Cited by 196HIV Research and TreatmentHIV/AIDS drug development and treatmentVirus-based gene therapy research

The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation

Open access
Abrahams, Melissa-Rose, Joseph, Sarah B., Garrett, Nigel, Tyers, Lynn, Moeser, Matthew, Archin, Nancie, Council, Olivia D., Matten, David +9 more·2019·Science Translational Medicine

Published version of a preprint

Abstract

Outgrowth virus phylogeny suggests that most of the long-lived, replication-competent HIV-1 reservoir is formed near the time of therapy initiation.

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Registry

Crossref · 10.1126/scitranslmed.aaw5589

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62 of 62 references verified0 citation errors · 0 not checkable

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  • Studies have suggested a close genetic relatedness of recovered viruses, suggesting that viral re- and deactivation and organ homing are interconnected for different body compartments.

    “Studies have suggested a close genetic relatedness of recovered viruses, suggesting that viral reand deactivation and organ homing are interconnected for different body compartments. 13,14,44,45”

    From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [45]

    The Discussion (page unavailable) reports that viral populations in blood and lymphoid tissue may be genetically linked and that latent viral populations appear largely equilibrated between blood and gut tissue. It does not establish the claimed connection between viral reactivation or deactivation and organ homing; the authors also state that they did not examine tissue reservoirs in this study. (LLM, conf=0.85)

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Research works printed but not linked: 1

  1. [32]Folks TM, Powell D, Lightfoote M, Koenig S, Fauci AS, Benn S, Rabson A, Daugherty D, Gendelman HE, Hoggan MD, Biological and biochemical characterization of a cloned Leu-3- cell surviving. J. Exp. Med 164, 280– 290 (1986). 3014036 PMC2188205

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Authors
Abrahams, M.-R., Joseph, S. B., Garrett, N., Tyers, L., Moeser, M., Archin, N., Council, O. D., Matten, D., Zhou, S., Doolabh, D., Anthony, C., Goonetilleke, N., Karim, S. A., Margolis, D. M., Pond, S. K., Williamson, C., & Swanstrom, R.
Affiliations
  • University of Cape Town (ZA)
  • University of North Carolina at Chapel Hill (US)
  • Centre for the AIDS Programme of Research in South Africa (ZA)
  • Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.
  • Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
  • National Health Laboratory Service (ZA)
Corresponding author
  • Williamson, Carolyn
  • Swanstrom, Ronald
Venue
Science Translational Medicine
Published
2019-10-09
Volume
11
Issue
513
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2980286610
Cited by
196
References
62
Citations by year
2026: 13 · 2025: 25 · 2024: 26 · 2023: 31 · 2022: 33 · 2021: 28 · 2020: 36 · 2019: 4
FWCI
14.15
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
NIH/MRC (R01 AI115981)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords
HIV-1 latent reservoir, antiretroviral therapy, viral quasispecies, women living with HIV
MeSH terms
Female, Humans, Phylogeny, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Viral Load, Anti-Retroviral Agents

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