The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated individuals is increasingly common but rarely results in severe disease, likely due to the enhanced potency and accelerated kinetics of memory immune responses. However, there have been few opportunities to rigorously study early recall responses during human viral infection. To better understand human immune memory and identify potential mediators of lasting vaccine efficacy, we used high-dimensional flow cytometry and SARS-CoV-2 antigen probes to examine immune responses in longitudinal samples from vaccinated individuals infected during the Omicron wave. These studies revealed heightened spike-specific responses during infection of vaccinated compared to unvaccinated individuals. Spike-specific cluster of differentiation (CD)4 T cells and plasmablasts expanded and CD8 T cells were robustly activated during the first week. In contrast, memory B cell activation, neutralizing antibody production and primary responses to nonspike antigens occurred during the second week. Collectively, these data demonstrate the functionality of vaccine-primed immune memory and highlight memory T cells as rapid responders during SARS-CoV-2 infection.
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“Recent findings have shown that vaccine-induced CD8+ T cell responses are important for long-term immunity and should also be considered as a correlate of protection29,30.”
From An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial (2024) · cites this paper as [30]
Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Khoury, D. S., Cromer, D., Reynaldi, A., Schlub, T. E., Wheatley, A. K., Juno, J. A., Subbarao, K., Kent, S. J., Triccas, J. A., & Davenport, M. P. (2021) · Nature Medicine · doi:10.1038/s41591-021-01377-8 · Cited by 3,742
Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., Rawlings, S. A., Sutherland, A., Premkumar, L., Jadi, R. S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.015 · Cited by 3,595
Self-citationEffectiveness of COVID-19 vaccines against the Omicron (B.1.1.529) variant of concern
Andrews, N., Stowe, J., Kirsebom, F., Toffa, S., Rickeard, T., Gallagher, E., Gower, C., Kall, M., Groves, N., O’Connell, A.-M., et al. (2021) · doi:10.1101/2021.12.14.21267615 · Cited by 2,420
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
Cao, Y., Wang, J., Jian, F., Xiao, T., Song, W., Yisimayi, A., Huang, W., Li, Q., Wang, P., An, R., et al. (2022) · Nature · doi:10.1038/s41586-021-04385-3 · Cited by 2,006
COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
Sahin, U., Muik, A., Derhovanessian, E., Vogler, I., Kranz, L. M., Vormehr, M., Baum, A., Pascal, K., Quandt, J., Maurus, D., et al. (2020) · Nature · doi:10.1038/s41586-020-2814-7 · Cited by 1,977
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
Rydyznski Moderbacher, C., Ramirez, S. I., Dan, J. M., Grifoni, A., Hastie, K. M., Weiskopf, D., Belanger, S., Abbott, R. K., Kim, C., Choi, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.038 · Cited by 1,790 · cited 1×
“Likewise, before widespread vaccination, coordinated immune responses with SARS-CoV-2-specific antibodies, CD4 T cells and CD8 T cells were associated with less severe COVID-19 compared to responses lacking one or more of these immune components 67 .”
