Animal models in SARS-CoV-2 research

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Blanco-Melo, D., Nilsson-Payant, B. E., Liu, W.-C., Uhl, S., Hoagland, D., Møller, R., Jordan, T. X., Oishi, K., Panis, M., Sachs, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.026 · Cited by 4,222 · see citing works

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Sia, S. F., Yan, L.-M., Chin, A. W. H., Fung, K., Choy, K.-T., Wong, A. Y. L., Kaewpreedee, P., Perera, R. A. P. M., Poon, L. L. M., Nicholls, J. M., et al. (2020) · Nature · doi:10.1038/s41586-020-2342-5 · Cited by 1,303 · see citing works

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Baum, A., Fulton, B. O., Wloga, E., Copin, R., Pascal, K. E., Russo, V., Giordano, S., Lanza, K., Negron, N., Ni, M., et al. (2020) · Science · doi:10.1126/science.abd0831 · Cited by 1,253 · see citing works

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Hansen, J., Baum, A., Pascal, K. E., Russo, V., Giordano, S., Wloga, E., Fulton, B. O., Yan, Y., Koon, K., Patel, K., et al. (2020) · Science · doi:10.1126/science.abd0827 · Cited by 1,210 · see citing works

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

Bao, L., Deng, W., Huang, B., Gao, H., Liu, J., Ren, L., Wei, Q., Yu, P., Xu, Y., Qi, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2312-y · Cited by 1,126 · see citing works

Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility

Chan, J., Zhang, A., Yuan, S.-F., Poon, V., Chan, C., Lee, A., Chan, W., Fan, Z., Tsoi, H.-W., Wen, L., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa325 · Cited by 1,034 · see citing works

Lethal Infection of K18- <i>hACE2</i> Mice Infected with Severe Acute Respiratory Syndrome Coronavirus

McCray, P. B., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., et al. (2007) · Journal of Virology · doi:10.1128/jvi.02012-06 · Cited by 1,010 · see citing works

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

Imai, M., Iwatsuki‐Horimoto, K., Hatta, M., Loeber, S. J., Halfmann, P., Nakajima, N., Watanabe, T., Ujie, M., Takahashi, K., Ito, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009799117 · Cited by 977 · see citing works

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

Winkler, E. S., Bailey, A. L., Kafai, N. M., Nair, S., McCune, B. T., Yu, J., Fox, J. M., Chen, R. E., Earnest, J. T., Keeler, S. P., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0778-2 · Cited by 901 · see citing works

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Kim, Y., Kim, S.-G., Kim, S.-M., Kim, E.-H., Park, S.-J., Yu, K.-M., Chang, J.-H., Kim, E. J., Lee, S., Casel, M. A. B., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.023 · Cited by 883 · see citing works

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

Chandrashekar, A., Liu, J., Martinot, A. J., McMahan, K., Mercado, N. B., Peter, L., Tostanoski, L. H., Yu, J., Maliga, Z., Nekorchuk, M., et al. (2020) · Science · doi:10.1126/science.abc4776 · Cited by 816 · see citing works

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Gu, H., Chen, Q., Yang, G., He, L., Fan, H., Deng, Y.-Q., Wang, Y., Teng, Y., Zhao, Z., Cui, Y., et al. (2020) · Science · doi:10.1126/science.abc4730 · Cited by 762 · see citing works

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

Williamson, B. N., Feldmann, F., Schwarz, B. H., Meade-White, K. D., Porter, D., Schulz, J. E., van Doremalen, N., Leighton, I. A., Yinda, C. K., Pérez-Pérez, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2423-5 · Cited by 696 · see citing works

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Vogel, A. B., Kanevsky, I., Che, Y., Swanson, K. A., Muik, A., Vormehr, M., Kranz, L. M., Walzer, K. C., Hein, S., Güler, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03275-y · Cited by 694 · see citing works

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Johnson, B. A., Xie, X., Bailey, A. L., Kalveram, B., Lokugamage, K. G., Muruato, A., Zou, J., Zhang, X., Juelich, T., Smith, J. K., et al. (2021) · Nature · doi:10.1038/s41586-021-03237-4 · Cited by 694 · see citing works

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

Dinnon, K. H., Leist, S. R., Schäfer, A., Edwards, C. E., Martinez, D. R., Montgomery, S. A., West, A., Yount, B. L., Hou, Y. J., Adams, L. E., et al. (2020) · Nature · doi:10.1038/s41586-020-2708-8 · Cited by 675 · see citing works

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Suzuki, R., Yamasoba, D., Kimura, I., Wang, L., Kishimoto, M., Ito, J., Morioka, Y., Nao, N., Nasser, H., Uriu, K., et al. (2022) · Nature · doi:10.1038/s41586-022-04462-1 · Cited by 655 · see citing works

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Halfmann, P., Iida, S., Iwatsuki‐Horimoto, K., Maemura, T., Kiso, M., Scheaffer, S. M., Darling, T. L., Joshi, A., Loeber, S. J., Singh, G., et al. (2022) · Nature · doi:10.1038/s41586-022-04441-6 · Cited by 654 · see citing works

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

Shuai, H., Chan, J. F.-W., Hu, B., Chai, Y., Yuen, T. T.-T., Yin, F., Huang, X., Yoon, C., Hu, J., Liu, H., et al. (2022) · Nature · doi:10.1038/s41586-022-04442-5 · Cited by 637 · see citing works

