Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Open accessAbstract
Naïve CD8+ T cells can differentiate into effector (T eff), memory (T mem) or exhausted (T ex) T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different functional capacities and therefore therapeutic potential. The molecular circuitry underlying these developmental trajectories and the extent of heterogeneity within T eff, T mem and T ex populations remain poorly understood. Here, we used the lymphocytic choriomeningitis virus model of acute-resolving and chronic infection to address these gaps by applying longitudinal single-cell RNA-sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) analyses. These analyses uncovered new subsets, including a subpopulation of T ex cells expressing natural killer cell-associated genes that is dependent on the transcription factor Zeb2, as well as multiple distinct TCF-1+ stem/progenitor-like subsets in acute and chronic infection. These data also revealed insights into the reshaping of T ex subsets following programmed death 1 (PD-1) pathway blockade and identified a key role for the cell stress regulator, Btg1, in establishing the T ex population. Finally, these results highlighted how the same biological circuits such as cytotoxicity or stem/progenitor pathways can be used by CD8+ T cell subsets with highly divergent underlying chromatin landscapes generated during different infections.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Compared to Tpex and tTex cells, cTem cells had transcriptomes more enriched in antigen-specific effector memory T cells in mice infected with acute LCMV and less enriched in exhausted T cells from chronic LCMV infection.
“Compared to Tpex and tTex cells, cTem cells had transcriptomes more enriched in antigen-specific effector memory T cells in mice infected with the acute Armstrong strain of lymphocytic choriomeningitis virus (LCMV) and less enriched in exhausted T cells from chronic LCMV infection.61”
From Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer (2025) · cites this paper as [61]
The Results sections describe effector-memory cells after acute Armstrong infection and exhausted T-cell subsets after chronic Cl13 infection, but they do not report the claimed transcriptomic-enrichment comparison. Searches for cTem, Tpex, tTex, and the comparative enrichment did not locate that analysis in our copy; the source may provide reference profiles, but it does not establish the citing sentence’s result. (LLM, conf=0.74)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070 · see citing works
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
McLane, L. M., Abdel-Hakeem, M. S., & Wherry, E. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055318 · Cited by 1,973 · see citing works
Self-citationLineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864 · see citing works
Self-citationJoshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861 · see citing works
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830 · see citing works
Self-citationTOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Khan, O., Giles, J. R., McDonald, S., Manne, S., Ngiow, S. F., Patel, K. P., Werner, M. T., Huang, A. C., Alexander, K. A., Wu, J. E., et al. (2019) · Nature · doi:10.1038/s41586-019-1325-x · Cited by 1,646 · see citing works
Self-citationPan-cancer single-cell landscape of tumor-infiltrating T cells
Zheng, L., Qin, S., Si, W., Wang, A., Xing, B., Gao, R., Ren, X., Wang, L., Wu, X., Zhang, J., et al. (2021) · Science · doi:10.1126/science.abe6474 · Cited by 1,402 · see citing works
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Pauken, K. E., Sammons, M. A., Odorizzi, P. M., Manne, S., Godec, J., Khan, O., Drake, A. M., Chen, Z., Sen, D. R., Kurachi, M., et al. (2016) · Science · doi:10.1126/science.aaf2807 · Cited by 1,348 · see citing works
Self-citationThe energetics of genome complexity.
Lane, N., & Martin, W. (2010) · Nature · doi:10.1038/nature09486 · Cited by 1,289 · see citing works
Corces, M. R., Buenrostro, J. D., Wu, B., Greenside, P. G., Chan, S. M., Koenig, J. L., Snyder, M. P., Pritchard, J. K., Kundaje, A., Greenleaf, W. J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3646 · Cited by 1,151 · see citing works
TOX is a critical regulator of tumour-specific T cell differentiation
Scott, A. C., Dündar, F., Zumbo, P., Chandran, S. S., Klebanoff, C. A., Shakiba, M., Trivedi, P., Menocal, L., Appleby, H., Camara, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1324-y · Cited by 1,106 · see citing works
Beltra, J., Manne, S., Abdel-Hakeem, M. S., Kurachi, M., Giles, J. R., Chen, Z., Casella, V., Ngiow, S. F., Khan, O., Huang, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.014 · Cited by 1,091 · see citing works
Self-citationUtzschneider, D. T., Charmoy, M., Chennupati, V., Pousse, L., Ferreira, D., Calderon-Copete, S. P., Danilo, M., Alfei, F., Hofmann, M., Wieland, D., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.021 · Cited by 1,026 · see citing works
The epigenetic landscape of T cell exhaustion
