Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)
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Abstract
Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. Herein, we report on the immune profiles of nine MIS-C cases. All MIS-C patients had evidence of prior SARS-CoV-2 exposure, mounting an antibody response with intact neutralization capability. Cytokine profiling identified elevated signatures of inflammation (IL-18 and IL-6), lymphocytic and myeloid chemotaxis and activation (CCL3, CCL4, and CDCP1), and mucosal immune dysregulation (IL-17A, CCL20, and CCL28). Immunophenotyping of peripheral blood revealed reductions of non-classical monocytes, and subsets of NK and T lymphocytes, suggesting extravasation to affected tissues. Finally, profiling the autoantigen reactivity of MIS-C plasma revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal, and immune-cell antigens. All patients were treated with anti-IL-6R antibody and/or IVIG, which led to rapid disease resolution.
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MIS-C has distinct immunological features from acute severe adult COVID-19 and Kawasaki disease in circulating cytokine profiles and T cell compartment composition.
“MIS-C has distinct immunological features different from the two with respect to circulating cytokine profiles and composition of the T cell compartment”
From COVID-19 and the human innate immune system (2021) · cites this paper as Gruber et al., 2020
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R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works
A novel coronavirus from patients with pneumonia in China, 2019
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244 · see citing works
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969 · see citing works
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
Gu, Z., Eils, R., & Schlesner, M. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw313 · Cited by 10,122 · see citing works
Virological assessment of hospitalized patients with COVID-2019
Wölfel, R., Corman, V. M., Guggemos, W., Seilmaier, M., Zange, S., Müller, M. A., Niemeyer, D., Jones, T. C., Vollmar, P., Rothe, C., et al. (2020) · Nature · doi:10.1038/s41586-020-2196-x · Cited by 6,661 · see citing works
Epidemiology of COVID-19 Among Children in China
Dong, Y., Mo, X., Hu, Y., Qi, X., Jiang, F., Jiang, Z., & Tong, S. (2020) · PEDIATRICS · doi:10.1542/peds.2020-0702 · Cited by 4,130 · see citing works
UpSetR: an R package for the visualization of intersecting sets and their properties
Conway, J. R., Lex, A., & Gehlenborg, N. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx364 · Cited by 3,586 · see citing works
Hyperinflammatory shock in children during COVID-19 pandemic
Riphagen, S. D., Gomez, X., González-Martínez, C., Wilkinson, N. M., & Theocharis, P. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31094-1 · Cited by 2,492 · see citing works
Verdoni, L., Mazza, A., Gervasoni, A., Martelli, L., Ruggeri, M., Ciuffreda, M., Bonanomi, E., & D’Antiga, L. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31103-x · Cited by 2,379 · see citing works
Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults
Ludvigsson, J. F. (2020) · Acta Paediatrica · doi:10.1111/apa.15270 · Cited by 2,313 · see citing works
Whittaker, E., Bamford, A., Kenny, J. M., Kaforou, M., Jones, C. E., Shah, P., Ramnarayan, P., Fraisse, A., Miller, O., Davies, P., et al. (2020) · JAMA · doi:10.1001/jama.2020.10369 · Cited by 1,996 · see citing works
A serological assay to detect SARS-CoV-2 seroconversion in humans
Amanat, F., Stadlbauer, D., Strohmeier, S., Nguyen, T. H. O., Chromikova, V., McMahon, M., Jiang, K., Arunkumar, G. A., Jurczyszak, D., Polanco, J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0913-5 · Cited by 1,769 · see citing works
Self-citationA New Infantile Acute Febrile Mucocutaneous Lymph Node Syndrome (MLNS) Prevailing in Japan
Kawasaki, T., Kosaki, F., Okawa, S., SHIGEMATSU, I., & Yanagawa, H. (1974) · PEDIATRICS · doi:10.1542/peds.54.3.271 · Cited by 1,506 · see citing works
Zheng, S., Fan, J., Yu, F., Feng, B., Lou, B., Zou, Q., Xie, G., Lin, S., Wang, R., Yang, X., et al. (2020) · BMJ · doi:10.1136/bmj.m1443 · Cited by 1,439 · see citing works
Kawasaki, T. (1967) · PubMed · Cited by 1,359 · see citing works
Toubiana, J., Poirault, C., Corsia, A., Bajolle, F., Fourgeaud, J., Angoulvant, F., Debray, A., Basmaci, R., Salvador, E., Biscardi, S., et al. (2020) · BMJ · doi:10.1136/bmj.m2094 · Cited by 1,143 · see citing works
CSF-1 receptor signaling in myeloid cells.
