The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
Open accessAbstract
T cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is characteristic, yet often attributed to treatment. We reveal that even treatment-naïve subjects and mice with GBM can harbor AIDS-level CD4 counts, as well as contracted, T cell–deficient lymphoid organs. Missing naïve T cells are instead found sequestered in large numbers in the bone marrow. This phenomenon characterizes not only GBM but a variety of other cancers, although only when tumors are introduced into the intracranial compartment. T cell sequestration is accompanied by tumor-imposed loss of S1P1 from the T cell surface and is reversible upon precluding S1P1 internalization. In murine models of GBM, hindering S1P1 internalization and reversing sequestration licenses T cell–activating therapies that were previously ineffective. Sequestration of T cells in bone marrow is therefore a tumor-adaptive mode of T cell dysfunction, whose reversal may constitute a promising immunotherapeutic adjunct. Patients with glioblastoma experience lymphopenia and sequestration of T cells in the bone marrow, which is recapitulated in mice with brain tumors, where the reversible nature of this effect is demonstrated by an approach that enables the efficacy of other immunotherapeutics.
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Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
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Cited by
Wen, P. Y., Weller, M., Lee, E. Q., Alexander, B. M., Barnholtz-Sloan, J. S., Barthel, F. P., Batchelor, T. T., Bindra, R. S., Chang, S. M., Chiocca, E. A., et al. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa106 · Cited by 1,168
Brain immunology and immunotherapy in brain tumours
Sampson, J. H., Gunn, M. D., Fecci, P. E., & Ashley, D. M. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0224-7 · Cited by 722
Self-citationGlioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer
Gimple, R. C., Bhargava, S., Dixit, D., & Rich, J. N. (2019) · Genes & Development · doi:10.1101/gad.324301.119 · Cited by 514
Finding a way out: S1P signaling and immune cell migration
Baeyens, A. A. L., & Schwab, S. R. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-081519-083952 · Cited by 123
Duerinck, J., Schwarze, J. K., Awada, G., Tijtgat, J., Vaeyens, F., Bertels, C., Geens, W., Klein, S., Seynaeve, L., Cras, L., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002296 · Cited by 113
Metadata
- Authors
- Chongsathidkiet, P., Jackson, C., Koyama, S., Loebel, F., Cui, X., Farber, S. H., Woroniecka, K., Elsamadicy, A. A., Dechant, C. A., Kemeny, H. R., Sanchez-Perez, L., Cheema, T. A., Souders, N. C., Herndon, J. E., Coumans, J.-V., Everitt, J. I., Nahed, B. V., Sampson, J. H., Gunn, M. D., Martuza, R. L., Dranoff, G., Curry, W. T., & Fecci, P. E.
- Venue
- Nature Medicine
- Published
- 2018-08-13
- Volume
- 24
- Issue
- 9
- Pages
- 1459-1468
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2887361912
- Cited by
- 668
- References
- 44
- FWCI
- 20.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Chongsathidkiet, P., Jackson, C., Koyama, S., Loebel, F., Cui, X., Farber, S. H., Woroniecka, K., Elsamadicy, A. A., Dechant, C. A., Kemeny, H. R., Sanchez-Perez, L., Cheema, T. A., Souders, N. C., Herndon, J. E., Coumans, J.-V., Everitt, J. I., Nahed, B. V., Sampson, J. H., Gunn, M. D., . . . Fecci, P. E. (2018). Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nature Medicine. https://doi.org/10.1038/s41591-018-0135-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
