Cited by 305Reproductive tract infections researchGut microbiota and healthOral microbiology and periodontitis research

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Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

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Serrano, Myrna G., Parikh, Hardik I., Brooks, J. Paul, Edwards, David J., Arodz, Tom J., Edupuganti, Laahirie, Huang, Bernice, Girerd, Philippe H., Bokhari, Yahya A., Bradley, Steven P., Brooks, Jamie L., Dickinson, Molly R., Drake, Jennifer I., Duckworth, Robert A., Fong, Stephen S., Glascock, Abigail L., Jean, Sophonie, Jimenez, Nicole R., Khoury, Joseph, Koparde, Vishal N., Lara, Ana M., Lee, Vladimir, Matveyev, Andrey V., Milton, Sarah H., Mistry, Shreni D., Rozycki, Sarah K., Sheth, Nihar U., Smirnova, Ekaterina, Vivadelli, Stephany C., Wijesooriya, N. Romesh, Xu, Jie, Xu, Ping, Chaffin, Donald O., Sexton, Amber L., Gravett, Michael G., Rubens, Craig E., Hendricks-Muñoz, Karen D., Jefferson, Kimberly K., Strauss, Jerome F., Fettweis, Jennifer M., Buck, Gregory A.·2019·Nature Medicine

DOI 10.1038/s41591-019-0465-8PMC PMC6746180

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Abstract

The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.

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Authors: Serrano, M. G., Parikh, H. I., Brooks, J. P., Edwards, D. J., Arodz, T. J., Edupuganti, L., Huang, B., Girerd, P. H., Bokhari, Y. A., Bradley, S. P., Brooks, J. L., Dickinson, M. R., Drake, J. I., Duckworth, R. A., Fong, S. S., Glascock, A. L., Jean, S., Jimenez, N. R., Khoury, J., Koparde, V. N., Lara, A. M., Lee, V., Matveyev, A. V., Milton, S. H., Mistry, S. D., Rozycki, S. K., Sheth, N. U., Smirnova, E., Vivadelli, S. C., Wijesooriya, N. R., Xu, J., Xu, P., Chaffin, D. O., Sexton, A. L., Gravett, M. G., Rubens, C. E., Hendricks-Muñoz, K. D., Jefferson, K. K., Strauss, J. F., Fettweis, J. M., & Buck, G. A.
Affiliations: Virginia Commonwealth University (US)
Global Alliance to Prevent Prematurity and Stillbirth (US)
University of Washington (US)
Corresponding author: Buck, Gregory A.
ORCID: Serrano, Myrna G.
Parikh, Hardik I.
Brooks, J. Paul
Edwards, David J.
Arodz, Tom J.
Edupuganti, Laahirie
Bokhari, Yahya A.
Brooks, Jamie L.
Drake, Jennifer I.
Fong, Stephen S.
Glascock, Abigail L.
Jimenez, Nicole R.
Rozycki, Sarah K.
Smirnova, Ekaterina
Xu, Ping
Gravett, Michael G.
Jefferson, Kimberly K.
Strauss, Jerome F.
Fettweis, Jennifer M.
Buck, Gregory A.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2019-05-29
Volume: 25
Issue: 6
Pages: 1001-1011
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/s41591-019-0465-8
PMC: PMC6746180
OpenAlex: W2947787281
Cited by: 300
References: 70
Citations by year: 2026: 28 · 2025: 31 · 2024: 40 · 2023: 58 · 2022: 46 · 2021: 52 · 2020: 33 · 2019: 12
FWCI: 26.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R25GM090084)
National Institute of Allergy and Infectious Diseases (UH2AI083263, UH3AI083263)
National Institute of Dental and Craniofacial Research (U54DE023786)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD080784, R01HD092415, R21HD092965)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: vaginal microbiota, pregnancy, racial and ethnic diversity, Lactobacillus, vaginal dysbiosis, African ancestry, Hispanic origin, socioeconomic status, reproductive tract microbiome, term birth
MeSH terms: Host Microbial Interactions, Adult, Black or African American, Cross-Sectional Studies, Female, Hispanic or Latino, Humans, Pregnancy, Social Class, Vagina, Cohort Studies, White People, Biodiversity, Microbiota

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Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

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