Stanley, E. R., & Chitu, V. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021857 · Cited by 825 · see citing works
Scola, B. L., Bideau, M. L., Andréani, J., Hoang, V. T., Grimaldier, C., Colson, P., Gautret, P., & Raoult, D. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-03913-9 · Cited by 812 · see citing works
Nishimoto, N., Terao, K., Mima, T., Nakahara, H., Takagi, N., & Kakehi, T. (2008) · Blood · doi:10.1182/blood-2008-05-155846 · Cited by 781 · see citing works
Macrophage inflammatory protein-1
Maurer, M., & von Stebut, E. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.10.019 · Cited by 769 · see citing works
COVID-19 and Kawasaki Disease: Novel Virus and Novel Case
Jones, V. G., Mills, M., Suarez, D., Hogan, C. A., Yeh, D., Segal, J., Nguyen, E. L., Barsh, G. R., Maskatia, S. A., & Mathew, R. (2020) · Hospital Pediatrics · doi:10.1542/hpeds.2020-0123 · Cited by 766 · see citing works
Zunder, E. R., Finck, R., Behbehani, G. K., Amir, E.-A. D., Krishnaswamy, S., Gonzalez, V. D., Lorang, C. G., Bjornson, Z., Spitzer, M. H., Bodenmiller, B., et al. (2015) · Nature Protocols · doi:10.1038/nprot.2015.020 · Cited by 596 · see citing works
Cheung, E. W., Zachariah, P., Gorelik, M., Boneparth, A. D., Kernie, S. G., Orange, J. S., & Milner, J. D. (2020) · JAMA · doi:10.1001/jama.2020.10374 · Cited by 568 · see citing works
Epidemiology of Kawasaki Disease in Asia, Europe, and the United States
Uehara, R., & Belay, E. D. (2012) · Journal of Epidemiology · doi:10.2188/jea.je20110131 · Cited by 552 · see citing works
Web‐Based Analysis and Publication of Flow Cytometry Experiments
Kotecha, N., Krutzik, P. O., & Irish, J. M. (2010) · Current Protocols in Cytometry · doi:10.1002/0471142956.cy1017s53 · Cited by 513 · see citing works
Sokka, T., Toloza, S., Cutolo, M., Kautiainen, H., Mäkinen, H., Gogus, F. N., Skakić, V., Badsha, H., Peets, T., Baranauskaitė, A., et al. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2591 · Cited by 476 · see citing works
Paleobiological Perspectives on Early Eukaryotic Evolution
Knoll, A. H. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016121 · Cited by 394 · see citing works
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy
Vilgelm, A. E., & Richmond, A. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00333 · Cited by 372 · see citing works
Autoantigen discovery with a synthetic human peptidome
Larman, H. B., Zhao, Z., Laserson, U., Li, M. Z., Ciccia, A., Gakidis, M. A. M., Church, G. M., Kesari, S., LeProust, E. M., Solimini, N. L., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1856 · Cited by 354 · see citing works
Self-citationHospitalizations for Kawasaki Syndrome Among Children in the United States, 1997–2007
Holman, R. C., Belay, E. D., Christensen, K. L. Y., Folkema, A. M., Steiner, C., & Schonberger, L. B. (2010) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181cf8705 · Cited by 341 · see citing works
Foell, D., Kucharzik, T., Kraft, M., Vogl, T., Sorg, C., Domschke, W., & Roth, J. (2003) · Gut · doi:10.1136/gut.52.6.847 · Cited by 279 · see citing works
Anti-Ro/SSA and La/SSB antibodies
Franceschini, F., & Cavazzana, I. (2005) · Autoimmunity · doi:10.1080/08916930400022954 · Cited by 265 · see citing works
Vahidy, F., Nicolas, J. C., Meeks, J. R., Khan, O. A., Pan, A. P., Jones, S. L., Masud, F. N., Sostman, H. D., Phillips, R. A., Andrieni, J., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-039849 · Cited by 247 · see citing works
Viral infections associated with Kawasaki disease
Chang, L., Lu, C., Shao, P., Lee, P., Lin, M., Fan, T.-Y., Cheng, A., Lee, W.-L., Hu, J., Yeh, S.-J., et al. (2014) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2013.12.008 · Cited by 235 · see citing works
Epidemiologic Features of Kawasaki Disease in Japan: Results of the 2007–2008 Nationwide Survey
Nakamura, Y., Yashiro, M., Uehara, R., Sadakane, A., Chihara, I., Aoyama, Y., Kotani, K., & Yanagawa, H. (2010) · Journal of Epidemiology · doi:10.2188/jea.je20090180 · Cited by 201 · see citing works
Seromic profiling of ovarian and pancreatic cancer
Gnjatic, S., Ritter, E., Büchler, M. W., Giese, N. A., Brors, B., Frei, C., Murray, A., Halama, N., Zörnig, I., Chen, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914213107 · Cited by 176 · see citing works
Self-citationRegulation of DNA Pairing in Homologous RecombinationPreprint
Daley, J. M., Gaines, W. A., Kwon, Y., & Sung, P. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017954 · Cited by 173 · see citing works
Functional Characteristics of the High Affinity IgG Receptor, FcγRI
van der Poel, C. E., Spaapen, R. M., van de Winkel, J. G. J., & Leusen, J. H. W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003526 · Cited by 173 · see citing works
Dissecting Kawasaki disease: a state-of-the-art review
Dietz, S. M., van Stijn, D., Burgner, D. P., Levin, M., Kuipers, I. M., Hutten, B. A., & Kuijpers, T. W. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-2937-5 · Cited by 171 · see citing works
