Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Tirosh, I., Izar, B., Prakadan, S. M., Wadsworth, M. H., Treacy, D., Trombetta, J. J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016) · Science · doi:10.1126/science.aad0501 · Cited by 4,944

Molecular and cellular insights into T cell exhaustion

Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Miller, B. C., Sen, D. R., Al Abosy, R., Bi, K., Virkud, Y. V., LaFleur, M. W., Yates, K. B., Lako, A., Felt, K., Naik, G. S., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0312-6 · Cited by 2,087

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

Pagès, F., Mlecnik, B., Marliot, F., Bindea, G., Ou, F.-S., Bifulco, C., Lugli, A., Zlobec, I., Rau, T. T., Berger, M. D., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30789-x · Cited by 2,075

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Sade-Feldman, M., Yizhak, K., Bjorgaard, S. L., Ray, J. P., de Boer, C. G., Jenkins, R. W., Lieb, D. J., Chen, J. H., Frederick, D. T., Barzily-Rokni, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.038 · Cited by 2,053

Defining ‘T cell exhaustion’

Blank, C. U., Haining, W. N., Held, W., Hogan, P. G., Kallies, A., Lugli, E., Lynn, R. C., Philip, M., Rao, A., Restifo, N. P., et al. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0221-9 · Cited by 1,603

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

Bruni, D., Angell, H. K., & Galon, J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0285-7 · Cited by 1,586

Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants

Revach, O., Cicerchia, A. M., Shorer, O., Palin, C. A., Petrova, B., Anderson, S., Liu, B., Park, J. C., Chen, L., Mehta, A., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102210 · Cited by 19

BiTE secretion by adoptively transferred stem-like T cells improves FRα+ ovarian cancer control

McGray, A. R., Chiello, J. L., Tsuji, T., Long, M. D., Maraszek, K. E., Gaulin, N., Rosario, S. R., Hess, S. M., Abrams, S. I., Kozbor, D., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-006863 · Cited by 15

Cd39 (Entpd1) in Tumors: A Potential Therapeutic Target and Prognostic Biomarker

Li, C., Zhang, L., Jin, Q., Jiang, H., & Wu, C. (2023) · Biomarkers in Medicine · doi:10.2217/bmm-2023-0202 · Cited by 13

Redox and detox: Malate shuttle metabolism keeps exhausted T cells fit

Kumar, A., & Delgoffe, G. M. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.11.005 · Cited by 12

Surgical stress induced tumor immune suppressive environment

Yang, F., Hua, Q., Zhu, X., & Xu, P. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae012 · Cited by 14

Machine learning analysis reveals tumor stiffness and hypoperfusion as biomarkers predictive of cancer treatment efficacy

Englezos, D., Voutouri, C., & Stylianopoulos, T. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.101944 · Cited by 12

Transcriptional elongation control of hypoxic response

Soliman, S. H. A., Iwanaszko, M., Zheng, B., Gold, S. R., Howard, B. C., Das, M., Chakrabarty, R. P., Chandel, N. S., & Shilatifard, A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321502121 · Cited by 13

A biomimetic nanoplatform mediates hypoxia-adenosine axis disruption and PD-L1 knockout for enhanced MRI-guided chemodynamic-immunotherapy

Sun, M., Ni, C., Li, A., Liu, J., Guo, H., Xu, F., Li, K., Cao, X., Shi, X., & Guo, R. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.06.021 · Cited by 12

Faithful modeling of terminal CD8+T cell dysfunction and epigenetic stabilization in vitro

Yousif, A., Saadey, A. A., Lowin, A. M., Yousif, A. M., Saini, A., Allison, M. R., Ptak, K., Oltz, E. M., & Ghoneim, H. E. (2025) · JCI Insight · doi:10.1172/jci.insight.191220 · Cited by 12

A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses

Todd, K. L., Lai, J., Sek, K., Huang, Y., Newman, D. M., Derrick, E. B., Koay, H., Nguyen, D. Q., Hoang, T. X., Petley, E. V., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42734-0 · Cited by 13

Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment

Moraly, J., Kondo, T., Benzaoui, M., DuSold, J., Talluri, S., Pouzolles, M., Chien, C. D., Dardalhon, V., & Taylor, N. N. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13691 · Cited by 12