Sen, D. R., Kaminski, J., Barnitz, R. A., Kurachi, M., Gerdemann, U., Yates, K. B., Tsao, H.-W., Godec, J., LaFleur, M. W., Brown, F. D., et al. (2016) · Science · doi:10.1126/science.aae0491 · Cited by 986 · see citing works
Self-citationChromatin states define tumour-specific T cell dysfunction and reprogramming
Philip, M., Fairchild, L., Sun, L., Horste, E. L., Camara, S., Shakiba, M., Scott, A. C., Viale, A., Lauer, P., Merghoub, T., et al. (2017) · Nature · doi:10.1038/nature22367 · Cited by 933 · see citing works
Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection
Paley, M., Kroy, D. C., Odorizzi, P. M., Johnnidis, J. B., Dolfi, D. V., Barnett, B. E., Bikoff, E. K., Robertson, E. J., Lauer, G. M., Reiner, S. L., et al. (2012) · Science · doi:10.1126/science.1229620 · Cited by 903 · see citing works
Self-citationTOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
Alfei, F., Kanev, K., Hofmann, M., Wu, M., Ghoneim, H. E., Roelli, P., Utzschneider, D. T., von Hoesslin, M., Cullen, J. G., Fan, Y., et al. (2019) · Nature · doi:10.1038/s41586-019-1326-9 · Cited by 900 · see citing works
TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision
Chen, Z., Ji, Z., Ngiow, S. F., Manne, S., Cai, Z., Huang, A. C., Johnson, J., Staupe, R. P., Bengsch, B., Xu, C., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.013 · Cited by 709 · see citing works
Self-citationAn Optimized microRNA Backbone for Effective Single-Copy RNAi
Fellmann, C., Hoffmann, T., Sridhar, V., Hopfgartner, B., Muhar, M., Roth, M., Lai, D. Y., Barbosa, I. A. M., Kwon, J. S., Guan, Y., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.020 · Cited by 705 · see citing works
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma
Huang, A. C. C., Orlowski, R. J., Xu, X., Mick, R., George, S. M., Yan, P., Manne, S., Kraya, A., Wubbenhorst, B. S., Dorfman, L. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0357-y · Cited by 680 · see citing works
Self-citationRunx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
Milner, J. J., Toma, C., Yu, B., Zhang, K., Omilusik, K., Phan, A. T., Wang, D., Getzler, A. J., Nguyen, T., Crotty, S., et al. (2017) · Nature · doi:10.1038/nature24993 · Cited by 677 · see citing works
Hudson, W. H., Gensheimer, J., Hashimoto, M., Wieland, A., Valanparambil, R. M., Li, P., Lin, J.-X., Konieczny, B. T., Im, S. J., Freeman, G. J., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.11.002 · Cited by 656 · see citing works
Tissue-Resident T Cells and Other Resident Leukocytes
Masopust, D., & Soerens, A. G. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053214 · Cited by 608 · see citing works
Zander, R. A., Schauder, D. M., Xin, G., Nguyen, C., Wu, X.-P., Zajac, A., & Cui, W. (2019) · Immunity · doi:10.1016/j.immuni.2019.10.009 · Cited by 576 · see citing works
Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade
Blackburn, S. D., Shin, H., Freeman, G. J., & Wherry, E. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801497105 · Cited by 575 · see citing works
Self-citationSingle-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection
Yao, C., Sun, H.-W., Lacey, N. E., Ji, Y., Moseman, E. A., Shih, H.-Y., Heuston, E. F., Kirby, M., Anderson, S., Cheng, J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0403-4 · Cited by 549 · see citing works
Self-citationStem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
Krishna, S., Lowery, F. J., Copeland, A. R., Bahadiroglu, E., Mukherjee, R., Jia, L., Anibal, J., Sachs, A., Adebola, S. O., Gurusamy, D., et al. (2020) · Science · doi:10.1126/science.abb9847 · Cited by 541 · see citing works
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
Wherry, E. J., Barber, D. L., Kaech, S. M., Blattman, J. N., & Ahmed, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407192101 · Cited by 495 · see citing works
Self-citationGenetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
Odorizzi, P. M., Pauken, K. E., Paley, M., Sharpe, A. H., & Wherry, E. J. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20142237 · Cited by 464 · see citing works
Self-citationMartin, M. D., & Badovinac, V. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02692 · Cited by 432 · see citing works
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Mathewson, N. D., Ashenberg, O., Tirosh, I., Gritsch, S., Perez, E. M., Marx, S., Jerby‐Arnon, L., Chanoch-Myers, R., Hara, T., Richman, A. R., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.022 · Cited by 402 · see citing works
An NK-like CAR T cell transition in CAR T cell dysfunction
Good, C. R., Aznar, M. A., Kuramitsu, S., Samareh, P., Agarwal, S., Donahue, G., Ishiyama, K., Wellhausen, N., Rennels, A. K., Ma, Y., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.016 · Cited by 396 · see citing works
The cis-Regulatory Atlas of the Mouse Immune System
Yoshida, H., Lareau, C. A., Ramírez, R. N., Rose, S. A., Maier, B. B., Wroblewska, A., Desland, F. A., Chudnovskiy, A., Mortha, A., Dominguez, C. X., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.036 · Cited by 375 · see citing works
Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells
Bowman, T. V., Merchant, A. A., Ramos, C. A., Whitehouse, N. L., Young, A., Shaw, C. A., & Goodell, M. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020301 · Cited by 363 · see citing works
NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines
van Montfoort, N., Borst, L., Korrer, M. J., Sluijter, M., Marijt, K. A., Santegoets, S. J. A. M., van Ham, V. J., Ehsan, I., Charoentong, P., André, P., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.028 · Cited by 334 · see citing works
Angelosanto, J., Blackburn, S. D., Crawford, A., & Wherry, E. J. (2012) · Journal of Virology · doi:10.1128/jvi.00889-12 · Cited by 285 · see citing works
Self-citationViral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection
Shin, H., Blackburn, S. D., Blattman, J. N., & Wherry, E. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061937 · Cited by 273 · see citing works
Self-citationDominguez, C. X., Amezquita, R., Guan, T.-X., Marshall, H. D., Joshi, N., Kleinstein, S., & Kaech, S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150186 · Cited by 265 · see citing works
Omilusik, K. D., Best, J. A., Yu, B., Goossens, S., Weidemann, A., Nguyen, J. V., Seuntjens, E., Stryjewska, A., Zweier, C., Roychoudhuri, R., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150194 · Cited by 260 · see citing works
Abdel-Hakeem, M. S., Manne, S., Beltra, J., Stelekati, E., Chen, Z., Nzingha, K., Ali, M.-A., Johnson, J. L., Giles, J. R., Mathew, D., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00975-5 · Cited by 254 · see citing works
Self-citationEpigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
Yates, K. B., Tonnerre, P., Martin, G. E., Gerdemann, U., Abosy, R. A., Comstock, D. E., Weiss, S. A., Wolski, D., Tully, D. C., Chung, R. T., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00979-1 · Cited by 253 · see citing works
Tumor suppressors BTG1 and BTG2: Beyond growth control
Yuniati, L., Scheijen, B., van der Meer, L. T., & van Leeuwen, F. N. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27407 · Cited by 231 · see citing works
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Chen, Z., Arai, E., Khan, O., Zhang, Z., Ngiow, S. F., He, Y. M., Huang, H., Manne, S., Cao, Z., Baxter, A. E., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.019 · Cited by 201 · see citing works
Self-citationBACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells
Yao, C., Lou, G., Sun, H., Zhu, Z., Sun, Y. E., Chen, Z., Chauss, D., Moseman, E. A., Cheng, J., D’Antonio, M. A., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00868-7 · Cited by 200 · see citing works
Self-citationExpression and function of NK cell receptors in CD8+ T cells
McMahon, C. W., & Raulet, D. H. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00242-9 · Cited by 169 · see citing works
Translation is actively regulated during the differentiation of CD8+ effector T cells
Araki, K., Morita, M., Bederman, A., Konieczny, B. T., Kissick, H. T., Sonenberg, N., & Ahmed, R. (2017) · Nature Immunology · doi:10.1038/ni.3795 · Cited by 164 · see citing works
McMahon, C. W., Zajac, A. J., Jamieson, A. M., Corral, L. G., Hammer, G. E., Ahmed, R., & Raulet, D. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1444 · Cited by 162 · see citing works
ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates
Guan, T., Dominguez, C. X., Amezquita, R. A., Laidlaw, B. J., Cheng, J., Henao‐Mejia, J., Williams, A., Flavell, R. A., Lü, J., & Kaech, S. M. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171352 · Cited by 159 · see citing works
Giles, J. R., Manne, S., Freilich, E., Oldridge, D. A., Baxter, A. E., George, S. M., Chen, Z., Huang, H., Chilukuri, L., Carberry, M., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.02.004 · Cited by 114 · see citing works
Self-citationEfficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies
Nüssing, S., House, I. G., Kearney, C. J., Chen, A. X. Y., Vervoort, S. J., Beavis, P. A., Oliaro, J., Johnstone, R. W., Trapani, J. A., & Parish, I. A. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901396 · Cited by 90 · see citing works
Chung, H., McDonald, B., & Kaech, S. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201730 · Cited by 86 · see citing works
Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function
Kurachi, M., Kurachi, J., Chen, Z., Johnson, J. L., Khan, O., Bengsch, B., Stelekati, E., Attanasio, J., McLane, L. M., Tomura, M., et al. (2017) · Nature Protocols · doi:10.1038/nprot.2017.083 · Cited by 78 · see citing works
Self-citationWill, B., Vogler, T. O., Bartholdy, B. A., Garrett-Bakelman, F., Mayer, J., Barreyro, L., Pandolfi, A., Todorova, T. I., Okoye-Okafor, U. C., Stanley, R. F., et al. (2013) · Nature Immunology · doi:10.1038/ni.2572 · Cited by 73 · see citing works
Raulet, D. H., Marcus, A., & Coscoy, L. (2017) · Immunological Reviews · doi:10.1111/imr.12600 · Cited by 65 · see citing works
Role of Lef1 in sustaining self-renewal in mouse embryonic stem cells
Huang, C. L., & Qin, D. (2010) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(09)60063-1 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,060 · see citing works