Concurrent Respiratory Viruses and Kawasaki Disease
Turnier, J. L., Anderson, M. S., Heizer, H. R., Jone, P., Glodé, M. P., & Dominguez, S. R. (2015) · PEDIATRICS · doi:10.1542/peds.2015-0950 · Cited by 168 · see citing works
Williams, I. R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.036 · Cited by 167 · see citing works
The genetics of Kawasaki disease
Onouchi, Y. (2017) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13218 · Cited by 137 · see citing works
Kariyazono, H., Ohno, T., Khajoee, V., Ihara, K., Kusuhara, K., Kinukawa, N., Mizuno, Y., & Hara, T. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000145280.26284.b9 · Cited by 125 · see citing works
CCL28 chemokine: An anchoring point bridging innate and adaptive immunity
Mohan, T., Deng, L., & Wang, B. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.012 · Cited by 121 · see citing works
DiMaggio, C. J., Klein, M., Berry, C., & Frangos, S. (2020) · Annals of Epidemiology · doi:10.1016/j.annepidem.2020.08.012 · Cited by 117 · see citing works
CD54 is a surrogate marker of antigen presenting cell activation
Sheikh, N. A., & Jones, L. A. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0474-9 · Cited by 115 · see citing works
Li, Y., Lee, P. Y., Sobel, E. S., Narain, S., Satoh, M., Segal, M. S., Reeves, W. H., & Richards, H. B. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2590 · Cited by 113 · see citing works
Rauf, A., Vijayan, A., John, S. T., Krishnan, R., & Latheef, A. (2020) · The Indian Journal of Pediatrics · doi:10.1007/s12098-020-03357-1 · Cited by 105 · see citing works
Concurrent Respiratory Viruses and Kawasaki Disease
(2015) · PEDIATRICS · doi:10.1542/peds.2015-0950d · Cited by 104 · see citing works
Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer
Xu, G. J., Shah, A. A., Li, M. Z., Xu, Q., Rosen, A., Casciola-Rosen, L. A., & Elledge, S. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615990113 · Cited by 103 · see citing works
Li, Y., Lee, P. Y., Kellner, E. S., Paulus, M., Switanek, J., Xu, Y., Zhuang, H., Sobel, E. S., Segal, M. S., Satoh, M., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3017 · Cited by 93 · see citing works
CONCOMITANT RESPIRATORY VIRAL INFECTIONS IN CHILDREN WITH KAWASAKI DISEASE
Jordán-Villegas, A., Chang, M., Ramilo, O., & Mejías, A. (2010) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181dba70b · Cited by 82 · see citing works
Increased Serum Levels of Vascular Endothelial Growth Factor in Kawasaki Disease
Maeno, N., Takei, S., Masuda, K., Akaike, H., Matsuo, K., Kitajima, I., Maruyama, I., & Miyata, K. (1998) · Pediatric Research · doi:10.1203/00006450-199810000-00021 · Cited by 74 · see citing works
Clinical spectrum of anti-Jo-1-associated disease
Monti, S. M., Montecucco, C., & Cavagna, L. (2017) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000434 · Cited by 52 · see citing works
Antisynthetase Syndrome: A Review of Etiopathogenesis, Diagnosis and Management
Mirrakhimov, A. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150514094935 · Cited by 44 · see citing works
Pietschmann, P., Stohlawetz, P. J., Brosch, S., Steiner, G. E., Smolen, J. S., & Peterlik, M. (1998) · Calcified Tissue International · doi:10.1007/s002239900535 · Cited by 43 · see citing works
Tanaka, M., Krutzik, S. R., Sieling, P. A., Lee, D. J., Rea, T. H., & Modlin, R. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801683 · Cited by 41 · see citing works
Vahidy, F., Nicolas, J. C., Meeks, J. R., et al. (2020) · medRxiv · doi:10.1101/2020.04.24.20073148 · Cited by 38 · see citing works
Grüter, T., Ott, A., Meyer, W., Jarius, S., Kinner, M., Motte, J., Pitarokoili, K., Gold, R., Komorowski, L., & Ayzenberg, I. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09614-4 · Cited by 33 · see citing works
Cardiel, M. H., Tak, P. P., Bensen, W., Burch, F. X., Forejtová, Š., Badurski, J. E., Kakkar, T., Bevirt, T., Ni, L., McCroskery, E., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3163 · Cited by 32 · see citing works
Hokibara, S., Kobayashi, N., Kobayashi, K., Shigemura, T., Nagumo, H., Takizawa, M., Yamazaki, T., & Agematsu, K. (2016) · Inflammation Research · doi:10.1007/s00011-016-0942-1 · Cited by 31 · see citing works
Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19
Klocperk, A., Paračková, Z., Dissou, J., Malcová, H., Pavlíček, P., Vymazal, T., Doležalová, P., & Šedivá, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01665 · Cited by 27 · see citing works
Anti‐ SSA antibodies are present in immunoglobulin preparations
Molen, R. G. V. D., Hamann, D., Jacobs, J. F. M., van der Meer, A., de Jong, J., Krämer, C., Strengers, P. F. W., & van der Meer, J. W. M. (2014) · Transfusion · doi:10.1111/trf.12922 · Cited by 20 · see citing works
DiMaggio, C. J., Klein, M., Berry, C., et al. (2020) · medRxiv · doi:10.1101/2020.05.14.20101691 · Cited by 14 · see citing works
Systemic inflammatory response and fast recovery in a pediatric patient with COVID-19Preprint