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

Sun, S.-H., Chen, Q., Gu, H.-J., Yang, G., Wang, Y.-X., Huang, X.-Y., Liu, S.-S., Zhang, N.-N., Li, X.-F., Xiong, R., et al. (2020) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2020.05.020 · Cited by 617 · see citing works

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

Leist, S. R., Dinnon, K. H., Schäfer, A., Tse, L. V., Okuda, K., Hou, Y. J., West, A., Edwards, C. E., Sanders, W., Fritch, E. J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.050 · Cited by 613 · see citing works

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

Saito, A., Irie, T., Suzuki, R., Maemura, T., Nasser, H., Uriu, K., Kosugi, Y., Shirakawa, K., Sadamasu, K., Kimura, I., et al. (2021) · Nature · doi:10.1038/s41586-021-04266-9 · Cited by 600 · see citing works

The N501Y spike substitution enhances SARS-CoV-2 transmission

Liu, Y., Liu, J., Plante, K. S., Plante, J. A., Xie, X., Zhang, X., Ku, Z., An, Z., Scharton, D., Schindewolf, C., et al. (2021) · doi:10.1101/2021.03.08.434499 · Cited by 574 · see citing works

The N501Y spike substitution enhances SARS-CoV-2 infection and transmission

Liu, Y., Liu, J., Plante, K. S., Plante, J. A., Xie, X., Zhang, X., Ku, Z., An, Z., Scharton, D., Schindewolf, C., et al. (2021) · Nature · doi:10.1038/s41586-021-04245-0 · Cited by 574 · see citing works

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2

Jiang, R.-D., Liu, M.-Q., Chen, Y., Shan, C., Zhou, Y.-W., Shen, X.-R., Li, Q., Zhang, L., Zhu, Y., Si, H.-R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.027 · Cited by 541 · see citing works

SARS-CoV-2 spike D614G change enhances replication and transmission

Zhou, B., Thao, T. T. N., Hoffmann, D., Taddeo, A., Ebert, N., Labroussaa, F., Pohlmann, A., King, J., Steiner, S., Kelly, J. N., et al. (2021) · Nature · doi:10.1038/s41586-021-03361-1 · Cited by 538 · see citing works

Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19)

Chan, J. F., Yuan, S., Zhang, J., Poon, V. K., Chan, C. C., Lee, A. C.-Y., Fan, Z., Li, C., Liang, R., Cao, J., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa644 · Cited by 529 · see citing works

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

Zheng, J. H., Wong, L.-Y. R., Li, K., Verma, A. K., Ortiz, M. E., Wohlford-Lenane, C., Leidinger, M., Knudson, C. M., Meyerholz, D. K., McCray, P. B., et al. (2020) · Nature · doi:10.1038/s41586-020-2943-z · Cited by 484 · see citing works

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L. B., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.011 · Cited by 477 · see citing works

SARS-CoV-2 M ^pro inhibitors with antiviral activity in a transgenic mouse model

Qiao, J., Li, Y.-S., Zeng, R., Liu, F.-L., Luo, R.-H., Huang, C., Wang, Y.-F., Zhang, J., Quan, B., Shen, C., et al. (2021) · Science · doi:10.1126/science.abf1611 · Cited by 465 · see citing works

Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

Deng, W., Bao, L., Liu, J., Xiao, C., Liu, J., Xue, J., Lv, Q., Qi, F., Gao, H., Yu, P., et al. (2020) · Science · doi:10.1126/science.abc5343 · Cited by 440 · see citing works

Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment

Sun, J., Zhuang, Z., Zheng, J. H., Li, K., Wong, R. L.-Y., Liu, D., Huang, J., He, J., Zhu, A., Zhao, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.010 · Cited by 434 · see citing works

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

Cox, R. M., Wolf, J. D., & Plemper, R. K. (2020) · Nature Microbiology · doi:10.1038/s41564-020-00835-2 · Cited by 391 · see citing works

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2

Uraki, R., Kiso, M., Iida, S., Imai, M., Takashita, E., Kuroda, M., Halfmann, P., Loeber, S. J., Maemura, T., Yamayoshi, S., et al. (2022) · Nature · doi:10.1038/s41586-022-04856-1 · Cited by 277 · see citing works

Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2

Wu, H., Xing, N., Meng, K., Fu, B., Xue, W., Dong, P., Tang, W., Xiao, Y., Liu, G., Luo, H., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.11.005 · Cited by 224 · see citing works

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., Li, W.-T., Okba, N. M. A., Albulescu, I., Widjaja, I., van Dieren, B., Fernández-Delgado, R., Sola, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21968-w · Cited by 187 · see citing works

Emerging SARS-CoV-2 variants expand species tropism to murines

Shuai, H., Chan, J. F., Yuen, T. T., Yoon, C., Hu, J., Wen, L., Hu, B., Yang, D., Wang, Y., Hou, Y., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103643 · Cited by 171 · see citing works

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

Bertholet, A. M., Natale, A. M., Bisignano, P., Suzuki, J., Fedorenko, A., Hamilton, J., Brustovetsky, T., Kazak, L., Garrity, R., Chouchani, E. T., et al. (2022) · Nature · doi:10.1038/s41586-022-04747-5 · Cited by 140 · see citing works

