The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation
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Abstract
Outgrowth virus phylogeny suggests that most of the long-lived, replication-competent HIV-1 reservoir is formed near the time of therapy initiation.
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Studies have suggested a close genetic relatedness of recovered viruses, suggesting that viral re- and deactivation and organ homing are interconnected for different body compartments.
“Studies have suggested a close genetic relatedness of recovered viruses, suggesting that viral reand deactivation and organ homing are interconnected for different body compartments. 13,14,44,45”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [45]
The Discussion (page unavailable) reports that viral populations in blood and lymphoid tissue may be genetically linked and that latent viral populations appear largely equilibrated between blood and gut tissue. It does not establish the claimed connection between viral reactivation or deactivation and organ homing; the authors also state that they did not examine tissue reservoirs in this study. (LLM, conf=0.85)
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Schou, M. D., Søgaard, O. S., & Rasmussen, T. A. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2273919 · Cited by 10 · see citing works
- Authors
- Abrahams, M.-R., Joseph, S. B., Garrett, N., Tyers, L., Moeser, M., Archin, N., Council, O. D., Matten, D., Zhou, S., Doolabh, D., Anthony, C., Goonetilleke, N., Karim, S. A., Margolis, D. M., Pond, S. K., Williamson, C., & Swanstrom, R.
- Affiliations
- University of Cape Town (ZA)
- University of North Carolina at Chapel Hill (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.
- Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
- National Health Laboratory Service (ZA)
- Corresponding author
- Williamson, Carolyn
- Swanstrom, Ronald
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-10-09
- Volume
- 11
- Issue
- 513
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7233356
- OpenAlex
- W2980286610
- Cited by
- 196
- References
- 62
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 26 · 2023: 31 · 2022: 33 · 2021: 28 · 2020: 36 · 2019: 4
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science Translational Medicine (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- NIH/MRC (R01 AI115981)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- HIV-1 latent reservoir, antiretroviral therapy, viral quasispecies, women living with HIV
- MeSH terms
- Female, Humans, Phylogeny, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Viral Load, Anti-Retroviral Agents
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