Epigenetics behind CD8+ T cell activation and exhaustion

Zu, H., & Chen, X. (2024) · Genes and Immunity · doi:10.1038/s41435-024-00307-1 · Cited by 13

Spatial omics technology potentially promotes the progress of tumor immunotherapy

Lan, Z., Yang, Y., Li, L., Wang, C., Sun, Z., Wang, Q., & Liu, Y. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03075-5 · Cited by 11

Monitoring immunomodulation strategies in type 1 diabetes

Krishnamurthy, B., Lacorcia, M., Kay, T. W. H., Thomas, H. E., & Mannering, S. I. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1206874 · Cited by 12

The role of dysregulated mRNA translation machinery in cancer pathogenesis and therapeutic value of ribosome-inactivating proteins

Jia, W., Yuan, J., Li, S., & Cheng, B. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189018 · Cited by 9

Tumor‐Resident Intracellular Bacteria Scavenger Activated In Situ Vaccines for Potent Cancer Photoimmunotherapy

Lv, B., Zhao, Y., Li, G., Jiang, H., Zhang, M., Li, Z., & Cao, J. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202404271 · Cited by 10

Tumor Microenvironment: Obstacles and Opportunities for T Cell–Based Tumor Immunotherapies

Hu, M., Zhao, Y., Zhang, N., Gong, F., Zhang, W., Dong, C., Dai, J., & Wang, J. (2025) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-24-0747 · Cited by 9

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression

Bodogai, M., Park, B. S., Braikia, F.-Z., Naqing, F., Kumaraswami, K., Chen, C., Ragonnaud, E., Stack, S. M., Ormanns, S., Guenther, M., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00966-3 · Cited by 9

Regulatory T Cell Metabolism in Cancer

Mortezaee, K. (2025) · Immunology · doi:10.1111/imm.70096 · Cited by 15

Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes

Selck, C., Jhala, G., George, D. J. D., Kwong, C.-T. J., Christensen, M. K., Pappas, E. G., Liu, X., Ge, T., Trivedi, P., Kallies, A., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315419121 · Cited by 10

Epigenetic landscapes drive CAR-T cell kinetics and fate decisions: Bridging persistence and resistance

Wang, K., Ou, K., Zeng, Y., Yue, C., Zhuo, Y., Wang, L., Chen, H., & Tu, S. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104729 · Cited by 9

CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis

Zhang, M., Xia, L., Peng, W., Xie, G., Li, F., Zhang, C., Syeda, M. Z., Hu, Y., Lan, F., Yan, F., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00608-8 · Cited by 8

Hepatocellular carcinoma cells induce γδ T cells through metabolic reprogramming into tumor-progressive subpopulation

Xia, J., Wang, C., & Li, B. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1451650 · Cited by 8

Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironment

van Dam, S., Krijgsman, D., Küçükköse, E., Verdonschot, M. E. L., Amini, M., Blokx, W. A. M., van Eijs, M. J. M., Verheijden, R. J., Kranenburg, O., Suijkerbuijk, K. P. M., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03137-8 · Cited by 9

Immunologically relevant effects of radiation therapy on the tumor microenvironment

Galassi, C., Klapp, V., Formenti, S. C., Demaria, S., & Galluzzi, L. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220248 · Cited by 8

Combination therapy of HIFα inhibitors and Treg depletion strengthen the anti‐tumor immunity in mice

Wei, P., Kou, W., Riaz, F., Zhang, K., Fu, J. L., & Pan, F. (2023) · European Journal of Immunology · doi:10.1002/eji.202250182 · Cited by 9

Impact and potential value of immunosenescence on solid gastrointestinal tumors

Zhang, T., Wen, R., Fan, H., Yu, Y., Jia, H., Peng, Z., Zhou, L., Yu, G., & Zhang, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1375730 · Cited by 8

Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells

DePeaux, K., Gunn, W. G., Rivadeneira, D. B., & Delgoffe, G. M. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009062 · Cited by 7

Understanding Immune Cell Adaptation to Tumor Hypoxia for Maximized Therapeutic Efficacy of Immunotherapy: Biology and Non-invasive Imaging Application

Oh, T., Kim, M.-W., Kang, G.-S., Ye, S., Choi, C., Park, W., Hay, M. P., Hirata, H., & Ahn, G. (2025) · Cancer Research and Treatment · doi:10.4143/crt.2025.200 · Cited by 7

