The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Three Es of Cancer Immunoediting
Abstract
After a century of controversy, the notion that the immune system regulates cancer development is experiencing a new resurgence. An overwhelming amount of data from animal models—together with compelling data from human patients—indicate that a functional cancer immunosurveillance process indeed exists that acts as an extrinsic tumor suppressor. However, it has also become clear that the immune system can facilitate tumor progression, at least in part, by sculpting the immunogenic phenotype of tumors as they develop. The recognition that immunity plays a dual role in the complex interactions between tumors and the host prompted a refinement of the cancer immunosurveillance hypothesis into one termed “cancer immunoediting.” In this review, we summarize the history of the cancer immunosurveillance controversy and discuss its resolution and evolution into the three Es of cancer immunoediting—elimination, equilibrium, and escape.
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Cites
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Cited by
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
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Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474
Self-citationThe immune contexture in human tumours: impact on clinical outcome
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Inflammation and cancer: triggers, mechanisms, and consequences
Greten, F. R., & Grivennikov, S. I. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.025 · Cited by 3,806
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
Zaretsky, J. M., Garcia-Diaz, A., Shin, D. S., Escuin-Ordinas, H., Hugo, W., Hu-Lieskovan, S., Torrejon, D. Y., Abril-Rodriguez, G., Sandoval, S., Barthly, L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1604958 · Cited by 3,237
Metadata
- Authors
- Dunn, G. P., Old, L. J., & Schreiber, R. D.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2004-04-01
- Volume
- 22
- Issue
- 1
- Pages
- 329-360
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2121626779
- Cited by
- 3,072
- References
- 9
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
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