Klocperk, A., Paračková, Z., Dissou, J., Malcová, H., ek, P. P., Vymazal, T., alov, P. D., & Šedivá, A. (2020) · doi:10.22541/au.158949134.47581105 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- DiMaggio C. Klein M. Berry C. Frangos S. Blacks/African Americans are 5 Times More Likely to Develop COVID-19: Spatial Modeling of New York City ZIP Code-level Testing Results MedRxiv 2020 2020.05.14.20101691 PMC7438213 32827672
Cited by
Sorted by citations
Adaptive immunity to SARS-CoV-2 and COVID-19
Sette, A., & Crotty, S. (2021) · Cell · doi:10.1016/j.cell.2021.01.007 · Cited by 1,860 · see citing works
Diverse functional autoantibodies in patients with COVID-19
Wang, E. Y., Mao, T., Klein, J., Dai, Y., Huck, J. D., Jaycox, J. R., Liu, F., Zhou, T., Israelow, B., Wong, P., et al. (2021) · Nature · doi:10.1038/s41586-021-03631-y · Cited by 999 · see citing works
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Consiglio, C. R., Cotugno, N., Sardh, F., Pou, C., Amodio, D., Rodriguez, L., Tan, Z., Zicari, S., Ruggiero, A., Pascucci, G. R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.016 · Cited by 919 · see citing works
COVID-19 and multisystem inflammatory syndrome in children and adolescents
Jiang, L., Tang, K., Levin, M., Irfan, O., Morris, S. K., Wilson, K. M., Klein, J. D., & Bhutta, Z. A. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30651-4 · Cited by 826 · see citing works
Self-citationCOVID-19 and the human innate immune system
Schultze, J. L., & Aschenbrenner, A. C. (2021) · Cell · doi:10.1016/j.cell.2021.02.029 · Cited by 714 · see citing works
Immune determinants of COVID-19 disease presentation and severity
Brodin, P. (2021) · Nature Medicine · doi:10.1038/s41591-020-01202-8 · Cited by 654 · see citing works
Systems vaccinology of the BNT162b2 mRNA vaccine in humans
Arunachalam, P. S., Scott, M. K. D., Hagan, T., Li, C., Feng, Y., Wimmers, F., Grigoryan, L., Trisal, M., Edara, V. V., Lai, L., et al. (2021) · Nature · doi:10.1038/s41586-021-03791-x · Cited by 539 · see citing works
Weisberg, S. P., Connors, T. J., Zhu, Y., Baldwin, M. R., Lin, W.-H. W., Wontakal, S. N., Szabo, P. A., Wells, S. B., Dogra, P., Gray, J. I., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-00826-9 · Cited by 540 · see citing works
New-onset IgG autoantibodies in hospitalized patients with COVID-19
Chang, S. E., Feng, A., Meng, W., Apostolidis, S. A., Mack, E., Artandi, M. K., Barman, L., Bennett, K., Chakraborty, S., Chang, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25509-3 · Cited by 488 · see citing works
Multisystem inflammatory syndrome in children related to COVID-19: a systematic review
Hoste, L., Paemel, R. V., & Haerynck, F. (2021) · European Journal of Pediatrics · doi:10.1007/s00431-021-03993-5 · Cited by 454 · see citing works
Wik, L., Nordberg, N., Broberg, J., Björkesten, J., Assarsson, E., Henriksson, S., Grundberg, I., Pettersson, E., Westerberg, C., Liljeroth, E., et al. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100168 · Cited by 453 · see citing works
The first 12 months of COVID-19: a timeline of immunological insights
Carvalho, T., Krammer, F., & Iwasaki, A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00522-1 · Cited by 448 · see citing works
Self-citationHenderson, L. A., Canna, S., Friedman, K. G., Gorelik, M., Lapidus, S., Bassiri, H., Behrens, E. M., Ferris, A. M., Kernan, K. F., Schulert, G. S., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41616 · Cited by 420 · see citing works
Kabeerdoss, J., Pilania, R. K., Karkhele, R., Kumar, S., Danda, D., & Singh, S. (2020) · Rheumatology International · doi:10.1007/s00296-020-04749-4 · Cited by 352 · see citing works
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors
Cheong, J.-G., Ravishankar, A., Sharma, S., Parkhurst, C. N., Grassmann, S. A., Wingert, C. K., Laurent, P., Ma, S., Paddock, L., Miranda, I. C., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.019 · Cited by 309 · see citing works
Henderson, L. A., Canna, S., Friedman, K. G., Gorelik, M., Lapidus, S., Bassiri, H., Behrens, E. M., Kernan, K. F., Schulert, G. S., Seo, P., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42062 · Cited by 304 · see citing works
Ramaswamy, A., Brodsky, N. N., Sumida, T. S., Comi, M., Asashima, H., Hoehn, K. B., Li, N., Liu, Y., Shah, A. S., Ravindra, N. G., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.003 · Cited by 270 · see citing works
Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison
Sharma, C., Ganigara, M., Galeotti, C., Burns, J., Berganza, F. M., Hayes, D. A., Singh‐Grewal, D., Bharath, S., Sajjan, S., & Bayry, J. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00709-9 · Cited by 258 · see citing works
Sacco, K., Castagnoli, R., Vakkilainen, S., Liu, C., Delmonte, O. M., Oguz, C., Kaplan, I. M., Alehashemi, S., Burbelo, P. D., Bhuyan, F., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01724-3 · Cited by 247 · see citing works
Yonker, L. M., Gilboa, T., Ogata, A. F., Senussi, Y., Lazarovits, R., Boribong, B. P., Bartsch, Y. C., Loiselle, M., Rivas, M. N., Porritt, R. A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149633 · Cited by 246 · see citing works
Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)
Sherif, Z. A., Gómez, C. R., Connors, T. J., Henrich, T. J., Reeves, W. B., & RECOVER Mechanistic Pathway Task Force (2023) · eLife · doi:10.7554/elife.86002 · Cited by 238 · see citing works
Neurological issues in children with COVID-19
Lin, J. E., Asfour, A., Sewell, T. B., Hooe, B. S., Pryce, P. A., Earley, C., Shen, M. Y., Kerner-Rossi, M., Thakur, K. T., Vargas, W. S., et al. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135567 · Cited by 238 · see citing works
Vogel, T. P., Top, K. A., Karatzios, C., Hilmers, D. C., Tapia, L. I., Moceri, P., Giovannini‐Chami, L., Wood, N. J., Chandler, R. E., Klein, N. P., et al. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.01.054 · Cited by 235 · see citing works
Vella, L. A., Giles, J. R., Baxter, A. E., Oldridge, D. A., Diorio, C. J., Kuri-Cervantes, L., Alanio, C., Pampena, M. B., Wu, J. E., Chen, Z., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abf7570 · Cited by 219 · see citing works
Dowell, A. C., Butler, M., Jinks, E., Tut, G., Lancaster, T., Sylla, P., Begum, J., Bruton, R. K., Pearce, H., Verma, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01089-8 · Cited by 195 · see citing works
Porritt, R. A., Paschold, L., Rivas, M. N., Cheng, M. H., Yonker, L. M., Chandnani, H. K., Lopez, M., Simnica, D., Schultheiß, C., Santiskulvong, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146614 · Cited by 186 · see citing works
Truong, D. T., Dionne, A., Muniz, J. C., McHugh, K. E., Portman, M. A., Lambert, L. M., Thacker, D., Elias, M. D., Li, J. S., Toro-Salazar, O. H., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.056583 · Cited by 182 · see citing works
Immunology of SARS-CoV-2 infection in children
Chou, J. S., Thomas, P. G., & Randolph, A. G. (2022) · Nature Immunology · doi:10.1038/s41590-021-01123-9 · Cited by 171 · see citing works
McMurray, J. C., May, J. W., Cunningham, M. W., & Jones, O. Y. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.626182 · Cited by 169 · see citing works
Humoral signatures of protective and pathological SARS-CoV-2 infection in children
Bartsch, Y. C., Wang, C., Zohar, T., Fischinger, S., Atyeo, C. G., Burke, J. S., Kang, J., Edlow, A. G., Fasano, A., Baden, L. R., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01263-3 · Cited by 166 · see citing works
Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
Lee, D., Pen, J. L., Yatim, A., Dong, B., Aquino, Y., Ogishi, M., Pescarmona, R., Talouarn, E., Rinchai, D., Zhang, P., et al. (2022) · Science · doi:10.1126/science.abo3627 · Cited by 158 · see citing works
The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children
Porritt, R. A., Binek, A., Paschold, L., Rivas, M. N., McArdle, A., Yonker, L. M., Alter, G., Chandnani, H. K., Lopez, M., Fasano, A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151520 · Cited by 155 · see citing works
COVID ‐19: immunopathology, pathophysiological mechanisms, and treatment options
van Eijk, L. E., Binkhorst, M., Bourgonje, A. R., Offringa, A. K., Mulder, D. J., Bos, E. M., Kolundžić, N., Abdulle, A. E., van der Voort, P. H. J., Rikkert, M. G. M. O., et al. (2021) · The Journal of Pathology · doi:10.1002/path.5642 · Cited by 153 · see citing works
Moreews, M., Gouge, K. L., Khaldi-Plassart, S., Pescarmona, R., Mathieu, A., Malcus, C., Djebali, S., Bellomo, A., Dauwalder, O., Perret, M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abh1516 · Cited by 149 · see citing works
SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Sancho‐Shimizu, V., Brodin, P., Cobat, A., Biggs, C. M., Toubiana, J., Lucas, C. L., Henrickson, S. E., Bélot, A., MIS-C@CHGE, Haddad, É., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210446 · Cited by 146 · see citing works
Coperchini, F., Chiovato, L., Ricci, G., Croce, L., Magri, F., & Rotondi, M. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.12.005 · Cited by 133 · see citing works
Esteve‐Solé, A., Antón, J., Pino-Ramirez, R. M., Sánchez-Manubens, J., Fumadó, V., Fortuny, C., Ríos-Barnés, M., Sánchez-de-Toledo, J., Girona‐Alarcón, M., Mosquera, J. M., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144554 · Cited by 131 · see citing works
In-Depth Evaluation of a Case of Presumed Myocarditis After the Second Dose of COVID-19 mRNA Vaccine
Muthukumar, A., Narasimhan, M., Li, Q., Mahimainathan, L., Hitto, I., Fuda, F. S., Batra, K., Jiang, X., Zhu, C., Schoggins, J. W., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.056038 · Cited by 128 · see citing works
Santos, M. D. O., Gonçalves, L. C., da Silva, P. A. N., Moreira, A. L. E., Ito, C. R. M., Peixoto, F. A. D. O., Wastowski, I. J., Carneiro, L. C., & Avelino, M. A. G. (2021) · Jornal de Pediatria · doi:10.1016/j.jped.2021.08.006 · Cited by 127 · see citing works
Zhao, Y., Yin, L., Patel, J. R., Tang, L., & Huang, Y. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26951 · Cited by 126 · see citing works
