Cited by 399Apelin-related biomedical researchMuscle Physiology and DisordersNutrition and Health in Aging

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The exerkine apelin reverses age-associated sarcopenia

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Vinel, Claire, Lukjanenko, Laura, Batut, Aurelie, Deleruyelle, Simon, Pradère, Jean-Philippe, Le Gonidec, Sophie, Dortignac, Alizée, Geoffre, Nancy, Pereira, Ophelie, Karaz, Sonia, Lee, Umji, Camus, Mylène, Chaoui, Karima, Mouisel, Etienne, Bigot, Anne, Mouly, Vincent, Vigneau, Mathieu, Pagano, Allan F., Chopard, Angèle, Pillard, Fabien, Guyonnet, Sophie, Cesari, Matteo, Burlet-Schiltz, Odile, Pahor, Marco, Feige, Jerome N., Vellas, Bruno, Valet, Philippe, Dray, Cedric·2018·Nature Medicine

DOI 10.1038/s41591-018-0131-6

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Abstract

Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition often responsible for the medical institutionalization of elderly individuals. Herein we report that production of the endogenous peptide apelin, induced by muscle contraction, is reduced in an age-dependent manner in humans and rodents and is positively associated with the beneficial effects of exercise in older persons. Mice deficient in either apelin or its receptor (APLNR) presented dramatic alterations in muscle function with increasing age. Various strategies that restored apelin signaling during aging further demonstrated that this peptide considerably enhanced muscle function by triggering mitochondriogenesis, autophagy and anti-inflammatory pathways in myofibers as well as enhancing the regenerative capacity by targeting muscle stem cells. Taken together, these findings revealed positive regulatory feedback between physical activity, apelin and muscle function and identified apelin both as a tool for diagnosis of early sarcopenia and as the target of an innovative pharmacological strategy to prevent age-associated muscle weakness and restore physical autonomy.

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Authors: Vinel, C., Lukjanenko, L., Batut, A., Deleruyelle, S., Pradère, J.-P., Le Gonidec, S., Dortignac, A., Geoffre, N., Pereira, O., Karaz, S., Lee, U., Camus, M., Chaoui, K., Mouisel, E., Bigot, A., Mouly, V., Vigneau, M., Pagano, A. F., Chopard, A., Pillard, F., Guyonnet, S., Cesari, M., Burlet-Schiltz, O., Pahor, M., Feige, J. N., Vellas, B., Valet, P., & Dray, C.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Nestlé (Switzerland) (CH)
École Polytechnique Fédérale de Lausanne (CH)
Centre National de la Recherche Scientifique (FR)
Institut des Technologies Avancées en sciences du Vivant (FR)
Université de Montpellier (FR)
University of Florida (US)
ORCID: Vinel, Claire
Deleruyelle, Simon
Pradère, Jean-Philippe
Lee, Umji
Camus, Mylène
Chaoui, Karima
Bigot, Anne
Mouly, Vincent
Pagano, Allan F.
Chopard, Angèle
Pillard, Fabien
Guyonnet, Sophie
Cesari, Matteo
Vellas, Bruno
Valet, Philippe
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2018-07-30
Volume: 24
Issue: 9
Pages: 1360-1371
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/s41591-018-0131-6
OpenAlex: W2884388698
Cited by: 398
References: 64
Citations by year: 2026: 61 · 2025: 54 · 2024: 54 · 2023: 38 · 2022: 59 · 2021: 47 · 2020: 46 · 2019: 33 · 2018: 5
FWCI: 21.14
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: www.springer.com/tdm (tdm)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Funders: Agence Nationale de la Recherche (ANR-16-CE18-0022)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Apelin-related biomedical research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: apelin, sarcopenia, aging, skeletal muscle function, physical activity, apelin receptor, mitochondrial biogenesis, autophagy, muscle stem cells, muscle regeneration, frailty, anti-inflammatory signaling, exerkines, muscle weakness
MeSH terms: Apelin, Apelin Receptors, Adenylate Kinase, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Animals, Organelle Biogenesis, Body Weight, Humans, Kinetics, Mice, Inbred C57BL, Regeneration, Protein Biosynthesis, Exercise, Muscle, Skeletal, Muscle Weakness, Muscle Cells, Satellite Cells, Skeletal Muscle, Ribosomal Protein S6 Kinases, 70-kDa, Proto-Oncogene Proteins c-akt, Sarcopenia

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The exerkine apelin reverses age-associated sarcopenia

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