T cell-derived small extracellular vesicles in cancer–immune interactions

Garcia, M. J. C., Hnit, S. S. T., Shklovskaya, E., & Wang, Y. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04109-w · Cited by 9

Adoptive cell therapy in colorectal cancer: Advances in chimeric antigen receptor T cells

Chen, M., Wang, C., Wang, Y., & Shi, M. (2025) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v17.i7.106723 · Cited by 7

Tumor-specific but immunosuppressive CD39+CD8+ T cells exhibit double-faceted roles in clear cell renal cell carcinoma

Lee, Y. J., Jeon, S. H., Yeo, J. H., Byeon, S., Jung, J. H., Nam, H., Jeon, M., Kim, E.-S., Jang, J. Y., Kim, C.-H., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102360 · Cited by 9

Exploring the Tumor Microenvironment in Osteosarcoma: Driver of Resistance and Progression

Schmidt, A. A., Prasad, A., Huisman, A. R., Wakefield, M. R., & Fang, Y. (2025) · Cancers · doi:10.3390/cancers17193106 · Cited by 9

Two-Dimensional Iridium(III)–Carbon Nitride Nanocomplexes Induce Simultaneous Oncosis and Necroptosis for Synergistic Chemo- and Sono-Immunotherapy in Hypoxic Melanoma

Wu, X., Li, Z., Yin, T., Shu, J., Xu, Y.-S., Liang, J., Zhang, X., & Chao, H. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c00241 · Cited by 9

The Prognostic Value of CD39 as a Marker of Tumor-Specific T Cells in Triple-Negative Breast Cancer in Asian Women

Meng, J., Tan, J. Y., Joseph, C. R., Ye, J., Lim, J. C. T., Goh, D. L. M., Xue, Y., Lim, X., Koh, V. C. Y., Wee, F. Y. T., et al. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2023.100303 · Cited by 7

T-cell dysfunction by pseudohypoxia and autocrine purinergic signaling in chronic lymphocytic leukemia

Montironi, C., Jacobs, C. F., Cretenet, G., Peters, F. S., Schomakers, B. V., van Weeghel, M., Kater, A. P., Simon‐Molas, H., & Eldering, E. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010305 · Cited by 7

Bayesian-based analysis of the causality between 731 immune cells and erectile dysfunction: a two-sample, bidirectional, and multivariable Mendelian randomization study

Chen, J., Liu, Y., Zhan, P., Gao, T., Zuo, J., Li, X., Zhang, F., Wang, H., & Fu, S. (2024) · Sexual Medicine · doi:10.1093/sexmed/qfae062 · Cited by 7

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapyPreprint

Revach, O., Cicerchia, A. M., Shorer, O., Petrova, B., Anderson, S., Park, J. C., Chen, L., Mehta, A., Wright, S. J., McNamee, N., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.12.579184 · Cited by 7

Hypoxia reconstructed colorectal tumor microenvironment weakening anti-tumor immunity: construction of a new prognosis predicting model through transcriptome analysis

Zhang, R., Gao, Y., Li, C., Tao, R., Mao, G., Song, T., Nie, W., Liu, S., Tao, K., & Li, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1425687 · Cited by 6

Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment

Huang, T., Li, F., Wang, Y., Gu, J., & Lü, L. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003450 · Cited by 7

Targeting suppressive feedback of adenosine immunometabolic pathway by tumor cell membranes-coated nanocapsules for chemo-photothermal therapy and enhanced immunotherapy

Tian, Y., Wang, S., Ren, S., Lin, X., Song, L., Zhang, L., & Wang, Z. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.163579 · Cited by 6

Hyaluronic acid and polyvinyl alcohol-based radioresponsive hydrogel for combined radioimmunotherapy of breast cancer bone metastasis

Li, L., Gu, Z., Wu, Y., Lin, S., Cheng, X., Zhang, L. W., Qin, J., Dong, Q., Wang, Y., & Wang, Y. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124108 · Cited by 6

Metabolic reprogramming through PIM3 inhibition reverses hypoxia-induced CAR-T cell dysfunction in solid tumors

Zhou, M., Xu, L., Hu, J., Chen, W., Hong, J., Wang, M.-H., & Guo, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07278-5 · Cited by 9