BackgroundSelf-citationPhenotypic and functional separation of memory and effector human CD8+ T cells
Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R., & Lier, R. A. W. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1407 · Cited by 1,366
The immune geography of IgA induction and function
Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2007) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,047
Research works printed but not linked: 2
- Andrews, N. et al. COVID-19 vaccine effectiveness against the Omicron (B.1.1.529) variant. N. Engl. J. Med. 386, 1532–1546 (2022). · DOI · Paper page
- Cromer, D. et al. Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis. Nat. Commun. 14, 1633 (2023). · DOI · Paper page
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mRNA vaccines for infectious diseases — advances, challenges and opportunities
Pardi, N., & Krammer, F. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01042-y · Cited by 252
Vaccine adjuvants: Tailoring innate recognition to send the right message
Lavelle, E. C., & McEntee, C. P. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.015 · Cited by 124
Johnston, T. S., Li, S. H., Painter, M. M., Atkinson, R. K., Douek, N. R., Reeg, D. B., Douek, D. C., Wherry, E. J., & Hensley, S. E. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.017 · Cited by 97
Self-citationB-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity
Lapuente, D., Winkler, T., & Tenbusch, M. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01095-w · Cited by 101
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cankat, S., Demael, M. U., & Swadling, L. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-01116-8 · Cited by 84
Metadata
- Authors
- Painter, M. M., Johnston, T. S., Lundgreen, K. A., Santos, J. J. S., Qin, J. S., Goel, R. R., Apostolidis, S. A., Mathew, D., Fulmer, B., Williams, J. C., McKeague, M. L., Pattekar, A., Goode, A., Nasta, S., Baxter, A. E., Giles, J. R., Skelly, A. N., Felley, L. E., McLaughlin, M., Weaver, J., BioBank, P. M., Ritchie, M. D., Feldman, M. D., Weaver, J., Naseer, N., Poindexter, A., Brock, A., Hu-Sain, K., Ko, Y.-A., Livingstone, M., Vadivieso, F., Kloter, A., DerOhannessian, S., Tran, T., Morrel, L., Haubein, N., Dunn, J., Verma, A., Morse, C., Risman, M., Judy, R., Verma, S. S., Bradford, Y., Dudek, S., Drivas, T., Kuthuru, O., Dougherty, J., Adamski, S., Long, S., Kee, M., Clendenin, C., da Silva Antunes, R., Grifoni, A., Weiskopf, D., Sette, A., Huang, A. C., Rader, D. J., Hensley, S. E., Bates, P., Greenplate, A. R., & Wherry, E. J.
- Affiliations
- University of Pennsylvania (US)
- National Institutes of Health (US)
- Parker Institute for Cancer Immunotherapy (US)
- University of Michigan (US)
- University of Pennsylvania Health System (US)
- La Jolla Institute for Immunology (US)
- Corresponding author
- Wherry, E. John
- ORCID
- Painter, Mark M.
- Johnston, Timothy S.
- Lundgreen, Kendall A.
- Santos, Jefferson J. S.
- Qin, Juliana S.
- Goel, Rishi R.
- Apostolidis, Sokratis A.
- Mathew, Divij
- Fulmer, Bria
- Williams, Justine C.
- McKeague, Michelle L.
- Pattekar, Ajinkya
- Baxter, Amy E.
- Giles, Josephine R.
- Skelly, Ashwin N.
- Ritchie, Marylyn D.
- Feldman, Michael D.
- Kuthuru, Oliva
- Dougherty, Jeanette
- Adamski, Sharon
- Long, Sherea
- Clendenin, Cynthia
- da Silva Antunes, Ricardo
- Grifoni, Alba
- Weiskopf, Daniela
- Sette, Alessandro
- Huang, Alexander C.
- Rader, Daniel J.
- Hensley, Scott E.
- Bates, Paul
- Greenplate, Allison R.
- Wherry, E. John
- Venue
- Nature Immunology
- Published
- 2023-09-21
- Volume
- 24
- Issue
- 10
- Pages
- 1711-1724
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W4386923860
- Cited by
- 106
- References
- 70
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 40 · 2023: 10
- FWCI
- 21.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (AI082630, AI108545, AI155577, AI149680, U19AI082630, 75N9301900065, AI152236)
- Parker Foundation
- U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (UL1TR001878)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- SARS-CoV-2, breakthrough infection, COVID-19 vaccination, memory T cells, CD4+ T cells, CD8+ T cells, plasmablasts, memory B cells, Omicron variant, recall immune response, neutralizing antibodies
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Memory B Cells, Memory T Cells, Breakthrough Infections, Adult, Antibodies, Viral, Female, Humans, Immunologic Memory, Lymphocyte Activation, Male, Middle Aged, Vaccination, CD8-Positive T-Lymphocytes, Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus
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