globig, A.-M., Zhao, S., Roginsky, J., Maltez, V. I., Güiza, J., Avina-Ochoa, N., Heeg, M., Hoffmann, F. A., Chaudhary, O., Wang, J., et al. (2023) · Nature · doi:10.1038/s41586-023-06568-6 · Cited by 319

cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

Li, W., Lu, L., Lu, J., Wang, X., Yang, C., Jin, J., Wu, L., Hong, X., Li, F., Cao, D., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay9013 · Cited by 305

Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade

Budimir, N., Thomas, G. D., Dolina, J. S., & Salek‐Ardakani, S. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0515 · Cited by 301

IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

Zhao, Y., Chen, J., Andreatta, M., Feng, B., Xie, Y., Wenes, M., Wang, Y., Gao, M., Hu, X., Romero, P. J., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-023-02060-8 · Cited by 309

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

ElTanbouly, M. A., Zhao, Y., Nowak, E. C., Li, J., Schaafsma, E., Mercier, I. L., Ceeraz, S., Lines, J. L., Peng, C., Carrière, C., et al. (2020) · Science · doi:10.1126/science.aay0524 · Cited by 301

How chemokines organize the tumour microenvironment

Mempel, T. R., Lill, J. K., & Altenburger, L. M. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00635-w · Cited by 317

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

Schenkel, J. M., Herbst, R. H., Canner, D. A., Li, A., Hillman, M., Shanahan, S.-L., Gibbons, G., Smith, O. C. G., Kim, J. Y., Westcott, P. M. K., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.026 · Cited by 287

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

Andrews, L. P., Butler, S. C., Cui, J., Cillo, A. R., Cardello, C., Liu, C., Brunazzi, E. A., Baessler, A., Xie, B., Kunning, S. R., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.016 · Cited by 302

The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

Dong, L., Chen, C., Zhang, Y., Guo, P., Wang, Z., Li, J., Liu, Y., Liu, J., Chang, R., Li, Y., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.04.016 · Cited by 281

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

Deak, L. C., Nicolini, V., Hashimoto, M., Karagianni, M., Schwalie, P. C., Lauener, L., Varypataki, E. M., Richard, M., Bommer, E., Sam, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05192-0 · Cited by 286

Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities

Pauken, K. E., Dougan, M., Rose, N. R., Lichtman, A. H., & Sharpe, A. H. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.04.002 · Cited by 280

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

Rodriguez, A. B., Peske, J. D., Woods, A. N., Leick, K. M., Mauldin, I. S., Meneveau, M. O., Young, S. J., Lindsay, R. S., Melssen, M. M., Cyranowski, S., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109422 · Cited by 286

Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2019) · Immunology · doi:10.1158/1538-7445.sabcs18-2701

Abstract A83: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller, B. C., Sen, D. R., Abosy, R. A., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6074.tumimm19-a83 · Cited by 3

Abstract A216: Functionally specialized subsets of exhausted CD8+ T-cells mediate tumor control and response to checkpoint blockade

Sen, D. R., Miller, B. C., Abosy, R. A., Bi, K., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K. D., Naik, G. S., Manos, M. P., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr18-a216

Abstract 4683: Distinct subsets of dysfunctional CD8+ T cells underlie response to checkpoint blockade

Miller, B. C., Sen, D. R., Al-Abosy, R., Bi, K., Yates, K. B., Gjini, E., Felt, K. D., Manguso, R. T., Rodig, S. J., Sharpe, A. H., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4683

Chromatin State and Immunotherapy

Haining, W. N. (2018) · Blood · doi:10.1182/blood-2018-99-109432