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

Harb, H., Benamar, M., Lai, P. S., Contini, P., Griffith, J. W., Crestani, E., Schmitz‐Abe, K., Chen, Q., Fong, J. J. H., Marri, L., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.002 · Cited by 129 · see citing works

A humanized mouse model of chronic COVID-19

Sefik, E., Israelow, B., Mirza, H., Zhao, J., Qu, R., Kaffe, E., Song, E., Halene, S., Meffre, E., Kluger, Y., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-01155-4 · Cited by 129 · see citing works

Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters

Zhang, J., Lee, A. C.-Y., Chu, H., Chan, J. F., Fan, Z., Li, C., Liu, F., Chen, Y., Yuan, S., Poon, V. K., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa995 · Cited by 123 · see citing works

Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

Huang, K., Zhang, Y., Hui, X., Zhao, Y., Gong, W., Wang, T., Zhang, S., Yang, Y., Deng, F., Zhang, Q., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103381 · Cited by 119 · see citing works

The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus.

Dong, W., Mead, H., Tian, L., Park, J., García, J. I., Jaramillo, S. A., Barr, T., Kollath, D. S., Coyne, V. K., Stone, N. E., et al. (2022) · PubMed Central · doi:10.1128/jvi.00964-21 · Cited by 103 · see citing works

Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice

Wang, J., Shuai, L., Wang, C., Liu, R., He, X., Zhang, X., Sun, Z., Shan, D., Ge, J., Wang, X., et al. (2020) · Protein & Cell · doi:10.1007/s13238-020-00767-x · Cited by 95 · see citing works

Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice

Bao, L., Gao, H., Deng, W., Lv, Q., Yu, H., Liu, M., Yü, P., Liu, J., Qu, Y., Gong, S., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa281 · Cited by 70 · see citing works

A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site

Onodera, T., Kita, S., Adachi, Y., Moriyama, S., Sato, A., Nomura, T., Sakakibara, S., Inoue, T., Tadokoro, T., Anraku, Y., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.025 · Cited by 59 · see citing works

Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model

Chen, Y., Li, C., Liu, F., Ye, Z., Song, W., Lee, A. C.-Y., Shuai, H., Lu, L., To, K. K., Chan, J. F., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2026741 · Cited by 43 · see citing works

Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications

Cerneckis, J., Cai, H., & Shi, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01809-0 · Cited by 452 · see citing works

Accelerating antiviral drug discovery: lessons from COVID-19

von Delft, A., Hall, M. D., Kwong, A. D., Purcell, L. A., Saikatendu, K. S., Schmitz, U., Tallarico, J. A., & Lee, A. A. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00692-8 · Cited by 223 · see citing works

SARS-CoV-2 biology and host interactions

Steiner, S., Kratzel, A., Barut, G. T., Lang, R. M., Moreira, É. A., Thomann, L., Kelly, J. N., & Thiel, V. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-023-01003-z · Cited by 208 · see citing works

The Role of Viral Infections in the Onset of Autoimmune Diseases

Sundaresan, B., Shirafkan, F., Ripperger, K., & Rattay, K. (2023) · Viruses · doi:10.3390/v15030782 · Cited by 194 · see citing works

COVID-19, Myocarditis and Pericarditis

Fairweather, D., Beetler, D. J., Di Florio, D. N., Musigk, N., Heidecker, B., & Cooper, L. T. (2023) · Circulation Research · doi:10.1161/circresaha.123.321878 · Cited by 181 · see citing works

Animal models for COVID-19: advances, gaps and perspectives

Fan, C., Wu, Y., Xiong, R., Yang, Y., Ling, C., Liu, S., Liu, S., & Wang, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01087-8 · Cited by 104 · see citing works

Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model

Garnsey, M. R., Robinson, M. C., Nguyen, L. T., Cardin, R. D., Tillotson, J., Mashalidis, E. H., Yu, A., Aschenbrenner, L. M., Balesano, A., Behzadi, A., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado4288 · Cited by 68 · see citing works

Lung repair and regeneration: Advanced models and insights into human disease

Basil, M. C., Alysandratos, K., Kotton, D. N., & Morrisey, E. E. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.02.009 · Cited by 64 · see citing works

Advances in Rodent Experimental Models of Sepsis

Cai, L., Rodgers, E. G., Schoenmann, N., & Raju, R. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119578 · Cited by 61 · see citing works

Modelling host–microbiome interactions in organ-on-a-chip platforms

Shin, Y. C., Than, N., Min, S., Shin, W., & Kim, H. J. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00130-9 · Cited by 57 · see citing works

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity

Yang, Z., Johnson, B. A., Meliopoulos, V., Ju, X., Zhang, P., Hughes, M. P., Wu, J., Koreski, K. P., Clary, J. E., Chang, T., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113965 · Cited by 56 · see citing works

Vaccine-induced protection against SARS-CoV-2 requires IFN-γ-driven cellular immune response

Wang, X., Yuen, T. T., Dou, Y., Hu, J., Li, R., Zeng, Z., Lin, X., Gong, H., Chan, C. H.-C., Yoon, C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39096-y · Cited by 42 · see citing works

SARS‐CoV‐2 and natural infection in animals

Qiu, X., Liu, Y., & Sha, A. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28147 · Cited by 42 · see citing works

