Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps

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Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

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Clinical use of current polygenic risk scores may exacerbate health disparities

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The personal and clinical utility of polygenic risk scores

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Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

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Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations

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Polygenic risk scores: from research tools to clinical instruments

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Medical apartheid: the dark history of medical experimentation on black Americans from Colonial times to the present

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Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

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Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults

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BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

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Improving polygenic prediction in ancestrally diverse populations

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Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

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The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

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Race and Genetic Ancestry in Medicine — A Time for Reckoning with Racism

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Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting

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Towards clinical utility of polygenic risk scores

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Predictive Accuracy of a Polygenic Risk Score–Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease

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Improving reporting standards for polygenic scores in risk prediction studies

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Variable prediction accuracy of polygenic scores within an ancestry group

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Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

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Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

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From race-based to race-conscious medicine: how anti-racist uprisings call us to act

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Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank

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The Global State of the Genetic Counseling Profession

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Development and standardization of an improved type 1 diabetes genetic risk score for use in newborn screening and incident diagnosis

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A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults

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The GWAS Diversity Monitor tracks diversity by disease in real time

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Genomic prediction of coronary heart disease

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Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine

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Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history

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Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial)

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The Behavioral Response to Personalized Genetic Information: Will Genetic Risk Profiles Motivate Individuals and Families to Choose More Healthful Behaviors?

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Patients With High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit From Alirocumab Treatment in the ODYSSEY OUTCOMES Trial

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CanRisk Tool—A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants

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A standardized framework for representation of ancestry data in genomics studies, with application to the NHGRI-EBI GWAS Catalog

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Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score

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Problems with Using Polygenic Scores to Select Embryos

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Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes

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A Model for Genome-First Care: Returning Secondary Genomic Findings to Participants and Their Healthcare Providers in a Large Research Cohort

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Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues

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Multilocus Genetic Risk Scores for Coronary Heart Disease Prediction

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A combined risk score enhances prediction of type 1 diabetes among susceptible children

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Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups

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Learning one’s genetic risk changes physiology independent of actual genetic risk

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Polygenic Scores for Height in Admixed Populations

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Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong

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Improving Polygenic Prediction in Ancestrally Diverse PopulationsPreprint

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Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland

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Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction

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CanRisk Tool-A Web Interface for the Prediction of Breast and Ovarian Cancer Risk and the Likelihood of Carrying Genetic Pathogenic Variants.

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Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis

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Improving reporting standards for polygenic scores in risk prediction studiesPreprint

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On What We Have Learned and Still Need to Learn about the Psychosocial Impacts of Genetic Testing

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Of Screening, Stratification, and Scores

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Explaining, not just predicting, drives interest in personal genomics

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