CD8+ T cells in the cancer-immunity cycle
Giles, J. R., Globig, A.-M., Kaech, S. M., & Wherry, E. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.005 · Cited by 467 · see citing works
Self-citationAndrews, L. P., Butler, S. C., Cui, J., Cillo, A. R., Cardello, C., Liu, C., Brunazzi, E. A., Baessler, A., Xie, B., Kunning, S. R., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.016 · Cited by 286 · see citing works
Self-citationCombined JAK inhibition and PD-1 immunotherapy for non–small cell lung cancer patients
Mathew, D., Marmarelis, M. E., Foley, C., Bauml, J. M., Ye, D., Ghinnagow, R., Ngiow, S. F., Klapholz, M., Jun, S., Zhang, Z., et al. (2024) · Science · doi:10.1126/science.adf1329 · Cited by 246 · see citing works
Self-citationStem-like exhausted and memory CD8+ T cells in cancer
Gebhardt, T., Park, S. L., & Parish, I. A. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00615-0 · Cited by 216 · see citing works
Heczey, A. A., Xu, X. Y., Courtney, A. N., Tian, G., Barragán, G. A., Guo, L., Martínez-Amador, C., Ghatwai, N., Rathi, P., Wood, M. S., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02363-y · Cited by 212 · see citing works
Self-citationBeltra, J., Abdel-Hakeem, M. S., Manne, S., Zhang, Z., Huang, H., Kurachi, M., Su, L., Picton, L. K., Ngiow, S. F., Muroyama, Y., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.11.005 · Cited by 141 · see citing works
Self-citationLocalization, tissue biology and T cell state — implications for cancer immunotherapy
Schenkel, J. M., & Pauken, K. E. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00884-8 · Cited by 139 · see citing works
Pichler, A., Carrié, N., Cuisinier, M., Ghazali, S., Voisin, A., Axisa, P., Tosolini, M., Mazzotti, C., Golec, D. P., Mahéo, S., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.007 · Cited by 118 · see citing works
Luo, Y., Xia, Y., Liu, D., Li, X., Li, H., Liu, J., Zhou, D., Dong, Y. J., Li, X., Qian, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.013 · Cited by 115 · see citing works
Wang, K., Coutifaris, P., Brocks, D., Wang, G., Azar, T., Solis, S., Nandi, A., Anderson, S., Han, N. A., Manne, S., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.08.007 · Cited by 120 · see citing works
Self-citationNgiow, S. F., Manne, S., Huang, Y., Azar, T., Chen, Z., Mathew, D., Chen, Q., Khan, O., Wu, J. E., Alcalde, V., et al. (2024) · Cell · doi:10.1016/j.cell.2024.07.018 · Cited by 112 · see citing works
Self-citationCytokine-mediated CAR T therapy resistance in AML
Bhagwat, A. S., Torres, L., Shestova, O. E., Shestov, M., Mellors, P. W., Fisher, H. R., Farooki, S., Frost, B. F., Loken, M. R., Gaymon, A. L., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03271-5 · Cited by 107 · see citing works
Regulation of CD8+ T memory and exhaustion by the mTOR signals
Chen, Y., Xu, Z., Sun, H., Ouyang, X.-X., Han, Y.-H., Yu, H., Wu, N.-B., Xie, Y., & Su, B. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-01064-3 · Cited by 91 · see citing works
In vitro modeling of CD8 + T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40
Wu, J. E., Manne, S., Ngiow, S. F., Baxter, A. E., Huang, H., Freilich, E., Clark, M. L., Lee, J. H., Chen, Z., Khan, O., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.ade3369 · Cited by 96 · see citing works
Self-citationGuo, X., Nie, H., Zhang, W., Li, J., Ge, J., Xie, B., Hu, W., Zhu, Y., Zhong, N., Zhang, X., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.01.001 · Cited by 100 · see citing works
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
Bulliard, Y., Andersson, B. S., Baysal, M. A., Damiano, J. S., & Tsimberidou, A. M. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01504-7 · Cited by 95 · see citing works
Exploiting temporal aspects of cancer immunotherapy
Zemek, R. M., Anagnostou, V., da Silva, I. P., Long, G. V., & Lesterhuis, W. (2024) · Nature Reviews. Cancer · doi:10.1038/s41568-024-00699-2 · Cited by 90 · see citing works
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
Fagerberg, E., Attanasio, J., Dien, C., Singh, J., Kessler, E., Abdullah, L., Shen, J., Hunt, B. G., Connolly, K. A., Brouwer, E. D., et al. (2025) · Science · doi:10.1126/science.adn2337 · Cited by 89 · see citing works
Self-citationRegulators of CD8+ T cell exhaustion
Sun, Q., & Dong, C. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01221-x · Cited by 90 · see citing works
Baxter, A. E., Huang, H., Giles, J. R., Chen, Z., Wu, J. E., Drury, S., Tuite-Dalton, K. A., Park, S. L., Torres, L., Simone, B. W., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.05.008 · Cited by 81 · see citing works
Self-citationCellular and molecular waypoints along the path of T cell exhaustion
Lan, X., Zebley, C. C., & Youngblood, B. (2023) · Science Immunology · doi:10.1126/sciimmunol.adg3868 · Cited by 84 · see citing works
Targeting mitochondria: restoring the antitumor efficacy of exhausted T cells
Yang, M., Zhang, S., Sun, L., Huang, L., Yu, J., Zhang, J.-H., Tian, Y., Han, C., & Ma, J. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02175-9 · Cited by 83 · see citing works