Organoids in virology

Chu, J. T. S., & Lamers, M. M. (2024) · npj Viruses · doi:10.1038/s44298-024-00017-5 · Cited by 30 · see citing works

SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure

Monu, M., Ahmad, F., Olson, R. M., Balendiran, V., & Singh, P. K. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012156 · Cited by 24 · see citing works

Adverse outcomes in SARS-CoV-2–infected pregnant mice are gestational age–dependent and resolve with antiviral treatment

Creisher, P. S., Perry, J. L., Zhong, W., Lei, J., Mulka, K. R., Ryan, W. H., Zhou, R., Akin, E., Liu, A., Mitzner, W., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170687 · Cited by 22 · see citing works

Interferons—Implications in the Immune Response to Respiratory Viruses

Bergeron, H. C., Hansen, M. R., & Tripp, R. A. (2023) · Microorganisms · doi:10.3390/microorganisms11092179 · Cited by 20 · see citing works

An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models

Yuen, C., Wong, W., Mak, L., Lam, J.-Y., Cheung, L.-Y., Cheung, D. T.-Y., Ng, Y.-Y., Lee, A. C.-Y., Zhong, N., Yuen, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42349-5 · Cited by 19 · see citing works

Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities

Kumar, R., Aktay-Cetin, Ö., Craddock, V. D., Morales‐Cano, D., Kosanovic, D., Cogolludo, A. L., Pérez‐Vizcaíno, F., Avdeev, S. N., Kumar, A., Ram, A. K., et al. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011063 · Cited by 16 · see citing works

Comparative pathogenicity of BA.2.12, BA.5.2 and XBB.1 with the Delta variant in Syrian hamsters

Mohandas, S., Shete, A. M., Kumar, A., Wakchaure, K., Rai, V., Mote, C., Dighe, H., Sarkale, P., Gawande, P., Yemul, J., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1183763 · Cited by 16 · see citing works

COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses

Chen, Y., Song, W., Li, C., Wang, J., Liu, F., Ye, Z., Ren, P., Tong, Y., Li, J., Ou, Z., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104485 · Cited by 16 · see citing works

Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

Andrade, V. M., Maricic, I., Kalia, R., Jachimowicz, L. A., Bedoya, O., Kulp, D. W., Humeau, L. M. P. F., & Smith, T. R. F. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2281733 · Cited by 15 · see citing works

Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations

Lima, G. G., Portilho, A., & Gaspari, E. D. D. (2022) · Pathogens · doi:10.3390/pathogens12010020 · Cited by 10 · see citing works

Targeting ACLY efficiently inhibits SARS-CoV-2 replication

Yuen, T. T., Chan, J. F., Yan, B., Shum, C. C.-Y., Liu, Y., Shuai, H., Hou, Y., Huang, X., Hu, B., Chai, Y., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72709 · Cited by 11 · see citing works

Schizophrenia and the COVID-19 pandemic: A narrative review from the biomedical perspective

Kowalski, K., & Misiak, B. (2023) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2023.04.002 · Cited by 12 · see citing works

The COVID-19 thrombus: distinguishing pathological, mechanistic, and phenotypic features and management

Becker, R. C., Tantry, U. S., Khan, M. H., & Gurbel, P. A. (2024) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-024-03028-4 · Cited by 12 · see citing works

Mechanistic insights into bone remodelling dysregulation by human viral pathogens

Caetano, C. C. D. S., Azamor, T., Meyer, N. M., Onwubueke, C., Calabrese, C. M., Calabrese, L. H., Visperas, A., Piuzzi, N. S., Husni, M. E., Foo, S., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01586-6 · Cited by 13 · see citing works

SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in a hamster model

Sardarni, U. K., Ambikan, A. T., Acharya, A., Johnson, S. D., Avedissian, S. N., Végvári, Á., Neogi, U., & Byrareddy, S. N. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.032 · Cited by 11 · see citing works

Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology

Ueki, H., Wang, I.-H., Kiso, M., Horie, K., Iida, S., Mine, S., Ujie, M., Hsu, H.-W., Wu, C.-H. H., Imai, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55272-0 · Cited by 11 · see citing works

Comparative Pathogenesis of Severe Acute Respiratory Syndrome Coronaviruses

Zhang, J., Rissmann, M., Kuiken, T., & Haagmans, B. L. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052620-121224 · Cited by 10 · see citing works

Characterization of Three Variants of SARS-CoV-2 In Vivo Shows Host-Dependent Pathogenicity in Hamsters, While Not in K18-hACE2 Mice

Chávez‐Calvillo, G., Burns, W., Garcia, L., Henry, G., Biancofiori, A., George, A., Duffy, C., Chu, J., Sides, M., Muñoz, M., et al. (2022) · Viruses · doi:10.3390/v14112584 · Cited by 10 · see citing works

Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine

Qin, J., Jeon, J. H., Xu, J., Langston, L. K., Marasini, R., Mou, S., Montoya, B., Melo‐Silva, C. R., Jeon, H. J., Zhu, T., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1126392 · Cited by 10 · see citing works

Pathogenicity of SARS-CoV-2 Omicron Subvariants JN.1, KP.2, and EG.5.1 in K18-hACE2 Transgenic Mice

