The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
Open accessAbstract
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV. Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.
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Cites
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Cited by
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Analysis of the effect of HDAC inhibitors on the formation of the HIV reservoir
Ling, L., Kim, M., Soper, A., Kovarova, M., Spagnuolo, R. A., Begum, N., Kirchherr, J., Archin, N., Battaglia, D., Cleveland, D., et al. (2024) · mBio · doi:10.1128/mbio.01632-24 · Cited by 14
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Metadata
- Authors
- The RV411 study group, Colby, D. J., Trautmann, L., Pinyakorn, S., Leyre, L., Pagliuzza, A., Kroon, E., Rolland, M., Takata, H., Buranapraditkun, S., Intasan, J., Chomchey, N., Muir, R., Haddad, E. K., Tovanabutra, S., Ubolyam, S., Bolton, D. L., Fullmer, B. A., Gorelick, R. J., Fox, L., Crowell, T. A., Trichavaroj, R., O’Connell, R., Chomont, N., Kim, J. H., Michael, N. L., Robb, M. L., Phanuphak, N., & Ananworanich, J.
- Venue
- Nature Medicine
- Published
- 2018-06-11
- Volume
- 24
- Issue
- 7
- Pages
- 923-926
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2807106468
- Cited by
- 331
- References
- 35
- FWCI
- 20.83
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- The RV411 study group, Colby, D. J., Trautmann, L., Pinyakorn, S., Leyre, L., Pagliuzza, A., Kroon, E., Rolland, M., Takata, H., Buranapraditkun, S., Intasan, J., Chomchey, N., Muir, R., Haddad, E. K., Tovanabutra, S., Ubolyam, S., Bolton, D. L., Fullmer, B. A., Gorelick, R. J., . . . Ananworanich, J. (2018). Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection. Nature Medicine. https://doi.org/10.1038/s41591-018-0026-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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