Immune cell profiling in atherosclerosis: role in research and precision medicine
Fernandez, D. M., & Giannarelli, C. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00589-2 · Cited by 124 · see citing works
Pawar, R. S., Gavade, V., Patil, N., Mali, V. T., Girwalkar, A., Tarkasband, V. A., Loya, S., Chavan, A., Nanivadekar, N., Shinde, R., et al. (2021) · Children · doi:10.3390/children8070572 · Cited by 125 · see citing works
SARS-CoV-2 infections in children: Understanding diverse outcomes
Brodin, P. (2022) · Immunity · doi:10.1016/j.immuni.2022.01.014 · Cited by 115 · see citing works
Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2
Esposito, S., & Principi, N. (2021) · Pediatric Drugs · doi:10.1007/s40272-020-00435-x · Cited by 115 · see citing works
Single-cell immunology of SARS-CoV-2 infection
Tian, Y., Carpp, L. N., Miller, H. E. R., Zager, M. A., Newell, E. W., & Gottardo, R. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-01131-y · Cited by 114 · see citing works
Godfred-Cato, S., Abrams, J. Y., Balachandran, N., Jaggi, P., Jones, K., Rostad, C. A., Lu, A. T., Fan, L., Jabbar, A., Anderson, E. J., et al. (2022) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003449 · Cited by 113 · see citing works
Longitudinal Outcomes for Multisystem Inflammatory Syndrome in Children
Farooqi, K. M., Chan, A., Weller, R. J., Mi, J., Jiang, P., Abrahams, E., Ferris, A. M., Krishnan, U., Pasumarti, N., Suh, S., et al. (2021) · PEDIATRICS · doi:10.1542/peds.2021-051155 · Cited by 111 · see citing works
Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Following COVID-19
Wu, E. Y., & Campbell, M. J. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01602-3 · Cited by 111 · see citing works
Rodriguez‐Smith, J., Verweyen, E. L., Clay, G. M., Esteban, Y., de Loizaga, S. R., Baker, E. J., Do, T., Dhakal, S., Lang, S. M., Grom, A. A., et al. (2021) · The Lancet Rheumatology · doi:10.1016/s2665-9913(21)00139-9 · Cited by 109 · see citing works
Mohandas, S., Jagannathan, P., Henrich, T. J., Sherif, Z. A., Bime, C., Quinlan, E. B., Portman, M. A., Gennaro, M. L., Rehman, J., & RECOVER Mechanistic Pathways Task Force (2023) · eLife · doi:10.7554/elife.86014 · Cited by 115 · see citing works
Lima‐Setta, F., de Magalhães‐Barbosa, M. C., Rodrigues-Santos, G., Figueiredo, E. A. D. N., Jacques, M. D. L., Zeitel, R. D. S., Sapolnik, R., Borges, C. T. D. S., Lanziotti, V. S., de Castro, R. E. V., et al. (2020) · Jornal de Pediatria · doi:10.1016/j.jped.2020.10.008 · Cited by 108 · see citing works
Rivas, M. N., Porritt, R. A., Cheng, M. H., Bahar, İ., & Arditi, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.941009 · Cited by 106 · see citing works
Molloy, E. J., Nakra, N. A., Gale, C., Dimitriades, V. R., & Lakshminrusimha, S. (2022) · Pediatric Research · doi:10.1038/s41390-022-02263-w · Cited by 105 · see citing works
Steinman, J. B., Lum, F., Ho, P. P.-K., Kaminski, N., & Steinman, L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012358117 · Cited by 103 · see citing works
Nonresolving inflammation redux
Nathan, C. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.016 · Cited by 103 · see citing works
A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment
Levey, A. I., Qiu, D., Zhao, L., Hu, W. T., Duong, D. M., Higginbotham, L. A., Dammer, E. B., Seyfried, N. T., Wingo, T. S., Hales, C. M., et al. (2021) · Brain · doi:10.1093/brain/awab452 · Cited by 101 · see citing works
Novelli, L., Motta, F., Santis, M. D., Ansari, A. A., Gershwin, M. E., & Selmi, C. F. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102592 · Cited by 100 · see citing works
Lessons learned: new insights on the role of cytokines in COVID-19
Buszko, M., Nita‐Lazar, A., Park, J., Schwartzberg, P. L., Verthelyi, D. I., Young, H. A., & Rosenberg, A. S. (2021) · Nature Immunology · doi:10.1038/s41590-021-00901-9 · Cited by 98 · see citing works
The cytokine storm and thyroid hormone changes in COVID-19
Croce, L., Gangemi, D., Ancona, G., Liboà, F., Bendotti, G., Minelli, L., & Chiovato, L. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01506-7 · Cited by 100 · see citing works
Why COVID-19 is less frequent and severe in children: a narrative review
Sinaei, R., Pezeshki, S., Parvaresh, S., & Sinaei, R. (2020) · World Journal of Pediatrics · doi:10.1007/s12519-020-00392-y · Cited by 93 · see citing works
Socioeconomic and Racial and/or Ethnic Disparities in Multisystem Inflammatory Syndrome
Javalkar, K., Robson, V. K., Gaffney, L. K., Bohling, A. M., Arya, P., Servattalab, S. E., Roberts, J. E., Campbell, J. I., Sekhavat, S., Newburger, J. W., et al. (2021) · PEDIATRICS · doi:10.1542/peds.2020-039933 · Cited by 88 · see citing works
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C
Hoste, L., Roels, L., Naesens, L., Bosteels, V., Vanhee, S., Dupont, S., Bosteels, C., Browaeys, R., Vandamme, N., Verstaen, K., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211381 · Cited by 87 · see citing works
Why Does the Severity of COVID-19 Differ With Age?