Patterson, L. D., Elsharkawy, A., Jahantigh, H. R., Nabi, Z., Stone, S., & Kumar, M. (2025) · Viruses · doi:10.3390/v17091177 · Cited by 9 · see citing works

SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice

Kim, E., Khan, M. S., Ferrari, A., Huang, S., Sammartino, J. C., Percivalle, E., Kenniston, T. W., Cassaniti, I., Baldanti, F., & Gambotto, A. A. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04363-22 · Cited by 10 · see citing works

A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster ModelPreprint

Prakash, S., Dhanushkodi, N. R., Singer, M., Quadiri, A., Zayou, L., Vahed, H., Coulon, P.-G. A., Ibraim, I. C., Tafoya, C., Hitchcock, L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.14.580225 · Cited by 9 · see citing works

A single immunization with intranasal Newcastle disease virus (NDV)-based XBB.1.5 variant vaccine reduces disease and transmission in animals against matched-variant challenge

Slamanig, S., Lemus, N., Lai, T. Y., Singh, G., Mishra, M., Abdeljawad, A., Boza, M., Dolange, V., Singh, G., Lee, B., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.126586 · Cited by 8 · see citing works

Helicobacter pullorum and Helicobacter canadensis: Etiology, pathogenicity, epidemiology, identification, and antibiotic resistance implicating food and public health

Akhlaghi, H., Javan, A. J., & Chashmi, S. H. E. (2024) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2024.110573 · Cited by 8 · see citing works

Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

Peidli, S., Nouailles, G., Wyler, E., Adler, J. M., Kunder, S., Voß, A., Kazmierski, J., Pott, F., Pennitz, P., Postmus, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114328 · Cited by 7 · see citing works

Ensemble modeling of SARS-CoV-2 immune dynamics in immunologically naïve rhesus macaques predicts that potent, early innate immune responses drive viral elimination

Byrne, C., & Schiffer, J. T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1426016 · Cited by 6 · see citing works

Sphingosine-1-Phosphate as Lung and Cardiac Vasculature Protecting Agent in SARS-CoV-2 Infection

Karam, M., & Auclair, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713088 · Cited by 7 · see citing works

Molnupiravir Revisited—Critical Assessment of Studies in Animal Models of COVID-19

Rasmussen, H. B., & Hansen, P. R. (2023) · Viruses · doi:10.3390/v15112151 · Cited by 7 · see citing works

Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant

Cianfarini, C. L., Hassler, L., Wysocki, J. A., Hassan, A., Nicolaescu, V. I., Elli, D., Gula, H., Ibrahim, A. M., Randall, G. C., Henkin, J., et al. (2024) · Cells · doi:10.3390/cells13030203 · Cited by 7 · see citing works

Lung disease characterised via synchrotron radiation micro-CT and digital volume correlation (DVC)

Arora, H., Kernot, D., Giron, L., Howells, D., Darcy, M., Hoshino, M., Uesugi, K., van Loon, R., TANAKA, G., & Sera, T. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117588 · Cited by 6 · see citing works

Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

Zheng, H., 中国科学院昆明动物研究所遗传资源与进化国家重点实验室, 生., Song, T., Zheng, Y., & 中国科学院昆明动物研究所模式动物表型与遗传研究国家重大科技基础设施(灵长类设施), 国. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2024.062 · Cited by 6 · see citing works

Predicting Clinical Outcomes of SARS‐CoV‐2 Drug Efficacy with a High‐Throughput Human Airway Microphysiological System

Quezada, L. A. L., Medie, F. M., Luu, R. J., Gaibler, R. B., Gabriel, E. P., Rubio, L. D., Mulhern, T. J., Marr, E. E., Borenstein, J. T., Fisher, C. R., et al. (2024) · Advanced Biology · doi:10.1002/adbi.202300511 · Cited by 9 · see citing works

Investigations on the Potential Role of Free-Ranging Wildlife as a Reservoir of SARS-CoV-2 in Switzerland

Kuhn, J., Marti, I. A., Ryser‐Degiorgis, M., Wernike, K., Jones, S., Tyson, G. B., Delalay, G., Scherrer, P., Borel, S., Hosie, M. J., et al. (2024) · Viruses · doi:10.3390/v16091407 · Cited by 6 · see citing works

An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters

Föderl-Höbenreich, E., Izadi, S., Hofacker, L., Kienzl, N. F., Castilho, A., Strasser, R., Tarrés-Freixas, F., Cantero, G., Roca, N., Pérez, M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-95494-w · Cited by 6 · see citing works

Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologies

Thomas, D., Yang, P. C.-M., Wu, J. C., & Sayed, N. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.09.008 · Cited by 5 · see citing works

Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells

Keitany, G. J., Rubin, B. E., Garrett, M. E., Musa, A., Tracy, J., Liang, Y., Ebert, P., Moore, A. J., Guan, J., Eggers, E. L., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.07.011 · Cited by 5 · see citing works

Development of a Mouse-Adapted Reporter SARS-CoV-2 as a Tool for Two-Photon In Vivo Imaging

Ueki, H., Kiso, M., Furusawa, Y., Iida, S., Yamayoshi, S., Nakajima, N., Imai, M., Suzuki, T., & Kawaoka, Y. (2024) · Viruses · doi:10.3390/v16040537 · Cited by 5 · see citing works

SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus

Lee, Y. S., Woo, J. S., Jhun, J., Choi, J. W., Lee, A. R., Lee, K. H., Choi, H., Park, S., & Cho, M. (2024) · Lupus Science & Medicine · doi:10.1136/lupus-2023-001104 · Cited by 5 · see citing works

Kidney Disease and Viral Infection in COVID-19: Why Are Kidney Organoid and Biopsy Studies Not in Agreement?