Architects of immunity: How dendritic cells shape CD8 + T cell fate in cancer
Bhandarkar, V., Dinter, T., & Spranger, S. (2025) · Science Immunology · doi:10.1126/sciimmunol.adf4726 · Cited by 83 · see citing works
Transgelin 2 guards T cell lipid metabolism and antitumour function
Hwang, S., Awasthi, D., Jeong, J., Sandoval, T. A., Chae, C.-S., Ramos, Y., Chen, T., Falco, M. M., Salvagno, C., Emmanuelli, A., et al. (2024) · Nature · doi:10.1038/s41586-024-08071-y · Cited by 78 · see citing works
An early precursor CD8+ T cell that adapts to acute or chronic viral infection
McManus, D. T., Valanparambil, R. M., Medina, C. B., Scharer, C. D., McGuire, D. J., Sobierajska, E., Hu, Y., Chang, D. Y., Wieland, A., Lee, J., et al. (2025) · Nature · doi:10.1038/s41586-024-08562-y · Cited by 75 · see citing works
Escape from T-cell–targeting immunotherapies in acute myeloid leukemia
Vadakekolathu, J. N., & Rutella, S. (2023) · Blood · doi:10.1182/blood.2023019961 · Cited by 73 · see citing works
Dolina, J. S., Lee, J., Brightman, S. E., McArdle, S., Hall, S. M., Thota, R. R., Zavala, K. S., Lanka, M., Premlal, A. L. R., Greenbaum, J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci164258 · Cited by 68 · see citing works
Attenuated effector T cells are linked to control of chronic HBV infection
Heim, K., Sagar, Sogukpinar, Ö., Llewellyn‐Lacey, S., Price, D. A., Emmerich, F., Kraft, A. R. M., Cornberg, M., Kielbassa, S., Knolle, P. A., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01928-4 · Cited by 67 · see citing works
FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells
Zhu, Z., Lou, G., Teng, X.-L., Wang, H., Luo, Y., Shi, W., Yihunie, K. D., Hao, S., DeGolier, K., Liao, C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01685-w · Cited by 66 · see citing works
Self-citationAhn, T., Bae, E., & Seo, H. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.04.004 · Cited by 70 · see citing works
Parry, E. M., Lemvigh, C. K., Deng, S., Dangle, N. J., Ruthen, N. G., Knisbacher, B. A., Broséus, J., Hergalant, S., Guièze, R., Li, S., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.08.013 · Cited by 63 · see citing works
Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction
Selli, M. E., Landmann, J. H., Terekhova, M., Lattin, J., Heard, A. D., Hsu, Y.-S., Chang, T.-C., Chang, J., Warrington, J. M., Ha, H., et al. (2023) · Blood · doi:10.1182/blood.2023020100 · Cited by 62 · see citing works
Exhausted CD8+ T cells face a developmental fork in the road
Zander, R., & Cui, W. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.02.006 · Cited by 61 · see citing works
Minnie, S. A., Waltner, O. G., Zhang, P., Takahashi, S., Nemychenkov, N. S., Ensbey, K. S., Schmidt, C. R., Legg, S. R. W., Comstock, M., Boiko, J. R., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adg1094 · Cited by 57 · see citing works
Morgan, D. M., Horton, B. L., Bhandarkar, V., Van, R., Dinter, T., Zagorulya, M., Love, J. C., & Spranger, S. (2024) · Science Immunology · doi:10.1126/sciimmunol.adi3487 · Cited by 59 · see citing works
Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement
Lan, X., Tian, M., Alli, S., Guy, C. S., Djekidel, M. N., Liu, X., Boi, S. K., Chowdhury, P. S., He, M.-H., Zehn, D., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01843-8 · Cited by 58 · see citing works
Rausch, L., & Kallies, A. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082223-044122 · Cited by 60 · see citing works
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
Huang, Y., Ngiow, S. F., Baxter, A. E., Manne, S., Park, S. L., Wu, J. E., Khan, O., Giles, J. R., & Wherry, E. J. (2025) · Science Immunology · doi:10.1126/sciimmunol.ado3032 · Cited by 53 · see citing works
Self-citationEpigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
Weiss, S. A., Huang, A. Y., Fung, M. E., Martínez, D., Chen, C.-Y., LaSalle, T. J., Miller, B. C., Scharer, C. D., Hegde, M., Nguyen, T. H., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01961-3 · Cited by 52 · see citing works
Self-citationACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses
Kaymak, I., Watson, M. J., Oswald, B. M., Ma, S., Johnson, B. K., DeCamp, L. M., Mabvakure, B. M., Luda, K. M., Ma, E. H., Lau, K. H., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20231820 · Cited by 53 · see citing works
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
Chen, X., Shen, Y., Choi, S., Abdel-Hafiz, H. A., Basu, M., Hoelzen, L., Tufano, M., Kailasam Mani, S. K., Ranjpour, M., Zhu, J., et al. (2025) · Nature · doi:10.1038/s41586-025-09071-2 · Cited by 50 · see citing works
Nutsch, K., Banta, K. L., Wu, T. D., Tran, C. W., Mittman, S., Duong, E., Nabet, B. Y., Qu, Y., Williams, K., Müller, S., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00870-6 · Cited by 49 · see citing works
The role of the CD8+ T cell compartment in ageing and neurodegenerative disorders
Terrabuio, E., Zenaro, E., & Constantin, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1233870 · Cited by 48 · see citing works
