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Repositioning TH cell polarization from single cytokines to complex help
Open accessAbstract
When helper T (T H) cell polarization was initially described three decades ago, the T H cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond T H 1 and T H 2 cells, this led to the coining of various T H 17 and regulatory (T reg) cell subsets as well as T H 22, T H 25, follicular helper (T FH), T H 3, T H 5 and T H 9 cells. High-dimensional single-cell analysis revealed that a categorization of T H cells into a single-cytokine-based nomenclature fails to capture the complexity and diversity of T H cells. Similar to the simple nomenclature used to describe innate lymphoid cells (ILCs), we propose that T H cell polarization should be categorized in terms of the help they provide to phagocytes (type 1), to B cells, eosinophils and mast cells (type 2) and to non-immune tissue cells, including the stroma and epithelium (type 3). Studying T H cells based on their helper function and the cells they help, rather than phenotypic features such as individual analyzed cytokines or transcription factors, better captures T H cell plasticity and conversion as well as the breadth of immune responses in vivo.
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“Th17 cells were established as an independent T helper cell subset with the discovery of signature cytokines IL-17A, IL-17F, and IL-22, lineage-specific differentiation factors, and dedicated or “master” transcription factors”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [14]
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“In 2006, the cytokines TGF-β and IL-6 were described as differentiation factors required to polarize naïve T cells into Th17 cells”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [14]
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Cites
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Self-citationPark, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Tolerance, Danger and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 5,107
Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 5,008
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
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Rafee, S. M. I. A., Alim, M. S.-U., Alam, S., & Salem, K. S. (2025) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2025.100916 · Cited by 9
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Metadata
- Authors
- Tuzlak, S., Dejean, A. S., Iannacone, M., Quintana, F. J., Waisman, A., Ginhoux, F., Korn, T., & Becher, B.
- Affiliations
- University of Zurich (CH)
- Centre National de la Recherche Scientifique (FR)
- Vita-Salute San Raffaele University (IT)
- Broad Institute (US)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Agency for Science, Technology and Research (SG)
- TUM Klinikum (DE)
- Corresponding author
- Korn, Thomas
- Becher, Burkhard
- ORCID
- Venue
- Nature Immunology
- Published
- 2021-09-20
- Volume
- 22
- Issue
- 10
- Pages
- 1210-1217
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W3200319266
- Cited by
- 171
- References
- 148
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 44 · 2023: 39 · 2022: 43 · 2021: 5
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- HAL (submittedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- National Multiple Sclerosis Society (RG4111A1, PA-1604-08459)
- European Molecular Biology Organization (RG4111A1)
- Gilead Sciences
- Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
- International Progressive MS Alliance (PA-1604-08459)
- Multiple Sclerosis Society (PA-1604-08459)
- Deutsche Forschungsgemeinschaft (SFB 1054, CRC1292, TRR‐156, EXC 2145, TRR-274, 390857198, TRR128, TRR156, CRC1292)
- Agence Nationale de la Recherche (ANR-16-CE15-0007)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (170320, 188450, 183478)
- Ministero della Salute (2018-, COVID-2020-12371617, RF-2018, RF-2018-12365801)
- Associazione Italiana per la Ricerca sul Cancro (19891 and 22737, 22737, 19891)
- National Institutes of Health (733 310030_170320, ES02530, RG4111A1, H2020, ES029136)
- Horizon 2020 Framework Programme (847782, 882424, 826121)
- Biomedical Research Council
- National Institute of Allergy and Infectious Diseases (R01AI126880)
- National Institute of Neurological Disorders and Stroke (R01NS102807)
- H2020 European Research Council (725038, 957502, 647215)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- T helper cell polarization, T helper subsets, helper functions, T helper type 1 cells, Th2 cells, T cell diversity, single-cell analysis, T cell help to B cells
- MeSH terms
- Cell Plasticity, Animals, B-Lymphocytes, Eosinophils, Epithelium, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Lymphocytes, Phagocytes, Cytokines
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