Zimmermann, P., & Curtis, N. C. (2021) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003413 · Cited by 85 · see citing works
Ghosh, P., Katkar, G. D., Shimizu, C., Kim, J., Khandelwal, S., Tremoulet, A. H., Kanegaye, J. T., Abe, N., Austin-Page, L., Bryl, A. W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30357-w · Cited by 85 · see citing works
Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children
Neeland, M. R., Bannister, S., Clifford, V., Dohle, K., Mulholland, K., SUTTON, P. R. N., Curtis, N. C., Steer, A. C., Burgner, D. P., Crawford, N. W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21414-x · Cited by 84 · see citing works
Damoiseaux, J. G. M. C., Dotan, A., Fritzler, M. J., Bogdanos, D. P., Meroni, P. L., Roggenbuck, D., Goldman, M., Landegren, N., Bastard, P., Shoenfeld, Y., et al. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.103012 · Cited by 84 · see citing works
Schlapbach, L. J., Andre, M. C., Grazioli, S., Schöbi, N., Ritz, N., Aebi, C., Agyeman, P., Albisetti, M., Bailey, D. G. N., Berger, C., et al. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.667507 · Cited by 80 · see citing works
Abolhassani, H., Landegren, N., Bastard, P., Materna, M., Modaresi, M., Du, L., Aranda‐Guillén, M., Sardh, F., Zuo, F., Zhang, P., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01215-7 · Cited by 79 · see citing works
de Cevins, C., Luka, M., Smith, N., Meynier, S., Magérus, A., Carbone, F., García-Paredes, V., Barnabei, L., Batignes, M., Boullé, A., et al. (2021) · Med · doi:10.1016/j.medj.2021.08.002 · Cited by 77 · see citing works
Caillon, A., Trimaille, A., Favre, J., Jesel, L., Morel, O., & Kauffenstein, G. (2021) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15566 · Cited by 79 · see citing works
Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19
van der Made, C. I., Netea, M. G., van de Veerdonk, F. L., & Hoischen, A. (2022) · Genome Medicine · doi:10.1186/s13073-022-01100-3 · Cited by 78 · see citing works
Diorio, C. J., Shraim, R., Vella, L. A., Giles, J. R., Baxter, A. E., Oldridge, D. A., Canna, S., Henrickson, S. E., McNerney, K. O., Balamuth, F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27544-6 · Cited by 77 · see citing works
Richter, A. G., Shields, A. M., Karim, A., Birch, D., Faustini, S. E., Steadman, L. G., Ward, K. E., Plant, T. D., Reynolds, G. M., Veenith, T., et al. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13623 · Cited by 74 · see citing works
Beckmann, N. D., Comella, P., Cheng, E., Lepow, L., Beckmann, A. G., Tyler, S. R., Mouskas, K., Simons, N. W., Hoffman, G. E., Francoeur, N. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24981-1 · Cited by 70 · see citing works
Self-citationFelsenstein, S., Willis, E., Lythgoe, H., McCann, L. J., Cleary, A. G., Mahmood, K., Porter, D., Jones, J., McDonagh, J. E. R., Chieng, A., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103293 · Cited by 73 · see citing works
Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C
Zhu, Y. P., Shamie, I., Lee, J. C., Nowell, C. J., Peng, W., Angulo, S., Le, L., Liu, Y., Miao, H., Xiong, H., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci147076 · Cited by 72 · see citing works
Pfeifer, J., Thurner, B., Kessel, C., Fadle, N., Kheiroddin, P., Regitz, E., Hoffmann, M.-C., Kos, I. A., Preuss, K., Fischer, Y., et al. (2022) · The Lancet Rheumatology · doi:10.1016/s2665-9913(22)00064-9 · Cited by 72 · see citing works
Coronavirus Disease 2019 in Children
Borrelli, M., Corcione, A., Castellano, F., Nastro, F. F., & Santamaria, F. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.668484 · Cited by 70 · see citing works
Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth
Wimmers, F., Burrell, A. R., Feng, Y., Zheng, H., Arunachalam, P. S., Hu, M., Spranger, S., Nyhoff, L. E., Joshi, D., Trisal, M., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.044 · Cited by 74 · see citing works
Current Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome in Children
Vella, L. A., & Rowley, A. H. (2021) · Current Pediatrics Reports · doi:10.1007/s40124-021-00257-6 · Cited by 69 · see citing works
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19
Makaremi, S., Asgarzadeh, A., Kianfar, H., Mohammadnia, A., Asghariazar, V., & Safarzadeh, E. (2022) · Inflammation Research · doi:10.1007/s00011-022-01596-w · Cited by 68 · see citing works
Candel, F. J., Barreiro, P., Román, J. S., Abanades, J. C., Barba, R., Barberán, J., Bibiano, C., Canora, J., Cantón, R., Calvo, C., et al. (2020) · Revista Española de Quimioterapia · doi:10.37201/req/120.2020 · Cited by 66 · see citing works
MIS-C: early lessons from immune profiling
Henderson, L. A., & Yeung, R. S. M. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00566-y · Cited by 66 · see citing works
Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae
Thompson, R. C., Simons, N. W., Wilkins, L., Cheng, E., Valle, D. M. D., Hoffman, G. E., Cervia, C., Fennessy, B., Mouskas, K., Francoeur, N. J., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02107-4 · Cited by 66 · see citing works
Self-citationSARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
Ravichandran, S., Tang, J., Grubbs, G., Lee, Y., Pourhashemi, S., Hussaini, L., Lapp, S. A., Jerris, R. C., Singh, V., Chahroudi, A., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01051-8 · Cited by 63 · see citing works
Haynes, W. A., Kamath, K., Bozekowski, J. D., Baum, E., Campbell, M., Casanovas‐Massana, A., Daugherty, P. S., Cruz, C. S. D., Dhal, A., Farhadian, S., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02835-2 · Cited by 60 · see citing works
Cell-Type Apoptosis in Lung during SARS-CoV-2 Infection
Liu, Y.-K., Garron, T. M., Chang, Q., Su, Z., Zhou, C., Qiu, Y., Gong, E. C., Zheng, J.-Y., Yin, Y., Ksiazek, T., et al. (2021) · Pathogens · doi:10.3390/pathogens10050509 · Cited by 36 · see citing works
Bükülmez, H. (2021) · Current Rheumatology Reports · doi:10.1007/s11926-021-01028-4 · Cited by 59 · see citing works
Syrimi, E., Fennell, É., Richter, A., Vrljicak, P., Stark, R., Ott, S., Murray, P. G., Al‐Abadi, E., Chikermane, A., Dawson, P., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103215 · Cited by 58 · see citing works
Understanding COVID-19 in children: immune determinants and post-infection conditions
Rotulo, G. A., & Palma, P. (2023) · Pediatric Research · doi:10.1038/s41390-023-02549-7 · Cited by 59 · see citing works
A streamlined whole blood CyTOF workflow defines a circulating immune cell signature of COVID ‐19
Geanon, D., Lee, B. H., Gonzalez‐Kozlova, E., Kelly, G., Handler, D., Upadhyaya, B., Leech, J. M., de Real, R. M., Herbinet, M., Magen, A., et al. (2021) · Cytometry Part A · doi:10.1002/cyto.a.24317 · Cited by 58 · see citing works
Self-citationMultiple Sclerosis and SARS-CoV-2: Has the Interplay Started?