Lactylation of HIF-1α at K172 drives HIF-1 complex assembly to promote hypoxia-induced immune evasion in esophageal squamous cell carcinoma

Cong, J., Zheng, S., Zhang, H., Li, Y., & Liu, Z. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218548 · Cited by 7

Multiomics Analysis of Disulfidptosis Patterns and Integrated Machine Learning to Predict Immunotherapy Response in Lung Adenocarcinoma

Liu, J., Li, H., Zhang, N., Dong, Q., & Liang, Z. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673313281240425050032 · Cited by 6

The [ 2Fe ‐ 2S ] cluster of mitochondrial outer membrane protein mitoNEET has an O2 ‐regulated nitric oxide access tunnel

Hoang, T. N., Wu‐Lu, M., Collauto, A., Hagedoorn, P., Alexandru, M., Henschel, M., Kordasti, S. Y., Mroginski, M. A., Roessler, M. M., & Ebrahimi, K. H. (2025) · FEBS Letters · doi:10.1002/1873-3468.15097 · Cited by 6

Predictive circulating biomarkers of the response to anti‐PD‐1 immunotherapy in advanced HER2 negative breast cancer

Wei, Y., Ge, H., Qi, Y., Zeng, C., Sun, X., Mo, H., & Ma, F. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70255 · Cited by 5

4-1BB stimulation with concomitant inactivation of adenosine A2B receptors enhances CD8+ T cell antitumor response

Ahn, J., Xie, P., Chen, S., Shi, G., Fan, J., Zhang, M., Tang, H., Zuckerman, A. R., Fang, D., Wan, Y., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci190841 · Cited by 6

Beyond the tumor microenvironment: Orchestrating systemic T‑cell response for next‑generation cancer immunotherapy (Review)

Lyu, X., Han, J., Chen, L., Zhou, Y., & Wang, W. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5762 · Cited by 6

Impact of Serum/Xeno‐Free Medium and Cytokine Supplementation on CAR‐T Cell Therapy Manufacturing in Stirred Tank Bioreactors

Couto, P. S., Stibbs, D. J., Springuel, P., Schultz, U., Effenberger, M. J. P., Goldrick, S., Velázquez, S. N., Juan, M., Herbst, L., Nießing, B., et al. (2025) · Biotechnology Journal · doi:10.1002/biot.70114 · Cited by 6

Tumor microenvironment squeezes out the juice from T cells

Thouenon, R., & Verdeil, G. (2024) · Cell Research · doi:10.1038/s41422-024-00987-4 · Cited by 6

CD4 + T cells are homeostatic regulators during Mtb reinfectionPreprint

Bromley, J. D., Ganchua, S. K. C., Nyquist, S. K., Maiello, P. A., Chao, M. C., Borish, H. J., Rodgers, M., Tomko, J. A., Kracinovsky, K. B., Mugahid, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.20.572669 · Cited by 6

Integration of single-cell and spatial transcriptome sequencing identifies CDKN2A as a senescent biomarker in endothelial cells implicating hepatocellular carcinoma malignancy

Ma, Y., Yi, C., Cai, N., & Chen, J. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-06017-5 · Cited by 5

Exhaustion of T cells after renal transplantation

Wang, X., Zhang, J., Zhong, P., & Wei, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1418238 · Cited by 6

Nanostrategies synergize with locoregional interventional therapies for boosting antitumor immunity

Luo, T., Ma, K., Zhang, Y., Xue, Q., Yu, J., Liang, X., & Liang, P. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.05.016 · Cited by 5

Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer

Jiang, L., Wu, T., Qu, X., Li, S., Jiang, Q., Ren, T., Liang, J., Ding, Y., Hua, K., Tang, Z., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03500-0 · Cited by 5

T cell exhaustion: early or late in tumour progression?