Corría-Osorio, J., Carmona, S. J., Stefanidis, E., Andreatta, M., Ortiz-Miranda, Y., Muller, T., Rota, I. A., Crespo, I., Seijo, B., Castro, W., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01477-2 · Cited by 47 · see citing works
CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia
Mazziotta, F., Biavati, L., Rimando, J. C., Rutella, S., Borcherding, N. C., Parbhoo, S., Mukhopadhyay, R., Chowdhury, S., Knaus, H. A., Valent, P., et al. (2024) · Blood · doi:10.1182/blood.2023021680 · Cited by 41 · see citing works
Landscapes and mechanisms of CD8+ T cell exhaustion in gastrointestinal cancer
Ding, J., Yang, K., Zhou, H., Huang, Y.-F., Li, H., & Zong, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1149622 · Cited by 41 · see citing works
Self-citationT follicular helper cells in cancer, tertiary lymphoid structures, and beyond
Cui, C., Craft, J. E., & Joshi, N. S. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101797 · Cited by 39 · see citing works
Advancing beyond the twists and turns of T cell exhaustion in cancer
van der Heide, V., Humblin, É., Vaidya, A. B., & Kamphorst, A. O. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo4997 · Cited by 39 · see citing works
Dimitri, A. J., Baxter, A. E., Chen, G. M., Hopkins, C. R., Rouin, G. T., Huang, H., Kong, W., Holliday, C., Wiebking, V., Bartoszek, R. L., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp9371 · Cited by 37 · see citing works
Self-citationIntegrative mapping of human CD8+ T cells in inflammation and cancer
Xue, Z., Wu, L., Tian, R., Gao, B. X., Zhao, Y. S., He, B., Sun, D., Zhao, B., Li, Y., Zhu, K., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02530-0 · Cited by 37 · see citing works
The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer
Zhang, J., Lei, F., & Tan, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1166128 · Cited by 36 · see citing works
Zhang, H., Luo, X.-J., Yang, W., Wu, Z., Zhao, Z., Pei, X., Zhang, X., Chen, C., Lei, J. H., Shi, Q., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53997-6 · Cited by 35 · see citing works
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
Xiong, D., Zhang, L., & Sun, Z. (2023) · Military Medical Research · doi:10.1186/s40779-023-00496-2 · Cited by 35 · see citing works
Kharel, A., Shen, J., Brown, R. J., Chen, Y., Nguyen, C. P., Alson, D., Bluemn, T., Fan, J., Gai, K., Zhang, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112649 · Cited by 31 · see citing works
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy
Xiong, D., Yu, H., & Sun, Z. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.04.022 · Cited by 31 · see citing works
Green, W. D., Gomez, A., Plotkin, A. L., Pratt, B. M., Merritt, E. F., Mullins, G. N., Kren, N. P., Modliszewski, J. L., Zhabotynsky, V., Woodcock, M. G., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.030 · Cited by 31 · see citing works
Tsui, C., Heyden, L., Wen, L., de Graça, C. G., Potemkin, N., Frolov, A., Rawlinson, D., Qin, L., Wimmer, V. C., Hadian-Jazi, M., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02276-7 · Cited by 31 · see citing works
Epigenetic regulation of T cell exhaustion in cancer
Kang, T. G., Johnson, J. T., Zebley, C. C., & Youngblood, B. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00883-y · Cited by 35 · see citing works
Chen, Z., Zhu, Z., Hu, T., Yao, C., & Wu, T. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01378-4 · Cited by 36 · see citing works
Byl, W. V. D., Nüssing, S., Peters, T. J., Ahn, A., Li, H., Ledergor, G., David, E., Koh, A. S., Wagle, M. V., Deguit, C. D. T., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.026 · Cited by 28 · see citing works
Roussot, N., Kaderbhaï, C., & Ghiringhelli, F. (2025) · Cancers · doi:10.3390/cancers17050906 · Cited by 29 · see citing works
Humoral determinants of checkpoint immunotherapy
Dai, Y., Aizenbud, L., Qin, K., Austin, M. R., Jaycox, J. R., Cunningham, J., Wang, E. Y., Zhang, L., Fischer, S., Carroll, S. M., et al. (2025) · Nature · doi:10.1038/s41586-025-09188-4 · Cited by 28 · see citing works
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors
Burn, T. N., Schröder, J., Gandolfo, L. C., Osman, M., Wainwright, E. N., Lam, E. Y. N., McDonald, K. M., Evans, R., Li, S., Rawlinson, D., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02347-9 · Cited by 32 · see citing works
Yu, A., Hu, J., Fu, L., Huang, G., Deng, D., Zhang, M., Wang, Y., Shu, G., Jing, L., Li, H., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007230 · Cited by 28 · see citing works
da Silva, J. G., Ferreira, D. P., Dumez, A., Wyss, T., Veber, R., Danilo, M., Pinschewer, D. D., Charmoy, M., & Held, W. (2023) · Science Immunology · doi:10.1126/sciimmunol.adh3113 · Cited by 27 · see citing works
CBX4 suppresses CD8 + T cell antitumor immunity by reprogramming glycolytic metabolism
Wang, J., Jia, W., Zhou, X. K., Ma, Z., Liu, J., & Lan, P. (2024) · Theranostics · doi:10.7150/thno.95748 · Cited by 26 · see citing works
Humblin, É., Korpas, I., Prokhnevska, N., Vaidya, A. B., Filipescu, D., Lu, J., van der Heide, V., Fraga, C. A. D. C., Bobrowski, T., Marks, A. R., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.06.001 · Cited by 26 · see citing works
