Cited by 172T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Repositioning TH cell polarization from single cytokines to complex help

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Tuzlak, Selma, Dejean, Anne S., Iannacone, Matteo, Quintana, Francisco J., Waisman, Ari, Ginhoux, Florent, Korn, Thomas, Becher, Burkhard·2021·Nature Immunology

DOI 10.1038/s41590-021-01009-w

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Abstract

When helper T (T H) cell polarization was initially described three decades ago, the T H cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond T H 1 and T H 2 cells, this led to the coining of various T H 17 and regulatory (T reg) cell subsets as well as T H 22, T H 25, follicular helper (T FH), T H 3, T H 5 and T H 9 cells. High-dimensional single-cell analysis revealed that a categorization of T H cells into a single-cytokine-based nomenclature fails to capture the complexity and diversity of T H cells. Similar to the simple nomenclature used to describe innate lymphoid cells (ILCs), we propose that T H cell polarization should be categorized in terms of the help they provide to phagocytes (type 1), to B cells, eosinophils and mast cells (type 2) and to non-immune tissue cells, including the stroma and epithelium (type 3). Studying T H cells based on their helper function and the cells they help, rather than phenotypic features such as individual analyzed cytokines or transcription factors, better captures T H cell plasticity and conversion as well as the breadth of immune responses in vivo.

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Authors: Tuzlak, S., Dejean, A. S., Iannacone, M., Quintana, F. J., Waisman, A., Ginhoux, F., Korn, T., & Becher, B.
Affiliations: University of Zurich (CH)
Centre National de la Recherche Scientifique (FR)
Vita-Salute San Raffaele University (IT)
Broad Institute (US)
University Medical Center of the Johannes Gutenberg University Mainz (DE)
Agency for Science, Technology and Research (SG)
TUM Klinikum (DE)
Corresponding author: Korn, Thomas
Becher, Burkhard
ORCID: Tuzlak, Selma
Dejean, Anne S.
Iannacone, Matteo
Quintana, Francisco J.
Waisman, Ari
Ginhoux, Florent
Korn, Thomas
Becher, Burkhard
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2021-09-20
Volume: 22
Issue: 10
Pages: 1210-1217
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/s41590-021-01009-w
OpenAlex: W3200319266
Cited by: 171
References: 148
Citations by year: 2026: 16 · 2025: 24 · 2024: 44 · 2023: 39 · 2022: 43 · 2021: 5
FWCI: 3.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
HAL (submittedVersion)
Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
mediaTUM (Technical University of Munich) (submittedVersion)
GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: National Science Foundation
National Multiple Sclerosis Society (RG4111A1, PA-1604-08459)
European Molecular Biology Organization (RG4111A1)
Gilead Sciences
Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
International Progressive MS Alliance (PA-1604-08459)
Multiple Sclerosis Society (PA-1604-08459)
Deutsche Forschungsgemeinschaft (SFB 1054, CRC1292, TRR‐156, EXC 2145, TRR-274, 390857198, TRR128, TRR156, CRC1292)
Agence Nationale de la Recherche (ANR-16-CE15-0007)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (170320, 188450, 183478)
Ministero della Salute (2018-, COVID-2020-12371617, RF-2018, RF-2018-12365801)
Associazione Italiana per la Ricerca sul Cancro (19891 and 22737, 22737, 19891)
National Institutes of Health (733 310030_170320, ES02530, RG4111A1, H2020, ES029136)
Horizon 2020 Framework Programme (847782, 882424, 826121)
Biomedical Research Council
National Institute of Allergy and Infectious Diseases (R01AI126880)
National Institute of Neurological Disorders and Stroke (R01NS102807)
H2020 European Research Council (725038, 957502, 647215)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: T helper cell polarization, T helper subsets, helper functions, T helper type 1 cells, Th2 cells, T cell diversity, single-cell analysis, T cell help to B cells
MeSH terms: Cell Plasticity, Animals, B-Lymphocytes, Eosinophils, Epithelium, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Lymphocytes, Phagocytes, Cytokines

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