Galluzzi, L. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01158-1 · Cited by 6

Hypoxia-adenosinergic regulation of B cell responses

Pruitt, L., & Abbott, R. K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1478506 · Cited by 4

One-carbon metabolism is distinct metabolic signature for proliferative intermediate exhausted T cells of ICB-resistant cancer patients

Park, Y.-C., Hwang, Y., Jeong, J. W., Lee, C. M., Kim, M., Jo, S., Joo, S., Hwang, N., & Fang, S. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02332-z · Cited by 4

Remodelling hypoxic TNBC microenvironment restores antitumor efficacy of Vγ9Vδ2 T cell therapy

Jing, Y.-Y., Wu, Y., Hu, Q., Wu, W., Li, D., Hu, W., Li, H., Fu, M., Huang, X., & Hu, Y. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-03045-x · Cited by 4

Simulating CD8 T cell exhaustion: A comprehensive approach

Manrique-Rincón, A., Foster, B., Horswell, S. D., Goulding, D., Adams, D. J., & Speak, A. O. (2025) · iScience · doi:10.1016/j.isci.2025.112897 · Cited by 5

OMIP‐117: 40‐Parameter/37‐Color Spectral Cytometry Panel for Robust Immunoprofiling of Human Lymphoid Subsets in Cancer Patients

Venglár, O., Radova, E., Broskevičová, L., Hájek, R., & Jelínek, T. (2025) · Cytometry Part A · doi:10.1002/cyto.a.24962 · Cited by 5

Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications

Zhao, Y., Shang, Y., Luan, T., Yu, Z., Yang, Y., Niu, X., Li, H., Wang, S., Wang, C., & Liu, L. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02674-x · Cited by 4

Single-cell RNA sequencing analysis reveals a lack of CXCL13+ T cell subsets associated with the recurrence of cervical squamous cell carcinoma following concurrent chemoradiotherapy

Li, X., Cheng, Y., Ji, M., Liu, J., Zhao, Z., & Zhao, Q. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04083-3 · Cited by 4

Transcript isoform diversity defines molecular subtypes and prognosis in acute myeloid leukemia through long-read sequencing

Shi, X., Wang, S., Yu, S., Jiang, F., Wang, J., Dai, Y., Li, J., Zhang, R., Yin, T., Dai, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116216 · Cited by 6

Balancing Intrinsic and Extrinsic Factors in CD8 + T Cell Therapy

Lee, D., & Lee, Y. (2026) · Immune Network · doi:10.4110/in.2026.26.e5 · Cited by 4

Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity

de Blas, A., Andreatta, M., Antoñana-Vildosola, A., Velasco-Beltrán, P., Egia‐Mendikute, L., Jiménez-Lasheras, B., Bosch, A., Barreira-Manrique, A., Oyenarte, I., Lee, S. Y., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-1246 · Cited by 3

Citraconate preserves T cell stemness and antitumor immunity

Li, W., Ge, M., Luo, Z., Ni, M., Tang, K., Han, C., J, Y., Ma, Y., Liu, X., Ma, K., et al. (2026) · Science Immunology · doi:10.1126/sciimmunol.adz0348 · Cited by 3

Tempering of exhausted T cells to comprehend their adaptive response for suitable clinical translation

Sharma, A., & Schmidt‐Wolf, I. G. H. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01031-y · Cited by 4

Elucidating the molecular and immune interplay between head and neck squamous cell carcinoma and diffuse large B-cell lymphoma through bioinformatics and machine learning

Zheng, J., Li, X., Gong, X., Hu, Y., & Tang, M. (2024) · Translational Cancer Research · doi:10.21037/tcr-24-1064 · Cited by 3

Research progress and prospect of tumor nanovaccine combination therapy strategy

Yin, Y., Guo, J., Zhang, S., Xu, M., Fu, Y. Z., Zhang, M., Ma, Z., Ji, J., Wu, S., Zhang, J., et al. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110771 · Cited by 5

Ex vivo modulation of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes

Hulen, T. M., Friese, C., Kristensen, N. P., Granhøj, J. S., Borch, T. H., Peeters, M. J. W., Donia, M., Andersen, M. H., Hadrup, S. R., Svane, I. M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1180997 · Cited by 3

Dysfunction of CD8+ T cells around tumor cells leads to occult lymph node metastasis in NSCLC patients

Li, C., Hu, M., Cai, S., Yang, G., Yang, L., Jing, H., Xing, L., & Sun, X. (2024) · Cancer Science · doi:10.1111/cas.16206 · Cited by 2

Bulk and single-cell RNA sequencing reveal the contribution of laminin γ2 -CD44 to the immune resistance in lymphocyte-infiltrated squamous lung cancer subtype

Song, T., Yang, Y., Yang, Y., Ni, Y., 杨永峰, & Zhang, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31299 · Cited by 3

Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies

Castro, V. D., Abdellaoui, O., Dehecq, B., Ndao, B., Mercier‐Letondal, P., Dauvé, A., Garnache‐Ottou, F., Adotévi, O., Loyon, R., & Godet, Y. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04065-5 · Cited by 4

Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 SignalingPreprint

Farkas, A. M., Youssef, D., Tran, M. A., Balan, S., Newman, J. H., Audenet, F., Anastos, H., Velazquez, L. G., Peros, A., Ananthanarayanan, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.30.591366 · Cited by 3

Stratified analysis identifies HIF-2 α as a therapeutic target for highly immune-infiltrated melanomasPreprint

Huang, A. Y., Burke, K. P., Porter, R. M., Meiger, L., Fatouros, P. R., Yang, J., Robitschek, E. J., Vokes, N. I., Ricker, C. A., Rosado, V., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.29.620300 · Cited by 3

Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF SyndromePreprint

Campos, J. S., Sayed, S. U., Dalalo, M. C., Mauracher, A. A., Knight, M., Conrey, P. E., Schultz, A. B., Hay, C. A., Lindell, R. B., Howard, C. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.12.626682 · Cited by 3

CD39 identifies a specific CD8 + T cell population in lung adenocarcinoma-related metastatic pleural effusion

Lv, L.-L., Wang, H., Zhang, Y.-X., Zhai, J., Shen, Y., Qu, Q., & Chen, C. (2023) · BMC Immunology · doi:10.1186/s12865-023-00590-z · Cited by 2

Decoding the hypoxic tumor microenvironment in colorectal cancer for prognostic modeling and therapeutic target discovery

Duan, X., Yan, Z., Feng, F., Jiang, H., Wang, M., Han, Z. W., Pang, H.-F., Liu, Y.-H., Jia, H.-Z., He, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1651749 · Cited by 2

Lpar5 regulates the CD8 T-cell response to persistent virus infection by altering exhaustion programming, survival, and NK receptor expression

D’Antonio, M. A., Ware, B. C., DiLisio, J. E., Michaels, M. J., Turner, J. A., Habenicht, L. M., Davenport, B., Morrison, T. E., Pelanda, R., Gapin, L., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf210 · Cited by 2

Hypoxia as a Central Regulator of Plasma Membrane Phosphohydrolase Enzymes: Possible Roles in Extracellular Phosphate Generation and Adenosine Metabolism

de Oliveira, P. H. S., Silva-Freitas, B. B., Meyer‐Fernandes, J. R., & Lacerda‐Abreu, M. A. (2025) · Membranes · doi:10.3390/membranes15120381 · Cited by 2

Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma

Tu, C., der Vreken, A. V., Meeus, F., van den Broecke, L., Brons, J., Veirman, K. D., Vanderkerken, K., Bruyne, E. D., Breckpot, K., & Menu, E. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00732-6 · Cited by 2

Single-fraction radiotherapy with a bioactive depot of CD39 blockade eradicates malignant tumors

Ye, C., Zheng, Y., He, H., Ji, J., Liu, L., Sun, Y., Peng, Y., Wang, S., Zhang, Y., & Zhong, Z. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114632 · Cited by 2

CD8+ T cell exhaustion driven by metabolic reprogramming

Deng, W., Li, C., Wang, Q., Jiang, X., & Xie, Y. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04287-2 · Cited by 2

Adenosine as a metabolic checkpoint in CD8+ T cell dysfunction

Edgerton, A. O., Reginato, M. J., Kutzler, M. A., & Haddad, E. K. (2026) · Trends in Immunology · doi:10.1016/j.it.2026.06.005 · Cited by 2

Heteroleptic ruthenium(II) complexes-based sonocatalysts trigger gasdermin D palmitoylation to augment hypoxia-resistant non-canonical pyroptotic immunotherapy

Xu, H., Wei, F., Hou, M., Zhong, L., Feng, Y., & Shen, X. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124447 · Cited by 2

Enhancing the Treating Efficacy of Immunotherapy through the Restructure of Tumor Microenvironment

Gong, B., Jia, W., Zhou, Y., Xu, Y., Ya, W., & Gao, H. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300061 · Cited by 2

Identification of hypoxic-related lncRNAs prognostic model for revealing clinical prognostic and immune infiltration characteristic of cutaneous melanoma