Bellucci, G., Rinaldi, V., Buscarinu, M. C., Reniè, R., Bigi, R., Pellicciari, G., Morena, E., Romano, C., Marrone, A., Mechelli, R., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.755333 · Cited by 59 · see citing works
Immune Response to Respiratory Viral Infections
Gambadauro, A., Galletta, F., Pomi, A. L., Manti, S., & Piedimonte, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116178 · Cited by 58 · see citing works
Early Echocardiographic and Cardiac MRI Findings in Multisystem Inflammatory Syndrome in Children
Sirico, D., Basso, A., Reffo, E., Cavaliere, A., Castaldi, B., Sabatino, J., Meneghel, A., Martini, G., Dalt, L. D., Zulian, F., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153360 · Cited by 55 · see citing works
Kawasaki Disease and Multisystem Inflammatory Syndrome in Children
Rivas, M. N., & Arditi, M. (2023) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2023.03.002 · Cited by 56 · see citing works
Interferon system deficiencies exacerbating severe pandemic virus infections
Stertz, S., & Hale, B. G. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.03.001 · Cited by 55 · see citing works
Coronavirus disease 2019 in patients with inborn errors of immunity: lessons learned
Bucciol, G., Tangye, S. G., & Meyts, I. (2021) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001062 · Cited by 55 · see citing works
Realigning the LIGHT signaling network to control dysregulated inflammation
Ware, C. F., Croft, M., & Neil, G. A. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220236 · Cited by 55 · see citing works
Molecular mimicry in multisystem inflammatory syndrome in children
Bodansky, A., Mettelman, R. C., Sabatino, J. J., Vazquez, S. E., Chou, J. S., Novak, T., Moffitt, K. L., Miller, H. S., Kung, A. F., Rackaityte, E., et al. (2024) · Nature · doi:10.1038/s41586-024-07722-4 · Cited by 62 · see citing works
Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676932 · Cited by 56 · see citing works
- Authors
- Gruber, C. N., Patel, R. S., Trachtman, R., Lepow, L., Amanat, F., Krammer, F., Wilson, K. M., Onel, K., Geanon, D., Tuballes, K., Patel, M., Mouskas, K., O’Donnell, T., Merritt, E., Simons, N. W., Barcessat, V., Del Valle, D. M., Udondem, S., Kang, G., Agashe, C., Karekar, N., Grabowska, J., Nie, K., Le Berichel, J., Xie, H., Beckmann, N., Gangadharan, S., Ofori-Amanfo, G., Laserson, U., Rahman, A., Kim-Schulze, S., Charney, A. W., Gnjatic, S., Gelb, B. D., Merad, M., & Bogunovic, D.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Bogunovic, Dusan
- ORCID
- Gruber, Conor N.
- Patel, Roosheel S.
- Trachtman, Rebecca
- Lepow, Lauren
- Amanat, Fatima
- Krammer, Florian
- Wilson, Karen M.
- Onel, Kenan
- Geanon, Daniel
- Tuballes, Kevin
- Patel, Manishkumar
- Mouskas, Konstantinos
- O’Donnell, Timothy
- Merritt, Elliot
- Simons, Nicole W.
- Barcessat, Vanessa
- Kang, Gurpawan
- Agashe, Charuta
- Grabowska, Joanna
- Nie, Kai
- Xie, Hui
- Beckmann, Noam
- Gangadharan, Sandeep
- Laserson, Uri
- Rahman, Adeeb
- Charney, Alexander W.
- Gnjatic, Sacha
- Gelb, Bruce D.
- Bogunovic, Dusan
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 183
- Issue
- 4
- Pages
- 982-995.e14
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7489877
- OpenAlex
- W3084924559
- Cited by
- 551
- References
- 69
- Citations by year
- 2026: 14 · 2025: 34 · 2024: 60 · 2023: 92 · 2022: 139 · 2021: 182 · 2020: 29
- FWCI
- 102.58
- Type
- journal article
- Language
- en
- Update notices
- erratum (2023-07-20)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by-nc-nd)
- Funders
- National Cancer Institute (CA224319, P01 CA190174, CA196521, U01 DK124165)
- National Institute of Allergy and Infectious Diseases (R01 AI127372, R21 AI129827, R21 AI134366, 5T32HD075735-07, R01 AI148963)
- National Institutes of Health
- U.S. Department of Defense (W81XWH-18-1-0528)
- Topics
- Health Sciences › Medicine › Surgery › Kawasaki Disease and Coronary Complications
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- multisystem inflammatory syndrome in children, SARS-CoV-2, COVID-19 pandemic, systemic inflammation, antibody response, neutralizing antibodies, cytokine profiling, IL-18, interleukin-6, chemokines, non-classical monocytes, natural killer cells, T cells, autoantibodies, anti-SSB antibodies, intravenous immunoglobulin, anti-IL-6 receptor antibody
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