Nicosia, R. F. (2023) · The Nephron journals/Nephron journals · doi:10.1159/000528460 · Cited by 5 · see citing works

Adaptation of SARS-CoV-2 to ACE2 H353K mice reveals new spike residues that drive mouse infection

Li, K., Verma, A., Li, P., Ortiz, M. E., Hawkins, G. M., Schnicker, N., Szachowicz, P. J., Pezzulo, A. A., Wohlford-Lenane, C., Kicmal, T., et al. (2024) · Journal of Virology · doi:10.1128/jvi.01510-23 · Cited by 5 · see citing works

Alterations of whole body glucose metabolism in a feline SARS-CoV-2 infection model

Rochowski, M. T., Jayathilake, K., Balcerak, J.-M., Selvan, M. T., Gunasekara, S., Rudd, J. M., Miller, C., & Lacombe, V. A. (2024) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00228.2023 · Cited by 5 · see citing works

Effects of immunoproteasome inhibition on acute respiratory infection with murine hepatitis virus strain 1

Steigmann, J. C., Zhou, X., Suttenberg, L. N., Salman, I., Rehmathullah, Z. F., & Weinberg, J. B. (2024) · Journal of Virology · doi:10.1128/jvi.01238-24 · Cited by 4 · see citing works

Generation of a lethal mouse model expressing human ACE2 and TMPRSS2 for SARS-CoV-2 infection and pathogenesis

Jeong, G., Hwang, I., Lee, W., Choi, J., Yoon, G., Kim, H. S., Yang, J.-S., Kim, K.-C., Lee, J.-Y., Kim, S.-J., et al. (2024) · Experimental and Molecular Medicine · doi:10.1038/s12276-024-01197-z · Cited by 4 · see citing works

A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV

Guan, X., Verma, A. K., Wang, G., Roy, A., Perlman, S. M., & Du, L. (2024) · Vaccines · doi:10.3390/vaccines12060605 · Cited by 4 · see citing works

An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection

Grabherr, S., Waltenspühl, A., Büchler, L., Lütge, M., Cheng, H., Firner, S., Ludewig, B., Krebs, P., & Pikor, N. B. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200533 · Cited by 4 · see citing works

Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity

Zhou, Y. M., Cheng, T., Tang, K., Li, H., Luo, C., Fu, Y., Xiao, F., Jin, L., Hung, I. F., Lu, L., et al. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110205 · Cited by 4 · see citing works

How SARS-CoV-2 Big Data Are Challenging Viral Taxonomy Rules

Focosi, D., & Maggi, F. (2023) · Viruses · doi:10.3390/v15030715 · Cited by 4 · see citing works

The PTP4A3 inhibitor KVX-053 reduces Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virulence, inflammation, and development of acute lung injury in K18-hACE2 mice

Biancatelli, R. M. L. C., Solopov, P. A., Woodson, C. M., Allen, I. C., Akhrymuk, I. V., Akhrymuk, M., Heath, B. N., Ivester, H. M., Day, T., Austin, D. E., et al. (2025) · Respiratory Research · doi:10.1186/s12931-025-03349-9 · Cited by 3 · see citing works

The use of performance-based outcomes in achieving better global harmonisation in the care and use of animals in research

Rowlands, D. K., & Guillén, J. (2025) · Laboratory Animals · doi:10.1177/00236772241309745 · Cited by 3 · see citing works

Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters

Fitzpatrick, C., Meunier, N., Poder, S. L., Dhorne‐Pollet, S., Costa, B. D., Klonjkowki, B., Eléouët, J., Burzio, V. A., Delmas, B., & Barrey, É. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102612 · Cited by 3 · see citing works

The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—SARS-CoV-2

Blacksell, S. D., Dhawan, S., Kusumoto, M., Le, K. K., Summermatter, K., O'Keefe, J., Kozlovac, J. P., Almuhairi, S. S., Sendow, I., Scheel, C. M., et al. (2023) · Applied Biosafety · doi:10.1089/apb.2022.0039 · Cited by 3 · see citing works

A humanized ACE2 mouse model recapitulating age‐ and sex‐dependent immunopathogenesis of COVID‐19

Park, U., Lee, J. H., Kim, U., Jeon, K., Kim, Y., Kim, H. R., Kang, J.-I., Park, M. Y., Park, S. H., Cha, J. S., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29915 · Cited by 3 · see citing works

Characterization of SARS‐CoV‐2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection

Bhattarai, S., Kaufmann, E., Liang, F., Zheng, Y., Gusev, E., Hamid, Q. A., Ding, J., Divangahi, M., & Petrof, B. J. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13705 · Cited by 3 · see citing works

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 HamstersPreprint

Dong, M., Lin, H., Pan, M., Huang, M., Liu, M., Jiang, R.-D., Lai, Y., Shi, A., Yao, B., Hu, B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.19.581112 · Cited by 3 · see citing works

Targeting P2X7 mitigates neurobehavioural alterations in a mouse model of post-acute sequelae of SARS-CoV-2 infection