Liao, C., Yang, J., Chen, L., & Ye, Z. (2024) · Aging · doi:10.18632/aging.205556 · Cited by 2

Unraveling the Therapeutic Benefit of Sequenced Chemo-immunotherapy

Vignali, P., & Luke, J. J. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3736 · Cited by 2

Oxygen and immunity to Leishmania infection

Bowman, B. A., & Novais, F. O. (2025) · Infection and Immunity · doi:10.1128/iai.00504-24 · Cited by 2

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

Alonso, S., Kaur, H., Luo, J., Nguyen, M.-U., Laguerta, A. M., Fong, A., Skariah, N., Argüello, R. J., Verzi, M. P., Swamy, M., et al. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.07.005 · Cited by 2

Unlocking Wnt's weak spot: Glycosylated nanoalbumins to reignite immune responses in MSS-CRC

Wei, X. P., Zuo, M., Liang, Q., Zhang, S., Wang, J., Li, Z., Yang, W., Ma, F., He, W., & Liu, T. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101412 · Cited by 2

Similar usage of T‐cell receptor β‐chain between tumor and adjacent normal tissue in hepatocellular carcinoma

Yang, J., Xu, S., Xiao, D., Li, J., Jin, X., & Dong, Y. (2024) · Cancer Medicine · doi:10.1002/cam4.70121 · Cited by 2

Somatic Evolution of Cancer: A New SynthesisPreprint

Baing, U., Kharate, R., & Watve, M. (2023) · Preprints.org · doi:10.20944/preprints202303.0431.v1 · Cited by 1

Somatic evolution of Cancer: A new synthesisPreprint

Baig, U. I., Kharate, R., & Watve, M. (2023) · Qeios · doi:10.32388/iaelog · Cited by 1

Inflammation and Cancer: A Temporal Perspective on Emerging Cellular and Molecular Mechanisms, Focusing on Gastrointestinal CancersPreprint

Akkız, H., Şinşek, H., Balcı, D., Ülger, Y., Onan, E., Ozturk, N. A., & Delik, A. (2024) · Preprints.org · doi:10.20944/preprints202410.1660.v1 · Cited by 1

Hypoxia and the Hypoxia-Inducible Factors in Lymphocyte Differentiation and Function

Boothby, M. R., & Cho, S. H. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-62731-6_6 · Cited by 1

Development and validation of a cell-based assay to determine the bioactivity of antibodies against CD39 targets

Xu, G., Ni, Y., Cui, C., Du, J., Duan, M., Yang, Y., & Yu, C. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.117021 · Cited by 1

ROS‐Activatable Cyclodextrin Nanoparticles Remodel Adenosine‐A2AR Pathway for Augmented Photo‐Immunotherapy

Wang, L., Yu, M., Li, J., Huang, W., He, S., Wang, H., Tong, F., Wang, Y., Xia, X., Wu, H., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202501072 · Cited by 1

Tumor hypoxia drives suppressor function in exhausted T cells limiting antitumor immunityPreprint

Delgoffe, G. M., Vignali, P., DePeaux, K., Watson, M. J., Lontos, K., McGaa, N., Scharping, N. E., & Menk, A. V. (2021) · Research Square · doi:10.21203/rs.3.rs-924657/v1 · Cited by 1

679 Tumor hypoxia drives suppressor function in exhausted T cells limiting antitumor immunity

Vignali, P., DePeaux, K., Watson, M. J., Scharping, N. E., Menk, A. V., & Delgoffe, G. M. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-sitc2021.679 · Cited by 1

CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8+ T Cells

Canale, F. P., Ramello, M. C., Núñez, N. G., Furlan, C. L. A., Bossio, S., Serrán, M. G., Tosello, J., del Castillo, A., Ledesma, M., Sedlik, C., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2684 · Cited by 413

Decrease of tumoral CD39+CD8+T cells promoted by hypoxia confers resistance to immunotherapy in NSCLCPreprint

Wu, J.-J., Zhai, J., Lv, L.-L., Zhang, Y., Shen, Y., Qu, Q., & Chen, C. (2025) · Research Square · doi:10.21203/rs.3.rs-7102657/v1

CD39 deletion in TCR-engineered T cells enhances antitumour immunity

Tsai, A. K., & Stromnes, I. M. (2023) · Gut · doi:10.1136/gutjnl-2023-330424 · Cited by 3