Intestinal tuft cell immune privilege enables norovirus persistence
Strine, M. S., Fagerberg, E., Darcy, P. W., Barrón, G. M., Filler, R. B., Alfajaro, M. M., D'Angelo-Gavrish, N. M., Wang, F., Graziano, V. R., Menasché, B. L., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adi7038 · Cited by 25 · see citing works
TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma
Bao, K., Gu, X., Song, Y., Zhou, Y., Chen, Y., Yu, X., Yuan, W., Shi, L., Zheng, J., & Hong, M. (2024) · Nature Communications · doi:10.1038/s41467-024-52252-2 · Cited by 25 · see citing works
Zhu, Z., Luo, Y., Lou, G., Yihunie, K. D., Wizzard, S., DeVilbiss, A., Muh, S., Ma, C., Shinde, S. S., Hoar, J., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adk2954 · Cited by 25 · see citing works
Blake, M. K., O’Connell, P. M., & Aldhamen, Y. A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1082195 · Cited by 26 · see citing works
Phenotypic and spatial heterogeneity of CD8+ tumour infiltrating lymphocytes
Sun, Y.-K., Yinwang, E., Wang, S.-D., Wang, Z.-N., Wang, F., Xue, Y., Zhang, W., Zhao, S.-Z., Mou, H., Chen, S.-X., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02104-w · Cited by 27 · see citing works
The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustion
Dahabieh, M. S., DeCamp, L. M., Oswald, B. M., Kitchen-Goosen, S. M., Fu, Z. F., Vos, M., Compton, S. E., Longo, J., Foy, N. M., Williams, K. S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02185-9 · Cited by 24 · see citing works
Enhancing personalized immune checkpoint therapy by immune archetyping and pharmacological targeting
Cerella, C., Dicato, M. A., & Diederich, M. F. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106914 · Cited by 24 · see citing works
Sustained AhR activity programs memory fate of early effector CD8 + T cells
Zhang, H., Yang, Z., Wu, Y., Liu, J., Luo, X. L., Zhang, Q., Li, Y., Chen, J., Zhou, Y., Lv, J., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317658121 · Cited by 22 · see citing works
Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
Lin, C., Levy, P. L., Alflen, A., Apriamashvili, G., Ligtenberg, M. A., Vredevoogd, D. W., Bleijerveld, O. B., Alkan, F., Malka, Y., Hoekman, L., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.02.016 · Cited by 21 · see citing works
Adapting systems biology to address the complexity of human disease in the single-cell era
Fischer, D. S., Villanueva, M. A., Winter, P. S., & Shalek, A. K. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-025-00821-6 · Cited by 30 · see citing works
Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor control
Ham, H., Hirdler, J. B., Bihnam, D., Mao, Z., Gicobi, J. K., Macedo, B. D. G., Rodriguez-Quevedo, M. F., Schultz, D. F., Correia, C., Zhong, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56931-6 · Cited by 20 · see citing works
Park, S. L., Painter, M. M., Manne, S., Alcalde, V., McLaughlin, M., Sullivan, M. A., Mathew, D., Torres, L., Huang, Y., Reeg, D. B., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02352-y · Cited by 21 · see citing works
Self-citationNK-like CD8 T cell: one potential evolutionary continuum between adaptive memory and innate immunity
Wang, Q., Chen, S., Guo, Z., Xia, S., & Zhang, M. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae038 · Cited by 20 · see citing works
SATB1 is a key regulator of quiescence in stem-like CD8+ T cells
Lin, S., Niu, H., Zhang, Y., Gai, K., Brown, R. J., Brown, A. K., Shen, J., Xu, Z., Shah, R. K., Schmeling, J. L., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02257-w · Cited by 19 · see citing works
Epigenetic regulation of CD8+ T cell exhaustion: recent advances and update
Li, C., Yuan, Y., Jiang, X., & Wang, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1700039 · Cited by 22 · see citing works
T cell adaptation in chronic infections and tumors
Luxenburger, H., Thimme, R., & Hofmann, M. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01405-y · Cited by 20 · see citing works
Immune checkpoint modulating T cells and NK cells response to Mycobacterium tuberculosis infection
Qin, Y., Wang, Q., & Shi, J. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127393 · Cited by 19 · see citing works
Bonté, P., Metoikidou, C., Heurtebise-Chrétien, S., Arribas, Y. A., Galy, A. S. D., Ye, M., Niborski, L. L., Zueva, E., Piaggio, E., Seguin‐Givelet, A., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adf8838 · Cited by 18 · see citing works
Tay, T., Bommakanti, G., Jaensch, E. S., Gorthi, A., Reddy, I. K., Hu, Y., Zhang, R., Doshi, A. S., Tan, S. L., Brucklacher-Waldert, V., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101804 · Cited by 23 · see citing works
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Lu, B. Y., Lucca, L. E., Lewis, W., Wang, J., Nogueira, C. V., Heer, S., Rayon-Estrada, V., Axisa, P., Reeves, S., Buitrago-Pocasangre, N., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-02023-4 · Cited by 18 · see citing works
Pauken, K. E., Alhalabi, O., Goswami, S., & Sharma, P. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.03.005 · Cited by 16 · see citing works