Szabó, D., Tod, P., Maácz, F., Gölöncsér, F., Iring-Varga, B., Török, B., Zsidei, G., Pályi, B., Kis, Z., & Sperlágh, B. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110566 · Cited by 2 · see citing works

Post Pandemic Problem, is there an animal model suitable to investigate PASC

van der Bie, J., Coléon, A., Visser, D., Bogers, W. M. J. M., den Dunnen, J., Spronk, H. M. H., Langermans, J. A. M., Willemen, H. L. D. M., de Melo, G. D., Middeldorp, J., et al. (2025) · npj Imaging · doi:10.1038/s44303-025-00101-2 · Cited by 2 · see citing works

Comparative study of the pathogenicity of SARS-CoV-2 B.1 AND B.1.617.2 lineages for syrian hamsters

Yakovlev, K. S., Mezhenskaya, D. А., Сивак, К. В., Георгиевна, Р. Л., & Николаевна, И.-С. И. (2022) · Medical academic journal · doi:10.17816/maj109066 · Cited by 2 · see citing works

Report from an ICT 2022 workshop on toxicology for Covid19 vaccines: Industry, regulatory and CRO perspectives

Gould, S., Wrzesinski, C., Stebbings, R., & Segal, L. M. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.08.040 · Cited by 2 · see citing works

Nsp1 facilitates SARS-CoV-2 replication through calcineurin-NFAT signaling

Lui, W., Ong, C. P., Cheung, P. H., Ye, Z., Chan, C., To, K. K., Yuen, K., & Jin, D. (2024) · mBio · doi:10.1128/mbio.00392-24 · Cited by 2 · see citing works

Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters

Handrejk, K., Schmitz, K. S., Kroeze, E. J. B. V., van Dijk, L. L. A., van Run, P., Haagmans, B. L., Moscona, A., Porotto, M., de Swart, R. L., de Vries, R. D., et al. (2024) · npj Viruses · doi:10.1038/s44298-024-00061-1 · Cited by 2 · see citing works

Characterization of Pulmonary Pathology in the Golden Syrian Hamster Model of COVID-19 Using Micro-Computed Tomography

Ramirez, J. A., Dunlap, M. D., Prosnitz, R., Watson, A., Montgomery, M. K., Gutman, M. R., Coskran, T., Levinson, S. L., Yang, K. L., Kanevsky, I., et al. (2024) · Toxicologic Pathology · doi:10.1177/01926233241300451 · Cited by 2 · see citing works

Revisiting the monocrotaline‐treated rat as a model of inflammatory lung disease: COVID ‐19 and future pandemic threats?

Kris, L. P., Dixon, D., Bihari, S., & Carr, J. M. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70099 · Cited by 2 · see citing works

Potential role of AIM2 inflammasome in SARS‐CoV ‐2 infection

Uresti‐Rivera, E. E., & García-Hernández, M. H. (2022) · Scandinavian Journal of Immunology · doi:10.1111/sji.13239 · Cited by 2 · see citing works

Vaccine Based on Recombinant Fusion Protein Combining Hepatitis B Virus PreS with SARS-CoV-2 Wild-Type- and Omicron-Derived Receptor Binding Domain Strongly Induces Omicron-Neutralizing Antibodies in a Murine Model

Gattinger, P., Kratzer, B., Sehgal, A. N. A., Ohradanova‐Repic, A., Gebetsberger, L., Tajti, G., Focke‐Tejkl, M., Schaar, M., Fuhrmann, V., Petrowitsch, L., et al. (2024) · Vaccines · doi:10.3390/vaccines12030229 · Cited by 2 · see citing works

Uncovering the Contrasts and Connections in PASC: Viral Load and Cytokine Signatures in Acute COVID-19 versus Post-Acute Sequelae of SARS-CoV-2 (PASC)

Compeer, B., Neijzen, T. R., van Lelyveld, S. F. L., Martina, B. E. E., Russell, C. A., & Goeijenbier, M. (2024) · Biomedicines · doi:10.3390/biomedicines12091941 · Cited by 2 · see citing works

Editorial: Emerging bioanalytical techniques and therapies for human disease models

Wang, X., Lu, J., Huang, Y., Liu, X., Fang, G., Yang, C., & Guo, Z. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1453813 · Cited by 2 · see citing works

Nontraditional models as research tools: the road not taken

Kiaris, H. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.07.005 · Cited by 1 · see citing works

Translational research on pandemic virus infection using nonhuman primate models

Ishigaki, H., & Itoh, Y. (2025) · Virology · doi:10.1016/j.virol.2025.110511 · Cited by 1 · see citing works

An in vivo NanoBiT-based pseudoviral biosensor for real-time monitoring of SARS-CoV-2 spike/hACE2 interactions and therapeutic screening

Lin, C., Lin, M., Yang, X., Chiang, H.-H., Wu, T.-H., Tsai, C.-H., & Lin, C. (2025) · Analytica Chimica Acta · doi:10.1016/j.aca.2025.344623 · Cited by 1 · see citing works

Exploiting Pharmacokinetic/Pharmacodynamic Methods for Optimizing and Accelerating Drug Development of Innovative Anti‐Infectives

Rox, K. (2026) · ChemMedChem · doi:10.1002/cmdc.202500743 · Cited by 1 · see citing works

Prolonged dysregulation and pathological changes in the upper respiratory tract of SARS-CoV-2 infected hamsters

Liu, F., Xia, Y., Lee, A. C.-Y., Chen, Y., Chen, Z., He, Y., Chan, C. H.-C., Cai, J., Yuen, T. T., Ye, Z., et al. (2026) · npj Viruses · doi:10.1038/s44298-026-00181-w · Cited by 1 · see citing works

SARS-CoV-2 Effects on Respiratory and Neurological Systems: Morphological Findings and Gene Expression in K18-hACE2 Mice Model

de Almeida, A. L. T., da Silva, A. M. V., Souza, M. M. E., Rodrigues, M. T., Coelho, F. S., da Rosa, L. C., Azamor, T., Várady, C. B. S., da Silva, B. J. D., de Almeida, A. C., et al. (2026) · Microorganisms · doi:10.3390/microorganisms14040852 · Cited by 1 · see citing works

Persistent neurological and behavioral alterations after SARS-CoV-2 infection in an optimized K18-hACE2 mouse model

Ruiz-Casas, C., Tarrés-Freixas, F., Roca, N., Pérez, M., Contreras, E., Martín, L., Bernaus, O., Olvera, À., Ruiz‐Riol, M., Brander, C., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1871084 · Cited by 1 · see citing works

Quality Management and Animal Welfare as Culture of Care for Animal Experiments under Biosafety Level-3, taking COVID-19 as a Practical Example

Richter, A., Wirz, K., Pilchová, V., Schulz, C., Volz, A., & von Köckritz‐Blickwede, M. (2024) · Journal of Applied Animal Ethics Research · doi:10.1163/25889567-bja10047 · Cited by 1 · see citing works

Elimination of olfactory sensory neurons by zinc sulfate inoculation prevents SARS-CoV-2 infection of the brain in K18-hACE2 transgenic mice

Lee, J.-H., Yoo, E., Kim, N.-W., Shim, W.-Y., Jeong, H.-B., Kim, D.-H., Park, Y.-J., Seo, S.-M., Yun, J.-W., Park, J. W., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-78538-5 · Cited by 1 · see citing works

American mink as an animal model to study SARS-CoV-2 and vaccine responsePreprint

Aaltonen, K., Virtanen, J. M. E., Kegler, K., Venkat, V., Kareinen, L., Korhonen, E. M., Niamsap, T., Malmgren, R., Korpela, J., Naves, R. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.10.658224 · Cited by 1 · see citing works

An autologous human iPSC-derived 3D organoid infection model for preclinical testing of antiviral T cellsPreprint

Daher, U., Vallone, V. B. F., Baumgardt, M., Obermayer, B., Wiese, N., Kirsch, A. K., Fisch, T., Löwa, A., Schmueck‐Henneresse, M., Hocke, A. C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.16.676521 · Cited by 1 · see citing works

Novel platelet glycoprotein VI and CLEC-2 targeting strategies

Navarro, S. (2023) · doi:10.26481/dis.20230425sn

TISSUE-SPECIFIC METABOLOMIC REPROGRAMMING DETERMINES THE DISEASE PATHOPHYSIOLOGY OF SARS-COV-2 VARIANTS IN HAMSTER MODELPreprint

Sardarni, U. K., Ambikan, A. T., Acharya, A., Johnson, S. D., Avedissian, S. N., Végvári, Á., Neogi, U., & Byrareddy, S. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.25.581989

Рroblems of diagnostics of dysfunctions of the olfactory analyzer of laboratory animals on the basis of behavioral and electrophysiological methods of research

Gorskaya, A., & Vasilev, D. S. (2024) · Сенсорные системы · doi:10.31857/s0235009224010017

Computational modeling and inhibition of SARS-COV-2 Papain-like protease enzyme: A potential therapeutic approach for COVID-19

Auwal, A. R., Baba, I. A., Hınçal, E., & Rihan, F. A. (2024) · Journal of Biosafety and Biosecurity · doi:10.1016/j.jobb.2024.07.001

Problems in the Diagnosis of Dysfunctions of the Olfactory Analyzer in Laboratory Animals Based on Behavioral and Electrophysiological Study Methods

Gorskaya, A., & Vasilev, D. S. (2024) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-024-01702-x

A survey of SARS-CoV-2 tropism

Jin, X., Ren, X., Ren, X., & Wang, J. (2025) · Infectious Diseases & Immunity · doi:10.1097/id9.0000000000000166

Poldip2 deficiency attenuates disease severity in a mouse model of COVID-19Preprint

Hu, R., Valdivia, A., White, T. E., Ju, W., Brockman, M. L., Zhang, Z., Qu, H., Gafford, G. M., Joseph, G., Burton, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.17.657579

A Multi-Antigen Broad-Spectrum Coronavirus Vaccine Induces Potent and Durable Cross- Protection Against Infection and Disease Caused by Multiple SARS-CoV-2 VariantsPreprint

Prakash, S., Dhanushkodi, N. R., Quadiri, A., Vahed, H., Chentoufi, A. A., Coulon, P.-G. A., Ibraim, I. C., Babsiri, A. E., Tifrea, D. F., Figueroa, C. J., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7208748/v1

Susceptibility of different mouse strains to SARS-CoV-2 spike receptor-binding domain protein-induced lung inflammation: a comparative study

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