Two-stage CD8+ CAR T-cell differentiation in patients with large B-cell lymphoma
Cao, G., Hu, Y., Pan, T., Tang, E., Asby, N. W., Althaus, T., Wan, J., Riedell, P. A., Bishop, M. R., Kline, J. P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59298-w · Cited by 16 · see citing works
Deciphering the role of histone modifications in memory and exhausted CD8 T cells
Huang, H., Baxter, A. E., Zhang, Z., Good, C. R., Alexander, K. A., Chen, Z., Garcia, P. A. A., Samareh, P., Collins, S. M., Glastad, K. M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-99804-0 · Cited by 16 · see citing works
Self-citationAtlas-guided discovery of transcription factors for T cell programming
Chung, H. K., Liu, C., Battu, A., Jambor, A. N., Pratt, B. M., Xie, F., Riesenberg, B., Casillas, E., Sun, M., Landoni, E., et al. (2026) · Nature · doi:10.1038/s41586-025-09989-7 · Cited by 17 · see citing works
Mazziotta, F., Martin, L. E., Egan, D. N., Bar, M., Kinsella, S. M., Paulson, K. G., Voillet, V., Lahman, M. C., Hunter, D. S., Schmitt, T. M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60394-0 · Cited by 15 · see citing works
Advances in Vaccines for Melanoma
Cui, C., Ott, P. A., & Wu, C. J. (2024) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2024.05.009 · Cited by 16 · see citing works
Zhang, B., Tan, H., Kuang, J., Zhou, B., Liang, S., Pang, X. Y., Ouyang, Y., Zhang, Z., Long, Y., & Zhang, H. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02487-4 · Cited by 15 · see citing works
BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells
Hu, T., Zhu, Z., Ying, L., Wizzard, S., Hoar, J., Shinde, S. S., Yihunie, K. D., Yao, C., & Wu, T. (2026) · Nature Immunology · doi:10.1038/s41590-025-02388-0 · Cited by 14 · see citing works
Bou-Dargham, M. J., Sha, L., Sarker, D. B., Krakora-Compagno, M. Z., Chen, Z., Zhang, J., & Sang, Q. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119355 · Cited by 14 · see citing works
IFNγ Expression Correlates with Enhanced Cytotoxicity in CD8+ T Cells
Pattu, V., Krause, E., Chang, H., Rettig, J., & Li, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26147024 · Cited by 13 · see citing works
Guardians of silence: transcriptional networks in T cell quiescence
Choi, J. O., Seo, Y., & Hwang, S. S. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01516-y · Cited by 13 · see citing works
McClory, S., Bardhan, O., Rome, K., Giles, J. R., Baxter, A. E., Xu, L., Gimotty, P. A., Faryabi, R. B., Wherry, E. J., Pear, W. S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112905 · Cited by 13 · see citing works
Self-citation
- Authors
- Giles, J. R., Ngiow, S. F., Manne, S., Baxter, A. E., Khan, O., Wang, P., Staupe, R., Abdel-Hakeem, M. S., Huang, H., Mathew, D., Painter, M. M., Wu, J. E., Huang, Y. J., Goel, R. R., Yan, P. K., Karakousis, G. C., Xu, X., Mitchell, T. C., Huang, A. C., & Wherry, E. J.
- Affiliations
- University of Pennsylvania (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Emory University (US)
- Parker Institute for Cancer Immunotherapy (US)
- Corresponding author
- Wherry, E. John
- ORCID
- Giles, Josephine R.
- Ngiow, Shin Foong
- Manne, Sasikanth
- Baxter, Amy E.
- Khan, Omar
- Wang, Ping
- Staupe, Ryan
- Abdel-Hakeem, Mohamed S.
- Huang, Hua
- Mathew, Divij
- Painter, Mark M.
- Wu, Jennifer E.
- Huang, Yinghui Jane
- Goel, Rishi R.
- Yan, Patrick K.
- Karakousis, Giorgos C.
- Xu, Xiaowei
- Mitchell, Tara C.
- Huang, Alexander C.
- Wherry, E. John
- Venue
- Nature Immunology
- Published
- 2022-10-21
- Volume
- 23
- Issue
- 11
- Pages
- 1600-1613
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC10408358
- OpenAlex
- W4307040885
- Cited by
- 264
- References
- 55
- Citations by year
- 2026: 71 · 2025: 81 · 2024: 65 · 2023: 44 · 2022: 3
- FWCI
- 18.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (P50 CA174523)
- Cancer Research Institute
- Damon Runyon Cancer Research Foundation
- American Association of Immunologists
- Parker Institute for Cancer Immunotherapy
- National Institutes of Health (CA210944, AI082630, AI149680, CA009140, AI108545)
- Stand Up To Cancer
- National Health and Medical Research Council (1111469)
- National Cancer Institute (K08CA230157, T32CA009140, P50CA174523, P50CA261608, P01CA210944)
- National Institute of Allergy and Infectious Diseases (AI 082630, AI108545, F30AI129263, U19AI149680, AI149680, U19AI117950, R01AI155577, U19AI082630, P01AI108545)
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK127768)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- CD8+ T cells, T cell exhaustion, effector T cells, memory T cells, T cell differentiation, lymphocytic choriomeningitis virus, chronic infection, acute infection, ZEB2, anti-PD-1 therapy, BTG1, chromatin accessibility, transcriptional circuits, cytotoxicity, single-cell transcriptomics, single-cell epigenomics
- MeSH terms
- Chromatin, Humans, Lymphocytic Choriomeningitis, Lymphocytic choriomeningitis virus, CD8-Positive T-Lymphocytes, Epigenesis, Genetic, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
